{"id":"https://openalex.org/W2891745772","doi":"https://doi.org/10.1039/c8nr03870h","title":"Visualising nanoscale restructuring of a cellular membrane triggered by polyelectrolyte microcapsules","display_name":"Visualising nanoscale restructuring of a cellular membrane triggered by polyelectrolyte microcapsules","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2891745772","doi":"https://doi.org/10.1039/c8nr03870h","mag":"2891745772","pmid":"https://pubmed.ncbi.nlm.nih.gov/30176032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6137606"},"language":"en","primary_location":{"id":"doi:10.1039/c8nr03870h","doi":"https://doi.org/10.1039/c8nr03870h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8nr03870h","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1039/c8nr03870h","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102708504","display_name":"Yuxiu Chen","orcid":"https://orcid.org/0009-0001-2218-1055","observed_orcids":["https://orcid.org/0009-0001-2218-1055"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yuxiu Chen","raw_affiliation_strings":["London E1 4NS","Queen Mary University of London","School of Engineering and Materials Science","UK","School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London E1 4NS","institution_ids":[]},{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"School of Engineering and Materials Science","institution_ids":[]},{"raw_affiliation_string":"UK","institution_ids":[]},{"raw_affiliation_string":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063248406","display_name":"Gleb B. Sukhorukov","orcid":"https://orcid.org/0000-0001-6213-0562","observed_orcids":["https://orcid.org/0000-0001-6213-0562"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gleb B. Sukhorukov","raw_affiliation_strings":["London E1 4NS","Queen Mary University of London","School of Engineering and Materials Science","UK","School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London E1 4NS","institution_ids":[]},{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"School of Engineering and Materials Science","institution_ids":[]},{"raw_affiliation_string":"UK","institution_ids":[]},{"raw_affiliation_string":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013401981","display_name":"Pavel Nov\u00e1k","orcid":"https://orcid.org/0000-0002-5461-0344","observed_orcids":["https://orcid.org/0000-0002-5461-0344"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Pavel Novak","raw_affiliation_strings":["London E1 4NS","Queen Mary University of London","School of Engineering and Materials Science","UK","School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK"],"raw_orcid":"https://orcid.org/0000-0002-5461-0344","affiliations":[{"raw_affiliation_string":"London E1 4NS","institution_ids":[]},{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"School of Engineering and Materials Science","institution_ids":[]},{"raw_affiliation_string":"UK","institution_ids":[]},{"raw_affiliation_string":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013401981","https://openalex.org/A5063248406"],"corresponding_institution_ids":["https://openalex.org/I166337079"],"apc_list":null,"apc_paid":{"value":1809,"currency":"EUR","value_usd":1951},"fwci":0.8144,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.61524214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"35","first_page":"16902","last_page":"16910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyelectrolyte-microcapsules","display_name":"polyelectrolyte microcapsules","score":0.9599999785423279},{"id":"https://openalex.org/keywords/microencapsulation","display_name":"microencapsulation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/intracellular-drug-delivery","display_name":"intracellular drug delivery","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.6340000033378601},{"id":"https://openalex.org/keywords/membrane-protrusions","display_name":"membrane protrusions","score":0.9670000076293945},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.7400000095367432},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/scanning-ion-conductance-microscopy","display_name":"scanning ion conductance microscopy","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.8276294469833374},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.7897676229476929},{"id":"https://openalex.org/C45237549","wikidata":"https://www.wikidata.org/wiki/Q1376796","display_name":"Restructuring","level":2,"score":0.7851418256759644},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5711883306503296},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5313470959663391},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5102989673614502},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.39549916982650757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23765474557876587},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.18715804815292358},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.13747861981391907},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12348833680152893},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09025654196739197},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1039/c8nr03870h","doi":"https://doi.org/10.1039/c8nr03870h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8nr03870h","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5128425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6137606","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6137606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6137606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Text"},{"id":"pmid:30176032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30176032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/44525","doi":null,"is_oa":true,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/44525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1039/c8nr03870h","doi":"https://doi.org/10.1039/c8nr03870h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c8nr03870h","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G517366671","display_name":"Targeted drug delivery to neurons and glia using light- and field-sensitive microcapsules","funder_award_id":"BB/J001473/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5660671562","display_name":"Mapping mechanotransduction mediated by primary cilia at nanoscale","funder_award_id":"109724/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6868616705","display_name":null,"funder_award_id":"/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1987637234","https://openalex.org/W2029899207","https://openalex.org/W2048736491","https://openalex.org/W2077743495","https://openalex.org/W2077813193","https://openalex.org/W2080923741","https://openalex.org/W2087591542","https://openalex.org/W2096781774","https://openalex.org/W2097840191","https://openalex.org/W2106509124","https://openalex.org/W2123673392","https://openalex.org/W2138036933","https://openalex.org/W2140796616","https://openalex.org/W2154895149","https://openalex.org/W2163428285","https://openalex.org/W2170750193","https://openalex.org/W2176370490","https://openalex.org/W2314125320","https://openalex.org/W2333282498","https://openalex.org/W2399530791","https://openalex.org/W2509948625","https://openalex.org/W2524232978","https://openalex.org/W3114623828"],"related_works":["https://openalex.org/W2785485690","https://openalex.org/W2410596565","https://openalex.org/W2234168478","https://openalex.org/W2639330194","https://openalex.org/W2523024347","https://openalex.org/W2751593216","https://openalex.org/W2045421008","https://openalex.org/W3084326325","https://openalex.org/W3213011286","https://openalex.org/W2292076867"],"abstract_inverted_index":{"Polymer-based":[0],"multilayer":[1],"microencapsulation":[2],"technology":[3],"represents":[4],"one":[5],"of":[6,65,85,112,123,127,140,147,155],"the":[7,62,74,83,121,135,141,145,148,151,163,168,171,188,197,200],"promising":[8],"strategies":[9],"for":[10],"intracellular":[11],"drug":[12],"delivery,":[13],"however,":[14],"membrane":[15,86,142,173,205],"processes":[16,43],"involved":[17],"in":[18,47,68,88,176],"vehicle":[19],"internalisation":[20,67,75,132],"are":[21,162],"not":[22,96],"fully":[23],"understood.":[24],"Here":[25],"we":[26],"employed":[27],"a":[28,97],"scanning":[29],"probe":[30],"microscopy":[31],"technique":[32],"called":[33],"Scanning":[34],"Ion":[35],"Conductance":[36],"Microscopy":[37],"(SICM)":[38],"to":[39,53,108,190],"study":[40],"these":[41,113,161],"complex":[42],"at":[44,196],"nanoscale":[45,110,181],"resolution":[46],"real":[48],"time.":[49],"We":[50],"were":[51],"able":[52],"image":[54],"topography":[55],"simultaneously":[56],"with":[57,180],"local":[58],"elastic":[59,128],"modulus":[60,129],"throughout":[61],"whole":[63,178],"course":[64],"microcapsule":[66],"A549":[69],"cell":[70],"culture":[71],"without":[72],"disrupting":[73],"process.":[76],"The":[77,183],"imaging":[78],"revealed":[79],"that":[80],"capsules":[81],"triggered":[82],"formation":[84],"protrusions":[87,114],"their":[89,177],"vicinity,":[90],"which":[91],"is":[92],"an":[93],"important":[94],"but":[95],"sufficient":[98],"step":[99],"towards":[100],"full":[101],"capsule":[102,131,149,156],"internalisation.":[103],"A":[104],"crucial":[105],"aspect":[106],"appeared":[107],"be":[109],"restructuring":[111],"into":[115,194],"smooth":[116],"thin":[117],"layers":[118],"extending":[119],"over":[120,144],"surface":[122,146],"capsules.":[124],"Simultaneous":[125],"mapping":[126],"during":[130,138],"allowed":[133],"monitoring":[134],"structural":[136],"changes":[137],"extension":[139],"sheets":[143],"and":[150,174,203],"subsequent":[152],"post-internalisation":[153],"phenomenon":[154],"buckling.":[157],"To":[158],"our":[159],"knowledge":[160],"first":[164],"experimental":[165],"data":[166],"capturing":[167],"interactions":[169,195],"between":[170,199],"cellular":[172,204],"microcapsules":[175],"complexity":[179],"resolution.":[182],"methodology":[184],"established":[185],"here":[186],"has":[187],"potential":[189],"provide":[191],"new":[192],"insights":[193],"interface":[198],"nanostructured":[201],"materials":[202],"under":[206],"physiological":[207],"conditions.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-27T00:00:00"}
