{"id":"https://openalex.org/W2891904697","doi":"https://doi.org/10.3892/ol.2018.9388","title":"Histone deacetylase inhibitors sensitize 5\u2011fluorouracil\u2011resistant MDA\u2011MB\u2011468 breast cancer cells to 5\u2011fluorouracil","display_name":"Histone deacetylase inhibitors sensitize 5\u2011fluorouracil\u2011resistant MDA\u2011MB\u2011468 breast cancer cells to 5\u2011fluorouracil","publication_year":2018,"publication_date":"2018-09-04","ids":{"openalex":"https://openalex.org/W2891904697","doi":"https://doi.org/10.3892/ol.2018.9388","mag":"2891904697","pmid":"https://pubmed.ncbi.nlm.nih.gov/30333885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6176421"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2018.9388","doi":"https://doi.org/10.3892/ol.2018.9388","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2018.9388","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2018.9388/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2018.9388/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060413124","display_name":"Tetsuya Minegaki","orcid":"https://orcid.org/0000-0001-7410-1566","observed_orcids":["https://orcid.org/0000-0001-7410-1566"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Minegaki","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791227","display_name":"Ai Suzuki","orcid":"https://orcid.org/0009-0003-1638-482X","observed_orcids":["https://orcid.org/0009-0003-1638-482X","https://orcid.org/0000-0003-4887-7314"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ai Suzuki","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055587043","display_name":"Misato Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misato Mori","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065456574","display_name":"Shiori Tsuji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiori Tsuji","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101426683","display_name":"Satoshi Yamamoto","orcid":"https://orcid.org/0000-0001-8278-4467","observed_orcids":["https://orcid.org/0000-0001-8278-4467"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yamamoto","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113850356","display_name":"Airi Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Airi Watanabe","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoyo Tsuzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyo Tsuzuki","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009168851","display_name":"Takaki Tsunoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaki Tsunoda","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102319574","display_name":"Asuka Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asuka Yamamoto","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015364418","display_name":"Masayuki Tsujimoto","orcid":"https://orcid.org/0000-0003-1325-8329","observed_orcids":["https://orcid.org/0000-0003-1325-8329"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Tsujimoto","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110247227","display_name":"Kohshi Nishiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohshi Nishiguchi","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto 607\u20118414, Japan","institution_ids":["https://openalex.org/I25998863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25998863"],"apc_list":null,"apc_paid":null,"fwci":0.7763,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66598614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"6202","last_page":"6208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/5-fluorouracil-resistance","display_name":"5-fluorouracil resistance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.925000011920929},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.6140000224113464},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dihydropyrimidine-dehydrogenase","display_name":"dihydropyrimidine dehydrogenase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9179999828338623},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.9142199754714966},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6963930130004883},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6274428367614746},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5398333668708801},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.517876148223877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5054709911346436},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5006065368652344},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3248295485973358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3188038468360901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31232595443725586},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.29451411962509155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11514130234718323},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07913669943809509}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/ol.2018.9388","doi":"https://doi.org/10.3892/ol.2018.9388","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2018.9388","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2018.9388/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5136317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6176421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30333885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30333885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6176421","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6176421/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ol.2018.9388","doi":"https://doi.org/10.3892/ol.2018.9388","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2018.9388","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2018.9388/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2655952414","display_name":null,"funder_award_id":"S1311035","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G632704655","display_name":null,"funder_award_id":"2013\u22122017","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2891904697.pdf","grobid_xml":"https://content.openalex.org/works/W2891904697.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1585890881","https://openalex.org/W1967631079","https://openalex.org/W1974426729","https://openalex.org/W1976415661","https://openalex.org/W1979692390","https://openalex.org/W1995135164","https://openalex.org/W2003837981","https://openalex.org/W2019126051","https://openalex.org/W2023237279","https://openalex.org/W2036507983","https://openalex.org/W2039167536","https://openalex.org/W2046479872","https://openalex.org/W2070193531","https://openalex.org/W2075821619","https://openalex.org/W2080666241","https://openalex.org/W2086499924","https://openalex.org/W2103846273","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2115984906","https://openalex.org/W2117640334","https://openalex.org/W2138779747","https://openalex.org/W2303340665","https://openalex.org/W2557636895","https://openalex.org/W2559497776","https://openalex.org/W2595647460","https://openalex.org/W2724336500","https://openalex.org/W7073656689"],"related_works":["https://openalex.org/W1965874948","https://openalex.org/W2114166108","https://openalex.org/W2022774864","https://openalex.org/W2969004544","https://openalex.org/W1996387142","https://openalex.org/W1991548839","https://openalex.org/W2117321270","https://openalex.org/W2005745992","https://openalex.org/W2023237279","https://openalex.org/W4407397977"],"abstract_inverted_index":{"Resistance":[0],"to":[1,18,46,90,99,138,170,191],"5\u2011fluorouracil":[2],"(5\u2011FU)":[3],"is":[4,14],"a":[5,56,127,141,173],"serious":[6],"problem":[7],"in":[8,16,31,50,70,149,154,172,193],"cancer":[9,23,32,59],"therapy":[10],"and":[11,64,108,112,162,195],"overcoming":[12],"it":[13,36],"required":[15],"order":[17],"improve":[19],"the":[20,53,65,87,123,133,145,166,178,181,189],"efficacy":[21],"of":[22,67,86,105,117,135,147,180],"chemotherapy.":[24],"Histone":[25],"deacetylase":[26],"(HDAC)":[27],"inhibitors":[28,42,69,187],"are":[29],"used":[30],"treatments":[33],"and,":[34],"recently,":[35],"has":[37],"been":[38],"reported":[39],"that":[40,185],"HDAC":[41,68,158,186],"can":[43],"overcome":[44],"resistance":[45,98],"various":[47],"anti\u2011cancer":[48],"drugs":[49],"vitro.":[51],"In":[52,176],"present":[54,182],"study,":[55],"5\u2011FU\u2011resistant":[57,76],"breast":[58],"cell":[60,77,168],"line":[61,78],"was":[62,81,94],"established,":[63],"effects":[66],"these":[71],"cells":[72,89,137],"were":[73],"examined.":[74],"The":[75,157],"MDA\u2011MB\u2011468":[79],"(MDA468/FU)":[80],"established":[82],"by":[83,96],"continuous":[84],"exposure":[85],"parental":[88,124],"5\u2011FU.":[91,139],"This":[92],"subline":[93],"characterized":[95],"high":[97],"5\u2011FU,":[100],"higher":[101],"mRNA":[102,114],"expression":[103,115],"levels":[104,116],"thymidylate":[106],"synthetase":[107,120],"dihydropyrimidine":[109],"dehydrogenase":[110],"(DPD),":[111],"lower":[113],"uridine":[118],"monophosphate":[119],"(UMPS)":[121],"than":[122],"cells.":[125,156,197],"Gimeracil,":[126],"DPD":[128],"inhibitor,":[129,143],"did":[130],"not":[131,153],"affect":[132],"sensitivity":[134,190],"MDA468/FU":[136,155],"Oteracil,":[140],"UMPS":[142],"decreased":[144],"cytotoxicity":[146],"5\u2011FU":[148,171,192],"MDA468":[150],"cells,":[151],"but":[152],"inhibitors,":[159],"valproic":[160],"acid":[161,164],"suberanilohydroxamic":[163],"sensitized":[165],"two":[167],"lines":[169],"concentration\u2011dependent":[174],"manner.":[175],"conclusion,":[177],"results":[179],"study":[183],"revealed":[184],"increase":[188],"5\u2011FU\u2011sensitive":[194],"\u2011resistant":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-09-27T00:00:00"}