{"id":"https://openalex.org/W2891908104","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","title":"Clinical trial in progress: A phase 3 study of maintenance bi-shRNA-furin/GM-CSF-expressing autologous tumor cell vaccine in women with stage IIIb-IV high-grade epithelial ovarian cancer.","display_name":"Clinical trial in progress: A phase 3 study of maintenance bi-shRNA-furin/GM-CSF-expressing autologous tumor cell vaccine in women with stage IIIb-IV high-grade epithelial ovarian cancer.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2891908104","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","mag":"2891908104"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.tps5604","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112586707","display_name":"Jonathan Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800124591","display_name":"Texas Oncology","ror":"https://ror.org/02ketev28","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800124591"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Oh","raw_affiliation_strings":["Texas Oncology, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Oncology, Dallas, TX;","institution_ids":["https://openalex.org/I2800124591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015591858","display_name":"Minal A. Barve","orcid":"https://orcid.org/0009-0007-4259-7457","observed_orcids":["https://orcid.org/0009-0007-4259-7457"]},"institutions":[{"id":"https://openalex.org/I2800124591","display_name":"Texas Oncology","ror":"https://ror.org/02ketev28","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800124591"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minal A. Barve","raw_affiliation_strings":["Texas Oncology, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Oncology, Dallas, TX;","institution_ids":["https://openalex.org/I2800124591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109777590","display_name":"Devansu S. Tewari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devansu Tewari","raw_affiliation_strings":["Kaiser Permanente, Newport Coast, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente, Newport Coast, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024129361","display_name":"John K. Chan","orcid":"https://orcid.org/0000-0003-3379-6829","observed_orcids":["https://orcid.org/0000-0003-3379-6829"]},"institutions":[{"id":"https://openalex.org/I1317822957","display_name":"Palo Alto Medical Foundation","ror":"https://ror.org/04rg6e566","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114073160","https://openalex.org/I1317822957"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John K. Chan","raw_affiliation_strings":["Palo Alto Medical Foundation, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palo Alto Medical Foundation, San Francisco, CA;","institution_ids":["https://openalex.org/I1317822957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113905258","display_name":"Elizabeth A. Grosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105083","display_name":"Cancer Care Northwest","ror":"https://ror.org/01c15bz20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Grosen","raw_affiliation_strings":["Cancer Care Northwest, Spokane, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Northwest, Spokane, WA;","institution_ids":["https://openalex.org/I4210105083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042371948","display_name":"Rodney Paul Rocconi","orcid":"https://orcid.org/0000-0001-8642-5859","observed_orcids":["https://orcid.org/0000-0001-8642-5859"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney Paul Rocconi","raw_affiliation_strings":["University of South Alabama, Mobile, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama, Mobile, AL;","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043199850","display_name":"Erin Stevens","orcid":"https://orcid.org/0000-0002-8876-2557","observed_orcids":["https://orcid.org/0000-0002-8876-2557"]},"institutions":[{"id":"https://openalex.org/I99840902","display_name":"Billings Clinic","ror":"https://ror.org/05arxpe18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I99840902"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Elizabeth Stevens","raw_affiliation_strings":["Billings Clinic, Billings, MT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Billings Clinic, Billings, MT;","institution_ids":["https://openalex.org/I99840902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081691207","display_name":"Leslie Robbins DeMars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Robbins DeMars","raw_affiliation_strings":["Dartmouth-Hitchcock Medical Center, Lebanon, NH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth-Hitchcock Medical Center, Lebanon, NH;","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049011165","display_name":"Sharad A. Ghamande","orcid":"https://orcid.org/0000-0003-2242-2215","observed_orcids":["https://orcid.org/0000-0003-2242-2215"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharad A. Ghamande","raw_affiliation_strings":["The Georgia Cancer Center at Augusta University, Augusta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Georgia Cancer Center at Augusta University, Augusta, GA;","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009234043","display_name":"Robert Louis Coleman","orcid":"https://orcid.org/0000-0001-9343-8754","observed_orcids":["https://orcid.org/0000-0001-9343-8754"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Coleman","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032051379","display_name":"Luisa Manning","orcid":"https://orcid.org/0000-0001-8568-1535","observed_orcids":["https://orcid.org/0000-0001-8568-1535"]},"institutions":[{"id":"https://openalex.org/I4210094538","display_name":"Gradalis (United States)","ror":"https://ror.org/00jv1ms45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa Manning","raw_affiliation_strings":["Gradalis, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gradalis, Inc., Dallas, TX;","institution_ids":["https://openalex.org/I4210094538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052040011","display_name":"Gladice Wallraven","orcid":"https://orcid.org/0000-0002-2145-3565","observed_orcids":["https://orcid.org/0000-0002-2145-3565"]},"institutions":[{"id":"https://openalex.org/I4210094538","display_name":"Gradalis (United States)","ror":"https://ror.org/00jv1ms45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gladice Wallraven","raw_affiliation_strings":["Gradalis, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gradalis, Inc., Dallas, TX;","institution_ids":["https://openalex.org/I4210094538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111839131","display_name":"Neil N. Senzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil N. Senzer","raw_affiliation_strings":["Mary Crowley Cancer Research Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Cancer Research Center, Dallas, TX;","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646950","display_name":"Martin J. Birkhofer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094538","display_name":"Gradalis (United States)","ror":"https://ror.org/00jv1ms45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Birkhofer","raw_affiliation_strings":["Gradalis, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gradalis, Inc., Dallas, TX;","institution_ids":["https://openalex.org/I4210094538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055054082","display_name":"John J. Nemunaitis","orcid":"https://orcid.org/0000-0002-2234-2381","observed_orcids":["https://orcid.org/0000-0002-2234-2381"]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Nemunaitis","raw_affiliation_strings":["Mary Crowley Cancer Research Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Cancer Research Center, Dallas, TX;","institution_ids":["https://openalex.org/I4210087725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"TPS5604","last_page":"TPS5604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6269999742507935},{"id":"https://openalex.org/keywords/autologous-tumor-cell-vaccine","display_name":"autologous tumor cell vaccine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/vigil","display_name":"vigil","score":0.7120000123977661},{"id":"https://openalex.org/keywords/furin","display_name":"furin","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9940000176429749},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tgf-beta-inhibition","display_name":"TGF-beta inhibition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.6259999871253967},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8650000095367432},{"id":"https://openalex.org/keywords/papillary-serous-carcinoma","display_name":"papillary serous carcinoma","score":0.6970000267028809},{"id":"https://openalex.org/keywords/clear-cell-carcinoma","display_name":"clear cell carcinoma","score":0.8029999732971191},{"id":"https://openalex.org/keywords/endometrioid-carcinoma","display_name":"endometrioid carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.6499999761581421},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.891442060470581},{"id":"https://openalex.org/C2778447413","wikidata":"https://www.wikidata.org/wiki/Q1238731","display_name":"Vigil","level":2,"score":0.5909008979797363},{"id":"https://openalex.org/C2781100745","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Debulking","level":4,"score":0.5786730051040649},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5566565990447998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5183426141738892},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4476296007633209},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4471302330493927},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4244518280029297},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.42391374707221985},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.41336870193481445},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.40127256512641907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3844708204269409},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3841474652290344},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3811313807964325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2052237093448639},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16865602135658264},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12065714597702026},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.07988482713699341},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.tps5604","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.tps5604","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133480631","https://openalex.org/W2065800215","https://openalex.org/W3097676887","https://openalex.org/W59268075","https://openalex.org/W2944256364","https://openalex.org/W74951144","https://openalex.org/W2377725145","https://openalex.org/W4255034425","https://openalex.org/W4286299135","https://openalex.org/W2891908104"],"abstract_inverted_index":{"TPS5604":[0],"Background:":[1],"Vigil":[2,53,88,112,144,175,207,262],"is":[3,101,179,199,215,290],"an":[4,43,277],"immuno-stimulatory":[5],"autologous":[6],"cellular":[7],"therapy,":[8],"which":[9],"uses":[10],"patient":[11],"tumor":[12,148],"cells":[13],"transfected":[14],"with":[15,92,115,236],"a":[16,82,102,135,140,157,237,255],"plasmid":[17],"encoding":[18],"genes":[19],"for":[20,229],"GM-CSF":[21],"and":[22,139,164,191,210,231,276],"furin":[23],"(to":[24],"down":[25],"regulate":[26],"TGF\u03b2":[27],"1&2).":[28],"In":[29],"Phase":[30,49,83,107],"I,":[31],"systemic":[32],"immune":[33],"activation":[34],"was":[35,96],"demonstrated":[36,61],"in":[37,58,90,113,245,284,309],"the":[38,211,246,264,303,312,317],"majority":[39],"of":[40,52,86,110,137,142,183,203,223,234,240,259,267,286],"patients":[41,91,225,272,280,296],"using":[42],"IFN\u0194":[44],"ELISPOT":[45],"assay.":[46],"A":[47],"randomized":[48,168,205,275],"2":[50],"assessment":[51],"maintenance":[54,87,111],"therapy":[55,89],"vs.":[56,187,193,208],"observation":[57],"ovarian":[59,94],"cancer":[60,95],"prolonged":[62],"relapse":[63],"free":[64],"survival":[65,217],"(RFS)":[66],"(Oh":[67],"J,":[68],"Barve":[69],"M,":[70],"et":[71],"al.":[72],"Gynecologic":[73],"Oncology,":[74],"2016;":[75],"143:":[76],"504\u2013510.).":[77],"Based":[78],"on":[79],"these":[80],"observations,":[81],"3":[84,108],"study":[85,109,318],"advanced":[93],"initiated":[97],"(NCT02346747).":[98],"Methods:":[99],"This":[100,249],"multicenter,":[103],"randomized,":[104],"double-blind,":[105],"placebo-controlled,":[106],"women":[114],"Stage":[116],"IIIb,c":[117],"or":[118,128,176],"IV":[119],"high-grade":[120],"papillary":[121],"serous/clear":[122],"cell/":[123],"endometrioid":[124],"ovarian,":[125],"fallopian":[126],"tube":[127],"primary":[129,151,162,197],"peritoneal":[130],"cancer.":[131],"Patients":[132,154],"will":[133],"have":[134,273],"minimum":[136],"4":[138],"maximum":[141],"12":[143],"doses":[145],"manufactured":[146],"from":[147,243,293],"obtained":[149,292],"at":[150,263,299],"debulking":[152],"surgery.":[153],"must":[155],"achieve":[156],"complete":[158],"clinical":[159],"remission":[160],"following":[161],"surgery":[163],"chemotherapy":[165,283],"before":[166],"being":[167,291],"1:1":[169],"to":[170,200,206,253],"receive":[171],"either":[172],"monthly":[173],"intradermal":[174],"placebo.":[177],"Randomization":[178],"stratified":[180],"by":[181],"extent":[182],"surgical":[184],"cytoreduction":[185],"(complete/microscopic":[186],"macroscopic":[188],"residual":[189],"disease)":[190],"neoadjuvant":[192],"adjuvant":[194],"chemotherapy.":[195],"The":[196,219],"objective":[198,214],"compare":[201],"RFS":[202,239],"subjects":[204],"placebo,":[209],"key":[212],"secondary":[213],"overall":[216],"(OS).":[218],"sample":[220],"size":[221],"calculation":[222],"222":[224],"assumes":[226],"24":[227],"months":[228,233,242],"accrual":[230],"36":[232],"follow-up":[235],"median":[238],"19":[241],"randomization,":[244],"control":[247],"group.":[248],"provides":[250],"90%":[251],"power":[252],"detect":[254],"hazard":[256],"ratio":[257],"(HR)":[258],"0.6":[260],"favoring":[261],"0.05":[265],"level":[266],"significance.":[268],"To":[269],"date,":[270],"61":[271],"been":[274],"additional":[278],"55":[279],"are":[281],"receiving":[282],"anticipation":[285],"randomization.":[287],"Tumor":[288],"tissue":[289],"approximately":[294],"20":[295],"per":[297],"month":[298],"multiple":[300],"sites":[301],"across":[302],"U.S.":[304],"At":[305],"their":[306],"last":[307],"meeting":[308],"January,":[310],"2017":[311],"independent":[313],"DSMB":[314],"recommended":[315],"that":[316],"continue":[319],"without":[320],"change.":[321],"Clinical":[322],"trial":[323],"information:":[324],"NCT02346747.":[325]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
