{"id":"https://openalex.org/W2892232015","doi":null,"title":"Towards a structural and functional understanding of human aquaporin 9","display_name":"Towards a structural and functional understanding of human aquaporin 9","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2892232015","mag":"2892232015"},"language":"en","primary_location":{"id":"pmh:oai:research.chalmers.se:113831","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/113831","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041215583","display_name":"Madelene Palmgren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madelene Palmgren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102173295","display_name":"Pia Eriksson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pia Eriksson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017316562","display_name":"Richard Neutze","orcid":"https://orcid.org/0000-0003-0986-6153","observed_orcids":["https://orcid.org/0000-0003-0986-6153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Neutze","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0986-6153","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079347888","display_name":"Stefan Hohmann","orcid":"https://orcid.org/0000-0002-0809-1985","observed_orcids":["https://orcid.org/0000-0002-0809-1985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Hohmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0809-1985","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082503662","display_name":"Karin Lindkvist\u2010Petersson","orcid":"https://orcid.org/0000-0002-5209-3160","observed_orcids":["https://orcid.org/0000-0002-5209-3160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin Lindkvist\u2010Petersson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5209-3160","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31338301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aqp9","display_name":"AQP9","score":0.972000002861023},{"id":"https://openalex.org/keywords/aquaglyceroporins","display_name":"aquaglyceroporins","score":0.8069999814033508},{"id":"https://openalex.org/keywords/glycerol-transport","display_name":"glycerol transport","score":0.8889999985694885},{"id":"https://openalex.org/keywords/urea-transport","display_name":"urea transport","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.3840000033378601},{"id":"https://openalex.org/keywords/pichia-pastoris-expression-system","display_name":"Pichia pastoris expression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/membrane-protein-purification","display_name":"membrane protein purification","score":0.5490000247955322},{"id":"https://openalex.org/keywords/transport-specificity","display_name":"transport specificity","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C154280991","wikidata":"https://www.wikidata.org/wiki/Q623090","display_name":"Aquaporin","level":2,"score":0.9721556305885315},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.8107322454452515},{"id":"https://openalex.org/C2781372317","wikidata":"https://www.wikidata.org/wiki/Q148697","display_name":"Pichia pastoris","level":4,"score":0.7706747055053711},{"id":"https://openalex.org/C2776305511","wikidata":"https://www.wikidata.org/wiki/Q10859825","display_name":"Arsenite","level":3,"score":0.737977921962738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5335541367530823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48136287927627563},{"id":"https://openalex.org/C177586851","wikidata":"https://www.wikidata.org/wiki/Q14905238","display_name":"Aquaporin 1","level":4,"score":0.42353999614715576},{"id":"https://openalex.org/C2992163139","wikidata":"https://www.wikidata.org/wiki/Q155930","display_name":"Water transport","level":3,"score":0.41115590929985046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3336982727050781},{"id":"https://openalex.org/C2775845273","wikidata":"https://www.wikidata.org/wiki/Q7973466","display_name":"Water channel","level":3,"score":0.3175519108772278},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.21774446964263916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13072431087493896},{"id":"https://openalex.org/C2988574769","wikidata":"https://www.wikidata.org/wiki/Q2259545","display_name":"Water flow","level":2,"score":0.07634806632995605},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.0658605694770813},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.0},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:research.chalmers.se:113831","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/113831","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:2892232015","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/113831","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2199816912","https://openalex.org/W2016537993","https://openalex.org/W2100096421","https://openalex.org/W7096420456","https://openalex.org/W1999156541","https://openalex.org/W2093092469","https://openalex.org/W2074644527","https://openalex.org/W2092041055","https://openalex.org/W1965210644","https://openalex.org/W2108792805"],"abstract_inverted_index":{"Human":[0],"aquaporin":[1,16,81],"9":[2],"(hAQP9)":[3],"is":[4,49,55,116],"one":[5],"of":[6,14,39,69,172,195],"the":[7,15,24,28,37,61,79,129,134,201],"glycerol":[8,32,59,174,205],"channels":[9],"that":[10,123],"are":[11,178,209],"a":[12,103,119,149,190],"member":[13],"family.":[17],"AQP9":[18,70,93,138,171],"have":[19,23,88,187],"been":[20,141],"shown":[21],"to":[22,57,75,101,106,117,164,183],"broadest":[25],"specificity":[26,132,203],"among":[27],"aquaporins.":[29],"Except":[30],"for":[31,193,204,211],"and":[33,43,54,136,146,162,175,206,214],"water":[34],"it":[35],"facilitates":[36],"transport":[38,58,202],"urea,":[40],"arsenite,":[41,173],"polyols":[42,177,208],"other":[44,176,207],"small":[45],"uncharged":[46],"solutes.":[47],"hAQP9":[48],"partly":[50],"expressed":[51,91,197],"in":[52,94,131,180,198],"hepatocytes":[53],"thought":[56],"into":[60],"liver.":[62],"Recently":[63],"an":[64],"electron":[65],"microscopy":[66],"projection":[67],"map":[68],"(from":[71],"rat)":[72],"was":[73,158],"published":[74],"7\u00c5":[76],"resolution":[77,121],"indicating":[78],"typical":[80],"tetrameric":[82],"structure.":[83],"In":[84],"our":[85],"lab,":[86],"we":[87],"successfully":[89,188],"over":[90],"human":[92,213],"Pichia":[95],"pastoris.":[96],"This":[97],"system":[98],"has":[99,139],"showed":[100],"be":[102,165],"suitable":[104],"host":[105],"express":[107],"eukaryotic":[108],"membrane":[109],"proteins":[110],"with":[111,143],"high":[112,120],"yield.":[113],"The":[114,155],"goal":[115],"attain":[118],"structure":[122],"will":[124],"reveal":[125],"what":[126],"lies":[127],"behind":[128],"differences":[130],"between":[133],"aquaporins":[135],"aquaglyceroporins.":[137],"further":[140],"solubilised":[142],"Foscholine-12":[144],"(Fos-C12)":[145],"purified":[147,156],"on":[148],"Ni-NTA":[150],"resin":[151],"followed":[152],"by":[153,160,170],"gelfiltration.":[154],"protein":[157],"detected":[159,189],"SDS-PAGE":[161],"estimated":[163],"90%":[166],"pure.":[167],"Transport":[168],"studies":[169],"performed":[179],"Saccharomyses":[181],"cervisiae":[182],"prove":[184],"functionality.":[185],"We":[186],"clear":[191],"sensitivity":[192],"arsenite":[194],"rAQP9":[196],"S.cerevisiae.":[199],"Currently,":[200],"tested":[210],"both":[212],"rat":[215],"AQP9.":[216]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2018-09-27T00:00:00"}
