{"id":"https://openalex.org/W2892052286","doi":"https://doi.org/10.1074/jbc.ra118.004716","title":"Conjugation inhibitors compete with palmitic acid for binding to the conjugative traffic ATPase TrwD, providing a mechanism to inhibit bacterial conjugation","display_name":"Conjugation inhibitors compete with palmitic acid for binding to the conjugative traffic ATPase TrwD, providing a mechanism to inhibit bacterial conjugation","publication_year":2018,"publication_date":"2018-09-12","ids":{"openalex":"https://openalex.org/W2892052286","doi":"https://doi.org/10.1074/jbc.ra118.004716","mag":"2892052286","pmid":"https://pubmed.ncbi.nlm.nih.gov/30201608"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra118.004716","doi":"https://doi.org/10.1074/jbc.ra118.004716","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.004716","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.ra118.004716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029683866","display_name":"Yolanda Garc\u00eda\u2010Cazorla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yolanda Garc\u00eda-Cazorla","raw_affiliation_strings":["From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041529549","display_name":"Mar\u00eda Getino","orcid":"https://orcid.org/0000-0002-2937-3420","observed_orcids":["https://orcid.org/0000-0002-2937-3420"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Getino","raw_affiliation_strings":["From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2937-3420","affiliations":[{"raw_affiliation_string":"From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025301247","display_name":"David J. Sanabria\u2010R\u00edos","orcid":"https://orcid.org/0000-0001-8797-1210","observed_orcids":["https://orcid.org/0000-0001-8797-1210"]},"institutions":[{"id":"https://openalex.org/I185665358","display_name":"InterAmerican University of Puerto Rico","ror":"https://ror.org/00xcgnn15","country_code":"PR","type":"education","lineage":["https://openalex.org/I185665358"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"David J. Sanabria-R\u00edos","raw_affiliation_strings":["the Inter-American University of Puerto Rico, Metropolitan Campus, Faculty of Science and Technology, San Juan, Puerto Rico 00919, and","Inter-American University of Puerto Rico, Metropolitan Campus, Faculty of Science and Technology, San Juan, Puerto Rico 00919"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Inter-American University of Puerto Rico, Metropolitan Campus, Faculty of Science and Technology, San Juan, Puerto Rico 00919, and","institution_ids":["https://openalex.org/I185665358"]},{"raw_affiliation_string":"Inter-American University of Puerto Rico, Metropolitan Campus, Faculty of Science and Technology, San Juan, Puerto Rico 00919","institution_ids":["https://openalex.org/I185665358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009377081","display_name":"N\u00e9stor M. Carballeira","orcid":"https://orcid.org/0000-0001-7404-0505","observed_orcids":["https://orcid.org/0000-0001-7404-0505"]},"institutions":[{"id":"https://openalex.org/I1662191","display_name":"University of Puerto Rico at R\u00edo Piedras","ror":"https://ror.org/0453v4r20","country_code":"PR","type":"education","lineage":["https://openalex.org/I1662191","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"N\u00e9stor M. Carballeira","raw_affiliation_strings":["the Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico 00925","Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico 00925"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico 00925","institution_ids":["https://openalex.org/I1662191"]},{"raw_affiliation_string":"Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico 00925","institution_ids":["https://openalex.org/I1662191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017358738","display_name":"Fernando de la Cruz","orcid":"https://orcid.org/0000-0003-4758-6857","observed_orcids":["https://orcid.org/0000-0003-4758-6857"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando de la Cruz","raw_affiliation_strings":["From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087583162","display_name":"Ignacio Ar\u00e9chaga","orcid":"https://orcid.org/0000-0002-1342-9370","observed_orcids":["https://orcid.org/0000-0002-1342-9370"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ignacio Arechaga","raw_affiliation_strings":["From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain, arechagai@unican.es","Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain, arechagai@unican.es","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010946849","display_name":"Elena Cabez\u00f3n","orcid":"https://orcid.org/0000-0002-6177-5016","observed_orcids":["https://orcid.org/0000-0002-6177-5016"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Elena Cabez\u00f3n","raw_affiliation_strings":["From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain, cabezone@unican.es","Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain, cabezone@unican.es","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular and Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-Consejo Superior de Investigaciones Cient\u00edficas, 39011 Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010946849","https://openalex.org/A5087583162"],"corresponding_institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6702,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.84040779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"293","issue":"43","first_page":"16923","last_page":"16930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-conjugation","display_name":"bacterial conjugation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/plasmid-r388","display_name":"plasmid R388","score":0.9639999866485596},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9430000185966492},{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.9399999976158142},{"id":"https://openalex.org/keywords/membrane-incorporation","display_name":"membrane incorporation","score":0.4819999933242798},{"id":"https://openalex.org/keywords/atpase-inhibition","display_name":"ATPase inhibition","score":0.7099999785423279},{"id":"https://openalex.org/keywords/binding-site-competition","display_name":"binding site competition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antibiotic-resistance-genes","display_name":"antibiotic resistance genes","score":0.7200000286102295},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.8284465670585632},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6144834756851196},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5929812788963318},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.537274956703186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47266659140586853},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4546816647052765},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4441755414009094},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4253595173358917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3696523606777191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08056369423866272},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1074/jbc.ra118.004716","doi":"https://doi.org/10.1074/jbc.ra118.004716","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.004716","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:30201608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30201608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:ucreareposit::a561fce4630ddb6537abac19bfc33bc8","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10902/15059","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem. 2018 Oct 26;293(43):16923-16930","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:5765740","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6204903","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6204903","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6204903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/190050","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/190050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:repositorio.unican.es:10902/15059","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10902/15059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem. 2018 Oct 26;293(43):16923-16930","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra118.004716","doi":"https://doi.org/10.1074/jbc.ra118.004716","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.004716","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1985705538","display_name":null,"funder_award_id":"BFU2016-78521-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G221861935","display_name":null,"funder_award_id":"P20GM103475\u201316","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2493727949","display_name":null,"funder_award_id":"BFU2014\u201355534","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W43134475","https://openalex.org/W1549932090","https://openalex.org/W1970191255","https://openalex.org/W1980735881","https://openalex.org/W1981106318","https://openalex.org/W1986953176","https://openalex.org/W1994428790","https://openalex.org/W2000152285","https://openalex.org/W2033941975","https://openalex.org/W2034512365","https://openalex.org/W2036467696","https://openalex.org/W2064783278","https://openalex.org/W2067359484","https://openalex.org/W2068833431","https://openalex.org/W2075514757","https://openalex.org/W2083498141","https://openalex.org/W2086959317","https://openalex.org/W2097958289","https://openalex.org/W2101078720","https://openalex.org/W2112870794","https://openalex.org/W2121592882","https://openalex.org/W2129397628","https://openalex.org/W2132659457","https://openalex.org/W2135771899","https://openalex.org/W2141993375","https://openalex.org/W2152042464","https://openalex.org/W2155293003","https://openalex.org/W2155364568","https://openalex.org/W2270786730","https://openalex.org/W2295922609","https://openalex.org/W2341425007","https://openalex.org/W2770786542"],"related_works":["https://openalex.org/W2101213130","https://openalex.org/W2084009662","https://openalex.org/W4255727335","https://openalex.org/W2068921937","https://openalex.org/W2062059821","https://openalex.org/W15905720","https://openalex.org/W768080024","https://openalex.org/W2130631724","https://openalex.org/W2354901943","https://openalex.org/W258712436"],"abstract_inverted_index":{"Bacterial":[0],"conjugation":[1,13],"is":[2,63,130],"a":[3,57,127,170,179,213],"key":[4],"mechanism":[5],"by":[6,133],"which":[7,70,226],"bacteria":[8],"acquire":[9],"antibiotic":[10,26],"resistance.":[11],"Therefore,":[12],"inhibitors":[14,222],"(COINs)":[15],"are":[16,86],"promising":[17],"compounds":[18],"in":[19,60,158,162,205,216],"the":[20,23,64,97,101,116,147,159,201,217],"fight":[21],"against":[22],"spread":[24],"of":[25,67,74,100,223],"resistance":[27],"genes":[28],"among":[29],"bacteria.":[30,233],"Unsaturated":[31],"fatty":[32,37],"acids":[33,197],"(uFAs)":[34],"and":[35,153,187,195],"alkynoic":[36],"acid":[38,43,95,142],"derivatives,":[39],"such":[40],"as":[41,49,96,151,178],"2-hexadecanoic":[42],"(2-HDA),":[44],"have":[45],"been":[46],"reported":[47],"previously":[48],"being":[50],"effective":[51,220],"COINs.":[52],"The":[53],"traffic":[54],"ATPase":[55,185],"TrwD,":[56],"VirB11":[58],"homolog":[59],"plasmid":[61],"R388,":[62],"molecular":[65,137],"target":[66],"these":[68,208],"compounds,":[69],"likely":[71],"affect":[72],"binding":[73,149,203],"TrwD":[75,107,125,184],"to":[76],"bacterial":[77,188,224],"membranes.":[78],"In":[79],"this":[80,163],"work,":[81],"we":[82,191],"demonstrate":[83,192],"that":[84,106,122,129,144,173,181,193],"COINs":[85,123],"abundantly":[87],"incorporated":[88],"into":[89],"Escherichia":[90],"coli":[91],"membranes,":[92],"replacing":[93],"palmitic":[94,109,134,141,196],"major":[98],"component":[99],"membrane.":[102,117],"We":[103,165],"also":[104,120,166],"show":[105],"binds":[108],"acid,":[110,169],"thus":[111],"facilitating":[112],"its":[113],"interaction":[114],"with":[115,140],"Our":[118],"findings":[119,210],"suggest":[121],"bind":[124],"at":[126],"site":[128,150,204],"otherwise":[131],"occupied":[132],"acid.":[135],"Accordingly,":[136],"docking":[138],"predictions":[139],"indicated":[143],"it":[145,156],"shares":[146],"same":[148,202],"uFAs":[152],"2-HDA,":[154],"although":[155],"differs":[157],"contacts":[160],"involved":[161],"interaction.":[164],"identified":[167],"2-bromopalmitic":[168,194],"palmitate":[171],"analog":[172],"inhibits":[174],"many":[175],"membrane-associated":[176],"enzymes,":[177],"compound":[180],"effectively":[182],"reduces":[183],"activity":[186],"conjugation.":[189],"Moreover,":[190],"both":[198],"compete":[199],"for":[200,219,230],"TrwD.":[206],"Altogether,":[207],"detailed":[209],"open":[211],"up":[212],"new":[214],"avenue":[215],"search":[218],"synthetic":[221],"conjugation,":[225],"may":[227],"be":[228],"pivotal":[229],"combating":[231],"multidrug-resistant":[232]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}