{"id":"https://openalex.org/W2891386079","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","title":"Genomic profiling of high-intermediate risk endometrial cancer to differentiate recurrence risk.","display_name":"Genomic profiling of high-intermediate risk endometrial cancer to differentiate recurrence risk.","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2891386079","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","mag":"2891386079"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.e17103","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055503557","display_name":"Zachary C. Dobbin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Christopher Dobbin","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072073638","display_name":"Emily E. Landers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily E. Landers","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063429803","display_name":"Angelina I. Londo\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelina I Londono","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112591955","display_name":"Ashwini A. Katre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwini A. Katre","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035724058","display_name":"Eddy Shih-Hsin Yang","orcid":"https://orcid.org/0000-0002-6450-2638","observed_orcids":["https://orcid.org/0000-0002-6450-2638"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddy Shih-Hsin Yang","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018884124","display_name":"Jonathan David Boone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan David Boone","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066510200","display_name":"Kerri S. Bevis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerri S. Bevis","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034799601","display_name":"John Michael Straughn","orcid":"https://orcid.org/0000-0003-1289-565X","observed_orcids":["https://orcid.org/0000-0003-1289-565X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Michael Straughn","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076400654","display_name":"Warner King Huh","orcid":"https://orcid.org/0000-0003-2881-9846","observed_orcids":["https://orcid.org/0000-0003-2881-9846"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warner King Huh","raw_affiliation_strings":["University of Alabama Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006402876","display_name":"Charles Alexander Leath","orcid":"https://orcid.org/0000-0002-4034-6845","observed_orcids":["https://orcid.org/0000-0002-4034-6845"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Leath","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058615793","display_name":"David K. Crossman","orcid":"https://orcid.org/0000-0002-0981-169X","observed_orcids":["https://orcid.org/0000-0002-0981-169X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Crossman","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009816072","display_name":"Ronald David Alvarez","orcid":"https://orcid.org/0000-0002-0933-5398","observed_orcids":["https://orcid.org/0000-0002-0933-5398"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald David Alvarez","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043625183","display_name":"Rebecca Christian Arend","orcid":"https://orcid.org/0000-0003-2108-3426","observed_orcids":["https://orcid.org/0000-0003-2108-3426"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Christian Arend","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"e17103","last_page":"e17103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/intermediate-high-risk","display_name":"high-intermediate risk","score":0.8460000157356262},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7710000276565552},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/myometrial-invasion","display_name":"myometrial invasion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.4790000021457672},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.5479999780654907},{"id":"https://openalex.org/keywords/nanostring","display_name":"NanoString","score":0.47099998593330383},{"id":"https://openalex.org/keywords/paraffin-embedded-tissue","display_name":"paraffin-embedded tissue","score":0.7440000176429749},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-signaling","display_name":"aryl hydrocarbon receptor signaling","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9141411781311035},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.695145845413208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6360316872596741},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5753524303436279},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.508522629737854},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4389580488204956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3890005946159363},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37914758920669556}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.e17103","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e17103","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2891405323","https://openalex.org/W3036731485","https://openalex.org/W4206383058","https://openalex.org/W3210401021","https://openalex.org/W2811295988","https://openalex.org/W2157216556","https://openalex.org/W3195512899","https://openalex.org/W4395676634","https://openalex.org/W3209260429","https://openalex.org/W2602982764"],"abstract_inverted_index":{"e17103":[0],"Background:":[1],"While":[2,48],"the":[3,16,77,177,183,187,198,266],"majority":[4],"of":[5,18,22,46,107,121,165,168,172,176,211,222],"patients":[6,23,41,85,98,139,237,303,314,334],"diagnosed":[7],"with":[8,24,304],"endometrial":[9],"cancer":[10,282,286],"(EMCA)":[11],"have":[12,42,151],"low-risk":[13],"disease":[14,27],"at":[15,89],"time":[17],"diagnosis,":[19],"a":[20,43,73,152,208,220,309,329],"subset":[21],"Stage":[25],"I":[26],"are":[28],"classified":[29],"as":[30],"high-intermediate":[31],"risk":[32,37,45,110],"(H-IR)":[33],"based":[34],"on":[35,320],"pathologic":[36,109,344],"factors.":[38],"H-IR":[39,102,235,305],"EMCA":[40,103,236,306],"30%":[44],"recurrence.":[47,153],"adjuvant":[49,132,339],"therapy":[50,133,340],"may":[51,324,336],"improve":[52],"progression":[53],"free":[54],"survival,":[55],"there":[56],"is":[57],"limited":[58],"data":[59],"to":[60,216,231,312,327,332],"suggest":[61],"an":[62],"improvement":[63],"in":[64,234,302],"overall":[65],"survival.":[66],"Methods:":[67],"Under":[68],"IRB":[69],"approval":[70],"we":[71],"performed":[72],"pilot":[74,295],"study":[75,296],"isolating":[76],"RNA":[78,174],"from":[79,83,338],"paraffin":[80],"embedded":[81],"tissue":[82],"16":[84],"who":[86,140,148,307],"underwent":[87],"surgery":[88],"UAB":[90],"between":[91,265],"July":[92],"2000":[93],"and":[94,145,170,201,219,258,276,289],"November":[95],"2010.":[96],"All":[97],"met":[99],"criteria":[100,345],"for":[101,157],"which":[104],"included":[105],"presence":[106,120,162],"1-3":[108],"factors:":[111],"a)":[112],"outer":[113],"1/2":[114],"or":[115,126,163,214],"1/3":[116],"myometrial":[117],"invasion;":[118],"b)":[119],"LVSI;":[122],"c)":[123],"grade":[124],"2":[125],"3":[127,143],"tumor.":[128,173],"No":[129],"patient":[130],"received":[131],"after":[134],"surgery.":[135],"We":[136],"selected":[137],"8":[138,146],"recurred":[141],"within":[142],"years":[144],"controls":[147],"did":[149],"not":[150,317],"Patients":[154],"were":[155,180,227,252,262],"matched":[156],"stage,":[158],"grade,":[159],"race,":[160],"age,":[161],"absence":[164],"LVSI,":[166],"depth":[167],"invasion,":[169],"size":[171],"expression":[175],"two":[178,267],"groups":[179,268],"compared":[181,311],"using":[182,197,269,343],"NanoString":[184],"platform":[185],"utilizing":[186],"nCounter":[188],"PanCancer":[189],"Pathways":[190],"Panel":[191],"(770":[192],"genes).":[193],"Data":[194],"was":[195],"analyzed":[196],"nSolver":[199],"Software":[200],"Ingenuity":[202],"Pathway":[203],"Analysis":[204],"(IPA).":[205],"Results:":[206],"Using":[207],"fold":[209],"change":[210],"greater":[212],"than":[213,342],"equal":[215],"\u00b1":[217],"1.5":[218],"p-value":[221],"<":[223],"0.05,":[224],"10":[225],"genes":[226,251,301],"significantly":[228,253,298],"up-regulated":[229],"(2":[230],"6":[232],"fold)":[233],"that":[238,315,335],"recurred:":[239],"MMP3,":[240],"INHBB,":[241],"TNF,":[242],"NR4A,":[243],"PLA2G3,":[244],"CLCF1,":[245],"LAMB3,":[246],"RAD51,":[247],"FOS,":[248],"LEFTY2.":[249],"Two":[250],"down-regulated":[254],"(1.5":[255],"fold):":[256],"COL27A1":[257],"BAIAP3.":[259],"Five":[260],"pathways":[261],"statistically":[263],"different":[264],"IPA:":[270],"Aryl":[271],"hydrocarbon":[272],"receptor":[273],"signaling,":[274],"cyclins":[275],"cell":[277],"cycle":[278],"regulation":[279],"pathway,":[280,284,288],"bladder":[281],"signaling":[283],"colorectal":[285],"metastasis":[287],"rheumatoid":[290],"arthritis":[291],"pathway.":[292],"Conclusions:":[293],"This":[294],"identified":[297],"differentially":[299],"expressed":[300],"experience":[308],"recurrence":[310],"those":[313],"do":[316],"recur.":[318],"Based":[319],"these":[321],"findings,":[322],"it":[323],"be":[325],"possible":[326],"develop":[328],"genetic":[330],"signature":[331],"identify":[333],"benefit":[337],"rather":[341],"alone.":[346]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-09-27T00:00:00"}
