{"id":"https://openalex.org/W2893743425","doi":"https://doi.org/10.1016/j.neuroscience.2018.09.014","title":"Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors","display_name":"Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors","publication_year":2018,"publication_date":"2018-09-22","ids":{"openalex":"https://openalex.org/W2893743425","doi":"https://doi.org/10.1016/j.neuroscience.2018.09.014","mag":"2893743425","pmid":"https://pubmed.ncbi.nlm.nih.gov/30248435"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2018.09.014","doi":"https://doi.org/10.1016/j.neuroscience.2018.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2018.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.neuroscience.2018.09.014","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022518220","display_name":"Ashley L. Russell","orcid":"https://orcid.org/0000-0003-1137-2769","observed_orcids":["https://orcid.org/0000-0003-1137-2769"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I4210139040","display_name":"Center for Neuroscience and Regenerative Medicine","ror":"https://ror.org/04dmgsx60","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210139040"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley L. Russell","raw_affiliation_strings":["Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I4210139040"]},{"raw_affiliation_string":"Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I4210139040"]},{"raw_affiliation_string":"Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042132328","display_name":"Robert J. Handa","orcid":"https://orcid.org/0000-0001-9131-2808","observed_orcids":["https://orcid.org/0000-0001-9131-2808"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Handa","raw_affiliation_strings":["Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046082760","display_name":"T. John Wu","orcid":"https://orcid.org/0000-0002-8274-0226","observed_orcids":["https://orcid.org/0000-0002-8274-0226"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I4210139040","display_name":"Center for Neuroscience and Regenerative Medicine","ror":"https://ror.org/04dmgsx60","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210139040"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. John Wu","raw_affiliation_strings":["Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: twu@usuhs.edu","Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: twu@usuhs.edu","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I4210139040"]},{"raw_affiliation_string":"Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I4210139040"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046082760"],"corresponding_institution_ids":["https://openalex.org/I148314036","https://openalex.org/I4210139040"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.1436,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.87160103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"392","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.20890000462532043,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.13339999318122864,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor-receptor-2","display_name":"CRFR2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor-receptor-1","display_name":"corticotropin-releasing hormone receptor 1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7480000257492065},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.996999979019165},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ventral-hippocampus","display_name":"ventral hippocampus","score":0.968999981880188},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9829999804496765},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.7599999904632568},{"id":"https://openalex.org/keywords/military-personnel","display_name":"military personnel","score":0.6259999871253967},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2778652331","wikidata":"https://www.wikidata.org/wiki/Q3122152","display_name":"Stria terminalis","level":3,"score":0.8534456491470337},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.7769374847412109},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7742109894752502},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5574759244918823},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5200405120849609},{"id":"https://openalex.org/C541082541","wikidata":"https://www.wikidata.org/wiki/Q192560","display_name":"Limbic system","level":3,"score":0.508449912071228},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.470855176448822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46364015340805054},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4139196574687958},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41212135553359985},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3974810838699341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29935696721076965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29917317628860474},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24317020177841187},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24002018570899963}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000099052","descriptor_name":"CRF Receptor, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroscience.2018.09.014","doi":"https://doi.org/10.1016/j.neuroscience.2018.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2018.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:30248435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30248435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroscience.2018.09.014","doi":"https://doi.org/10.1016/j.neuroscience.2018.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2018.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1907961579","display_name":null,"funder_award_id":"CNRM-85-3389","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W938644236","https://openalex.org/W1572525448","https://openalex.org/W1633118497","https://openalex.org/W1659705459","https://openalex.org/W1703928389","https://openalex.org/W1971994650","https://openalex.org/W1974570740","https://openalex.org/W1981069634","https://openalex.org/W1982804068","https://openalex.org/W1986576876","https://openalex.org/W1996743601","https://openalex.org/W1998821779","https://openalex.org/W2007696393","https://openalex.org/W2010047148","https://openalex.org/W2020098484","https://openalex.org/W2023694353","https://openalex.org/W2027246921","https://openalex.org/W2027953236","https://openalex.org/W2030900991","https://openalex.org/W2035240522","https://openalex.org/W2038662778","https://openalex.org/W2040829849","https://openalex.org/W2040975346","https://openalex.org/W2042431879","https://openalex.org/W2042940424","https://openalex.org/W2049638289","https://openalex.org/W2053152793","https://openalex.org/W2056884334","https://openalex.org/W2067003329","https://openalex.org/W2069281265","https://openalex.org/W2071801067","https://openalex.org/W2071967920","https://openalex.org/W2086642462","https://openalex.org/W2104969272","https://openalex.org/W2110664545","https://openalex.org/W2118238128","https://openalex.org/W2127054028","https://openalex.org/W2127482905","https://openalex.org/W2128066728","https://openalex.org/W2143629083","https://openalex.org/W2149971432","https://openalex.org/W2150941374","https://openalex.org/W2155194789","https://openalex.org/W2164292837","https://openalex.org/W2165304067","https://openalex.org/W2169828275","https://openalex.org/W2175205943","https://openalex.org/W2254443919","https://openalex.org/W2266819934","https://openalex.org/W2279922805","https://openalex.org/W2294380550","https://openalex.org/W2319758206","https://openalex.org/W2324677701","https://openalex.org/W2343079527","https://openalex.org/W2345917271","https://openalex.org/W2410015058","https://openalex.org/W2497164688","https://openalex.org/W2511496957","https://openalex.org/W2513863858","https://openalex.org/W2580492137","https://openalex.org/W2736091234","https://openalex.org/W2793612613","https://openalex.org/W2801172808","https://openalex.org/W3046000100"],"related_works":["https://openalex.org/W2898982907","https://openalex.org/W2801172808","https://openalex.org/W3208776668","https://openalex.org/W2754427319","https://openalex.org/W2944581482","https://openalex.org/W2473387389","https://openalex.org/W2056187403","https://openalex.org/W3089358209","https://openalex.org/W4283591832","https://openalex.org/W2345917271"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-05T00:00:00"}