{"id":"https://openalex.org/W2893375018","doi":"https://doi.org/10.1021/acschemneuro.8b00189","title":"Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-like PC12 Cells","display_name":"Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-like PC12 Cells","publication_year":2018,"publication_date":"2018-09-24","ids":{"openalex":"https://openalex.org/W2893375018","doi":"https://doi.org/10.1021/acschemneuro.8b00189","mag":"2893375018","pmid":"https://pubmed.ncbi.nlm.nih.gov/30247872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7583493"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.8b00189","doi":"https://doi.org/10.1021/acschemneuro.8b00189","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.8b00189","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7583493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084795451","display_name":"Andrew D. Chapp","orcid":"https://orcid.org/0000-0003-4457-1772","observed_orcids":["https://orcid.org/0000-0003-4457-1772"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Chapp","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":"https://orcid.org/0000-0003-4457-1772","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":"Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047123464","display_name":"Jessica E. Behnke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica E. Behnke","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069983134","display_name":"Kyle M. Driscoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle M. Driscoll","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582179","display_name":"Yuanyuan Fan","orcid":"https://orcid.org/0000-0002-2307-063X","observed_orcids":["https://orcid.org/0000-0002-2307-063X"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Fan","raw_affiliation_strings":["Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031799737","display_name":"Eileen Hoban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Hoban","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082321377","display_name":"Zhiying Jenny Shan","orcid":"https://orcid.org/0000-0002-9763-205X","observed_orcids":["https://orcid.org/0000-0002-9763-205X"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiying Shan","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":"Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051705892","display_name":"Qing\u2010Hui Chen","orcid":"https://orcid.org/0000-0002-1639-5292","observed_orcids":["https://orcid.org/0000-0002-1639-5292"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing-Hui Chen","raw_affiliation_strings":["Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":"Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051705892"],"corresponding_institution_ids":["https://openalex.org/I11957088"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7966,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.65181571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"235","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.7080000042915344},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8130000233650208},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.7590000033378601},{"id":"https://openalex.org/keywords/alcohol-related-brain-damage","display_name":"alcohol-related brain damage","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8260642290115356},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.7679156064987183},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.6131053566932678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5965334177017212},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5698559284210205},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5349318981170654},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5160626769065857},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.501317024230957},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49152788519859314},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43562179803848267},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4299575388431549},{"id":"https://openalex.org/C2777836312","wikidata":"https://www.wikidata.org/wiki/Q4386371","display_name":"Dizocilpine","level":4,"score":0.42261725664138794},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4179283380508423},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3857894837856293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33547672629356384},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.321499764919281},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2616782784461975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22235363721847534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.198712557554245},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.15982040762901306},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019346","descriptor_name":"Sodium Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acschemneuro.8b00189","doi":"https://doi.org/10.1021/acschemneuro.8b00189","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.8b00189","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmid:30247872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30247872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7583493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7583493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.mtu.edu:michigantech-p-1582","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.mtu.edu/michigantech-p/586","pdf_url":null,"source":{"id":"https://openalex.org/S4377196391","display_name":"Digital Commons - Michigan Tech (Michigan Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11957088","host_organization_name":"Michigan Technological University","host_organization_lineage":["https://openalex.org/I11957088"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Michigan Tech Publications, Part 1","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7583493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7583493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3194130361","display_name":"ER stress and reduced SK channel function in PVN in rats with high salt intake","funder_award_id":"R15HL122952","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5625601751","display_name":"Brain (Pro)renin Receptor and Sympathetic Activation in Salt Sensitive Hypertension","funder_award_id":"1r15hl129213-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5930087231","display_name":"Acetate as an Active Metabolite of Ethanol: Neural and Cardiovascular Implications","funder_award_id":"16PRE27780121","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G7795578305","display_name":"Neural Mechanism of Sympathetic Activation in Heart Failure","funder_award_id":"R15HL145655","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G965297717","display_name":null,"funder_award_id":"R15 HL129213","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1037983775","https://openalex.org/W1447824855","https://openalex.org/W1542332928","https://openalex.org/W1546298995","https://openalex.org/W1555529117","https://openalex.org/W1590640462","https://openalex.org/W1592971871","https://openalex.org/W1678311389","https://openalex.org/W1803760021","https://openalex.org/W1965654099","https://openalex.org/W1968084996","https://openalex.org/W1971330591","https://openalex.org/W1979523405","https://openalex.org/W1980306413","https://openalex.org/W1983724172","https://openalex.org/W1995217021","https://openalex.org/W1996039145","https://openalex.org/W1998804640","https://openalex.org/W2000963707","https://openalex.org/W2001725826","https://openalex.org/W2002664835","https://openalex.org/W2007437927","https://openalex.org/W2007734988","https://openalex.org/W2009227466","https://openalex.org/W2009962309","https://openalex.org/W2011270193","https://openalex.org/W2013960132","https://openalex.org/W2025514567","https://openalex.org/W2031144646","https://openalex.org/W2036840150","https://openalex.org/W2039252406","https://openalex.org/W2043076732","https://openalex.org/W2043819837","https://openalex.org/W2044635335","https://openalex.org/W2046597237","https://openalex.org/W2053204532","https://openalex.org/W2057478802","https://openalex.org/W2058045877","https://openalex.org/W2060199546","https://openalex.org/W2066165879","https://openalex.org/W2068253249","https://openalex.org/W2068397664","https://openalex.org/W2070079297","https://openalex.org/W2076598575","https://openalex.org/W2081765126","https://openalex.org/W2083399000","https://openalex.org/W2086562792","https://openalex.org/W2090785150","https://openalex.org/W2093840338","https://openalex.org/W2095405363","https://openalex.org/W2099540110","https://openalex.org/W2107402265","https://openalex.org/W2109794592","https://openalex.org/W2112929255","https://openalex.org/W2115358392","https://openalex.org/W2127125055","https://openalex.org/W2135104877","https://openalex.org/W2144215771","https://openalex.org/W2144957675","https://openalex.org/W2149845791","https://openalex.org/W2171351482","https://openalex.org/W2217747628","https://openalex.org/W2247733493","https://openalex.org/W2265901329","https://openalex.org/W2316833375","https://openalex.org/W2320244329","https://openalex.org/W2398263784","https://openalex.org/W2399296544","https://openalex.org/W2485966153","https://openalex.org/W2594658513","https://openalex.org/W2619419337","https://openalex.org/W4230119926","https://openalex.org/W4230208549","https://openalex.org/W4300592217"],"related_works":["https://openalex.org/W4389026023","https://openalex.org/W4389022213","https://openalex.org/W2794309262","https://openalex.org/W2183396468","https://openalex.org/W4360604244","https://openalex.org/W3177071926","https://openalex.org/W3044000231","https://openalex.org/W2148813323","https://openalex.org/W2604727721","https://openalex.org/W2025601212"],"abstract_inverted_index":{"Neuronal":[0],"excitotoxicity":[1],"is":[2,215],"the":[3,11,23,46,71,130,161,226],"major":[4],"cause":[5],"of":[6,25,45,55,61,73,132,181,191,196,217,225,248],"alcohol-related":[7],"brain":[8],"damage,":[9],"yet":[10],"underlying":[12],"mechanism":[13],"remains":[14],"poorly":[15],"understood.":[16],"Using":[17],"dopaminergic-like":[18],"PC12":[19,36,56],"cells,":[20],"we":[21],"evaluated":[22],"effect":[24],"N":[26],"-methyl-":[27],"d":[28],"-aspartate":[29],"receptors":[30],"(NMDAR)":[31],"on":[32],"acetate-induced":[33,207],"changes":[34,128],"in":[35,70,129,147,151,206],"cells:":[37],"cell":[38,78,92,208],"death,":[39],"cytosolic":[40,86,148,219],"calcium,":[41],"and":[42,85,107,115,200,222],"expression":[43,179,223],"levels":[44,180,224],"pro-inflammatory":[47,227],"cytokine":[48,228],"tumor":[49],"necrosis":[50],"factor":[51],"alpha":[52],"(TNF\u03b1).":[53],"Treatment":[54],"cells":[57,74,133,168],"with":[58,153,160,170],"increasing":[59,218],"concentrations":[60,221],"acetate":[62,104,171,197,214,237],"for":[63,77,103,113,118,136,174,251],"4":[64,175],"h":[65,176],"caused":[66,144],"a":[67],"dose-dependent":[68],"increase":[69,146],"percentage":[72],"staining":[75,134],"positive":[76,135],"death":[79,235],"using":[80,91],"propidium":[81],"iodide":[82],"(PI)":[83],"exclusion":[84],"reactive":[87],"oxygen":[88],"species":[89],"(ROS)":[90],"ROX":[93],"detection":[94],"analyzed":[95],"via":[96],"flow":[97],"cytometry.":[98],"The":[99],"EC":[100],"50":[101],"value":[102],"was":[105,156,187,238],"calculated":[106],"found":[108],"to":[109,122,184],"be":[110],"4.40":[111],"mM":[112,117,124],"PI":[114,137],"1.81":[116],"ROS.":[119,139],"Ethanol":[120],"up":[121],"100":[123],"had":[125,177,202],"no":[126,203],"apparent":[127,204],"percent":[131],"or":[138],"Acetate":[140],"(6":[141,172,198],"mM)":[142,173,199],"treatment":[143],"an":[145,231],"calcium":[149,220],"measured":[150],"real-time":[152],"Fluo-4AM,":[154],"which":[155,186],"abolished":[157,188],"by":[158,189],"coapplication":[159,190],"NMDAR":[162,242,249],"blocker":[163],"memantine":[164,192,201],"(10":[165,193],"\u03bcM).":[166,194],"Furthermore,":[167],"treated":[169],"increased":[178],"TNF\u03b1":[182,229],"relative":[183],"control,":[185],"Co-application":[195],"reduction":[205],"death.":[209],"These":[210],"findings":[211],"suggest":[212],"that":[213],"capable":[216],"through":[230,241],"NMDAR-dependent":[232],"mechanism.":[233],"Cell":[234],"from":[236],"not":[239],"reduced":[240],"blockade,":[243],"suggesting":[244],"alternative":[245],"pathways":[246],"independent":[247],"activation":[250],"excitotoxicity.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-05T00:00:00"}
