{"id":"https://openalex.org/W2890904044","doi":"https://doi.org/10.1016/j.celrep.2018.08.053","title":"Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer","display_name":"Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2890904044","doi":"https://doi.org/10.1016/j.celrep.2018.08.053","mag":"2890904044","pmid":"https://pubmed.ncbi.nlm.nih.gov/30232005"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2018.08.053","doi":"https://doi.org/10.1016/j.celrep.2018.08.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.08.053","pdf_url":"http://www.cell.com/article/S2211124718313391/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124718313391/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060026988","display_name":"Roy Zvi Granit","orcid":"https://orcid.org/0000-0002-6487-2559","observed_orcids":["https://orcid.org/0000-0002-6487-2559"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Roy Z. Granit","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026137475","display_name":"Hadas Masury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hadas Masury","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079144278","display_name":"Reba Condiotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Reba Condiotti","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049060360","display_name":"Yaakov Fixler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaakov Fixler","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011329227","display_name":"Yael Gabai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yael Gabai","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074003754","display_name":"Tzofia Glikman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tzofia Glikman","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010257353","display_name":"Simona Dalin","orcid":"https://orcid.org/0000-0001-5024-9718","observed_orcids":["https://orcid.org/0000-0001-5024-9718"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Simona Dalin","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084617315","display_name":"Eitan E. Winter","orcid":"https://orcid.org/0009-0009-4936-6023","observed_orcids":["https://orcid.org/0009-0009-4936-6023"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I4210144006","display_name":"Israeli Centers for Research Excellence","ror":"https://ror.org/03w2v9593","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210144006"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eitan Winter","raw_affiliation_strings":["Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I4210144006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041984452","display_name":"Yuval Nevo","orcid":"https://orcid.org/0000-0001-6757-5675","observed_orcids":["https://orcid.org/0000-0001-6757-5675"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I4210144006","display_name":"Israeli Centers for Research Excellence","ror":"https://ror.org/03w2v9593","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210144006"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yuval Nevo","raw_affiliation_strings":["Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I4210144006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010259750","display_name":"Einat Carmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Einat Carmon","raw_affiliation_strings":["Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058754904","display_name":"Tamar Sella","orcid":"https://orcid.org/0000-0002-4155-9172","observed_orcids":["https://orcid.org/0000-0002-4155-9172"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tamar Sella","raw_affiliation_strings":["Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002724338","display_name":"Amir Sonnenblick","orcid":"https://orcid.org/0000-0003-1954-4633","observed_orcids":["https://orcid.org/0000-0003-1954-4633"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amir Sonnenblick","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075618091","display_name":"Tamar Peretz","orcid":"https://orcid.org/0000-0001-8016-4010","observed_orcids":["https://orcid.org/0000-0001-8016-4010"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tamar Peretz","raw_affiliation_strings":["Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101625025","display_name":"Ulrich Lehmann","orcid":"https://orcid.org/0000-0003-2350-6584","observed_orcids":["https://orcid.org/0000-0003-2350-6584"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Lehmann","raw_affiliation_strings":["Institute of Pathology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Medizinische Hochschule Hannover, 30625 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045798","display_name":"Keren Paz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keren Paz","raw_affiliation_strings":["Champions Oncology, Inc., Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champions Oncology, Inc., Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000745052","display_name":"Federica Piccioni","orcid":"https://orcid.org/0000-0003-1210-3210","observed_orcids":["https://orcid.org/0000-0003-1210-3210"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federica Piccioni","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004067604","display_name":"Aviv Regev","orcid":"https://orcid.org/0000-0003-3293-3158","observed_orcids":["https://orcid.org/0000-0003-3293-3158"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aviv Regev","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA","Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086771961","display_name":"David E. Root","orcid":"https://orcid.org/0000-0001-5122-861X","observed_orcids":["https://orcid.org/0000-0001-5122-861X","https://orcid.org/0000-0003-0096-4830"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Root","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078514927","display_name":"Ittai Ben\u2010Porath","orcid":"https://orcid.org/0000-0001-7815-1165","observed_orcids":["https://orcid.org/0000-0001-7815-1165"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ittai Ben-Porath","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address: ittaibp@mail.huji.ac.il","Department of Developmental Biology and Cancer Research, Institute for Medical Research\u2013Israel-Canada, The Hebrew University\u2013Hadassah Medical School, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address: ittaibp@mail.huji.ac.il","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]},{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, Institute for Medical Research\u2013Israel-Canada, The Hebrew University\u2013Hadassah Medical School, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5078514927"],"corresponding_institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":1.6531,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88007495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"12","first_page":"3237","last_page":"3250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.07159999758005142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"asymmetric cell division","score":0.9010000228881836},{"id":"https://openalex.org/keywords/symmetric-cell-division","display_name":"symmetric cell division","score":0.9860000014305115},{"id":"https://openalex.org/keywords/luminal-progenitors","display_name":"luminal progenitors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-cell-composition","display_name":"tumor cell composition","score":0.5}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6851807832717896},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5486850738525391},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.5024406909942627},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49437499046325684},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45962440967559814},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4573407471179962},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44679027795791626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41315364837646484},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3952294588088989},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3652074933052063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2735116481781006},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26694512367248535},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23208671808242798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12588784098625183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08021381497383118},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051541","descriptor_name":"Hepatocyte Nuclear Factor 3-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051541","descriptor_name":"Hepatocyte Nuclear Factor 3-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060049","descriptor_name":"Asymmetric Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.celrep.2018.08.053","doi":"https://doi.org/10.1016/j.celrep.2018.08.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.08.053","pdf_url":"http://www.cell.com/article/S2211124718313391/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:30232005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30232005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:17fd09a8613d4560b76a4fa0d578df12","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/17fd09a8613d4560b76a4fa0d578df12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 24, Iss 12, Pp 3237-3250 (2018)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/118749","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0001-5024-9718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elsevier","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2018.08.053","doi":"https://doi.org/10.1016/j.celrep.2018.08.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.08.053","pdf_url":"http://www.cell.com/article/S2211124718313391/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1873874938","display_name":null,"funder_award_id":"2309/15","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G3436912842","display_name":null,"funder_award_id":"2511/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G7027512875","display_name":null,"funder_award_id":"2015205","funder_id":"https://openalex.org/F4320320950","funder_display_name":"United States-Israel Binational Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306740","display_name":"Israel Cancer Research Fund","ror":"https://ror.org/02h43gk75"},{"id":"https://openalex.org/F4320320950","display_name":"United States-Israel Binational Science Foundation","ror":"https://ror.org/00j8z2m73"},{"id":"https://openalex.org/F4320322250","display_name":"Israel Cancer Association","ror":"https://ror.org/03yxd7304"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2890904044.pdf","grobid_xml":"https://content.openalex.org/works/W2890904044.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W84060708","https://openalex.org/W1514939178","https://openalex.org/W1674293076","https://openalex.org/W1775309324","https://openalex.org/W1792532087","https://openalex.org/W1811320802","https://openalex.org/W1833050134","https://openalex.org/W1835915349","https://openalex.org/W1942221962","https://openalex.org/W1966564846","https://openalex.org/W1974202442","https://openalex.org/W1987012261","https://openalex.org/W1995547197","https://openalex.org/W1998728654","https://openalex.org/W1999591980","https://openalex.org/W2001144553","https://openalex.org/W2004380688","https://openalex.org/W2008878539","https://openalex.org/W2011336811","https://openalex.org/W2012117840","https://openalex.org/W2023316892","https://openalex.org/W2023457181","https://openalex.org/W2032087197","https://openalex.org/W2041263494","https://openalex.org/W2045414448","https://openalex.org/W2045909049","https://openalex.org/W2065161292","https://openalex.org/W2078556843","https://openalex.org/W2080457126","https://openalex.org/W2082239705","https://openalex.org/W2087849201","https://openalex.org/W2088813072","https://openalex.org/W2096977686","https://openalex.org/W2112270062","https://openalex.org/W2127197885","https://openalex.org/W2129375080","https://openalex.org/W2135925682","https://openalex.org/W2137162822","https://openalex.org/W2148227665","https://openalex.org/W2150329946","https://openalex.org/W2153051750","https://openalex.org/W2163493404","https://openalex.org/W2166311434","https://openalex.org/W2169530734","https://openalex.org/W2180840042","https://openalex.org/W2512004978","https://openalex.org/W2588274991","https://openalex.org/W2601637062","https://openalex.org/W2769379242","https://openalex.org/W2804088280"],"related_works":["https://openalex.org/W2899946591","https://openalex.org/W4283793980","https://openalex.org/W4391684663","https://openalex.org/W1537839278","https://openalex.org/W3202531348","https://openalex.org/W2096977686","https://openalex.org/W6922605114","https://openalex.org/W2606309350","https://openalex.org/W4211139795","https://openalex.org/W2553568946"],"abstract_inverted_index":{"Differentiation":[0],"events":[1],"contribute":[2,90],"to":[3,15,56,91],"phenotypic":[4],"cellular":[5,95,152],"heterogeneity":[6,23],"within":[7,24],"tumors":[8],"and":[9,13,48,79,85,113,122,128,143,145],"influence":[10],"disease":[11],"progression":[12],"response":[14],"therapy.":[16],"Here,":[17],"we":[18],"dissect":[19],"mechanisms":[20],"controlling":[21],"intratumoral":[22],"triple-negative":[25],"basal-like":[26],"breast":[27,150],"cancers.":[28],"Tumor":[29],"cells":[30,50,65,108,121],"expressing":[31],"the":[32,92,103,110,116],"cytokeratin":[33],"K14":[34,77,81,106,119],"possess":[35],"a":[36,53],"differentiation":[37,141],"state":[38,54],"that":[39,43,57,64,86,101,137,148],"is":[40],"associated":[41],"with":[42],"of":[44,58,94,105,118,125],"normal":[45],"luminal":[46,60],"progenitors,":[47],"K14-negative":[49],"are":[51],"in":[52,109],"closer":[55],"mature":[59],"cells.":[61],"We":[62,97],"show":[63],"can":[66],"transition":[67],"between":[68],"these":[69,87],"states":[70],"through":[71],"asymmetric":[72,88,138],"divisions,":[73,127],"which":[74],"produce":[75],"one":[76,80],"+":[78,107,120],"\u2212":[82],"daughter":[83],"cell,":[84],"divisions":[89,139],"generation":[93],"heterogeneity.":[96],"identified":[98],"several":[99],"regulators":[100],"control":[102,149],"proportion":[104],"population.":[111],"EZH2":[112],"Notch":[114],"increase":[115],"numbers":[117],"their":[123],"rates":[124],"symmetric":[126],"FOXA1":[129],"has":[130],"an":[131],"opposing":[132],"effect.":[133],"Our":[134],"findings":[135],"demonstrate":[136],"generate":[140],"transitions":[142],"heterogeneity,":[144],"identify":[146],"pathways":[147],"cancer":[151],"composition.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-09-27T00:00:00"}