{"id":"https://openalex.org/W28913435","doi":null,"title":"[Cost-effectiveness of pharmacologic treatments for the reduction of blood lipids].","display_name":"[Cost-effectiveness of pharmacologic treatments for the reduction of blood lipids].","publication_year":1995,"publication_date":"1995-09-23","ids":{"openalex":"https://openalex.org/W28913435","mag":"28913435","pmid":"https://pubmed.ncbi.nlm.nih.gov/7500685"},"language":"es","primary_location":{"id":"pmid:7500685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7500685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina clinica","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112387218","display_name":"P Plans Rubi\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157913058","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P Plans Rubi\u00f3","raw_affiliation_strings":["Departament de Sanitat i Seguretat Social, Generalitat de Catalunya, Facultad de Ciencias Econ\u00f3micas, Universidad de Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Sanitat i Seguretat Social, Generalitat de Catalunya, Facultad de Ciencias Econ\u00f3micas, Universidad de Barcelona","institution_ids":["https://openalex.org/I157913058","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":null,"display_name":"J Rovira Forns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Rovira Forns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.304,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.58051425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"105","issue":"9","first_page":"327","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.878000020980835},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gemfibrozil","display_name":"gemfibrozil","score":0.9959999918937683},{"id":"https://openalex.org/keywords/coronary-heart-disease-prevention","display_name":"coronary heart disease prevention","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5640000104904175},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.6169999837875366},{"id":"https://openalex.org/keywords/framingham-risk-function","display_name":"Framingham risk equation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/catalan-population","display_name":"Catalan population","score":0.597000002861023},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.4569999873638153},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.953000009059906},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.9416495561599731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8663833141326904},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.701748251914978},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.6561020016670227},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.5195258259773254},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.44141411781311035},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43693971633911133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38892602920532227},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.3597932755947113},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.19344821572303772},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15763893723487854},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7500685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7500685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina clinica","raw_type":"Clinical Trial"},{"id":"mag:28913435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7500685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W2005526239","https://openalex.org/W1527874749","https://openalex.org/W2010802040","https://openalex.org/W2074576093","https://openalex.org/W2116472408","https://openalex.org/W2073746011","https://openalex.org/W2095217602","https://openalex.org/W2142364986","https://openalex.org/W2148522029","https://openalex.org/W2031212222","https://openalex.org/W2113439382","https://openalex.org/W2022758805","https://openalex.org/W2076658021","https://openalex.org/W2046683144","https://openalex.org/W1967185435","https://openalex.org/W2029446405","https://openalex.org/W2062700139","https://openalex.org/W2119506420","https://openalex.org/W2084192678","https://openalex.org/W257340931","https://openalex.org/W2131427649","https://openalex.org/W2168133698","https://openalex.org/W1984068087","https://openalex.org/W2151827426","https://openalex.org/W2093361250","https://openalex.org/W2113687948","https://openalex.org/W2126957346","https://openalex.org/W2097367553","https://openalex.org/W1995630908","https://openalex.org/W2516628047","https://openalex.org/W2050448306","https://openalex.org/W2104348960","https://openalex.org/W2150201082","https://openalex.org/W2051206940","https://openalex.org/W2050045165","https://openalex.org/W2012141674","https://openalex.org/W2015761412"],"related_works":["https://openalex.org/W2031708483","https://openalex.org/W2031643250","https://openalex.org/W4252119993","https://openalex.org/W2470318840","https://openalex.org/W2117234271","https://openalex.org/W7214223919","https://openalex.org/W2064756084","https://openalex.org/W1982057440","https://openalex.org/W2083059885","https://openalex.org/W1839290569"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,43,71,105,139,224,295],"cost-effectiveness":[2,44,213,225,266],"of":[3,50,54,61,74,93,96,115,146,165,170,179,236,240,260,272,276,291,297,304],"hypolipemiant":[4,84,313],"treatment":[5,69,85,314],"with":[6,64,83,167],"lovastatine":[7,204,305],"(0.02,":[8],"0.04":[9],"and":[10,15,20,23,88,108,119,125,158,206,221,255],"0.08":[11,205],"g/day),":[12,17],"cholestyramine":[13],"(12":[14],"24":[16],"cholestipol":[18],"(10":[19],"20":[21],"g/day)":[22,26],"gemfibrocyl":[24],"(1.2":[25],"was":[27,46,77,231,267],"estimated":[28,91],"in":[29,48,127,243,279,315],"individuals":[30],"presenting":[31,245,281],"hypercholesterolemia":[32],"(>":[33],"200":[34],"mg/dl":[35,172,252,285],"or":[36],"5.17":[37],"mmol/l)":[38,174,254,287],"following":[39],"dietetic":[40],"treatment.":[41],"METHODS:":[42],"relationship":[45],"measured":[47],"terms":[49],"cost":[51,60,73,143],"per":[52,144,177,238,274],"year":[53,145,178,239,275],"life":[55,120,147,180,241,277],"gained":[56,148,181,242,278],"comparing":[57],"the":[58,62,75,80,90,94,102,109,113,128,136,175,212,227,258,265,289,302,310],"net":[59,72],"program":[63,76],"its":[65],"effectiveness":[66],"for":[67,185,188,191,194,197,200,203,208,226],"each":[68],"studied.":[70],"calculated":[78],"taking":[79],"costs":[81,95,176],"associated":[82],"into":[86],"account":[87],"subtracting":[89],"reduction":[92],"coronary":[97,317],"heart":[98,318],"disease":[99],"attributed":[100],"to":[101,112,123,134,141],"prevention":[103],"program.":[104],"Framingham":[106],"equation":[107],"information":[110],"concerning":[111],"prevalence":[114],"cardiovascular":[116],"risk":[117],"factors":[118],"expectancy":[121],"according":[122],"age":[124,166,259,290],"sex":[126],"Catalonian":[129],"(Spain)":[130],"population":[131],"were":[132,182,214],"used":[133],"estimate":[135],"effectiveness.":[137],"RESULTS:":[138],"lesser":[140],"greater":[142],"is":[149,309],"lovastatine-0.02,":[150,186],"cholestyramine-12,":[151,189],"cholestipol-12,":[152],"lovastatine-0.04,":[153,192],"gemfibrocyl,":[154,195],"cholestyramine-24,":[155,198],"cholestipol-10,":[156,201],"lovastatine-0.08":[157],"cholestipol-20.":[159,209],"In":[160,210,263],"males":[161,244],"from":[162],"45-49":[163],"years":[164],"cholesterol":[168,247],"concentration":[169,248],"300":[171,251],"(7.76":[173,253],"3.4":[183],"millions":[184],"4.6":[187],"4.8":[190],"5.4":[193],"6.5":[196],"7.8":[199],"8.1":[202],"11.6":[207],"women":[211,264],"11.6,":[215],"15.4,":[216],"17.7,":[217],"21.3,":[218],"25.4,":[219],"25.9":[220],"37.1,":[222],"respectively.":[223],"most":[228,311],"effective":[229,312],"treatments":[230],"less":[232],"than":[233,250,269,283],"5":[234],"million":[235,271],"pesetas":[237,273],"a":[246],"higher":[249],"those":[256,280],"under":[257,288],"65":[261,292],"years.":[262,293],"lower":[268],"10":[270],"more":[282],"340":[284],"(8.79":[286],"CONCLUSIONS:":[294],"results":[296],"this":[298],"study":[299],"demonstrate":[300],"that":[301],"administration":[303],"at":[306],"0.02":[307],"g/day":[308],"preventing":[316],"disease.":[319]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}