{"id":"https://openalex.org/W2891455682","doi":"https://doi.org/10.2147/cmar.s169074","title":"CD8+ tumor-infiltrating lymphocytes as a novel prognostic biomarker in lung sarcomatoid carcinoma, a rare subtype of lung cancer","display_name":"CD8+ tumor-infiltrating lymphocytes as a novel prognostic biomarker in lung sarcomatoid carcinoma, a rare subtype of lung cancer","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2891455682","doi":"https://doi.org/10.2147/cmar.s169074","mag":"2891455682","pmid":"https://pubmed.ncbi.nlm.nih.gov/30271199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6145683"},"language":"en","primary_location":{"id":"doi:10.2147/cmar.s169074","doi":"https://doi.org/10.2147/cmar.s169074","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s169074","pdf_url":null,"source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/cmar.s169074","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026018498","display_name":"Jiewei Chen","orcid":"https://orcid.org/0000-0002-5399-725X","observed_orcids":["https://orcid.org/0000-0002-5399-725X"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiewei Chen","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068036067","display_name":"Qing\u2010Mei He","orcid":"https://orcid.org/0000-0002-3973-7566","observed_orcids":["https://orcid.org/0000-0002-3973-7566"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingmei He","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361979","display_name":"Jun Liu","orcid":"https://orcid.org/0000-0002-9001-9498","observed_orcids":["https://orcid.org/0000-0002-9001-9498","https://orcid.org/0000-0003-2198-2579"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Liu","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101170500","display_name":"Yongbo Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongbo Xiao","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Canhua Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Canhua Xiao","raw_affiliation_strings":["Department of Pathology, Qingyuan People's Hospital, Qingyuan, 511581, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Qingyuan People's Hospital, Qingyuan, 511581, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864517","display_name":"Keming Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keming Chen","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075846774","display_name":"Dan Xie","orcid":"https://orcid.org/0000-0003-2242-3138","observed_orcids":["https://orcid.org/0000-0003-2242-3138","https://orcid.org/0009-0001-8570-7341"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dan Xie","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101784762","display_name":"Xinke Zhang","orcid":"https://orcid.org/0000-0002-3527-2140","observed_orcids":["https://orcid.org/0000-0002-3527-2140"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinke Zhang","raw_affiliation_strings":["Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China, xiedan@sysucc.org.cn; zhangxk@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075846774","https://openalex.org/A5101784762"],"corresponding_institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.6914,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.88275327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"Volume 10","issue":null,"first_page":"3505","last_page":"3511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7879999876022339},{"id":"https://openalex.org/keywords/clinicopathological-stage","display_name":"clinicopathological stage","score":0.8980000019073486},{"id":"https://openalex.org/keywords/t-stage","display_name":"T stage","score":0.5920000076293945},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6790199279785156},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6063211560249329},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5957245230674744},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.58698970079422},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5777170658111572},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5262842774391174},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.49331894516944885},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4838501513004303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47234809398651123},{"id":"https://openalex.org/C2780808757","wikidata":"https://www.wikidata.org/wiki/Q7423598","display_name":"Sarcomatoid carcinoma","level":3,"score":0.46817746758461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4653846323490143},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4415293335914612},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43136662244796753},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41134339570999146},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27042677998542786},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2371719777584076},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.21770957112312317},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19962307810783386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12557926774024963},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09179309010505676},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08352366089820862},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/cmar.s169074","doi":"https://doi.org/10.2147/cmar.s169074","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s169074","pdf_url":null,"source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5104783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6145683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6145683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6145683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Manag Res","raw_type":"Text"},{"id":"pmid:30271199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30271199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer management and research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b1b000f043654c27a7ec1ce8bcde85a1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b1b000f043654c27a7ec1ce8bcde85a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Management and Research, Vol Volume 10, Pp 3505-3511 (2018)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/40589","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/cd8-tumor-infiltrating-lymphocytes-as-a-novel-prognostic-biomarker-in--peer-reviewed-article-CMAR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/cmar.s169074","doi":"https://doi.org/10.2147/cmar.s169074","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s169074","pdf_url":null,"source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1540696654","https://openalex.org/W1962147066","https://openalex.org/W2024384252","https://openalex.org/W2030511761","https://openalex.org/W2032326904","https://openalex.org/W2032530158","https://openalex.org/W2048499831","https://openalex.org/W2060100686","https://openalex.org/W2060230558","https://openalex.org/W2062497620","https://openalex.org/W2071793654","https://openalex.org/W2089220120","https://openalex.org/W2097173066","https://openalex.org/W2110097314","https://openalex.org/W2120338564","https://openalex.org/W2142300779","https://openalex.org/W2143124333","https://openalex.org/W2175538234","https://openalex.org/W2222106751","https://openalex.org/W2275461305","https://openalex.org/W2299408353","https://openalex.org/W2337795947","https://openalex.org/W2338650367","https://openalex.org/W2418942707","https://openalex.org/W2486664701","https://openalex.org/W2508032561","https://openalex.org/W2521963431","https://openalex.org/W2560174513","https://openalex.org/W2574558552","https://openalex.org/W2606572020","https://openalex.org/W2618327597","https://openalex.org/W2730279430","https://openalex.org/W2753911561"],"related_works":["https://openalex.org/W2989888847","https://openalex.org/W4390055395","https://openalex.org/W2015892480","https://openalex.org/W2982175285","https://openalex.org/W1981876938","https://openalex.org/W4412491604","https://openalex.org/W2789763378","https://openalex.org/W1827997917","https://openalex.org/W4379534861","https://openalex.org/W1484926749"],"abstract_inverted_index":{"Purpose:":[0],"The":[1,35,67,94,124],"aim":[2],"of":[3,11,13,37,56,74,76,89,118,129,136,155,169,180,205],"this":[4],"study":[5],"was":[6,48,64,79,139,143,172],"to":[7],"investigate":[8],"the":[9,54,72,83,119,167],"degree":[10,73],"infiltration":[12,75],"CD8+":[14,38,57,77,110,137,156,170,188,206,220],"tumor-infiltrating":[15],"lymphocytes":[16],"(TILs)":[17],"including":[18],"high":[19,134,203],"and":[20,28,33,53,62,86,109,201],"low":[21,153],"density":[22,36,135,154,168,204],"in":[23,40,149,208],"lung":[24,217],"sarcomatoid":[25,218],"carcinoma":[26],"(LSC)":[27],"their":[29],"clinicopathological":[30,60,84,101],"significance.":[31],"Patients":[32],"methods:":[34],"TILs":[39,58,78,111,138,157,171,189,207],"paraffin-embedded":[41],"tissue":[42,210],"sections":[43],"from":[44],"100":[45],"LSC":[46,90,130,181,199],"patients":[47,120,131,150,182],"detected":[49],"by":[50],"immunohistochemical":[51],"staining,":[52],"relationship":[55],"with":[59,82,132,151],"features":[61],"prognosis":[63,117,223],"analyzed.":[65],"Results:":[66],"chi-squared":[68],"test":[69],"showed":[70],"that":[71,98,115,166],"significantly":[80,144],"correlated":[81],"stage":[85,88],"T":[87,103],"(":[91,121,158],"P":[92,122,159,185],"<0.05).":[93,123,160,186],"univariate":[95],"analysis":[96,164],"demonstrated":[97],"tumor":[99,209],"size,":[100],"stage,":[102,104,106,108],"N":[105],"M":[107],"are":[112],"risk":[113],"factors":[114],"affect":[116],"mean":[125],"overall":[126],"survival":[127],"(OS)":[128],"a":[133,152,202,213],"92.3":[140],"months,":[141],"which":[142],"higher":[145],"than":[146],"31.2":[147],"months":[148],"Cox":[161],"regression":[162],"multivariate":[163],"confirmed":[165],"an":[173,194],"independent":[174],"prognostic":[175,196],"factor":[176],"for":[177,198],"OS":[178],"time":[179],"(hazard":[183],"ratio=0.455,":[184],"Conclusion:":[187],"could":[190],"be":[191],"used":[192],"as":[193],"effective":[195],"index":[197],"patients,":[200],"may":[211],"predict":[212],"better":[214],"outcome.":[215],"Keywords:":[216],"carcinoma,":[219],"TILs,":[221],"immunohistochemistry,":[222]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-09-27T00:00:00"}