{"id":"https://openalex.org/W2893007486","doi":"https://doi.org/10.3205/16dkou624","title":"Eos-FP, a pH-sensitive recombinant fluorescent dye to monitor phagocytosis and digestion of pathogens in patients with trauma, systemic inflammation and sepsis and septic shock","display_name":"Eos-FP, a pH-sensitive recombinant fluorescent dye to monitor phagocytosis and digestion of pathogens in patients with trauma, systemic inflammation and sepsis and septic shock","publication_year":2016,"publication_date":"2016-10-10","ids":{"openalex":"https://openalex.org/W2893007486","doi":"https://doi.org/10.3205/16dkou624","mag":"2893007486"},"language":"en","primary_location":{"id":"pmh:oai:oai-gms.dimdi.de:GM16dkou624","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.3205/16dkou624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402251","display_name":"German Medical Science (German Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126796","host_organization_name":"German Heart Research Foundation","host_organization_lineage":["https://openalex.org/I4210126796"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutscher Kongress f\u00fcr Orthop\u00e4die und Unfallchirurgie (DKOU 2016);\\n 20161025-20161028;\\n Berlin;\\n \\n DOCPO18-1521\\n /20161010/\\n","raw_type":"conferenceObject"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doi.org/10.3205/16dkou624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082124714","display_name":"Rainer Hess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hess, Rainer","raw_affiliation_strings":["Uniklinik Ulm, Sektion Experimentelle An\u00e4sthesie, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Sektion Experimentelle An\u00e4sthesie, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005777328","display_name":"Leonhard Schreiner","orcid":"https://orcid.org/0009-0004-3272-6866","observed_orcids":["https://orcid.org/0009-0004-3272-6866"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Schreiner, Leonhard","raw_affiliation_strings":["Uniklinik Ulm, Sektion Experimentelle An\u00e4sthesie, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Sektion Experimentelle An\u00e4sthesie, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Schneider, Julian M.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Schneider, Julian M.","raw_affiliation_strings":["Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089980419","display_name":"Laura Mettke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mettke, Laura","raw_affiliation_strings":["Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024003678","display_name":"Markus Stefan Huber-Lang","orcid":"https://orcid.org/0000-0003-2359-6516","observed_orcids":["https://orcid.org/0000-0003-2359-6516"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Huber-Lang, Markus","raw_affiliation_strings":["Uniklinik Ulm, Klinik f\u00fcr Chirurgie III, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Klinik f\u00fcr Chirurgie III, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110851296","display_name":"Stephan Paschke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paschke, Stephan","raw_affiliation_strings":["Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Ulm, Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28778843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-fluorescent-dye","display_name":"pH-sensitive fluorescent dye","score":0.9610000252723694},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/granulocyte-function","display_name":"granulocyte function","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.996999979019165},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.9309999942779541},{"id":"https://openalex.org/keywords/secondary-infection","display_name":"secondary infection","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8341153264045715},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7577556371688843},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7526806592941284},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5795544981956482},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.48378250002861023},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.47124582529067993},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.465717077255249},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4481356739997864},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4439904987812042},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41503986716270447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38486790657043457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3739771842956543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26445814967155457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15198737382888794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12816259264945984},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09496051073074341},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oai-gms.dimdi.de:GM16dkou624","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.3205/16dkou624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402251","display_name":"German Medical Science (German Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126796","host_organization_name":"German Heart Research Foundation","host_organization_lineage":["https://openalex.org/I4210126796"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutscher Kongress f\u00fcr Orthop\u00e4die und Unfallchirurgie (DKOU 2016);\\n 20161025-20161028;\\n Berlin;\\n \\n DOCPO18-1521\\n /20161010/\\n","raw_type":"conferenceObject"},{"id":"doi:10.3205/16dkou624","doi":"https://doi.org/10.3205/16dkou624","is_oa":true,"landing_page_url":"https://doi.org/10.3205/16dkou624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402251","display_name":"German Medical Science (German Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126796","host_organization_name":"German Heart Research Foundation","host_organization_lineage":["https://openalex.org/I4210126796"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:oai-gms.dimdi.de:GM16dkou624","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.3205/16dkou624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402251","display_name":"German Medical Science (German Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126796","host_organization_name":"German Heart Research Foundation","host_organization_lineage":["https://openalex.org/I4210126796"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutscher Kongress f\u00fcr Orthop\u00e4die und Unfallchirurgie (DKOU 2016);\\n 20161025-20161028;\\n Berlin;\\n \\n DOCPO18-1521\\n /20161010/\\n","raw_type":"conferenceObject"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081630054","https://openalex.org/W2075992805","https://openalex.org/W2079298368","https://openalex.org/W2793664464","https://openalex.org/W2048523247","https://openalex.org/W2887357835","https://openalex.org/W7034583017","https://openalex.org/W2463806950","https://openalex.org/W2296546985","https://openalex.org/W2022715156"],"abstract_inverted_index":{"Objectives:":[0],"The":[1],"function":[2],"of":[3,7],"phagocytic":[4],"cells":[5],"is":[6],"crucial":[8],"importance":[9],"to":[10,20,37,47],"i)":[11],"ingest":[12],"and":[13,18,29],"degrade":[14],"the":[15,22,48],"infectious":[16],"agent,":[17],"ii)":[19],"sensitize":[21],"host":[23],"against":[24],"secondary":[25],"infections.":[26],"Measuring":[27],"phagocytosis":[28],"oxygen":[30],"radical":[31],"formation":[32],"has":[33],"long":[34],"been":[35],"accepted":[36],"monitor":[38],"granulocyte":[39],"function.":[40],"Thus":[41],"chemiluminescence[for":[42],"full":[43],"text,":[44],"please":[45],"go":[46],"a.m.":[49],"URL]":[50]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2018-10-05T00:00:00"}