{"id":"https://openalex.org/W2891265331","doi":"https://doi.org/10.1534/g3.118.200289","title":"Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation","display_name":"Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2891265331","doi":"https://doi.org/10.1534/g3.118.200289","mag":"2891265331","pmid":"https://pubmed.ncbi.nlm.nih.gov/30194090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6222566"},"language":"en","primary_location":{"id":"doi:10.1534/g3.118.200289","doi":"https://doi.org/10.1534/g3.118.200289","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200289","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1534/g3.118.200289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091506191","display_name":"Theodore W. Peters","orcid":"https://orcid.org/0009-0003-6577-2255","observed_orcids":["https://orcid.org/0009-0003-6577-2255"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theodore W Peters","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072312286","display_name":"Christopher S. Nelson","orcid":"https://orcid.org/0000-0002-5608-2338","observed_orcids":["https://orcid.org/0000-0002-5608-2338"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S Nelson","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045604443","display_name":"Akos A. Gerencser","orcid":"https://orcid.org/0000-0002-8052-3711","observed_orcids":["https://orcid.org/0000-0002-8052-3711"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akos A Gerencser","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062768680","display_name":"Kathleen J. Dumas","orcid":"https://orcid.org/0000-0003-2694-079X","observed_orcids":["https://orcid.org/0000-0003-2694-079X"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen J Dumas","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054021231","display_name":"Brandon Tavshanjian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Tavshanjian","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091552515","display_name":"Kyu Chul Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyu Chul Chang","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036740389","display_name":"Gordon J. Lithgow","orcid":"https://orcid.org/0000-0002-8953-3043","observed_orcids":["https://orcid.org/0000-0002-8953-3043"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon J Lithgow","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107834034","display_name":"Robert E. Hughes","orcid":"https://orcid.org/0009-0006-5650-2802","observed_orcids":["https://orcid.org/0009-0006-5650-2802"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert E Hughes","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945 robert.hughes.phd@gmail.com tpeters@alderbio.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato CA, 94945 robert.hughes.phd@gmail.com tpeters@alderbio.com","institution_ids":["https://openalex.org/I1337826666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091506191","https://openalex.org/A5107834034"],"corresponding_institution_ids":["https://openalex.org/I1337826666"],"apc_list":{"value":2709,"currency":"USD","value_usd":2709},"apc_paid":{"value":2709,"currency":"USD","value_usd":2709},"fwci":0.3412,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.5004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"11","first_page":"3421","last_page":"3431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyglutamine-aggregation","display_name":"polyglutamine aggregation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/huntingtin","display_name":"huntingtin","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nedd4","display_name":"NEDD4","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.796999990940094},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.7049999833106995},{"id":"https://openalex.org/keywords/natural-genetic-variation","display_name":"natural genetic variation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.335999995470047},{"id":"https://openalex.org/keywords/protein-folding-diseases","display_name":"protein folding diseases","score":0.6940000057220459},{"id":"https://openalex.org/keywords/modifier-loci","display_name":"modifier loci","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7085856795310974},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.6070140600204468},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.577452540397644},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5478742122650146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5312556624412537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5064643621444702},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49483054876327515},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.4811186194419861},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4456171989440918},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.4221998453140259},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4145798683166504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32558149099349976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075702","descriptor_name":"Nedd4 Ubiquitin Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1534/g3.118.200289","doi":"https://doi.org/10.1534/g3.118.200289","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200289","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5171201","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6222566","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6222566","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6222566","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"},{"id":"pmid:30194090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30194090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:21cf586f07fa4cc2bb6f00f7365e300d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/21cf586f07fa4cc2bb6f00f7365e300d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1534/g3.118.200289","doi":"https://doi.org/10.1534/g3.118.200289","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200289","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2231512330","display_name":"Huntingtin interacting proteins as modifiers of Huntington's disease","funder_award_id":"R01NS055247","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3714231161","display_name":"GENETIC DISSECTION OF NATURAL VARIATION IN CALORIC RESTRICTION-INDUCED CELLULAR L","funder_award_id":"F32AG047024","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6377461900","display_name":"Pharmacology of Lifespan Extension","funder_award_id":"R01AG029631","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6634470750","display_name":"Mechanisms of RRAS regulation of huntingtin and turnover","funder_award_id":"R56NS093392","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306725","display_name":"Hereditary Disease Foundation","ror":"https://ror.org/02a3w7r50"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W119810657","https://openalex.org/W1511237419","https://openalex.org/W1561188835","https://openalex.org/W1895398290","https://openalex.org/W1964918543","https://openalex.org/W1966792908","https://openalex.org/W1970964234","https://openalex.org/W1975277932","https://openalex.org/W1977537173","https://openalex.org/W1978794287","https://openalex.org/W1980342220","https://openalex.org/W1985474993","https://openalex.org/W1987928566","https://openalex.org/W1995171819","https://openalex.org/W1995181798","https://openalex.org/W2003609221","https://openalex.org/W2011681733","https://openalex.org/W2013754033","https://openalex.org/W2027988262","https://openalex.org/W2028380145","https://openalex.org/W2042904623","https://openalex.org/W2046465905","https://openalex.org/W2054046372","https://openalex.org/W2054079358","https://openalex.org/W2061935777","https://openalex.org/W2062682951","https://openalex.org/W2066290751","https://openalex.org/W2067297186","https://openalex.org/W2068294690","https://openalex.org/W2076159058","https://openalex.org/W2076544864","https://openalex.org/W2078271301","https://openalex.org/W2086431203","https://openalex.org/W2093258646","https://openalex.org/W2095865716","https://openalex.org/W2103151604","https://openalex.org/W2103675937","https://openalex.org/W2104177210","https://openalex.org/W2113051923","https://openalex.org/W2117936512","https://openalex.org/W2121642311","https://openalex.org/W2124800531","https://openalex.org/W2127342428","https://openalex.org/W2128679613","https://openalex.org/W2130088593","https://openalex.org/W2131926693","https://openalex.org/W2136816588","https://openalex.org/W2137209191","https://openalex.org/W2140408658","https://openalex.org/W2141153456","https://openalex.org/W2160779871","https://openalex.org/W2160925669","https://openalex.org/W2163581448","https://openalex.org/W2176178968","https://openalex.org/W2291779372","https://openalex.org/W2491428042","https://openalex.org/W2600639051","https://openalex.org/W4240065971"],"related_works":["https://openalex.org/W1963807880","https://openalex.org/W4206741280","https://openalex.org/W2160779871","https://openalex.org/W2168068293","https://openalex.org/W4206603084","https://openalex.org/W3023715805","https://openalex.org/W2061238000","https://openalex.org/W1511237419","https://openalex.org/W2008575808","https://openalex.org/W2560758662"],"abstract_inverted_index":{"Abstract":[0],"A":[1,43],"feature":[2],"common":[3],"to":[4,33,45,49,61,80,165,177],"late":[5],"onset":[6],"proteinopathic":[7],"disorders":[8],"is":[9,48],"an":[10],"accumulation":[11],"of":[12,40,77,88,97,107,137,148,173,194,211,220],"toxic":[13],"protein":[14,55,91,161,244,255],"conformers":[15],"and":[16,68,115,152,197,246,253],"aggregates":[17],"in":[18,102,159,163,223],"affected":[19],"tissues.":[20],"In":[21],"the":[22,38,86,99,130,142,149,153,174,185,192,206,221,238],"search":[23],"for":[24,251],"potential":[25],"drug":[26],"targets,":[27],"many":[28],"studies":[29],"used":[30],"high-throughput":[31],"screens":[32],"find":[34],"genes":[35],"that":[36,53,64,84,123,205,242],"modify":[37,124,243],"cytotoxicity":[39],"misfolded":[41,138],"proteins.":[42],"complement":[44],"this":[46],"approach":[47],"focus":[50],"on":[51,199],"strategies":[52],"use":[54,72],"aggregation":[56,87,175,245],"as":[57],"a":[58,89,94,111,178,182],"phenotypic":[59],"readout":[60],"identify":[62],"pathways":[63],"control":[65],"aggregate":[66],"formation":[67],"maintenance.":[69],"Here":[70],"we":[71,203],"natural":[73],"variation":[74],"between":[75,113],"strains":[76,118],"budding":[78],"yeast":[79,117],"genetically":[81],"map":[82],"loci":[83,122],"influence":[85],"polyglutamine-containing":[90],"derived":[92,109],"from":[93,110],"mutant":[95],"form":[96],"huntingtin,":[98],"causative":[100],"agent":[101],"Huntington":[103],"disease.":[104],"Linkage":[105],"analysis":[106,169],"progeny":[108],"cross":[112],"wild":[114],"laboratory":[116],"revealed":[119],"two":[120],"polymorphic":[121],"polyglutamine":[125,217,228,252],"aggregation.":[126,201,218,229],"One":[127],"locus":[128,180],"contains":[129],"gene":[131,183],"RFU1":[132,196],"which":[133],"modifies":[134],"ubiquitination":[135],"states":[136],"proteins":[139],"targeted":[140],"by":[141],"E3-ubiquitin":[143],"ligase":[144],"complex":[145],"Rsp5.":[146],"Activity":[147],"Rsp5":[150],"complex,":[151],"mammalian":[154],"homolog":[155],"NEDD4,":[156],"are":[157],"critical":[158],"maintaining":[160],"homeostasis":[162],"response":[164],"proteomic":[166],"stress.":[167],"Our":[168],"also":[170,214],"showed":[171],"linkage":[172],"phenotype":[176],"distinct":[179],"containing":[181],"encoding":[184],"Rsp5-interacting":[186],"Bul2":[187],"protein.":[188],"Allele-swap":[189],"experiments":[190],"validated":[191],"impact":[193],"both":[195],"BUL2":[198],"huntingtin":[200],"Furthermore,":[202],"found":[204],"nematode":[207],"Caenorhabditis":[208],"elegans\u2019":[209],"ortholog":[210],"Rsp5,":[212],"wwp-1,":[213],"negatively":[215],"regulates":[216],"Knockdown":[219],"NEDD4":[222],"human":[224],"cells":[225],"likewise":[226],"altered":[227],"Taken":[230],"together,":[231],"these":[232],"results":[233],"implicate":[234],"conserved":[235],"processes":[236],"involving":[237],"ubiquitin":[239],"regulation":[240],"network":[241],"provide":[247],"novel":[248],"therapeutic":[249],"targets":[250],"other":[254],"folding":[256],"diseases.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}
