{"id":"https://openalex.org/W2892279456","doi":"https://doi.org/10.4103/2277-5706.241431","title":"Antioxidant status in patients with metabolic syndrome as measured by ferric reducing ability of plasma (FRAP) assay","display_name":"Antioxidant status in patients with metabolic syndrome as measured by ferric reducing ability of plasma (FRAP) assay","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2892279456","doi":"https://doi.org/10.4103/2277-5706.241431","mag":"2892279456"},"language":"en","primary_location":{"id":"doi:10.4103/2277-5706.241431","doi":"https://doi.org/10.4103/2277-5706.241431","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2277-5706.241431","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/2277-5706.241431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049975136","display_name":"Aparna Rajeshwar Rao Bitla","orcid":"https://orcid.org/0000-0003-2726-2222","observed_orcids":["https://orcid.org/0000-0003-2726-2222"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bitla AR","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096244597","display_name":"Kumari NM","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kumari NM","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071256563","display_name":"Reddy NS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reddy NS","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015764759","display_name":"K.V. Nagaraju","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagaraju KV","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090807456","display_name":"Alok Sachan","orcid":"https://orcid.org/0000-0002-4183-4699","observed_orcids":["https://orcid.org/0000-0002-4183-4699"]},"institutions":[{"id":"https://openalex.org/I107740395","display_name":"Sri Venkateswara Institute of Medical Sciences","ror":"https://ror.org/039thcs93","country_code":"IN","type":"education","lineage":["https://openalex.org/I107740395"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sachan A","raw_affiliation_strings":["Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati","institution_ids":["https://openalex.org/I107740395"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kumar VP","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kumar VP","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059132765","display_name":"Mustur Manohar Suchitra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suchitra\\ MM","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065132486","display_name":"SrinivasaRao PVLN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107740395","display_name":"Sri Venkateswara Institute of Medical Sciences","ror":"https://ror.org/039thcs93","country_code":"IN","type":"education","lineage":["https://openalex.org/I107740395"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"SrinivasaRao PVLN","raw_affiliation_strings":["Department of Biochemistry , S.V. Institute of Medical Sciences , Tirupati","Departments of Biochemistry ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , S.V. Institute of Medical Sciences , Tirupati","institution_ids":["https://openalex.org/I107740395"]},{"raw_affiliation_string":"Departments of Biochemistry ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049975136"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2016,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.48745207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"3","first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ferric-reducing-ability-of-plasma","display_name":"ferric reducing ability of plasma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.765999972820282},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.949999988079071},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8531487584114075},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.8336365818977356},{"id":"https://openalex.org/C2780116811","wikidata":"https://www.wikidata.org/wiki/Q5445334","display_name":"Ferric reducing ability of plasma","level":4,"score":0.7930587530136108},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7718016505241394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7223845720291138},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7146013975143433},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.6772061586380005},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5810704827308655},{"id":"https://openalex.org/C2778402494","wikidata":"https://www.wikidata.org/wiki/Q599756","display_name":"National Cholesterol Education Program","level":4,"score":0.5657601356506348},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5560657978057861},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5503754019737244},{"id":"https://openalex.org/C2777693730","wikidata":"https://www.wikidata.org/wiki/Q1140549","display_name":"Abdominal obesity","level":4,"score":0.5354732275009155},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.5331857204437256},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5180466175079346},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.49595651030540466},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.46604645252227783},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4353976547718048},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.38505125045776367},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.20600193738937378},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16666731238365173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07450845837593079}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/2277-5706.241431","doi":"https://doi.org/10.4103/2277-5706.241431","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2277-5706.241431","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},{"id":"doi:10.15380/2277-5706.jcsr.12.032","doi":"https://doi.org/10.15380/2277-5706.jcsr.12.032","is_oa":true,"landing_page_url":"https://doi.org/10.15380/2277-5706.jcsr.12.032","pdf_url":"https://doi.org/10.15380/2277-5706.jcsr.12.032","source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:80b15dcce12d47c8bc27438ad04bd5e1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/80b15dcce12d47c8bc27438ad04bd5e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Scientific Research, Vol 1, Iss 3, Pp 114-120 (2012)","raw_type":"article"},{"id":"mag:2184216705","doi":null,"is_oa":false,"landing_page_url":"https://svimstpt.ap.nic.in/jcsr/jul-sep%2012_files/jul-sep%202012/oa1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4103/2277-5706.241431","doi":"https://doi.org/10.4103/2277-5706.241431","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2277-5706.241431","pdf_url":null,"source":{"id":"https://openalex.org/S2764498497","display_name":"The Journal of Clinical and Scientific Research","issn_l":"2277-5706","issn":["2277-5706","2277-8357"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Scientific Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2892279456.pdf","grobid_xml":"https://content.openalex.org/works/W2892279456.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1505675828","https://openalex.org/W1967444481","https://openalex.org/W1970438085","https://openalex.org/W1973127639","https://openalex.org/W1974894423","https://openalex.org/W1976422365","https://openalex.org/W1980338958","https://openalex.org/W1986349550","https://openalex.org/W2004535053","https://openalex.org/W2008615879","https://openalex.org/W2019283193","https://openalex.org/W2021294790","https://openalex.org/W2021755837","https://openalex.org/W2021834384","https://openalex.org/W2023577438","https://openalex.org/W2024884385","https://openalex.org/W2025038536","https://openalex.org/W2040923416","https://openalex.org/W2052654083","https://openalex.org/W2056934131","https://openalex.org/W2060883679","https://openalex.org/W2068181311","https://openalex.org/W2083352000","https://openalex.org/W2095150869","https://openalex.org/W2123289485","https://openalex.org/W2124821727","https://openalex.org/W2126524259","https://openalex.org/W2129784234","https://openalex.org/W2144810869","https://openalex.org/W2146722679","https://openalex.org/W2148309471","https://openalex.org/W2149330575","https://openalex.org/W2165292984","https://openalex.org/W2169467581","https://openalex.org/W2234926771","https://openalex.org/W2324813476","https://openalex.org/W2412229729","https://openalex.org/W4233941760","https://openalex.org/W4255578182","https://openalex.org/W6887851299"],"related_works":["https://openalex.org/W2184216705","https://openalex.org/W2224207334","https://openalex.org/W2004535053","https://openalex.org/W2160539615","https://openalex.org/W2233591013","https://openalex.org/W2062711935","https://openalex.org/W2781240085","https://openalex.org/W2183541396","https://openalex.org/W2792850511","https://openalex.org/W2129596805"],"abstract_inverted_index":{"Background:":[0],"Oxidative":[1],"stress":[2,190],"is":[3,18,29,36],"involved":[4],"in":[5,94,122,125,143,191,202,224,233],"the":[6,19,58,126,134,144,149,153,182,186,199,217,226],"pathophysiology":[7],"of":[8,13,22,60,92,115,155,181,188],"diabetes":[9],"and":[10,25,73,161,172,229],"cardiovascular":[11,200,227],"complications":[12],"metabolic":[14,23,46,156,194],"syndrome.Endothelial":[15],"dysfunction":[16],"which":[17,196],"key":[20],"feature":[21],"syndrome":[24,47,157,195],"its":[26],"vascular":[27],"complication":[28],"intimately":[30],"linked":[31],"to":[32,39,133,148,216],"insulin":[33],"resistance.This":[34],"relationship":[35],"partly":[37],"due":[38],"oxidative":[40,189],"stress.Methods:":[41],"Twenty":[42],"five":[43],"patients":[44,192],"with":[45,70,106,166,177,193,207],"(mean":[48,78],"age":[49,72,79],"47.3":[50],"\u00b1":[51,81],"2.6":[52],"years,":[53,83],"13":[54],"males)":[55,85],"diagnosed":[56],"on":[57],"basis":[59],"National":[61],"Cholesterol":[62],"Education":[63],"Programme/Adult":[64],"Treatment":[65],"Panel":[66],"(NCEP/ATPIII)":[67],"criteria":[68],"along":[69,105],"25":[71],"gender":[74],"matched":[75],"healthy":[76],"controls":[77],"42.1":[80],"1.8":[82],"11":[84],"were":[86,141],"studied.Malondialdehyde":[87],"(MDA),":[88],"as":[89,99,111,138],"an":[90],"index":[91],"changes":[93],"lipid":[95],"peroxidation":[96],"was":[97,129],"estimated":[98],"thiobarbituric":[100],"acid":[101],"reactive":[102],"substances":[103],"(TBARS)":[104],"plasma":[107,116],"total":[108],"antioxidant":[109],"capacity":[110],"ferric":[112],"reducing":[113,221],"ability":[114],"(FRAP).Results:":[117],"A":[118],"significant":[119],"increase":[120],"(p=0.001)":[121],"MDA":[123,167],"levels":[124,140,168],"study":[127,145,184],"group":[128,146,151],"observed":[130],"when":[131],"compared":[132,147],"control":[135,150],"group,":[136],"where":[137],"FRAP":[139,212],"decreased":[142],"(p=0.001).Among":[152],"components":[154],"hyperglycaemia,":[158,170],"hypertriglyceridaemia,":[159],"hypertension":[160],"waist":[162,173],"circumference":[163,174],"positively":[164],"correlated":[165,175],"whereas":[169],"hypertriglyceridaemia":[171],"negatively":[176],"FRAP.":[178],"Conclusions:The":[179],"findings":[180],"present":[183],"suggest":[185],"presence":[187],"further":[197],"increases":[198],"risk":[201,232],"these":[203,234],"patients.Antioxidant":[204],"therapy":[205],"monitored":[206],"a":[208],"simple":[209],"assay":[210],"like":[211,220],"would":[213],"definitely":[214],"add":[215],"existing":[218],"measures":[219],"abdominal":[222],"obesity":[223],"preventing":[225],"sequelae":[228],"hence":[230],"CVD":[231],"patients.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-09-27T00:00:00"}