{"id":"https://openalex.org/W2893115477","doi":"https://doi.org/10.1021/acsbiomaterials.8b00714","title":"Characterization of Cell Damage and Proliferative Ability during and after Bioprinting","display_name":"Characterization of Cell Damage and Proliferative Ability during and after Bioprinting","publication_year":2018,"publication_date":"2018-09-24","ids":{"openalex":"https://openalex.org/W2893115477","doi":"https://doi.org/10.1021/acsbiomaterials.8b00714","mag":"2893115477","pmid":"https://pubmed.ncbi.nlm.nih.gov/33429605"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.8b00714","doi":"https://doi.org/10.1021/acsbiomaterials.8b00714","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00714","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032723509","display_name":"Liqun Ning","orcid":"https://orcid.org/0000-0002-3651-7410","observed_orcids":["https://orcid.org/0000-0002-3651-7410"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liqun Ning","raw_affiliation_strings":["Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3651-7410","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065651556","display_name":"Nicholas Betancourt","orcid":"https://orcid.org/0000-0002-9935-1788","observed_orcids":["https://orcid.org/0000-0002-9935-1788"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicholas Betancourt","raw_affiliation_strings":["Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111560642","display_name":"David J. Schreyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David J. Schreyer","raw_affiliation_strings":["Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OW3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OW3, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100696404","display_name":"Daniel Chen","orcid":"https://orcid.org/0000-0002-4716-549X","observed_orcids":["https://orcid.org/0000-0002-4716-549X"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Xiongbiao Chen","raw_affiliation_strings":["Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada","Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100696404"],"corresponding_institution_ids":["https://openalex.org/I32625721"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9677,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.92050316,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"11","first_page":"3906","last_page":"3918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioprinting","display_name":"bioprinting","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cell-damage","display_name":"cell damage","score":0.8799999952316284},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8500000238418579},{"id":"https://openalex.org/keywords/extensional-stress","display_name":"extensional stress","score":1.0},{"id":"https://openalex.org/keywords/process-induced-stress","display_name":"process-induced stress","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":1.0},{"id":"https://openalex.org/keywords/rheometer","display_name":"rheometer","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.6339859962463379},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.6257095336914062},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6116948127746582},{"id":"https://openalex.org/C96035792","wikidata":"https://www.wikidata.org/wiki/Q43606218","display_name":"Shear (geology)","level":2,"score":0.48261985182762146},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4775194227695465},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.452475905418396},{"id":"https://openalex.org/C196445361","wikidata":"https://www.wikidata.org/wiki/Q1424279","display_name":"Rheometer","level":3,"score":0.4488808512687683},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4325340688228607},{"id":"https://openalex.org/C136137745","wikidata":"https://www.wikidata.org/wiki/Q19515659","display_name":"Extensional definition","level":3,"score":0.41141799092292786},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3068634569644928},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.20583057403564453},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17079710960388184},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.08780643343925476},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C77928131","wikidata":"https://www.wikidata.org/wiki/Q193343","display_name":"Tectonics","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsbiomaterials.8b00714","doi":"https://doi.org/10.1021/acsbiomaterials.8b00714","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00714","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"pmid:33429605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33429605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1162470753","https://openalex.org/W1484951544","https://openalex.org/W1799879229","https://openalex.org/W1926427589","https://openalex.org/W1981741136","https://openalex.org/W1983720999","https://openalex.org/W1992218414","https://openalex.org/W1996795547","https://openalex.org/W1998402731","https://openalex.org/W2002940147","https://openalex.org/W2003187059","https://openalex.org/W2003495582","https://openalex.org/W2003878542","https://openalex.org/W2016058943","https://openalex.org/W2031541574","https://openalex.org/W2033446731","https://openalex.org/W2034407235","https://openalex.org/W2034722366","https://openalex.org/W2041692576","https://openalex.org/W2045047041","https://openalex.org/W2048644480","https://openalex.org/W2049769334","https://openalex.org/W2067516141","https://openalex.org/W2068149454","https://openalex.org/W2080883766","https://openalex.org/W2084610464","https://openalex.org/W2089457249","https://openalex.org/W2091893634","https://openalex.org/W2108596064","https://openalex.org/W2131899821","https://openalex.org/W2135633868","https://openalex.org/W2147936936","https://openalex.org/W2151587819","https://openalex.org/W2179255723","https://openalex.org/W2182678773","https://openalex.org/W2188090492","https://openalex.org/W2197557991","https://openalex.org/W2295454854","https://openalex.org/W2308034507","https://openalex.org/W2434780740","https://openalex.org/W2508326269","https://openalex.org/W2560714653","https://openalex.org/W2618007632","https://openalex.org/W2809346419","https://openalex.org/W4210439647"],"related_works":["https://openalex.org/W3162774097","https://openalex.org/W3049691363","https://openalex.org/W6964688616","https://openalex.org/W4288068477","https://openalex.org/W4381547350","https://openalex.org/W4391250373","https://openalex.org/W1983720999","https://openalex.org/W7207769177","https://openalex.org/W2806641818","https://openalex.org/W4416665892"],"abstract_inverted_index":{"When":[0],"a":[1,81,121],"biomaterial":[2],"solution":[3],"containing":[4],"living":[5],"cells":[6,12,129,219,253],"is":[7,106,132,140,162,201,215,261],"subject":[8],"to":[9,30,47,84,109,113,142,179,198,209,226],"bioprinting,":[10],"the":[11,40,49,58,68,71,88,118,123,135,144,165,168,173,183,192,203,228,237,240,247,255,264,268],"experience":[13],"process-induced":[14,22,124,205,269],"stresses,":[15],"including":[16],"shear":[17,52,94,114,125,151,180,211],"and":[18,27,37,86,95,134,172,212,220,233,249],"extensional":[19,61,96,160,187,196,213],"stresses.":[20],"These":[21],"stresses":[23,97,214],"breach":[24],"cell":[25,31,35,55,89,103,111,137,147,156,170,176,199,206,274],"membranes":[26],"can":[28],"lead":[29],"damage,":[32],"thus":[33],"reducing":[34],"viability":[36,248,275],"functioning":[38],"within":[39],"printed":[41],"constructs.":[42],"Studies":[43],"have":[44],"been":[45,64],"conducted":[46],"determine":[48],"influence":[50],"of":[51,60,75,146,175,186,239,252],"stress":[53,62,115,126,152,161,188,197],"on":[54,117],"damage;":[56],"however,":[57],"effect":[59],"has":[63],"typically":[65],"ignored":[66],"in":[67,98,130,153,243,254],"literature":[69],"until":[70],"recently":[72],"collected":[73],"evidence":[74],"its":[76],"importance.":[77],"This":[78],"paper":[79],"presents":[80],"novel":[82],"method":[83],"characterize":[85],"quantify":[87],"damage":[90,104,112,138,148,157,171,177,200,207],"caused":[91,149,158],"by":[92,128,150,159],"both":[93,210],"bioprinting.":[99,282],"In":[100],"this":[101,244],"method,":[102],"law":[105],"first":[107,256],"established":[108,136],"relate":[110],"based":[116],"experiments":[119],"with":[120,263],"rheometer;":[122],"experienced":[127],"bioprinting":[131,204,260],"represented,":[133],"model":[139,193],"applied":[141],"calculate":[143],"degree":[145],"bioprinting;":[154],"then":[155],"inferred":[163],"from":[164,189],"difference":[166],"between":[167,231],"total":[169],"amount":[174],"attributed":[178,208],"stress.":[181],"With":[182],"obtained":[184],"magnitude":[185],"fluidic":[190],"simulation,":[191],"that":[194,267],"relates":[195],"established;":[202],"therefore":[216],"presented.":[217],"Schwann":[218],"myoblasts":[221],"were":[222],"used":[223],"as":[224],"examples":[225],"validate":[227],"models.":[229],"Comparison":[230],"experimental":[232],"simulation":[234],"results":[235,265],"shows":[236],"effectiveness":[238],"models":[241],"presented":[242],"paper.":[245],"Moreover,":[246],"proliferative":[250,279],"ability":[251,280],"72":[257],"h":[258],"after":[259,281],"investigated,":[262],"illustrating":[266],"forces":[270],"affect":[271],"not":[272],"only":[273],"but":[276],"also":[277],"their":[278]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-05T00:00:00"}
