{"id":"https://openalex.org/W2891027642","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","title":"The prognostic significance of ATRX in pulmonary carcinoid tumors.","display_name":"The prognostic significance of ATRX in pulmonary carcinoid tumors.","publication_year":2018,"publication_date":"2018-05-20","ids":{"openalex":"https://openalex.org/W2891027642","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","mag":"2891027642"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.15_suppl.e20543","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040290239","display_name":"Hao Xie","orcid":"https://orcid.org/0000-0002-9640-4055","observed_orcids":["https://orcid.org/0000-0002-9640-4055","https://orcid.org/0009-0009-4778-2912"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Xie","raw_affiliation_strings":["Division of Medical Oncology, Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085660617","display_name":"Simone Barreto Siqueira Parrilha Terra","orcid":"https://orcid.org/0000-0001-7560-2346","observed_orcids":["https://orcid.org/0000-0001-7560-2346"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone Terra","raw_affiliation_strings":["Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN, US;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN, US;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006980511","display_name":"Jennifer M. Boland","orcid":"https://orcid.org/0000-0002-2723-9586","observed_orcids":["https://orcid.org/0000-0002-2723-9586"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Boland","raw_affiliation_strings":["Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Scott Mansfield","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038755935","display_name":"Julian R. Molina","orcid":"https://orcid.org/0000-0002-9962-4635","observed_orcids":["https://orcid.org/0000-0002-9962-4635"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian R. Molina","raw_affiliation_strings":["Division of Medical Oncology, Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034226178","display_name":"Anja Christiane Roden","orcid":"https://orcid.org/0000-0001-8948-4758","observed_orcids":["https://orcid.org/0000-0001-8948-4758"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anja Roden","raw_affiliation_strings":["Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine &amp; Pathology, Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"15_suppl","first_page":"e20543","last_page":"e20543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrx","display_name":"ATRX","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bronchial-carcinoid","display_name":"bronchial carcinoid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/atypical-carcinoid","display_name":"atypical carcinoid","score":0.8790000081062317},{"id":"https://openalex.org/keywords/typical-carcinoid","display_name":"typical carcinoid","score":0.9549999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/atrx-loss","display_name":"ATRX loss","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nuclear-expression","display_name":"nuclear expression","score":0.6439999938011169},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8140000104904175},{"id":"https://openalex.org/keywords/histological-classification","display_name":"histological classification","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.8050000071525574},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2776689207","wikidata":"https://www.wikidata.org/wiki/Q17835753","display_name":"ATRX","level":4,"score":0.8711709976196289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7966132760047913},{"id":"https://openalex.org/C2778506435","wikidata":"https://www.wikidata.org/wiki/Q1734755","display_name":"Carcinoid tumors","level":2,"score":0.5526731610298157},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.5521336197853088},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4981231689453125},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49691084027290344},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.4412234127521515},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.43648669123649597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40449434518814087},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37913256883621216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34452012181282043},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.15573853254318237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11578062176704407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.15_suppl.e20543","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e20543","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2971715277","https://openalex.org/W2791443609","https://openalex.org/W6940401544","https://openalex.org/W2887975246","https://openalex.org/W2147094583","https://openalex.org/W2897696908","https://openalex.org/W2083310634","https://openalex.org/W1909875799","https://openalex.org/W2991508819","https://openalex.org/W7213364366"],"abstract_inverted_index":{"e20543":[0],"Background:":[1],"Loss":[2,152,177,272],"of":[3,27,66,111,153,175,178,225,232,266,273,301,306],"ATRX,":[4],"a":[5,163],"transcriptional":[6],"regulator,":[7],"has":[8,277],"been":[9],"associated":[10,184,239],"with":[11,16,31,108,169,185,190,227,240,246,285],"reduced":[12],"survival":[13,101,224,245],"in":[14,29,35,283,289,303],"patients":[15,30,105,126,132,226,284],"pancreatic":[17],"neuroendocrine":[18],"tumors.":[19],"We":[20],"aimed":[21],"to":[22,37,51,84,216,291],"evaluate":[23],"the":[24,38,86,172,218,223,264,292,299,304],"prognostic":[25,220],"role":[26],"ATRX":[28,58,89,154,179,233,274,302],"pulmonary":[32,43,187,228,286,307],"carcinoid":[33,44,188,229,287,308],"tumors":[34,45,138,149,288,309],"addition":[36,290],"histological":[39,209,294],"classification.":[40,295],"Methods:":[41],"Resected":[42],"and":[46,56,76,93,205,263,280,310],"clinical":[47],"information":[48],"from":[49,166],"1995":[50],"2017":[52],"were":[53,82,98,116],"retrospectively":[54],"identified":[55,165],"recorded.":[57],"expression":[59,156,181,235,276],"by":[60,70],"immunohistochemistry":[61],"was":[62,121,157,182,236],"recorded":[63],"as":[64,159],"percentage":[65],"tumor":[67,189,259],"nuclei":[68],"staining":[69],"two":[71],"pathologists":[72],"independently.":[73],"Logistic":[74],"regression":[75],"receiver":[77],"operating":[78],"characteristic":[79],"curve":[80,173],"(ROC)":[81],"used":[83,99],"establish":[85],"cutoff":[87,164],"for":[88,100,202,222,258],"expression.":[90],"Kaplan-Meier":[91],"method":[92],"Cox":[94],"proportional":[95],"hazards":[96],"model":[97],"analysis.":[102],"Results:":[103],"120":[104],"(38%":[106],"male)":[107],"median":[109,119],"age":[110],"59.7":[112],"years":[113],"(range,":[114],"14.8-87)":[115],"included.":[117],"The":[118],"follow-up":[120],"4.2":[122],"years.":[123],"52":[124],"(43%)":[125],"had":[127,133,139,150],"atypical":[128,186],"carcinoid;":[129],"68":[130],"(57%)":[131],"typical":[134,213],"carcinoid.":[135],"74":[136],"(62%)":[137],"<":[140],"2":[141],"mitoses":[142],"per":[143],"10":[144],"high-power":[145],"field.":[146],"15":[147],"(12%)":[148],"necrosis.":[151],"nuclear":[155,180,234,275],"defined":[158],"less":[160],"than":[161],"7.5%,":[162],"ROC":[167],"curves":[168],"area":[170],"under":[171],"(AUC)":[174],"0.61.":[176],"independently":[183,238],"odds":[191],"ratio":[192,248],"8.6":[193,249],"(95%":[194,250],"CI:":[195],"3.0-29,":[196],"p":[197,253],"=":[198,254],"0.0002),":[199],"after":[200,256],"adjusting":[201,257],"lymphovascular":[203,261],"invasion":[204],"perineural":[206],"invasion.":[207],"Although":[208],"classification":[210],"(atypical":[211],"vs.":[212],"histology)":[214],"remains":[215],"be":[217],"best":[219],"predictor":[221],"tumors,":[230],"loss":[231],"also":[237],"shorter":[241],"disease":[242,268],"specific":[243],"overall":[244],"hazard":[247],"CI":[251],"1.6-46,":[252],"0.01),":[255],"necrosis,":[260],"invasion,":[262],"presence":[265],"metastatic":[267],"at":[269],"diagnosis.":[270],"Conclusions:":[271],"significant":[278],"diagnostic":[279],"predictive":[281],"roles":[282],"current":[293],"Further":[296],"studies":[297,313],"on":[298],"function":[300],"pathogenesis":[305],"larger":[311],"outcome":[312],"are":[314],"needed.":[315]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-09-27T00:00:00"}