{"id":"https://openalex.org/W2892375665","doi":null,"title":"Heterogeneity of excitatory synapses in parvalbumin interneurons","display_name":"Heterogeneity of excitatory synapses in parvalbumin interneurons","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2892375665","mag":"2892375665"},"language":"fi","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt4pq5n63p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4pq5n63p","pdf_url":"https://escholarship.org/uc/item/4pq5n63p","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/4pq5n63p","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009971384","display_name":"Laura Sancho","orcid":"https://orcid.org/0000-0003-0889-1031","observed_orcids":["https://orcid.org/0000-0003-0889-1031"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura Sancho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0889-1031","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009971384"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvalbumin-positive-interneurons","display_name":"parvalbumin interneurons","score":0.9769999980926514},{"id":"https://openalex.org/keywords/excitatory-synapses","display_name":"excitatory synapses","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.8149999976158142},{"id":"https://openalex.org/keywords/calcium-permeable-ampa-receptors","display_name":"calcium-permeable AMPA receptors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7379999756813049},{"id":"https://openalex.org/keywords/action-potential-timing","display_name":"action potential timing","score":0.6850000023841858},{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.9240000247955322},{"id":"https://openalex.org/keywords/synaptic-heterogeneity","display_name":"synaptic heterogeneity","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8014650344848633},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7551063299179077},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.7041422724723816},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.6452325582504272},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.6184201836585999},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5838481187820435},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.5678266286849976},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.5547385215759277},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5467925071716309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5057661533355713},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.4902358651161194},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4728800654411316},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.43152499198913574},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.1893620491027832},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1882152557373047},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.11042383313179016},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt4pq5n63p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4pq5n63p","pdf_url":"https://escholarship.org/uc/item/4pq5n63p","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt4pq5n63p","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/4pq5n63p","pdf_url":"http://www.escholarship.org/uc/item/4pq5n63p","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sancho, Laura. (2018). Heterogeneity of excitatory synapses in parvalbumin interneurons. UC San Diego: Neurosciences. Retrieved from: http://www.escholarship.org/uc/item/4pq5n63p","raw_type":"dissertation"},{"id":"mag:2892375665","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt4pq5n63p/qt4pq5n63p.pdf?t=pf1meb","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt4pq5n63p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4pq5n63p","pdf_url":"https://escholarship.org/uc/item/4pq5n63p","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2892375665.pdf","grobid_xml":"https://content.openalex.org/works/W2892375665.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W1507804974","https://openalex.org/W1516250632","https://openalex.org/W1530683023","https://openalex.org/W1560661705","https://openalex.org/W1574935607","https://openalex.org/W1592130608","https://openalex.org/W1597375909","https://openalex.org/W1599788775","https://openalex.org/W1944155217","https://openalex.org/W1964945221","https://openalex.org/W1965377078","https://openalex.org/W1966698297","https://openalex.org/W1970690750","https://openalex.org/W1971347175","https://openalex.org/W1971547287","https://openalex.org/W1972815737","https://openalex.org/W1974916659","https://openalex.org/W1975255652","https://openalex.org/W1976177936","https://openalex.org/W1976229146","https://openalex.org/W1977850041","https://openalex.org/W1979009696","https://openalex.org/W1982785464","https://openalex.org/W1986246844","https://openalex.org/W1986435945","https://openalex.org/W1988358598","https://openalex.org/W1990501032","https://openalex.org/W1991272982","https://openalex.org/W1993222366","https://openalex.org/W1996051526","https://openalex.org/W1997862361","https://openalex.org/W2000053474","https://openalex.org/W2006214613","https://openalex.org/W2006969689","https://openalex.org/W2008795575","https://openalex.org/W2009759904","https://openalex.org/W2013115334","https://openalex.org/W2013644564","https://openalex.org/W2015062907","https://openalex.org/W2018554421","https://openalex.org/W2021235911","https://openalex.org/W2022286642","https://openalex.org/W2022833815","https://openalex.org/W2023130009","https://openalex.org/W2024776216","https://openalex.org/W2027205525","https://openalex.org/W2028363992","https://openalex.org/W2029919762","https://openalex.org/W2032008843","https://openalex.org/W2034965090","https://openalex.org/W2038605015","https://openalex.org/W2039746020","https://openalex.org/W2039789498","https://openalex.org/W2040879146","https://openalex.org/W2041373424","https://openalex.org/W2043166209","https://openalex.org/W2043212816","https://openalex.org/W2046033738","https://openalex.org/W2046503384","https://openalex.org/W2046924947","https://openalex.org/W2049517487","https://openalex.org/W2051378734","https://openalex.org/W2051493425","https://openalex.org/W2053980736","https://openalex.org/W2059334396","https://openalex.org/W2059890547","https://openalex.org/W2059918991","https://openalex.org/W2061469173","https://openalex.org/W2061960110","https://openalex.org/W2065527300","https://openalex.org/W2065582606","https://openalex.org/W2066507838","https://openalex.org/W2067853970","https://openalex.org/W2068904459","https://openalex.org/W2070264536","https://openalex.org/W2071318481","https://openalex.org/W2072652550","https://openalex.org/W2072969178","https://openalex.org/W2076936216","https://openalex.org/W2077208091","https://openalex.org/W2077458610","https://openalex.org/W2082628782","https://openalex.org/W2082642969","https://openalex.org/W2084328300","https://openalex.org/W2085402579","https://openalex.org/W2091187766","https://openalex.org/W2091980908","https://openalex.org/W2092348167","https://openalex.org/W2092445728","https://openalex.org/W2093573816","https://openalex.org/W2096006516","https://openalex.org/W2100171700","https://openalex.org/W2100438317","https://openalex.org/W2105805026","https://openalex.org/W2106257834","https://openalex.org/W2106389606","https://openalex.org/W2106414999","https://openalex.org/W2109399781","https://openalex.org/W2109779479","https://openalex.org/W2110014634","https://openalex.org/W2115624750","https://openalex.org/W2116635659","https://openalex.org/W2120809634","https://openalex.org/W2121071682","https://openalex.org/W2121446334","https://openalex.org/W2122623728","https://openalex.org/W2124683806","https://openalex.org/W2125926448","https://openalex.org/W2126890658","https://openalex.org/W2133850147","https://openalex.org/W2135998787","https://openalex.org/W2136008443","https://openalex.org/W2137689860","https://openalex.org/W2139828787","https://openalex.org/W2145085279","https://openalex.org/W2145504425","https://openalex.org/W2145935269","https://openalex.org/W2146521940","https://openalex.org/W2146655366","https://openalex.org/W2149246533","https://openalex.org/W2149561999","https://openalex.org/W2160819536","https://openalex.org/W2161713570","https://openalex.org/W2163982179","https://openalex.org/W2166572577","https://openalex.org/W2176995869","https://openalex.org/W2177855681","https://openalex.org/W2286046377","https://openalex.org/W2317883772","https://openalex.org/W2330756578","https://openalex.org/W2331925520","https://openalex.org/W2335913578","https://openalex.org/W2345447579","https://openalex.org/W2401943522","https://openalex.org/W2406725268","https://openalex.org/W2521563432","https://openalex.org/W2560111916","https://openalex.org/W2623753023","https://openalex.org/W2727054874","https://openalex.org/W2739648918","https://openalex.org/W2740983034","https://openalex.org/W2751530999","https://openalex.org/W4298196678","https://openalex.org/W6983794798","https://openalex.org/W7098488779","https://openalex.org/W7214220836"],"related_works":["https://openalex.org/W2888271572","https://openalex.org/W2161713570","https://openalex.org/W4366997966","https://openalex.org/W2157867129","https://openalex.org/W2126890658","https://openalex.org/W2017706994","https://openalex.org/W2954787410","https://openalex.org/W2132570740","https://openalex.org/W2041502078","https://openalex.org/W1798313689"],"abstract_inverted_index":{"Glutamatergic":[0],"excitatory":[1],"synapses":[2,16,96,116,150],"are":[3,27,107,117,151,178,187],"one":[4],"of":[5,9,23,66,85,126,144,183,192],"the":[6,10,63,74,123,127,142,161,181,184,190],"main":[7],"currencies":[8],"mammalian":[11],"central":[12],"nervous":[13],"system.":[14],"Excitatory":[15],"have":[17,46,81],"been":[18,47],"most":[19],"well-characterized":[20],"in":[21,50,73,160,189],"terms":[22],"dendritic":[24,95,136],"spines,":[25],"which":[26],"small":[28],"membranous":[29],"protrusions.":[30],"Dendritic":[31],"spines":[32,86,175],"influence":[33],"synapse":[34],"function":[35],"by":[36,141,180],"boosting":[37],"synaptic":[38],"potentials":[39,146],"and":[40,94,100,176],"sequestering":[41],"synaptically-generated":[42],"second":[43],"messengers.":[44],"Spines":[45],"extensively":[48],"studied":[49],"densely":[51],"spiny":[52,68],"principal":[53],"neurons,":[54],"but":[55,105,156],"little":[56],"is":[57,138],"known":[58],"about":[59],"how":[60],"they":[61,186],"expand":[62],"information-gathering":[64],"capabilities":[65],"sparsely":[67],"interneurons":[69],"(INs).":[70],"We":[71],"find":[72],"mouse":[75],"primary":[76],"visual":[77],"cortex,":[78],"parvalbumin-positive":[79],"INs":[80],"a":[82],"low":[83],"density":[84],"that":[87],"enclose":[88],"functional":[89],"glutamatergic":[90],"synapses.":[91,111],"Both":[92],"spine":[93,110,115,149,166],"contain":[97],"calcium-permeable":[98],"AMPA":[99],"NMDA":[101],"receptors":[102,173],"(CP-AMPARs,":[103],"NMDARs),":[104],"NMDARs":[106],"enriched":[108],"at":[109,134],"Despite":[112],"these":[113],"similarities,":[114],"embued":[118],"with":[119],"distinct":[120],"sensitivities":[121],"to":[122,154],"ongoing":[124],"activity":[125,158,182,194],"neuron.":[128],"Glutamate":[129],"receptor-mediated":[130],"calcium":[131],"(Ca)":[132],"influx":[133],"proximal":[135],"sites":[137],"bi-directionally":[139],"modulated":[140,179],"timing":[143],"action":[145],"(APs).":[147],"Surprisingly,":[148],"largely":[152],"insensitive":[153],"APs":[155],"coincident":[157,193],"originating":[159],"adjacent":[162],"dendrite":[163],"strongly":[164],"influences":[165],"NMDAR-mediated":[167],"Ca":[168],"influx.":[169],"Thus,":[170],"while":[171],"glutamate":[172],"on":[174],"dendrites":[177],"neuron,":[185],"distinctive":[188],"type":[191],"detected.":[195]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-27T00:00:00"}