{"id":"https://openalex.org/W2891360169","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","title":"Immune marker profiling and PD-L1, PD-L2 expression mechanisms across non-small cell lung cancer mutations.","display_name":"Immune marker profiling and PD-L1, PD-L2 expression mechanisms across non-small cell lung cancer mutations.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2891360169","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","mag":"2891360169"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.9076","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019551393","display_name":"Maria I Toki","orcid":"https://orcid.org/0000-0002-7074-7148","observed_orcids":["https://orcid.org/0000-0002-7074-7148"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Toki","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002620104","display_name":"Nikita Lavanya Mani","orcid":"https://orcid.org/0000-0003-4688-7770","observed_orcids":["https://orcid.org/0000-0003-4688-7770"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikita Mani","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058805895","display_name":"James William Smithy","orcid":"https://orcid.org/0000-0003-3126-1193","observed_orcids":["https://orcid.org/0000-0003-3126-1193"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James William Smithy","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364310","display_name":"Yuting Liu","orcid":"https://orcid.org/0000-0001-8380-2882","observed_orcids":["https://orcid.org/0000-0001-8380-2882"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuting Liu","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039160380","display_name":"Mehmet Altan","orcid":"https://orcid.org/0000-0001-9229-156X","observed_orcids":["https://orcid.org/0000-0001-9229-156X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Altan","raw_affiliation_strings":["Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027790861","display_name":"Brad E Wasserman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Wasserman","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069499235","display_name":"Rasikh Tuktamyshov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasikh Tuktamyshov","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524954","display_name":"Konstantinos Nikolaos Syrigos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos N. Syrigos","raw_affiliation_strings":["National and Kapodistrian University of Athens School of Medicine, Athens, Greece;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National and Kapodistrian University of Athens School of Medicine, Athens, Greece;","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"9076","last_page":"9076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pd-l2","display_name":"PD-L2","score":1.0},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.746999979019165},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":1.0},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.703000009059906},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7887222766876221},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6641936898231506},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.6640406847000122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6534755229949951},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5392353534698486},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4301798343658447},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.39968374371528625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3883613646030426},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30748251080513},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29279768466949463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2822788655757904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23790568113327026},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.18627408146858215}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.9076","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.9076","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2894023816","https://openalex.org/W2293064244","https://openalex.org/W3197405122","https://openalex.org/W2147592245","https://openalex.org/W2901340123","https://openalex.org/W4289943251","https://openalex.org/W3094304212","https://openalex.org/W3003015741","https://openalex.org/W2898567386","https://openalex.org/W3002899570"],"abstract_inverted_index":{"9076":[0],"Background:":[1],"PD-1/PD-L1":[2],"axis":[3],"inhibitors":[4],"have":[5],"been":[6],"proven":[7],"effective,":[8],"especially":[9],"in":[10,21,67,98,112,151,228,234,258,263,274,304,309],"patients":[11,22,205],"expressing":[12],"Programmed":[13],"Death":[14],"Ligand":[15],"1":[16],"(PD-L1).":[17],"Their":[18],"clinical":[19],"efficacy":[20],"with":[23,41,104,195,254,271,282,340],"epidermal":[24],"growth":[25],"factor":[26],"receptor":[27],"(EGFR)":[28],"activating":[29],"mutations":[30,36],"is":[31],"still":[32],"unclear,":[33],"while":[34,169,266],"KRAS":[35,156,179,235],"seem":[37],"to":[38,83,90,155,317,323],"be":[39,321,338],"associated":[40,270,339],"high":[42,218,291,341],"response":[43,302,319],"rates.":[44],"In":[45,232],"this":[46,305,310],"study":[47],"we":[48,247],"investigated":[49],"the":[50,76,115,229,283,298,312],"expression":[51,88,147,188,257,315,324],"of":[52,64,79,175,204,220,286,293,328],"PD-L1,":[53],"PD-L2":[54,87,176,184],"and":[55,86,89,94,122,124,140,145,161,186,199,344],"Tumor":[56],"Infiltrating":[57],"Lymphocyte":[58],"(TIL)":[59],"status":[60,66,97,210],"as":[61,325],"a":[62,131,172,216,326],"function":[63],"mutation":[65,106],"Non-Small":[68],"Cell":[69],"Lung":[70],"Cancer":[71],"(NSCLC).":[72],"Methods:":[73],"We":[74],"used":[75],"AQUA":[77],"method":[78],"quantitative":[80],"fluorescence":[81],"(QIF)":[82],"compare":[84],"PD-L1":[85,143,256,273,314,342],"characterize":[91],"TILs":[92,208,222,238,295,345],"populations":[93],"their":[95,207],"activation":[96,109,127,209,268],"over":[99],"150":[100],"NSCLC":[101],"patient":[102,306],"tumors":[103],"known":[105],"status.":[107],"EGFR":[108,121,152,213,252,259,264,287],"was":[110,128,148,269],"assessed":[111,129],"situ":[113],"using":[114,130],"proximity":[116],"ligation":[117],"assay":[118,135],"(PLA)":[119],"for":[120],"GRB2":[123],"T":[125],"cell":[126],"novel":[132],"multiplexed":[133],"QIF":[134],"including":[136],"CD3,":[137],"Granzyme":[138],"B":[139],"Ki67.":[141],"Results:":[142],"tumor":[144,185,230],"stroma":[146,187],"significantly":[149,182],"lower":[150,183],"mutant":[153,157,288],"compared":[154],"(p":[158,165],"=":[159],"0.009)":[160],"EGFR/KRAS":[162,275],"Wild":[163],"Type":[164],"<":[166],"0.0001)":[167],"tumors,":[168],"they":[170,190,241],"had":[171,181,215],"higher":[173,196,272],"frequency":[174,219,292],"expression.":[177],"Conversely,":[178],"mutants":[180,214,260],"but":[189,261],"were":[191,226,239,242],"also":[192],"more":[193],"inflamed":[194],"CD4+,":[197],"CD8+":[198],"CD20+":[200],"TILs.":[201],"Subgroup":[202],"analysis":[203],"by":[206],"revealed":[211],"that":[212,249],"very":[217],"inactive":[221,294],"even":[223],"though":[224],"lymphocytes":[225],"present":[227],"microenvironment.":[231],"contrast,":[233],"mutants,":[236],"when":[237],"present,":[240],"almost":[243],"always":[244],"active.":[245],"Finally,":[246],"find":[248],"PLA-defined":[250],"activated":[251],"correlated":[253],"increased":[255],"not":[262],"WT,":[265],"TIL":[267],"WT.":[276],"Conclusions:":[277],"Our":[278],"findings":[279],"are":[280],"consistent":[281],"unique":[284],"biology":[285],"tumors.":[289],"The":[290],"could":[296],"explain":[297],"low":[299],"immune":[300,334],"therapy":[301],"rates":[303],"group.":[307],"Similarly,":[308],"group,":[311],"reason":[313],"fails":[316],"predict":[318],"may":[320],"due":[322],"result":[327],"constitutive":[329],"oncogenic":[330],"signaling":[331],"rather":[332],"than":[333],"signaling,":[335],"which":[336],"would":[337],"levels":[343],"activation.":[346]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-09-27T00:00:00"}