{"id":"https://openalex.org/W2891129377","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","title":"Anti-GD2 immunotherapy in adults with high-risk neuroblastoma (HR-NB): The Memorial Sloan Kettering Cancer Center (MSKCC) experience.","display_name":"Anti-GD2 immunotherapy in adults with high-risk neuroblastoma (HR-NB): The Memorial Sloan Kettering Cancer Center (MSKCC) experience.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2891129377","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","mag":"2891129377"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.10550","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080426443","display_name":"Maya Suzuki","orcid":"https://orcid.org/0000-0003-0573-8795","observed_orcids":["https://orcid.org/0000-0003-0573-8795"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya Suzuki","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043729995","display_name":"Brian H. Kushner","orcid":"https://orcid.org/0000-0002-8916-0697","observed_orcids":["https://orcid.org/0000-0002-8916-0697"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian H. Kushner","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034325765","display_name":"Kim Kramer","orcid":"https://orcid.org/0000-0002-3803-878X","observed_orcids":["https://orcid.org/0000-0002-3803-878X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Kramer","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016432846","display_name":"Ellen M. Basu","orcid":"https://orcid.org/0000-0002-4555-220X","observed_orcids":["https://orcid.org/0000-0002-4555-220X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen M. Basu","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026950879","display_name":"Stephen S. Roberts","orcid":"https://orcid.org/0000-0001-8258-756X","observed_orcids":["https://orcid.org/0000-0001-8258-756X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S. Roberts","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002140630","display_name":"Michael P. LaQuaglia","orcid":"https://orcid.org/0000-0002-7059-9851","observed_orcids":["https://orcid.org/0000-0002-7059-9851"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P LaQuaglia","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Kong V. Cheung","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105830310","display_name":"Shakeel I. Modak","orcid":"https://orcid.org/0000-0002-7280-1726","observed_orcids":["https://orcid.org/0000-0002-7280-1726"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shakeel Modak","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"10550","last_page":"10550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anti-gd2-immunotherapy","display_name":"anti-GD2 immunotherapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9390000104904175},{"id":"https://openalex.org/keywords/stage-4-neuroblastoma","display_name":"stage IV neuroblastoma","score":0.753000020980835},{"id":"https://openalex.org/keywords/atrx-mutation","display_name":"ATRX mutation","score":0.800000011920929},{"id":"https://openalex.org/keywords/alk-mutations","display_name":"ALK mutations","score":0.9890000224113464},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7329999804496765},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.546999990940094},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307682514190674},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5767966508865356},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5510596632957458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5107204914093018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5062410235404968},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4801770746707916},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33995428681373596},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3353416919708252},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.10550","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.10550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794119464","https://openalex.org/W3001801043","https://openalex.org/W4379281150","https://openalex.org/W3203674894","https://openalex.org/W4396237823","https://openalex.org/W2144152847","https://openalex.org/W3207302741","https://openalex.org/W2151310238","https://openalex.org/W3137819618","https://openalex.org/W2176479197"],"abstract_inverted_index":{"10550":[0],"Background:":[1],"The":[2,84],"diagnosis":[3],"of":[4,52,135,196,261,276],"NB":[5,59,164,271],"in":[6,33,44,256],"adulthood":[7],"is":[8,12,21,30,280,294],"rare":[9],"and":[10,17,65,95,101,110,120,182,191,220,279,293],"little":[11],"known":[13],"about":[14],"its":[15,38],"biology":[16],"clinical":[18],"course.":[19],"There":[20],"no":[22,243],"established":[23],"therapy":[24],"for":[25,80,139,231,240],"adult":[26],"NB.":[27],"Anti-GD2":[28],"immunotherapy":[29,250,287],"now":[31],"standard":[32],"children":[34],"with":[35,55,160,253],"HR-NB":[36],"but":[37,124],"use":[39],"has":[40],"not":[41,125,235],"been":[42],"reported":[43],"adults.":[45],"Methods:":[46],"After":[47],"obtaining":[48],"IRB":[49],"waiver,":[50],"records":[51],"all":[53],"patients":[54,103,128,142,159,207],"adult-onset":[56],"(\u226518":[57],"years)":[58],"seen":[60],"at":[61,131,215],"MSKCC":[62],"between":[63],"1983":[64],"2015":[66],"were":[67,86],"reviewed.":[68],"Overall":[69],"survival":[70,149,292],"(OS)":[71],"was":[72,78,143,234,251],"tested":[73],"by":[74],"log-rank":[75],"test.":[76],"Cox-regression":[77],"used":[79],"multivariate":[81,257],"analysis.":[82],"Results:":[83],"subjects":[85],"42":[87],"adults":[88],"(median:":[89],"25;":[90],"range18-71":[91],"years);":[92],"23":[93],"male":[94],"19":[96],"female.":[97],"Five,":[98],"1,":[99,107],"1":[100],"35":[102,170],"had":[104,225],"INSS":[105],"stage":[106,146,162,167,171,246,269],"2,":[108],"3":[109],"4":[111,141,147,163,172,174,247,270],"disease,":[112],"respectively.":[113],"Genetic":[114],"abnormalities":[115],"included":[116],"somatic":[117,277],"ATRX":[118],"(59%)":[119],"ALK":[121],"mutations":[122,278],"(43%)":[123],"MYCN-amplification.":[126],"16":[127],"remain":[129],"alive":[130],"a":[132,273],"median":[133],"follow-up":[134],"5.3":[136,152],"years.":[137],"OS":[138,227,255],"non-stage":[140],"superior":[144,226],"to":[145,166,265,289],"(median":[148],"14.6":[150],"vs":[151,242],"years;":[153],"p":[154],"<":[155,161,229],"0.05).":[156],"However":[157],"5/7":[158],"progressed":[165],"4.":[168],"Among":[169],"patients,":[173,248],"achieved":[175],"complete":[176],"remission":[177],"(CR)":[178],"after":[179],"induction":[180],"chemotherapy":[181],"surgery,":[183],"11":[184],"underwent":[185],"autologous":[186],"stem":[187],"cell":[188],"transplant":[189],"(ASCT)":[190],"15":[192],"received":[193],"multiple":[194],"cycles":[195],"anti-GD2":[197,223,249,262,286],"antibodies":[198,224],"3F8":[199],"or":[200],"hu3F8":[201],"without":[202],"complications.":[203],"In":[204],"univariate":[205],"analysis,":[206],"\u2264":[208],"29":[209],"years":[210],"old":[211],"(n":[212],"=":[213,238],"24)":[214],"diagnosis,":[216],"those":[217,221],"achieving":[218],"CR,":[219],"receiving":[222],"(p":[228,237],"0.05":[230],"each).":[232],"ASCT":[233,241],"beneficial":[236],"0.3":[239],"ASCT).":[244],"For":[245],"associated":[252],"favorable":[254],"analysis":[258],"(95%":[259],"CI":[260],"antibody:":[263],"1.270":[264],"7.990).":[266],"Conclusions:":[267],"Adult-onset":[268],"demonstrates":[272],"high":[274],"incidence":[275],"only":[281],"partially":[282],"chemosensitive.":[283],"However,":[284],"3F8/hu3F8-based":[285],"appears":[288],"improve":[290],"long-term":[291],"well":[295],"tolerated.":[296]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2018-09-27T00:00:00"}