{"id":"https://openalex.org/W2893554173","doi":"https://doi.org/10.1111/cen3.12475","title":"Neuroinflammation in mouse models of Alzheimer's disease","display_name":"Neuroinflammation in mouse models of Alzheimer's disease","publication_year":2018,"publication_date":"2018-09-23","ids":{"openalex":"https://openalex.org/W2893554173","doi":"https://doi.org/10.1111/cen3.12475","mag":"2893554173","pmid":"https://pubmed.ncbi.nlm.nih.gov/30546389","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6282739"},"language":"en","primary_location":{"id":"doi:10.1111/cen3.12475","doi":"https://doi.org/10.1111/cen3.12475","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cen3.12475","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen3.12475","source":{"id":"https://openalex.org/S25654872","display_name":"Clinical and Experimental Neuroimmunology","issn_l":"1759-1961","issn":["1759-1961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Neuroimmunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen3.12475","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013301564","display_name":"Takashi Saito","orcid":"https://orcid.org/0000-0002-9659-9251","observed_orcids":["https://orcid.org/0000-0002-9659-9251"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4405286286","display_name":"Research Institute of Environmental Medicine, Nagoya University","ror":"https://ror.org/01qvr7m20","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286286","https://openalex.org/I60134161"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Saito","raw_affiliation_strings":["Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Wako, Japan","RIKEN Center for Brain Science, Laboratory for Proteolytic Neuroscience, Wako, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9659-9251","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Wako, Japan","institution_ids":["https://openalex.org/I4405286286","https://openalex.org/I60134161"]},{"raw_affiliation_string":"RIKEN Center for Brain Science, Laboratory for Proteolytic Neuroscience, Wako, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023317571","display_name":"Takaomi C. Saido","orcid":"https://orcid.org/0000-0003-1970-6903","observed_orcids":["https://orcid.org/0000-0003-1970-6903"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takaomi C. Saido","raw_affiliation_strings":["RIKEN Center for Brain Science, Laboratory for Proteolytic Neuroscience, Wako, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1970-6903","affiliations":[{"raw_affiliation_string":"RIKEN Center for Brain Science, Laboratory for Proteolytic Neuroscience, Wako, Japan","institution_ids":["https://openalex.org/I2800939219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013301564","https://openalex.org/A5023317571"],"corresponding_institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4405286286","https://openalex.org/I60134161"],"apc_list":{"value":2710,"currency":"USD","value_usd":2710},"apc_paid":{"value":2710,"currency":"USD","value_usd":2710},"fwci":0.9601,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.71870794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"211","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6179999709129333},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.9200000166893005},{"id":"https://openalex.org/keywords/peripheral-inflammation","display_name":"peripheral inflammation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mouse-models-of-alzheimer-s-disease","display_name":"mouse models of Alzheimer's disease","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ad-pathogenesis","display_name":"AD pathogenesis","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8017288446426392},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.752737820148468},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7034899592399597},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6165133714675903},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5737625956535339},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4807131588459015},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45892149209976196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42696475982666016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26593947410583496},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2474883794784546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18909227848052979},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1111/cen3.12475","doi":"https://doi.org/10.1111/cen3.12475","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cen3.12475","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen3.12475","source":{"id":"https://openalex.org/S25654872","display_name":"Clinical and Experimental Neuroimmunology","issn_l":"1759-1961","issn":["1759-1961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Neuroimmunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5256265","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6282739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6282739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6282739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Neuroimmunol","raw_type":"Text"},{"id":"pmid:30546389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30546389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & experimental neuroimmunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cen3.12475","doi":"https://doi.org/10.1111/cen3.12475","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cen3.12475","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen3.12475","source":{"id":"https://openalex.org/S25654872","display_name":"Clinical and Experimental Neuroimmunology","issn_l":"1759-1961","issn":["1759-1961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Neuroimmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2022895025","display_name":"\u30cd\u30d7\u30ea\u30e9\u30a4\u30b7\u30f3\u6d3b\u6027\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u3068\u305d\u306e\u5fdc\u7528","funder_award_id":"18dm0107070h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4761992808","display_name":null,"funder_award_id":"JP18dm027001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7697529639","display_name":null,"funder_award_id":"26290019","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320309809","display_name":"Cell Science Research Foundation","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320338111","display_name":"Precursory Research for Embryonic Science and Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2893554173.pdf","grobid_xml":"https://content.openalex.org/works/W2893554173.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W207124143","https://openalex.org/W1597068157","https://openalex.org/W1764460837","https://openalex.org/W1951572307","https://openalex.org/W1967464880","https://openalex.org/W1968014528","https://openalex.org/W1971915082","https://openalex.org/W1972784541","https://openalex.org/W1993976394","https://openalex.org/W1995111570","https://openalex.org/W1998477180","https://openalex.org/W2001339909","https://openalex.org/W2001618696","https://openalex.org/W2004349171","https://openalex.org/W2016575029","https://openalex.org/W2021373355","https://openalex.org/W2047585900","https://openalex.org/W2049691960","https://openalex.org/W2052316972","https://openalex.org/W2057249855","https://openalex.org/W2061590643","https://openalex.org/W2068477037","https://openalex.org/W2082429191","https://openalex.org/W2083556882","https://openalex.org/W2088538089","https://openalex.org/W2088685810","https://openalex.org/W2090620788","https://openalex.org/W2093241348","https://openalex.org/W2110888808","https://openalex.org/W2117000810","https://openalex.org/W2117029190","https://openalex.org/W2150537556","https://openalex.org/W2160031422","https://openalex.org/W2160881303","https://openalex.org/W2161331700","https://openalex.org/W2164008528","https://openalex.org/W2164386968","https://openalex.org/W2164490896","https://openalex.org/W2171250577","https://openalex.org/W2190404250","https://openalex.org/W2208442878","https://openalex.org/W2329336071","https://openalex.org/W2399263775","https://openalex.org/W2460612985","https://openalex.org/W2508003049","https://openalex.org/W2521074193","https://openalex.org/W2537448032","https://openalex.org/W2563078526","https://openalex.org/W2572710398","https://openalex.org/W2626078173","https://openalex.org/W2727423291","https://openalex.org/W2731000069","https://openalex.org/W2740213823","https://openalex.org/W2755017474","https://openalex.org/W2765468584","https://openalex.org/W2769484728","https://openalex.org/W2771127066","https://openalex.org/W2773966647","https://openalex.org/W2777928756","https://openalex.org/W2779463443","https://openalex.org/W2782531296","https://openalex.org/W2784234930","https://openalex.org/W2791832923","https://openalex.org/W2793659354","https://openalex.org/W2793872352","https://openalex.org/W2794987222","https://openalex.org/W2802395419","https://openalex.org/W2805863706","https://openalex.org/W2807256450","https://openalex.org/W2808629492","https://openalex.org/W2851624943","https://openalex.org/W2988470961"],"related_works":["https://openalex.org/W3012229530","https://openalex.org/W2537448032","https://openalex.org/W3017070515","https://openalex.org/W4360828794","https://openalex.org/W7095192445","https://openalex.org/W2232520593","https://openalex.org/W3101159832","https://openalex.org/W4406049932","https://openalex.org/W4319924663","https://openalex.org/W2358666620"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,52,117],"(AD)":[2],"is":[3],"the":[4,22,32,43,51,77,81,108,123,132,140,163,174,212,215],"most":[5],"common":[6],"type":[7],"of":[8,31,45,50,66,76,87,113,125,134,158,165,214,217],"neurocognitive":[9],"disorder.":[10,192],"Although":[11],"both":[12,172],"amyloid":[13],"\u03b2":[14],"peptide":[15],"deposition":[16],"and":[17,84,130,204],"neurofibrillary":[18],"tangle":[19],"formation":[20],"in":[21,38,63,107,211],"AD":[23,46,91,126,143,166,185,202],"brain":[24,109,175],"have":[25,98],"been":[26],"established":[27],"as":[28,73,151,162,176,178,189],"pathological":[29],"hallmarks":[30],"disease,":[33],"many":[34,157],"other":[35],"factors":[36],"contribute":[37],"a":[39,64,111,152,190],"complex":[40],"manner":[41],"to":[42,61,127,138,149,155,170,186,197],"pathogenesis":[44,92,124,164,216],"before":[47],"clinical":[48],"symptoms":[49],"become":[53,182],"apparent.":[54],"Longitudinal":[55],"pathophysiological":[56],"processes":[57],"cause":[58],"patients'":[59],"brains":[60],"exist":[62],"state":[65],"chronic":[67],"neuroinflammation,":[68],"with":[69],"glial":[70,88,105,209],"cells":[71,106],"acting":[72],"key":[74,153],"regulators":[75],"neuroinflammatory":[78],"state.":[79],"However,":[80],"detailed":[82],"molecular":[83],"cellular":[85],"mechanisms":[86],"function":[89,210],"underlying":[90],"remain":[93],"elusive.":[94],"Furthermore,":[95,161],"recent":[96],"studies":[97],"shown":[99],"that":[100],"peripheral":[101],"inflammatory":[102],"conditions":[103,171],"affect":[104],"through":[110],"process":[112],"neuroimmune":[114],"communication.":[115],"Such":[116],"complexities":[118],"make":[119],"it":[120,180],"difficult":[121],"for":[122,184,207],"be":[128,168,187],"understood,":[129],"impede":[131],"development":[133],"effective":[135],"therapeutic":[136],"strategies":[137],"combat":[139],"disease.":[141],"Relevant":[142],"animal":[144],"models":[145],"are":[146],"thus":[147],"likely":[148],"serve":[150],"resource":[154],"overcome":[156],"these":[159],"issues.":[160],"might":[167,181],"linked":[169],"within":[173],"well":[177],"peripherally,":[179],"necessary":[183],"studied":[188],"whole-body":[191],"The":[193],"present":[194],"review":[195],"aimed":[196],"summarize":[198],"insights":[199],"regarding":[200],"current":[201],"research,":[203],"share":[205],"perspectives":[206],"understanding":[208],"context":[213],"AD.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-05T00:00:00"}
