{"id":"https://openalex.org/W2892358097","doi":"https://doi.org/10.21873/anticanres.12537","title":"Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)","display_name":"Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)","publication_year":2018,"publication_date":"2018-05-02","ids":{"openalex":"https://openalex.org/W2892358097","doi":"https://doi.org/10.21873/anticanres.12537","mag":"2892358097","pmid":"https://pubmed.ncbi.nlm.nih.gov/29715115"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.12537","doi":"https://doi.org/10.21873/anticanres.12537","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.12537","pdf_url":"https://ar.iiarjournals.org/content/anticanres/38/5/2903.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ar.iiarjournals.org/content/anticanres/38/5/2903.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064877484","display_name":"Daniel Almquist","orcid":"https://orcid.org/0000-0002-2541-0685","observed_orcids":["https://orcid.org/0000-0002-2541-0685"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DANIEL ALMQUIST","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha, NE, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha, NE, U.S.A","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112683526","display_name":"Nabin Khanal","orcid":"https://orcid.org/0009-0008-9590-9319","observed_orcids":["https://orcid.org/0009-0008-9590-9319"]},"institutions":[{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NABIN KHANAL","raw_affiliation_strings":["Creighton University Medical Center, Omaha, NE, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University Medical Center, Omaha, NE, U.S.A","institution_ids":["https://openalex.org/I2800482329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073881520","display_name":"Lynette Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LYNETTE SMITH","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha, NE, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha, NE, U.S.A","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024497224","display_name":"Apar Kishor Ganti","orcid":"https://orcid.org/0000-0003-3724-2671","observed_orcids":["https://orcid.org/0000-0003-3724-2671"]},"institutions":[{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"APAR KISHOR GANTI","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha, NE, U.S.A. aganti@unmc.edu","Veterans Affairs Nebraska-Western Iowa Health Care System, University of Nebraska Medical Center, Omaha, NE, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha, NE, U.S.A. aganti@unmc.edu","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Veterans Affairs Nebraska-Western Iowa Health Care System, University of Nebraska Medical Center, Omaha, NE, U.S.A","institution_ids":["https://openalex.org/I4210155874","https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2994,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.80856635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"38","issue":"5","first_page":"2903","last_page":"2907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/early-stage-lung-cancer","display_name":"early-stage lung cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lobectomy","display_name":"lobectomy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.859000027179718},{"id":"https://openalex.org/keywords/diffusing-capacity-for-carbon-monoxide","display_name":"diffusing capacity for carbon monoxide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9020000100135803},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.9959999918937683},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.871999979019165},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7885864973068237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7157059907913208},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.6293150782585144},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5674980282783508},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5597513914108276},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5082919001579285},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4662432074546814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46273431181907654},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4474138617515564},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3609763979911804},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3409556448459625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12119132280349731},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011013","descriptor_name":"Pneumonectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.12537","doi":"https://doi.org/10.21873/anticanres.12537","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.12537","pdf_url":"https://ar.iiarjournals.org/content/anticanres/38/5/2903.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:29715115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29715115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.12537","doi":"https://doi.org/10.21873/anticanres.12537","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.12537","pdf_url":"https://ar.iiarjournals.org/content/anticanres/38/5/2903.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2892358097.pdf","grobid_xml":"https://content.openalex.org/works/W2892358097.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1517652155","https://openalex.org/W1586553111","https://openalex.org/W1984354998","https://openalex.org/W2008036272","https://openalex.org/W2023685666","https://openalex.org/W2035207446","https://openalex.org/W2044466923","https://openalex.org/W2054841768","https://openalex.org/W2065551973","https://openalex.org/W2079566109","https://openalex.org/W2102832251","https://openalex.org/W2158294624","https://openalex.org/W2767522521","https://openalex.org/W6816763534"],"related_works":["https://openalex.org/W3216997987","https://openalex.org/W2375834813","https://openalex.org/W2099694563","https://openalex.org/W2314850269","https://openalex.org/W1517652155","https://openalex.org/W2050020987","https://openalex.org/W2106304024","https://openalex.org/W2045335572","https://openalex.org/W2896945515","https://openalex.org/W2279285757"],"abstract_inverted_index":{"BACKGROUND:":[0],"Preoperative":[1,234],"pulmonary":[2],"function":[3],"tests":[4],"(PFTs)":[5],"predict":[6,218,238,247],"operative":[7],"morbidity":[8],"and":[9,29,62,71,87,98,124],"mortality":[10],"after":[11],"resection":[12,55],"in":[13,25,77],"lung":[14,33],"cancer.":[15],"However,":[16],"the":[17,119,135,144],"impact":[18],"of":[19,49,121,126,137,143,166,191,205,227,229],"preoperative":[20],"PFTs":[21,73,107,215,223,235],"on":[22,134,211],"overall":[23,110],"outcomes":[24],"surgically-resected":[26],"stage":[27,60,160],"I":[28,61,161],"II":[30,63],"non-small":[31],"cell":[32,184],"cancer":[34],"(NSCLC)":[35],"has":[36],"not":[37,217,237],"been":[38],"well":[39],"studied.":[40],"PATIENTS":[41],"AND":[42],"METHODS:":[43],"This":[44],"is":[45],"a":[46,66,169,202],"retrospective":[47],"study":[48],"149":[50],"patients":[51,167,193],"who":[52],"underwent":[53,168],"surgical":[54],"as":[56],"first-line":[57],"treatment":[58],"for":[59,109,219,239,248],"NSCLC":[64,162],"at":[65],"single":[67],"center":[68],"between":[69],"2003":[70],"2014.":[72],"[forced":[74],"expiratory":[75],"volume":[76],"1":[78],"sec":[79],"(FEV1),":[80],"Diffusing":[81],"Capacity":[82],"(DLCO)],":[83],"both":[84],"absolute":[85],"values":[86,90],"percent":[88],"predicted":[89,108],"were":[91,102,224],"categorized":[92],"into":[93],"quartiles.":[94],"The":[95,140,149,164,173,188],"Kaplan-Meier":[96],"method":[97],"Cox":[99],"regression":[100,114],"analysis":[101],"used":[103,116],"to":[104,117,200],"determine":[105],"whether":[106],"survival":[111,240],"(OS).":[112],"Logistic":[113],"was":[115,146,151,177,194,198],"estimate":[118],"risk":[120],"postoperative":[122,220],"complications":[123],"length":[125,228],"stay":[127,230,251],"(LOS)":[128],"greater":[129],"than":[130],"10":[131],"days":[132],"based":[133],"results":[136],"PFTs.":[138],"RESULTS:":[139],"median":[141,189],"age":[142],"cohort":[145,150],"68":[147],"years.":[148],"predominantly":[152],"males":[153],"(98.6%),":[154],"current":[155],"or":[156],"ex-smokers":[157],"(98%),":[158],"with":[159],"(82.76%).":[163],"majority":[165],"lobectomy":[170],"(n=121,":[171],"81.21%).":[172],"predominant":[174],"tumor":[175],"histology":[176],"adenocarcinoma":[178],"(n=70,":[179],"47%)":[180],"followed":[181],"by":[182],"squamous":[183],"carcinoma":[185],"(n=61,":[186],"41%).":[187],"follow-up":[190],"surviving":[192],"53.2":[195],"months.":[196],"DLCO":[197],"found":[199],"be":[201],"significant":[203,225],"predictor":[204],"OS":[206],"(HR=0.93,":[207],"95%":[208],"CI=0.87-0.99;":[209],"p=0.03)":[210],"univariate":[212],"analysis.":[213],"Although":[214],"did":[216,236,246],"complications,":[221],"worse":[222],"predictors":[226],">10":[231],"days.":[232],"CONCLUSION:":[233],"from":[241],"resected":[242],"early-stage":[243],"NSCLC,":[244],"but":[245],"prolonged":[249],"hospital":[250],"following":[252],"surgery.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-27T00:00:00"}