{"id":"https://openalex.org/W2891434837","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","title":"Depletion of Brain Perivascular Macrophages Mitigates Depressive\u2010like Behavioral Consequences of Chronic Mild Stress","display_name":"Depletion of Brain Perivascular Macrophages Mitigates Depressive\u2010like Behavioral Consequences of Chronic Mild Stress","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2891434837","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","mag":"2891434837"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.991.8","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052089761","display_name":"Jan\u2010Sebastian Grigoleit","orcid":"https://orcid.org/0000-0003-2432-3245","observed_orcids":["https://orcid.org/0000-0003-2432-3245"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan\u2010Sebastian Grigoleit","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elena Alvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Alvarez","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062926072","display_name":"Catherine Borna Farrokhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Borna Farrokhi","raw_affiliation_strings":["Behavior Testing Core Salk Institute for Biological Studies La Jolla CA","#N#2Behavior Testing Core, Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavior Testing Core Salk Institute for Biological Studies La Jolla CA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"#N#2Behavior Testing Core, Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028880120","display_name":"Paul E. Sawchenko","orcid":"https://orcid.org/0000-0002-8258-1296","observed_orcids":["https://orcid.org/0000-0002-8258-1296"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul E. Sawchenko","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function Salk Institute for Biological Studies La Jolla CA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"#N#1Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19628647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.43799999356269836,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-mild-stress","display_name":"chronic mild stress","score":0.8960000276565552},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.781000018119812},{"id":"https://openalex.org/keywords/clodronate-liposomes","display_name":"clodronate liposomes","score":0.953000009059906},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/sucrose-intake","display_name":"sucrose intake","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.781000018119812},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.6389999985694885},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.5479999780654907},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.6880000233650208},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.7079294919967651},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3886237144470215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35505324602127075},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27249675989151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.991.8","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.991.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4371895801","display_name":null,"funder_award_id":"GR4370/1\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000218958","display_name":null,"funder_award_id":"NS21182","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2358869464","https://openalex.org/W3014403291","https://openalex.org/W4307335761","https://openalex.org/W4414207068","https://openalex.org/W2513446130","https://openalex.org/W4200195244","https://openalex.org/W2787368117","https://openalex.org/W7133347677","https://openalex.org/W4206523373","https://openalex.org/W2782362767"],"abstract_inverted_index":{"Despite":[0],"intensive":[1],"research,":[2],"the":[3,14,23,46,54,66,90,93,101,116,123,130,158,167,184,206,244,293,300,303,311,327,333,337,349,357,376,397],"etiology":[4],"of":[5,16,25,42,48,56,86,103,115,126,132,154,171,176,197,208,218,226,266,290,302,336,359],"depression":[6,209],"remains":[7],"poorly":[8],"understood.":[9],"Stress":[10],"is":[11,37,352],"implicated":[12],"in":[13,45,50,65,99,129,284,292,310,323,326,332,345,381,404,408],"pathogenesis":[15],"most":[17],"depressive":[18,405],"disorders,":[19],"as":[20,83,96,235],"reflected":[21],"by":[22,52,136,230],"preponderance":[24],"animal":[26],"models":[27],"that":[28,341,399],"employ":[29],"chronic":[30,137,198,410],"stress":[31,106,138,200,412],"to":[32,92,121,165,174,194,215,261,355,367],"induce":[33],"depressive\u2010like":[34,133,267],"behavior.":[35,268],"There":[36],"increasing":[38],"evidence":[39],"for":[40,205,299],"involvement":[41,125],"immune/inflammatory":[43],"mechanisms":[44],"genesis":[47],"depression,":[49,227],"part":[51],"mediating":[53,100],"effects":[55],"stress,":[57],"with":[58],"microglia":[59],"and":[60,110,212,242],"also":[61,97],"macrophage\u2010type":[62],"immune":[63],"cells":[64],"brain":[67,77,127,185,400],"being":[68],"implicated.":[69],"Recent":[70],"work":[71],"from":[72,89,369,375],"our":[73],"laboratory":[74],"has":[75],"identified":[76],"perivascular":[78],"macrophages":[79],"(PVM),":[80],"not":[81,181,343],"only":[82],"crucial":[84],"mediators":[85],"inflammatory":[87,111],"signaling":[88],"periphery":[91],"CNS,":[94],"but":[95,180],"involved":[98,403],"consequences":[102],"acute":[104],"emotional":[105],"on":[107],"central":[108],"neuroendocrine":[109],"responses.":[112],"The":[113],"objective":[114],"current":[117],"pilot":[118],"experiment":[119],"was":[120,228,280,297,308,342],"evaluate":[122],"potential":[124],"PVM":[128],"induction":[131,207],"behaviors":[134,406],"caused":[135],"exposure.":[139],"Adult":[140],"male":[141],"rats":[142,363],"either":[143],"remained":[144],"untreated":[145],"(":[146,162],"n":[147,163],"=6)":[148],"or":[149,415],"received":[150],"an":[151,339],"intracerebroventricular":[152],"injection":[153],"mannosylated":[155],"liposomes":[156],"containing":[157],"pro\u2010apoptotic":[159],"drug,":[160],"clodronate":[161],"=6),":[164],"exploit":[166],"constitutive":[168],"phagocytic":[169],"activity":[170,384],"PVM,":[172],"leading":[173],"depletion":[175],"this":[177],"cell":[178],"type,":[179],"microglia,":[182],"throughout":[183],"within":[186],"3\u20135":[187],"d.":[188],"Both":[189],"groups":[190,389],"were":[191,259,386],"then":[192],"subjected":[193],"5":[195],"weeks":[196],"mild":[199,219,411],"(CMS),":[201],"a":[202,216,223,236,281,320,370,409],"well\u2010established":[203],"protocol":[204],"through":[210],"repeated":[211],"unpredictable":[213],"exposure":[214],"variety":[217],"insults.":[220],"Anhedonic":[221],"behavior,":[222],"key":[224,264],"component":[225],"assessed":[229],"monitoring":[231],"sucrose":[232,272,285],"intake":[233,286],"(provided":[234],"2%":[237],"solution":[238],"twice":[239],"weekly":[240],"before":[241],"during":[243],"CMS":[245,291],"phase).":[246],"Additional":[247],"behavioral":[248],"tests":[249],"(open":[250],"field/OF,":[251],"elevated":[252],"plus":[253],"maze/EPM,":[254],"Porsolt":[255],"forced":[256],"swim":[257],"test/PFST)":[258],"used":[260,354],"assess":[262,356],"further":[263],"components":[265],"All":[269],"animals":[270,318,374],"preferred":[271],"strongly":[273],"over":[274],"normal":[275],"drinking":[276],"water.":[277],"However,":[278],"there":[279],"significant":[282,321],"drop":[283],"after":[287],"1":[288],"week":[289],"control":[294,317,377],"group,":[295],"which":[296,351],"sustained":[298],"duration":[301],"experiment.":[304],"No":[305,379],"such":[306],"effect":[307,340],"observed":[309,344,387],"PVM\u2010depleted":[312,346,362],"group.":[313,378],"In":[314,348],"addition,":[315],"stressed":[316],"displayed":[319],"decrease":[322],"exploratory":[324],"behavior":[325],"EPM,":[328],"remaining":[329],"almost":[330],"exclusively":[331],"closed":[334],"arms":[335],"maze,":[338],"rats.":[347],"PFST,":[350],"often":[353],"potency":[358],"anti\u2010depressant":[360],"drugs,":[361],"tried":[364],"significantly":[365],"longer":[366],"escape":[368],"water\u2010filled":[371],"jar":[372],"than":[373],"differences":[380],"general":[382],"locomotor":[383],"(OF)":[385],"among":[388],"at":[390],"any":[391],"time":[392],"point.":[393],"These":[394],"findings":[395],"support":[396],"hypothesis":[398],"PVMs":[401],"are":[402],"seen":[407],"model.":[413],"Support":[414],"Funding":[416],"Information":[417],"NIH":[418],"grant":[419,429],"NS21182,":[420],"Clayton":[421],"Medical":[422],"Research":[423,426],"Foundation,":[424],"German":[425],"Foundation":[427],"(DFG)":[428],"GR4370/1\u20101,":[430],"CONACyT":[431],"Mexico":[432]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2018-09-27T00:00:00"}