{"id":"https://openalex.org/W2892009646","doi":"https://doi.org/10.1111/bjh.15552","title":"An open\u2010label phase 2 trial of entospletinib in indolent non\u2010Hodgkin lymphoma and mantle cell lymphoma","display_name":"An open\u2010label phase 2 trial of entospletinib in indolent non\u2010Hodgkin lymphoma and mantle cell lymphoma","publication_year":2018,"publication_date":"2018-09-05","ids":{"openalex":"https://openalex.org/W2892009646","doi":"https://doi.org/10.1111/bjh.15552","mag":"2892009646","pmid":"https://pubmed.ncbi.nlm.nih.gov/30183069"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.15552","doi":"https://doi.org/10.1111/bjh.15552","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15552","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15552","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045105562","display_name":"David Jacob Andorsky","orcid":"https://orcid.org/0000-0002-5699-4644","observed_orcids":["https://orcid.org/0000-0002-5699-4644"]},"institutions":[{"id":"https://openalex.org/I4210140702","display_name":"Rocky Mountain Cancer Centers","ror":"https://ror.org/03ynhs115","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210140702"]},{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Andorsky","raw_affiliation_strings":["Rocky Mountain Cancer Centers/The US Oncology Network Boulder CO USA","Rocky Mountain Cancer Centers/The US Oncology Network, Boulder, CO, USA"],"raw_orcid":"https://orcid.org/0000-0002-5699-4644","affiliations":[{"raw_affiliation_string":"Rocky Mountain Cancer Centers/The US Oncology Network Boulder CO USA","institution_ids":["https://openalex.org/I4210140702","https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Rocky Mountain Cancer Centers/The US Oncology Network, Boulder, CO, USA","institution_ids":["https://openalex.org/I4210140702","https://openalex.org/I4210151469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009060912","display_name":"Kathryn S. Kolibaba","orcid":"https://orcid.org/0000-0003-1099-4638","observed_orcids":["https://orcid.org/0000-0003-1099-4638"]},"institutions":[{"id":"https://openalex.org/I4210095874","display_name":"Compass Oncology","ror":"https://ror.org/00rq7v092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095874"]},{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn S. Kolibaba","raw_affiliation_strings":["Compass Oncology/The US Oncology Network Vancouver WA USA","Compass Oncology/The US Oncology Network, Vancouver, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Compass Oncology/The US Oncology Network Vancouver WA USA","institution_ids":["https://openalex.org/I4210095874","https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Compass Oncology/The US Oncology Network, Vancouver, WA, USA","institution_ids":["https://openalex.org/I4210095874","https://openalex.org/I4210151469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074729432","display_name":"Sarit E. Assouline","orcid":"https://orcid.org/0000-0002-7638-1589","observed_orcids":["https://orcid.org/0000-0002-7638-1589"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sarit Assouline","raw_affiliation_strings":["Gerald Bronfman Centre McGill University Montreal QC Canada","Gerald Bronfman Centre, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gerald Bronfman Centre McGill University Montreal QC Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Gerald Bronfman Centre, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046549002","display_name":"Andres Forero","orcid":"https://orcid.org/0000-0002-1360-1695","observed_orcids":["https://orcid.org/0000-0002-1360-1695","https://orcid.org/0000-0001-5161-8319"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres Forero\u2010Torres","raw_affiliation_strings":["University of Alabama at Birmingham School of Medicine Birmingham AL USA","University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham School of Medicine Birmingham AL USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063520696","display_name":"Vicky E. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicky Jones","raw_affiliation_strings":["North Star Lodge Cancer Center Yakima WA USA","North Star Lodge Cancer Center, Yakima, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Star Lodge Cancer Center Yakima WA USA","institution_ids":[]},{"raw_affiliation_string":"North Star Lodge Cancer Center, Yakima, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090935889","display_name":"Leonard M. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard M. Klein","raw_affiliation_strings":["Illinois Cancer Specialists/The US Oncology Network Niles IL USA","Illinois Cancer Specialists/The US Oncology Network, Niles, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illinois Cancer Specialists/The US Oncology Network Niles IL USA","institution_ids":["https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Illinois Cancer Specialists/The US Oncology Network, Niles, IL, USA","institution_ids":["https://openalex.org/I4210151469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072273907","display_name":"Dipti Patel\u2010Donnelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122908","display_name":"Virginia Cancer Specialists","ror":"https://ror.org/03tbabt10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122908"]},{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipti Patel\u2010Donnelly","raw_affiliation_strings":["Virginia Cancer Specialists/The US Oncology Network Fairfax VA USA","Virginia Cancer Specialists/The US Oncology Network, Fairfax, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Cancer Specialists/The US Oncology Network Fairfax VA USA","institution_ids":["https://openalex.org/I4210122908","https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Virginia Cancer Specialists/The US Oncology Network, Fairfax, VA, USA","institution_ids":["https://openalex.org/I4210122908","https://openalex.org/I4210151469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089854184","display_name":"Mitchell Reed Smith","orcid":"https://orcid.org/0000-0003-1428-8765","observed_orcids":["https://orcid.org/0000-0003-1428-8765"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Smith","raw_affiliation_strings":["School of Medicine &amp; Health Sciences The George Washington University Washington DC USA","School of Medicine & Health Sciences, The George Washington University, Washington, DC, USA"],"raw_orcid":"https://orcid.org/0000-0003-1428-8765","affiliations":[{"raw_affiliation_string":"School of Medicine &amp; Health Sciences The George Washington University Washington DC USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"School of Medicine & Health Sciences, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448686","display_name":"Wei Ye","orcid":"https://orcid.org/0000-0002-2908-1305","observed_orcids":["https://orcid.org/0000-0002-2908-1305"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Ye","raw_affiliation_strings":["Gilead Sciences, Inc. Foster City CA USA","Gilead Sciences, Inc., Foster City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc. Foster City CA USA","institution_ids":["https://openalex.org/I4210140816"]},{"raw_affiliation_string":"Gilead Sciences, Inc., Foster City, CA, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102944619","display_name":"Wen Shi","orcid":"https://orcid.org/0000-0002-4079-7427","observed_orcids":["https://orcid.org/0000-0002-4079-7427"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Shi","raw_affiliation_strings":["Gilead Sciences, Inc. Foster City CA USA","Gilead Sciences, Inc., Foster City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc. Foster City CA USA","institution_ids":["https://openalex.org/I4210140816"]},{"raw_affiliation_string":"Gilead Sciences, Inc., Foster City, CA, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062430369","display_name":"Christopher A. Yasenchak","orcid":"https://orcid.org/0000-0003-0591-156X","observed_orcids":["https://orcid.org/0000-0003-0591-156X"]},"institutions":[{"id":"https://openalex.org/I4210148213","display_name":"Willamette Valley Cancer Institute and Research Center","ror":"https://ror.org/05jr8e497","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148213"]},{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Yasenchak","raw_affiliation_strings":["Willamette Valley Cancer Institute and Research Center/The US Oncology Network Eugene OR USA","Willamette Valley Cancer Institute and Research Center/The US Oncology Network, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Willamette Valley Cancer Institute and Research Center/The US Oncology Network Eugene OR USA","institution_ids":["https://openalex.org/I4210148213","https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Willamette Valley Cancer Institute and Research Center/The US Oncology Network, Eugene, OR, USA","institution_ids":["https://openalex.org/I4210148213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013007045","display_name":"Jeff Porter Sharman","orcid":"https://orcid.org/0000-0001-5611-6115","observed_orcids":["https://orcid.org/0000-0001-5611-6115"]},"institutions":[{"id":"https://openalex.org/I4210148213","display_name":"Willamette Valley Cancer Institute and Research Center","ror":"https://ror.org/05jr8e497","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148213"]},{"id":"https://openalex.org/I4210151469","display_name":"The US Oncology Network","ror":"https://ror.org/05xc20j70","country_code":"US","type":"other","lineage":["https://openalex.org/I4210151469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff P. Sharman","raw_affiliation_strings":["Willamette Valley Cancer Institute and Research Center/The US Oncology Network Eugene OR USA","Willamette Valley Cancer Institute and Research Center/The US Oncology Network, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Willamette Valley Cancer Institute and Research Center/The US Oncology Network Eugene OR USA","institution_ids":["https://openalex.org/I4210148213","https://openalex.org/I4210151469"]},{"raw_affiliation_string":"Willamette Valley Cancer Institute and Research Center/The US Oncology Network, Eugene, OR, USA","institution_ids":["https://openalex.org/I4210148213"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5045105562"],"corresponding_institution_ids":["https://openalex.org/I4210140702","https://openalex.org/I4210151469"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":4.3406,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95115205,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"184","issue":"2","first_page":"215","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entospletinib","display_name":"entospletinib","score":1.0},{"id":"https://openalex.org/keywords/spleen-tyrosine-kinase-inhibitor","display_name":"spleen tyrosine kinase inhibitor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/indolent-non-hodgkin-lymphoma","display_name":"indolent non-Hodgkin lymphoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lymphoplasmacytic-lymphoma","display_name":"lymphoplasmacytic lymphoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/marginal-zone-lymphoma","display_name":"marginal zone lymphoma","score":1.0},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8939999938011169},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8214203119277954},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.7564886808395386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7134838700294495},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6793671250343323},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5582268238067627},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.5324085354804993},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5113381743431091},{"id":"https://openalex.org/C2778563104","wikidata":"https://www.wikidata.org/wiki/Q18553449","display_name":"Marginal zone B-cell lymphoma","level":5,"score":0.496006578207016},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.46419015526771545},{"id":"https://openalex.org/C2778476748","wikidata":"https://www.wikidata.org/wiki/Q1138590","display_name":"Non-Hodgkin's lymphoma","level":3,"score":0.4326319098472595},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42850032448768616},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1914752721786499},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18115440011024475},{"id":"https://openalex.org/C2779921676","wikidata":"https://www.wikidata.org/wiki/Q6760434","display_name":"Marginal zone","level":4,"score":0.1644097864627838},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.11253026127815247},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bjh.15552","doi":"https://doi.org/10.1111/bjh.15552","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15552","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:30183069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30183069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:6585960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Br J Haematol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/bjh.15552","doi":"https://doi.org/10.1111/bjh.15552","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15552","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2892009646.pdf","grobid_xml":"https://content.openalex.org/works/W2892009646.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1605230984","https://openalex.org/W1972593274","https://openalex.org/W1976058906","https://openalex.org/W1976402300","https://openalex.org/W1989593746","https://openalex.org/W2009872889","https://openalex.org/W2018010296","https://openalex.org/W2030968642","https://openalex.org/W2063915767","https://openalex.org/W2076690627","https://openalex.org/W2099909147","https://openalex.org/W2130853856","https://openalex.org/W2133192145","https://openalex.org/W2133201432","https://openalex.org/W2160093471","https://openalex.org/W2299919795","https://openalex.org/W2324715724","https://openalex.org/W2339774970","https://openalex.org/W2501821641","https://openalex.org/W2503110302","https://openalex.org/W2544102289","https://openalex.org/W2564045455","https://openalex.org/W2624931958","https://openalex.org/W2740311049","https://openalex.org/W2955705410","https://openalex.org/W2978344467"],"related_works":["https://openalex.org/W2748273929","https://openalex.org/W2109553227","https://openalex.org/W2124950930","https://openalex.org/W2016314378","https://openalex.org/W4324128694","https://openalex.org/W4210937207","https://openalex.org/W2005973506","https://openalex.org/W2061814199","https://openalex.org/W2044056025","https://openalex.org/W2404063949"],"abstract_inverted_index":{"Spleen":[0],"tyrosine":[1],"kinase":[2],"(Syk)":[3],"mediates":[4],"B-cell":[5],"receptor":[6],"signalling":[7],"in":[8,25,144,159,194],"normal":[9],"and":[10,66,95,104,118,126,134,164,180],"malignant":[11],"B":[12],"cells.":[13],"Entospletinib":[14,21,186],"is":[15],"an":[16],"oral,":[17],"selective":[18],"Syk":[19],"inhibitor.":[20],"monotherapy":[22],"was":[23,75,148,167],"evaluated":[24],"a":[26,76],"multicentre,":[27],"phase":[28],"2":[29],"study":[30],"of":[31],"patients":[32,69,92,100],"with":[33,93,101,191],"relapsed":[34],"or":[35,40,86],"refractory":[36],"indolent":[37],"non-Hodgkin":[38],"lymphoma":[39,43,54,64],"mantle":[41],"cell":[42],"(MCL).":[44],"Subjects":[45],"received":[46],"800":[47],"mg":[48],"entospletinib":[49],"twice":[50],"daily.":[51],"Forty-one":[52],"follicular":[53],"(FL),":[55],"17":[56,61],"lymphoplasmacytoid":[57],"lymphoma/Waldenstr\u00f6m":[58],"macroglobulinaemia":[59],"(LPL/WM),":[60],"marginal":[62],"zone":[63],"(MZL)":[65],"39":[67],"MCL":[68,94,146,163],"were":[70,112,123,137],"evaluated.":[71],"The":[72,106],"primary":[73],"endpoint":[74],"progression-free":[77],"survival":[78],"(PFS)":[79],"rate":[80],"(defined":[81],"as":[82],"not":[83],"experiencing":[84],"progression":[85],"death)":[87],"at":[88,96,141,156],"16":[89,142],"weeks":[90,98,143,158],"for":[91,99],"24":[97,157],"FL,":[102,161],"LPL/WM":[103],"MZL.":[105],"most":[107],"common":[108],"treatment-emergent":[109],"adverse":[110],"events":[111],"fatigue,":[113],"nausea,":[114],"diarrhoea,":[115],"vomiting,":[116],"headache":[117],"cough.":[119],"Common":[120],"laboratory":[121],"abnormalities":[122],"anaemia,":[124],"neutropenia":[125],"thrombocytopenia;":[127],"aspartate":[128],"transaminase,":[129,131],"alanine":[130],"total":[132],"bilirubin":[133],"serum":[135],"creatinine":[136],"all":[138],"increased.":[139],"PFS":[140,155],"the":[145,160],"cohort":[147],"63\u00b79%":[149],"[95%":[150],"confidence":[151],"interval":[152],"(CI)":[153],"45-77\u00b78%];":[154],"LPL/WM,":[162],"MZL":[165],"cohorts":[166],"51\u00b75%":[168],"(95%":[169,173,177,182],"CI":[170,174,178,183],"32\u00b78-67\u00b74%),":[171],"69\u00b78%":[172],"31\u00b78-89\u00b74%),":[175],"56\u00b76%":[176],"37\u00b75-71\u00b78%)":[179],"46\u00b72%":[181],"18\u00b75-70\u00b72%),":[184],"respectively.":[185],"had":[187],"limited":[188],"single-agent":[189],"activity":[190],"manageable":[192],"toxicity":[193],"these":[195],"patient":[196],"populations.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
