{"id":"https://openalex.org/W2891856808","doi":"https://doi.org/10.21037/cco.2018.08.12","title":"Hepatocellular carcinoma surgical therapy: perspectives on the current limits to resection","display_name":"Hepatocellular carcinoma surgical therapy: perspectives on the current limits to resection","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2891856808","doi":"https://doi.org/10.21037/cco.2018.08.12","mag":"2891856808","pmid":"https://pubmed.ncbi.nlm.nih.gov/30395716"},"language":"en","primary_location":{"id":"doi:10.21037/cco.2018.08.12","doi":"https://doi.org/10.21037/cco.2018.08.12","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2018.08.12","pdf_url":null,"source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/cco.2018.08.12","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032656184","display_name":"Akhil Chawla","orcid":"https://orcid.org/0000-0003-3122-6873","observed_orcids":["https://orcid.org/0000-0003-3122-6873"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akhil Chawla","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061627885","display_name":"Cristina Rosa Ferrone","orcid":"https://orcid.org/0000-0002-6295-1085","observed_orcids":["https://orcid.org/0000-0002-6295-1085"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ferrone","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. cferrone@mgh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. cferrone@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5012,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90076883,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"5","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.9169999957084656},{"id":"https://openalex.org/keywords/advanced-liver-cancer","display_name":"advanced liver cancer","score":0.5709999799728394},{"id":"https://openalex.org/keywords/bclc-staging","display_name":"Barcelona Clinic Liver Cancer staging","score":0.7519999742507935},{"id":"https://openalex.org/keywords/local-treatment","display_name":"local therapy","score":0.46299999952316284},{"id":"https://openalex.org/keywords/resectability","display_name":"resectability","score":0.5220000147819519},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9575661420822144},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7653608322143555},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6675302386283875},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.6345548033714294},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.592839241027832},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5707750916481018},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4817790687084198},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.41684022545814514},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.41071751713752747},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3343648314476013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18140462040901184},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21037/cco.2018.08.12","doi":"https://doi.org/10.21037/cco.2018.08.12","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2018.08.12","pdf_url":null,"source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:30395716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30395716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese clinical oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/cco.2018.08.12","doi":"https://doi.org/10.21037/cco.2018.08.12","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2018.08.12","pdf_url":null,"source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947753690","https://openalex.org/W2551980871","https://openalex.org/W7025162476","https://openalex.org/W2716210406","https://openalex.org/W2792361498","https://openalex.org/W3024308557","https://openalex.org/W3135060221","https://openalex.org/W4255004392","https://openalex.org/W7214995786","https://openalex.org/W2888292351"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"patients":[3,20,136],"often":[4],"present":[5],"with":[6,21],"late":[7],"stage":[8],"disease,":[9],"which":[10],"removes":[11],"surgical":[12,31,62,104,133],"resection":[13,63,105,134],"from":[14],"the":[15,41,46,59,77,88,101,109,119,126,130],"therapeutic":[16],"treatment":[17,74,84],"options.":[18],"Only":[19],"very":[22],"early":[23],"disease":[24,67,94],"are":[25],"recommended":[26],"for":[27,53,64,90,106],"a":[28,143],"potentially":[29],"curative":[30],"resection.":[32],"These":[33],"guidelines":[34,122,128],"have":[35],"been":[36],"broadly":[37],"challenged":[38],"due":[39],"to":[40,135,141],"lack":[42],"of":[43,48,61,76,103,118,132],"evidence":[44],"supporting":[45],"use":[47],"local":[49],"therapies":[50],"over":[51],"surgery":[52,91],"resectable":[54],"disease.":[55],"This":[56],"review":[57],"highlights":[58],"role":[60,89],"HCC":[65],"by":[66],"stage,":[68],"and":[69],"reports":[70],"data":[71],"that":[72,115],"supports":[73],"outside":[75],"accepted":[78],"Barcelona":[79],"Clinic":[80],"Liver":[81],"Cancer":[82],"(BCLC)":[83],"algorithm.":[85],"As":[86],"such,":[87],"in":[92],"advanced":[93],"is":[95,113],"also":[96,99],"reviewed.":[97],"We":[98],"highlight":[100],"limitations":[102],"HCC.":[107],"With":[108],"available":[110],"data,":[111],"it":[112],"crucial":[114],"an":[116],"update":[117],"current":[120,127],"clinical":[121],"be":[123,139],"introduced,":[124],"as":[125],"prohibit":[129],"benefit":[131],"who":[137],"may":[138],"able":[140],"achieve":[142],"survival":[144],"benefit.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}