{"id":"https://openalex.org/W2892045696","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","title":"Selective benefit of adjuvant chemoradiation in resectable pancreatic cancer.","display_name":"Selective benefit of adjuvant chemoradiation in resectable pancreatic cancer.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2892045696","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","mag":"2892045696"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.4122","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022126101","display_name":"Jesse P. Wright","orcid":"https://orcid.org/0000-0003-0243-4112","observed_orcids":["https://orcid.org/0000-0003-0243-4112"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse P Wright","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nasvhille, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nasvhille, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056342989","display_name":"Cameron E. Schlegel","orcid":"https://orcid.org/0000-0002-0650-8222","observed_orcids":["https://orcid.org/0000-0002-0650-8222"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron Schlegel","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015699036","display_name":"Rebecca Anne Snyder","orcid":"https://orcid.org/0000-0002-2485-2481","observed_orcids":["https://orcid.org/0000-0002-2485-2481","https://orcid.org/0000-0002-4355-2185"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A Snyder","raw_affiliation_strings":["Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liping Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Du","raw_affiliation_strings":["Department of Cancer Biostatistics, Vanderbilt Ingram Cancer Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biostatistics, Vanderbilt Ingram Cancer Center, Nashville, TN;","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Shyr","raw_affiliation_strings":["Department of Cancer Biostatistics, Vanderbilt Ingram Cancer Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biostatistics, Vanderbilt Ingram Cancer Center, Nashville, TN;","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010469485","display_name":"Dana Backlund Cardin","orcid":"https://orcid.org/0000-0002-0269-9615","observed_orcids":["https://orcid.org/0000-0002-0269-9615"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Backlund Cardin","raw_affiliation_strings":["Vanderbilt University Ingram Cancer Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Ingram Cancer Center, Nashville, TN;","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016606073","display_name":"Nipun B. Merchant","orcid":"https://orcid.org/0000-0002-3399-9776","observed_orcids":["https://orcid.org/0000-0002-3399-9776"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nipun B. Merchant","raw_affiliation_strings":["Department of Surgical Oncology, University of Miami Medical Center, Miami, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, University of Miami Medical Center, Miami, FL;","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013889334","display_name":"Alexander A. Parikh","orcid":"https://orcid.org/0000-0002-2730-2354","observed_orcids":["https://orcid.org/0000-0002-2730-2354"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Parikh","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"4122","last_page":"4122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/adjuvant-chemoradiotherapy","display_name":"adjuvant chemoradiotherapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/resectable-pancreatic-cancer","display_name":"resectable pancreatic cancer","score":0.8939999938011169},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.968999981880188},{"id":"https://openalex.org/keywords/lymph-node-status","display_name":"lymph node status","score":0.9309999942779541},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.9179999828338623},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8735750913619995},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5170639157295227},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5048442482948303},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47517555952072144},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.46469777822494507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4396677017211914},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33870017528533936}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.4122","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.4122","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116600000","https://openalex.org/W3199608660","https://openalex.org/W2283350127","https://openalex.org/W2967426461","https://openalex.org/W2293363820","https://openalex.org/W2914289499","https://openalex.org/W7166703223","https://openalex.org/W4381376814","https://openalex.org/W2603251348","https://openalex.org/W4285506731"],"abstract_inverted_index":{"4122":[0],"Background:":[1],"Although":[2],"level":[3],"1":[4],"data":[5],"supports":[6],"the":[7,18,34,66,112,211,292],"use":[8,213,293],"of":[9,20,28,36,101,115,173,214,238,294],"adjuvant":[10,21],"chemotherapy":[11],"(ACT)":[12],"in":[13,119,194,246,255,280],"resected":[14],"pancreatic":[15],"adenocarcinoma":[16],"(PDAC),":[17],"role":[19],"chemoradiation":[22],"(ACRT)":[23],"remains":[24],"controversial.":[25],"The":[26,236],"objective":[27],"this":[29],"study":[30,221],"is":[31],"to":[32,39,90,110,192,234,240,282,289],"investigate":[33],"impact":[35],"adding":[37],"ACRT":[38,84,140,163,215,226,239],"ACT":[40,80,116,146,175,193,224],"on":[41,46,75,275],"overall":[42],"survival":[43],"(OS),":[44],"based":[45,74,274],"lymph":[47],"node":[48],"(LN)":[49],"and":[50,58,83,105,117,137,151,176,181,205,225,260,277],"margin":[51,106,259,278],"status.":[52],"Methods:":[53],"Resected":[54],"AJCC":[55],"Stage":[56],"I":[57],"II":[59],"PDAC":[60],"patients":[61,195,248,256,273,285],"from":[62,210,291],"2004-2013":[63],"identified":[64],"within":[65],"National":[67],"Cancer":[68],"Database":[69],"were":[70,88,108,127,155],"classified":[71],"into":[72],"groups":[73],"treatment:":[76],"surgery":[77],"alone":[78],"(SX),":[79],"alone,":[81],"ACT+ACRT,":[82,136],"only.":[85],"Kaplan-Meier":[86],"analyses":[87],"performed":[89],"determine":[91,283],"median":[92],"OS.":[93],"Multivariable":[94],"(MV)":[95],"Cox":[96],"regression":[97],"models":[98],"with":[99,103,129,132,135,139,188,196,202,229,249,257],"interactions":[100],"treatment":[102],"LN":[104,206,261,276],"status":[107,279],"constructed":[109],"examine":[111],"independent":[113],"effects":[114],"ACT+ACRT":[118,152,177,254],"these":[120],"subgroups.":[121],"Results:":[122],"Of":[123],"31,348":[124],"patients,":[125],"30%":[126,131],"treated":[128],"SX,":[130],"ACT,":[133,241],"38%":[134],"2%":[138],"alone.":[141],"Median":[142],"OS":[143,171,190,231],"(mos.)":[144],"for":[145,179],"(22.5,":[147],"95%":[148],"CI":[149],"21.9-23.1)":[150],"(23.7,":[153],"23.3-24.2)":[154],"significantly":[156],"longer":[157],"than":[158],"SX":[159],"(14,":[160],"13.4-14.5)":[161],"or":[162],"(11.2,":[164],"9.8-12.9).":[165],"MV":[166],"analysis":[167],"confirmed":[168],"a":[169],"significant":[170],"benefit":[172,209,290],"both":[174,258],"controlling":[178],"patient":[180],"tumor":[182],"related":[183],"factors.":[184],"ACRT+ACT":[185],"was":[186,243],"associated":[187,228],"improved":[189,230],"compared":[191,233],"positive":[197,250],"margins":[198,204,251],"and/or":[199,252],"LN.":[200,253],"Those":[201],"negative":[203,262],"did":[207],"not":[208,265],"additional":[212],"(Table).":[216],"Conclusions:":[217],"This":[218],"large":[219],"hospital-based":[220],"demonstrates":[222],"that":[223],"are":[227,286],"when":[232],"SX.":[235],"addition":[237],"however,":[242],"only":[244],"beneficial":[245],"high-risk":[247],"disease":[263],"may":[264],"be":[266],"warranted.":[267],"Future":[268],"clinical":[269],"trials":[270],"should":[271],"stratify":[272],"order":[281],"which":[284],"most":[287],"likely":[288],"ACRT.":[295],"[Table:":[296],"see":[297],"text]":[298]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-09-27T00:00:00"}