{"id":"https://openalex.org/W2891308783","doi":"https://doi.org/10.1186/s12888-018-1850-4","title":"Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression","display_name":"Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression","publication_year":2018,"publication_date":"2018-09-04","ids":{"openalex":"https://openalex.org/W2891308783","doi":"https://doi.org/10.1186/s12888-018-1850-4","mag":"2891308783","pmid":"https://pubmed.ncbi.nlm.nih.gov/30180828","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6122720"},"language":"en","primary_location":{"id":"doi:10.1186/s12888-018-1850-4","doi":"https://doi.org/10.1186/s12888-018-1850-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-018-1850-4","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-018-1850-4","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-018-1850-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005871738","display_name":"Dilys Lam","orcid":"https://orcid.org/0000-0002-9713-1861","observed_orcids":["https://orcid.org/0000-0002-9713-1861"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dilys Lam","raw_affiliation_strings":["Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009296549","display_name":"Marie\u2010Laure Ancelin","orcid":"https://orcid.org/0000-0002-1149-4320","observed_orcids":["https://orcid.org/0000-0002-1149-4320"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086651","display_name":"Neuropsychiatrie : Recherche Epidemiologique et Clinique","ror":"https://ror.org/0022kfb81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1294671590","https://openalex.org/I183935753","https://openalex.org/I19894307","https://openalex.org/I4210086651","https://openalex.org/I4210137371","https://openalex.org/I4210139971"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Laure Ancelin","raw_affiliation_strings":["INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210086651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075011135","display_name":"Karen A. Ritchie","orcid":"https://orcid.org/0000-0002-0688-8982","observed_orcids":["https://orcid.org/0000-0002-0688-8982"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086651","display_name":"Neuropsychiatrie : Recherche Epidemiologique et Clinique","ror":"https://ror.org/0022kfb81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1294671590","https://openalex.org/I183935753","https://openalex.org/I19894307","https://openalex.org/I4210086651","https://openalex.org/I4210137371","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Karen Ritchie","raw_affiliation_strings":["Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210086651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049346464","display_name":"Rosanne Freak\u2010Poli","orcid":"https://orcid.org/0000-0003-4072-8699","observed_orcids":["https://orcid.org/0000-0003-4072-8699"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rosanne Freak-Poli","raw_affiliation_strings":["Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082673477","display_name":"Richard Saffery","orcid":"https://orcid.org/0000-0002-9510-4181","observed_orcids":["https://orcid.org/0000-0002-9510-4181","https://orcid.org/0000-0002-5623-9008"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard Saffery","raw_affiliation_strings":["Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia","Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081383005","display_name":"Joanne L. Ryan","orcid":"https://orcid.org/0000-0002-7039-6325","observed_orcids":["https://orcid.org/0000-0002-7039-6325"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210086651","display_name":"Neuropsychiatrie : Recherche Epidemiologique et Clinique","ror":"https://ror.org/0022kfb81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1294671590","https://openalex.org/I183935753","https://openalex.org/I19894307","https://openalex.org/I4210086651","https://openalex.org/I4210137371","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","FR"],"is_corresponding":true,"raw_author_name":"Joanne Ryan","raw_affiliation_strings":["Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia. joanne.ryan@monash.edu","Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia. joanne.ryan@monash.edu","Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. joanne.ryan@monash.edu","INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France. joanne.ryan@monash.edu","INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0002-7039-6325","affiliations":[{"raw_affiliation_string":"Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia. joanne.ryan@monash.edu","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia. joanne.ryan@monash.edu","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. joanne.ryan@monash.edu","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France. joanne.ryan@monash.edu","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210086651"]},{"raw_affiliation_string":"INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210086651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5081383005"],"corresponding_institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I154526488","https://openalex.org/I165779595","https://openalex.org/I4210086651","https://openalex.org/I4210150290","https://openalex.org/I56590836"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":4.293,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.96230984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"282","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.4794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.4794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter-gene","display_name":"serotonin transporter gene","score":0.8949999809265137},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/geriatric-depression","display_name":"geriatric depression","score":0.8920000195503235},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7540000081062317},{"id":"https://openalex.org/keywords/5-httlpr","display_name":"5-HTTLPR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/promoter-cpg-sites","display_name":"promoter CpG sites","score":0.7950000166893005},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5699999928474426},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6919999718666077},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7820000052452087},{"id":"https://openalex.org/keywords/serotonergic-signaling","display_name":"serotonergic signaling","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7731128334999084},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.7510102987289429},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6325324773788452},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6021618843078613},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5741361975669861},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.49108028411865234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43303436040878296},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4327410161495209},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4294695556163788},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.411301851272583},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35271763801574707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3387945890426636},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28932443261146545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2826707363128662},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07855311036109924},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057566","descriptor_name":"Self Report","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12888-018-1850-4","doi":"https://doi.org/10.1186/s12888-018-1850-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-018-1850-4","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-018-1850-4","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5080285","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6122720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6122720","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6122720","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"Text"},{"id":"pmid:30180828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30180828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/271185","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/271185","pdf_url":"http://hdl.handle.net/11343/271185","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:monash.edu:openaire/f830727a-3881-4a39-8478-bcae6ca81eca","doi":null,"is_oa":true,"landing_page_url":"https://research.monash.edu/files/252405442/252405294_oa.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lam, D, Ancelin, M L, Ritchie, K, Freak-Poli, R, Saffery, R & Ryan, J 2018, 'Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression', BMC Psychiatry, vol. 18, no. 1, 282. https://doi.org/10.1186/s12888-018-1850-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:inserm-02060774v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-02060774v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Psychiatry, 2018, 18 (1), pp.282. ⟨10.1186/s12888-018-1850-4⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:16bc2775014741ffb34e4d2c096c8dc4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16bc2775014741ffb34e4d2c096c8dc4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Psychiatry, Vol 18, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/32032bd7-2615-422b-9fd7-9308cc2997d3","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/99436721/document_3_.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lam, D, Ancelin, M-L, Ritchie, K, Freak-Poli, R, Saffery, R & Ryan, J 2018, 'Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression', BMC Psychiatry, vol. 18, no. 1. https://doi.org/10.1186/s12888-018-1850-4","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12888-018-1850-4","doi":"https://doi.org/10.1186/s12888-018-1850-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-018-1850-4","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-018-1850-4","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315122","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321571","display_name":"Conseil R\u00e9gional Languedoc-Roussillon","ror":"https://ror.org/045dnqy78"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2891308783.pdf","grobid_xml":"https://content.openalex.org/works/W2891308783.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W336580706","https://openalex.org/W1573857414","https://openalex.org/W1966865235","https://openalex.org/W1980921374","https://openalex.org/W1984455353","https://openalex.org/W1990367960","https://openalex.org/W1990958459","https://openalex.org/W1992324972","https://openalex.org/W1992525659","https://openalex.org/W2000904449","https://openalex.org/W2010803460","https://openalex.org/W2014117996","https://openalex.org/W2017977378","https://openalex.org/W2019092555","https://openalex.org/W2022452929","https://openalex.org/W2029033394","https://openalex.org/W2029211701","https://openalex.org/W2033482605","https://openalex.org/W2035269052","https://openalex.org/W2038734841","https://openalex.org/W2039399819","https://openalex.org/W2063353671","https://openalex.org/W2071154008","https://openalex.org/W2072289007","https://openalex.org/W2075744925","https://openalex.org/W2082950662","https://openalex.org/W2086510987","https://openalex.org/W2095271108","https://openalex.org/W2098307144","https://openalex.org/W2099465258","https://openalex.org/W2106095564","https://openalex.org/W2106158410","https://openalex.org/W2109270323","https://openalex.org/W2112778345","https://openalex.org/W2115203342","https://openalex.org/W2117347068","https://openalex.org/W2119353857","https://openalex.org/W2128016314","https://openalex.org/W2129579709","https://openalex.org/W2130523009","https://openalex.org/W2148637867","https://openalex.org/W2151396264","https://openalex.org/W2157025275","https://openalex.org/W2158503648","https://openalex.org/W2159011576","https://openalex.org/W2165402895","https://openalex.org/W2311884719","https://openalex.org/W2316537321","https://openalex.org/W2508772170","https://openalex.org/W2521479851","https://openalex.org/W2756436005","https://openalex.org/W2767520553","https://openalex.org/W2906253013","https://openalex.org/W3026624461","https://openalex.org/W4247665917","https://openalex.org/W4297851198"],"related_works":["https://openalex.org/W6921360552","https://openalex.org/W2899701947","https://openalex.org/W2942047699","https://openalex.org/W1992324972","https://openalex.org/W2072289007","https://openalex.org/W4400867716","https://openalex.org/W4392674025","https://openalex.org/W4295292788","https://openalex.org/W2035269052","https://openalex.org/W3138378284"],"abstract_inverted_index":{"BACKGROUND:":[0],"Disrupted":[1],"serotonergic":[2],"signaling":[3],"is":[4],"often":[5],"a":[6,102,246],"feature":[7],"of":[8,13,54,72,105,111,191],"depression":[9,68,95,184,212],"and":[10,63,89,127,169,201,239,253],"the":[11,14,35,44,52,58,82,133,189,198],"role":[12,247],"serotonin":[15,21],"transporter":[16],"gene":[17,59,84],"(SLC6A4),":[18],"responsible":[19],"for":[20,135,197,233],"re-uptake,":[22],"has":[23],"received":[24],"much":[25],"attention":[26],"in":[27,81,188,248],"this":[28,73],"regard.":[29],"Most":[30],"studies":[31,49],"have":[32,50],"focused":[33],"on":[34,60],"polymorphic":[36],"5-HTTLPR":[37,200],"upstream":[38],"repeat,":[39],"or":[40],"DNA":[41,61,87,170,179],"methylation":[42,148,171,180,205,238,251],"at":[43,172,206],"promoter":[45,86,250],"CpG":[46,174],"island.":[47],"Few":[48],"explored":[51],"influence":[53],"genetic":[55,79,161],"variation":[56,80],"across":[57],"methylation,":[62,88],"their":[64],"combined":[65],"association":[66,255],"with":[67,94,183,211,256],"risk.":[69],"The":[70,98],"aim":[71],"study":[74,100],"was":[75,117,143,181,209],"to":[76,120,145,217,225],"determine":[77],"whether":[78,90],"SLC6A4":[83,147,160,237],"influences":[85],"these":[91],"are":[92],"associated":[93,182,210],"status.":[96],"METHOD:":[97],"ESPRIT":[99],"involves":[101],"community-based":[103],"population":[104],"older":[106],"individuals":[107,195],"(>":[108],"65":[109],"years":[110],"age).":[112],"Major":[113],"depressive":[114,129],"disorder":[115],"(MDD)":[116],"diagnosed":[118],"according":[119],"DSM-IV":[121],"(American":[122],"Psychiatric":[123],"Association,":[124],"1994)":[125],"criteria,":[126],"severe":[128],"symptoms":[130],"assessed":[131],"by":[132],"Centre":[134],"Epidemiological":[136],"Studies":[137],"Depression":[138],"(CES-D)":[139],"Scale.":[140],"Sequenom":[141],"MassARRAY":[142],"used":[144],"measure":[146],"status":[149],"(n":[150],"=":[151,214,219,223,227],"302).":[152],"RESULTS:":[153],"Nominally":[154],"significant":[155],"associations":[156,235],"were":[157],"observed":[158],"between":[159,236],"variants":[162,242],"(5-HTTLPR,":[163],"rs140700,":[164],"rs4251417,":[165],"rs6354,":[166],"rs25528,":[167],"rs25531)":[168],"several":[173],"sites.":[175],"In":[176,194],"multivariate":[177],"regression,":[178],"status,":[185],"but":[186],"only":[187],"presence":[190],"specific":[192],"genotypes.":[193],"homozygous":[196],"short":[199],"5-HTTLPR/r25531":[202],"alleles,":[203],"lower":[204],"two":[207],"CpGs":[208],"(\u03b2":[213],"-":[215,220],"0.44":[216],"\u03b2":[218],"0.31;":[221],"p":[222,226],"0.001":[224],"0.038).":[228],"CONCLUSION:":[229],"We":[230],"present":[231],"evidence":[232],"genotype-dependent":[234],"depression.":[240,257],"Genetic":[241],"may":[243],"also":[244],"play":[245],"influencing":[249],"levels":[252],"its":[254]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-09-27T00:00:00"}