{"id":"https://openalex.org/W2891982921","doi":"https://doi.org/10.1002/alr.22208","title":"Pro\u2010inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps","display_name":"Pro\u2010inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps","publication_year":2018,"publication_date":"2018-09-14","ids":{"openalex":"https://openalex.org/W2891982921","doi":"https://doi.org/10.1002/alr.22208","mag":"2891982921","pmid":"https://pubmed.ncbi.nlm.nih.gov/30216703"},"language":"en","primary_location":{"id":"doi:10.1002/alr.22208","doi":"https://doi.org/10.1002/alr.22208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alr.22208","pdf_url":null,"source":{"id":"https://openalex.org/S2506670899","display_name":"International Forum of Allergy & Rhinology","issn_l":"2042-6976","issn":["2042-6976","2042-6984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Forum of Allergy & Rhinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030404626","display_name":"Ru Tang","orcid":"https://orcid.org/0000-0002-1464-2544","observed_orcids":["https://orcid.org/0000-0002-1464-2544"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Tang","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhi\u2010Peng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi\u2010Peng Li","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming\u2010Xian Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming\u2010Xian Li","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324938","display_name":"Dawei Li","orcid":"https://orcid.org/0000-0001-9150-5159","observed_orcids":["https://orcid.org/0000-0001-9150-5159"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da\u2010Wei Li","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102922424","display_name":"Haibo Ye","orcid":"https://orcid.org/0000-0001-8200-0685","observed_orcids":["https://orcid.org/0000-0001-8200-0685"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai\u2010Bo Ye","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai\u2010Ming Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai\u2010Ming Su","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045242838","display_name":"Hai Peng Lin","orcid":"https://orcid.org/0000-0001-8383-469X","observed_orcids":["https://orcid.org/0000-0001-8383-469X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai Lin","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108666105","display_name":"Wei\u2010Tian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei\u2010Tian Zhang","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045242838"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":2.6502,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89701249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"11","first_page":"1334","last_page":"1341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-rhinosinusitis-with-nasal-polyps","display_name":"chronic rhinosinusitis with nasal polyps","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trpc6","display_name":"TRPC6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6840000152587891},{"id":"https://openalex.org/keywords/eosinophilic-crswnp","display_name":"eosinophilic CRSwNP","score":0.847000002861023},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.6470000147819519},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8119999766349792},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/il-25","display_name":"IL-25","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-nasal-epithelial-cells","display_name":"human nasal epithelial cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9470000267028809},{"id":"https://openalex.org/keywords/1-oleoyl-2-acetyl-sn-glycerol","display_name":"OAG","score":0.609000027179718},{"id":"https://openalex.org/keywords/skf-96365","display_name":"SKF96365","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pro-inflammatory-pathways","display_name":"pro-inflammatory pathways","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C128448793","wikidata":"https://www.wikidata.org/wiki/Q14914578","display_name":"TRPC6","level":4,"score":0.8213269710540771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6976173520088196},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.661858856678009},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.6423584222793579},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.504982054233551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.495736688375473},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.41074681282043457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3909505605697632},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37599799036979675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33107876777648926},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.17741134762763977}],"mesh":[{"descriptor_ui":"D000071737","descriptor_name":"Stromal Interaction Molecule 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071737","descriptor_name":"Stromal Interaction Molecule 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000071740","descriptor_name":"ORAI1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071740","descriptor_name":"ORAI1 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000074287","descriptor_name":"TRPC6 Cation Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000074287","descriptor_name":"TRPC6 Cation Channel","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/alr.22208","doi":"https://doi.org/10.1002/alr.22208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alr.22208","pdf_url":null,"source":{"id":"https://openalex.org/S2506670899","display_name":"International Forum of Allergy & Rhinology","issn_l":"2042-6976","issn":["2042-6976","2042-6984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Forum of Allergy & Rhinology","raw_type":"journal-article"},{"id":"pmid:30216703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30216703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International forum of allergy & rhinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4759226184","display_name":null,"funder_award_id":"16ZR1426100","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1607477602","https://openalex.org/W1861265689","https://openalex.org/W1978596588","https://openalex.org/W2088149329","https://openalex.org/W2124204692","https://openalex.org/W2135071059","https://openalex.org/W2219124685","https://openalex.org/W2275028388","https://openalex.org/W2326848568","https://openalex.org/W2427182891","https://openalex.org/W2462860861","https://openalex.org/W2469239379","https://openalex.org/W2517452923","https://openalex.org/W2547721329","https://openalex.org/W2554506152","https://openalex.org/W2594646902","https://openalex.org/W2609071178","https://openalex.org/W2742572965","https://openalex.org/W2755287478","https://openalex.org/W2755709159","https://openalex.org/W2758624196","https://openalex.org/W2763526200","https://openalex.org/W2770824493","https://openalex.org/W2780402932","https://openalex.org/W2782082535","https://openalex.org/W2791425351","https://openalex.org/W2793414915"],"related_works":["https://openalex.org/W4395049845","https://openalex.org/W2891861979","https://openalex.org/W7138949894","https://openalex.org/W4380147590","https://openalex.org/W2105700400","https://openalex.org/W4293234683","https://openalex.org/W3026584314","https://openalex.org/W7128784609","https://openalex.org/W1978570564","https://openalex.org/W3009558940"],"abstract_inverted_index":{"Background":[0],"The":[1,90,202],"pathogenesis":[2,34,251],"of":[3,24,35,92,124,147,162,185,204,252],"chronic":[4],"rhinosinusitis":[5],"with":[6,76,176,182,196],"nasal":[7,112],"polyps":[8],"(CRSwNP)":[9],"has":[10],"not":[11],"been":[12],"fully":[13],"elucidated.":[14],"This":[15],"study":[16],"sought":[17],"to":[18,42,53,141],"explore":[19],"the":[20,33,119,143,183,250],"role":[21,248],"and":[22,61,86,99,117,136,145,152,165,187,198,210,228,236],"mechanism":[23],"transient":[25],"receptor":[26],"potential":[27],"canonical":[28],"channel":[29,65],"6":[30],"(TRPC6)":[31],"in":[32,73,170,174,214,217,249],"CRSwNP.":[36],"Methods":[37],"Immunohistochemistry":[38],"(IHC)":[39],"was":[40,51,127,168,193],"employed":[41],"evaluate":[43],"TRPC6":[44,148,153,191,244],"immunolabeling.":[45],"Real\u2010time":[46],"polymerase":[47],"chain":[48],"reaction":[49],"(PCR)":[50],"conducted":[52,140],"assay":[54,106],"TRPC6,":[55,163,222],"stromal":[56],"interaction":[57],"molecule":[58],"1":[59,67],"(STIM1),":[60],"calcium":[62,64],"release\u2010activated":[63],"protein":[66],"(Orai1)":[68],"messenger":[69],"RNA":[70],"(mRNA)":[71],"levels":[72,167],"70":[74],"patients":[75],"CRSwNP,":[77,215],"including":[78,95,207],"eosinophilic":[79],"CRSwNP":[80,84,171,253],"(ECRSwNP)":[81],"or":[82],"non\u2010eosinophilic":[83],"(nECRSwNP),":[85],"28":[87],"control":[88],"subjects.":[89],"concentrations":[91,203],"inflammatory":[93,205,229],"mediators,":[94,206],"interleukin":[96],"(IL)\u20101\u03b2,":[97],"IL\u20105,":[98,209],"IL\u201025,":[100,211],"were":[101,138,212,231,239],"assayed":[102,128],"by":[103,129,233,241],"enzyme\u2010linked":[104],"immunosorbent":[105],"(ELISA).":[107],"In":[108,219],"experiments":[109],"on":[110,158],"human":[111],"epithelial":[113],"cell":[114],"(HNEC)":[115],"culture":[116],"stimulation,":[118],"mean":[120],"fluorescence":[121],"intensity":[122],"(MFI)":[123],"intracellular":[125],"Ca2+":[126,225,256],"flow":[130],"cytometry.":[131],"Western":[132],"blotting,":[133],"real\u2010time":[134],"PCR,":[135],"ELISA":[137],"also":[139],"assess":[142],"effects":[144],"mechanisms":[146],"activator":[149],"1\u2010oleoyl\u20102\u2010acetyl\u2010glycerol":[150],"(OAG)":[151],"inhibitor":[154],"1\u2010[2\u2010(4\u2010methoxyphenyl)\u20102\u2010[3\u2010(4\u2010methoxyphenyl)":[155],"propoxy]ethyl\u20101H\u2010imidazole":[156],"(SKF\u201096365)":[157],"HNECs.":[159],"Results":[160],"Upregulation":[161],"STIM1,":[164,223],"Orai1":[166,199],"found":[169],"patients,":[172],"particularly":[173],"those":[175],"ECRSwNP.":[177,218],"TRPC6\u2010positive":[178],"cells":[179],"correlated":[180,195],"positively":[181,194],"numbers":[184],"eosinophils":[186],"neutrophils,":[188],"respectively.":[189],"Moreover,":[190],"mRNA":[192,200],"STIM1":[197],"levels.":[201],"IL\u20101\u03b2,":[208],"elevated":[213],"especially":[216],"cultured":[220],"HNECs,":[221],"Orai1,":[224],"MFI":[226],"levels,":[227],"mediators":[230],"upregulated":[232],"lipopolysaccharide":[234],"(LPS)":[235],"OAG":[237],"but":[238],"inhibited":[240],"SKF\u201096365.":[242],"Conclusion":[243],"plays":[245],"a":[246],"pro\u2010inflammatory":[247],"via":[254],"regulating":[255],"flow.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}