{"id":"https://openalex.org/W2892294553","doi":"https://doi.org/10.1093/protein/gzy015","title":"A novel dual-cytokine\u2013antibody fusion protein for the treatment of CD38-positive malignancies","display_name":"A novel dual-cytokine\u2013antibody fusion protein for the treatment of CD38-positive malignancies","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2892294553","doi":"https://doi.org/10.1093/protein/gzy015","mag":"2892294553","pmid":"https://pubmed.ncbi.nlm.nih.gov/29982719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6157721"},"language":"en","primary_location":{"id":"doi:10.1093/protein/gzy015","doi":"https://doi.org/10.1093/protein/gzy015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzy015","pdf_url":"https://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering, Design and Selection","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041586621","display_name":"Roberto De Luca","orcid":"https://orcid.org/0000-0001-7519-8689","observed_orcids":["https://orcid.org/0000-0001-7519-8689"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roberto De Luca","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Vladimir-Prelog-Weg 4, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7519-8689","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Vladimir-Prelog-Weg 4, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012660985","display_name":"Paul Kachel","orcid":"https://orcid.org/0000-0002-9021-5309","observed_orcids":["https://orcid.org/0000-0002-9021-5309"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paul Kachel","raw_affiliation_strings":["Department of Hematology, University Hospital and University of Zurich, R\u00e4mistrasse 100, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital and University of Zurich, R\u00e4mistrasse 100, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002696803","display_name":"Klara Kropiv\u0161ek","orcid":"https://orcid.org/0000-0003-1866-4094","observed_orcids":["https://orcid.org/0000-0003-1866-4094"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Klara Kropivsek","raw_affiliation_strings":["Department of Biology, Institute of Molecular System Biology, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Auguste-Piccard-Hof 1, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Institute of Molecular System Biology, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Auguste-Piccard-Hof 1, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046176713","display_name":"Berend Snijder","orcid":"https://orcid.org/0000-0003-3386-6583","observed_orcids":["https://orcid.org/0000-0003-3386-6583"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Berend Snijder","raw_affiliation_strings":["Department of Biology, Institute of Molecular System Biology, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Auguste-Piccard-Hof 1, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Institute of Molecular System Biology, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Auguste-Piccard-Hof 1, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008095018","display_name":"Markus Gabriel Manz","orcid":"https://orcid.org/0000-0002-4676-7931","observed_orcids":["https://orcid.org/0000-0002-4676-7931"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Markus G Manz","raw_affiliation_strings":["Department of Hematology, University Hospital and University of Zurich, R\u00e4mistrasse 100, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital and University of Zurich, R\u00e4mistrasse 100, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020168745","display_name":"Dario Neri","orcid":"https://orcid.org/0000-0001-5234-7370","observed_orcids":["https://orcid.org/0000-0001-5234-7370"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Dario Neri","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Vladimir-Prelog-Weg 4, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Z\u00fcrich), Vladimir-Prelog-Weg 4, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020168745"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":{"value":4656,"currency":"USD","value_usd":4656},"apc_paid":null,"fwci":0.6223,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.60897863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"31","issue":"5","first_page":"173","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.7789999842643738},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9480000138282776},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.7409999966621399},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/antibody-fusion-proteins","display_name":"antibody fusion proteins","score":0.7940000295639038},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.5870000123977661},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.8299711346626282},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.6973767280578613},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5974149703979492},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5918729901313782},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5645294189453125},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.558068037033081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4695841670036316},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4627217650413513},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.46054571866989136},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.43289411067962646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33727216720581055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.326588898897171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3218006491661072},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.16190817952156067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15554413199424744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0763009786605835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051997","descriptor_name":"ADP-ribosyl Cyclase 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051997","descriptor_name":"ADP-ribosyl Cyclase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1093/protein/gzy015","doi":"https://doi.org/10.1093/protein/gzy015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzy015","pdf_url":"https://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering, Design and Selection","raw_type":"journal-article"},{"id":"pmid:29982719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29982719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein engineering, design & selection : PEDS","raw_type":"Journal Article"},{"id":"pmh:oai:repozitorij.ung.si:IzpisGradiva.php?id=9467","doi":null,"is_oa":false,"landing_page_url":"https://repozitorij.ung.si/IzpisGradiva.php?id=9467","pdf_url":null,"source":{"id":"https://openalex.org/S7407055115","display_name":"RUNG","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1741-0126","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:5157115","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6157721","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6157721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6157721/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Protein Eng Des Sel","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/300630","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/300630","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Engineering, Design & Selection, 31 (5)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:153322","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/153322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"De Luca, Roberto; Kachel, Paul; Kropivsek, Klara; Snijder, Berend; Manz, Markus G; Neri, Dario (2018). A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies. Protein Engineering, Design & Selection, 31(5):173-179.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/143345","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/143345","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"De Luca, R., Kachel, P., Kropivsek, K., Snijder, B., Manz, M. G., & Neri, D. (2018). A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies. Protein Engineering, Design & Selection, 31, 173\u2013179. https://doi.org/10.1093/protein/gzy015","raw_type":"Journal Article"},{"id":"doi:10.3929/ethz-b-000300630","doi":"https://doi.org/10.3929/ethz-b-000300630","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000300630","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/protein/gzy015","doi":"https://doi.org/10.1093/protein/gzy015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzy015","pdf_url":"https://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering, Design and Selection","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4500704790","display_name":"Understanding and Exploiting the Molecular Targeting of Tumor Neo-vasculature","funder_award_id":"163479","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320320998","display_name":"Kommission f\u00fcr Technologie und Innovation","ror":"https://ror.org/012y9zp98"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2892294553.pdf","grobid_xml":"https://content.openalex.org/works/W2892294553.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W269359229","https://openalex.org/W1871005600","https://openalex.org/W1902692042","https://openalex.org/W1967008538","https://openalex.org/W1979578972","https://openalex.org/W1992443497","https://openalex.org/W2010552629","https://openalex.org/W2025229648","https://openalex.org/W2025309900","https://openalex.org/W2033577259","https://openalex.org/W2038512117","https://openalex.org/W2043944189","https://openalex.org/W2045927984","https://openalex.org/W2047351266","https://openalex.org/W2086416870","https://openalex.org/W2094445639","https://openalex.org/W2097690999","https://openalex.org/W2105441981","https://openalex.org/W2120529614","https://openalex.org/W2141502099","https://openalex.org/W2152548352","https://openalex.org/W2153875966","https://openalex.org/W2156037313","https://openalex.org/W2158616782","https://openalex.org/W2160088903","https://openalex.org/W2182681254","https://openalex.org/W2237119306","https://openalex.org/W2310716991","https://openalex.org/W2331621530","https://openalex.org/W2339658711","https://openalex.org/W2476500971","https://openalex.org/W2512106959","https://openalex.org/W2519440960","https://openalex.org/W2526225966","https://openalex.org/W2526792170","https://openalex.org/W2528329272","https://openalex.org/W2568399389","https://openalex.org/W2608694784","https://openalex.org/W2735962215","https://openalex.org/W2741083064","https://openalex.org/W2772566228","https://openalex.org/W2781388087","https://openalex.org/W2793698281","https://openalex.org/W4232326942"],"related_works":["https://openalex.org/W2903642090","https://openalex.org/W4400014968","https://openalex.org/W2055360721","https://openalex.org/W4313238144","https://openalex.org/W2531501303","https://openalex.org/W2979567113","https://openalex.org/W4362592476","https://openalex.org/W4387477744","https://openalex.org/W3193730623","https://openalex.org/W3083502878"],"abstract_inverted_index":{"A":[0],"novel":[1,48],"dual-cytokine-antibody":[2],"fusion":[3,49],"protein,":[4,50],"consisting":[5],"of":[6,20,65,81,105,117,122],"an":[7],"antibody":[8],"directed":[9],"against":[10],"CD38":[11],"[a":[12],"tumor-associated":[13],"antigen":[14,60],"mainly":[15],"expressed":[16,42,61],"on":[17,62],"the":[18,63,78,102,120],"surface":[19,64],"multiple":[21],"myeloma":[22],"(MM)":[23],"cells],":[24],"simultaneously":[25],"fused":[26],"to":[27,45,55,85],"both":[28,92],"tumor":[29],"necrosis":[30],"factor":[31],"ligand":[32],"superfamily":[33],"member":[34],"10":[35],"(TRAIL)":[36],"and":[37,43,67,97],"interleukin-2":[38],"(IL2),":[39],"was":[40,53,83],"designed,":[41],"purified":[44],"homogeneity.":[46],"The":[47,108],"termed":[51],"IL2-\u03b1CD38-\u03b1CD38-scTRAIL,":[52],"able":[54,84],"selectively":[56],"recognize":[57],"its":[58],"cognate":[59],"MM":[66,94,106,125],"lymphoma":[68],"cell":[69,88,95],"lines,":[70],"as":[71],"evidenced":[72],"by":[73],"flow":[74],"cytometry":[75],"analysis.":[76],"Moreover,":[77],"targeted":[79],"version":[80],"TRAIL":[82],"induce":[86],"cancer":[87],"death":[89],"in":[90],"vitro,":[91],"with":[93,98,124],"lines":[96],"fresh":[99],"isolates":[100],"from":[101],"bone":[103],"marrow":[104],"patients.":[107],"experiments":[109],"provide":[110],"a":[111],"rationale":[112],"for":[113,119],"possible":[114],"future":[115],"applications":[116],"IL2-\u03b1CD38-\u03b1CD38-scTRAIL":[118],"treatment":[121],"patients":[123],"or":[126],"other":[127],"CD38-positive":[128],"malignancies.":[129]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-09-27T00:00:00"}