{"id":"https://openalex.org/W2890697107","doi":"https://doi.org/10.1021/acsabm.8b00225","title":"Injectable in Situ Shape-Forming Osteogenic Nanocomposite Hydrogel for Regenerating Irregular Bone Defects","display_name":"Injectable in Situ Shape-Forming Osteogenic Nanocomposite Hydrogel for Regenerating Irregular Bone Defects","publication_year":2018,"publication_date":"2018-09-05","ids":{"openalex":"https://openalex.org/W2890697107","doi":"https://doi.org/10.1021/acsabm.8b00225","mag":"2890697107","pmid":"https://pubmed.ncbi.nlm.nih.gov/34996144"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.8b00225","doi":"https://doi.org/10.1021/acsabm.8b00225","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.8b00225","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020970207","display_name":"Sivashanmugam Amirthalingam","orcid":"https://orcid.org/0000-0002-0982-4634","observed_orcids":["https://orcid.org/0000-0002-0982-4634"]},"institutions":[{"id":"https://openalex.org/I1282879092","display_name":"Amrita Institute of Medical Sciences and Research Centre","ror":"https://ror.org/05ahcwz21","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1282879092"]},{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sivashanmugam Amirthalingam","raw_affiliation_strings":["Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India","institution_ids":["https://openalex.org/I1282879092","https://openalex.org/I81556334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053699043","display_name":"Ashvin Ramesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282879092","display_name":"Amrita Institute of Medical Sciences and Research Centre","ror":"https://ror.org/05ahcwz21","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1282879092"]},{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashvin Ramesh","raw_affiliation_strings":["Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India","institution_ids":["https://openalex.org/I1282879092","https://openalex.org/I81556334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086648710","display_name":"Seunghun S. Lee","orcid":"https://orcid.org/0000-0002-9654-8577","observed_orcids":["https://orcid.org/0000-0002-9654-8577"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seunghun S. Lee","raw_affiliation_strings":["School of Chemical and Biological Engineering, NBio Institute, Institute of Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9654-8577","affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, NBio Institute, Institute of Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075710060","display_name":"Nathaniel Suk-Yeon Hwang","orcid":"https://orcid.org/0000-0003-3735-7727","observed_orcids":["https://orcid.org/0000-0003-3735-7727"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nathaniel S. Hwang","raw_affiliation_strings":["School of Chemical and Biological Engineering, NBio Institute, Institute of Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3735-7727","affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, NBio Institute, Institute of Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055353126","display_name":"R. Jayakumar","orcid":"https://orcid.org/0000-0002-0066-4208","observed_orcids":["https://orcid.org/0000-0002-0066-4208"]},"institutions":[{"id":"https://openalex.org/I1282879092","display_name":"Amrita Institute of Medical Sciences and Research Centre","ror":"https://ror.org/05ahcwz21","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1282879092"]},{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rangasamy Jayakumar","raw_affiliation_strings":["Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India"],"raw_orcid":"https://orcid.org/0000-0002-0066-4208","affiliations":[{"raw_affiliation_string":"Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India","institution_ids":["https://openalex.org/I1282879092","https://openalex.org/I81556334"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055353126","https://openalex.org/A5075710060"],"corresponding_institution_ids":["https://openalex.org/I1282879092","https://openalex.org/I139264467","https://openalex.org/I81556334"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4219,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.79299623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1","issue":"4","first_page":"1037","last_page":"1046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-forming-hydrogels","display_name":"in situ forming hydrogels","score":0.8859999775886536},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8519999980926514},{"id":"https://openalex.org/keywords/oxidized-alginate","display_name":"oxidized alginate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/skull-defects","display_name":"cranial defects","score":0.7670000195503235},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.6620000004768372},{"id":"https://openalex.org/keywords/gelation-time","display_name":"gelation time","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.7649372816085815},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6920236349105835},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.6872513294219971},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6079214215278625},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5722116231918335},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5059131979942322},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47058358788490295},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.44620436429977417},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.43012678623199463},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4200842082500458},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.41388311982154846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35969269275665283},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.19138109683990479},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18713602423667908},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13950473070144653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07216745615005493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsabm.8b00225","doi":"https://doi.org/10.1021/acsabm.8b00225","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.8b00225","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:34996144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34996144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1552518518","display_name":null,"funder_award_id":"NRF-2017K1A3A1A19070731","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2989521087","display_name":null,"funder_award_id":"INT/Korea/P-41","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3108996244","display_name":null,"funder_award_id":"INT/ROK/IKRI-2/2016","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G4288012786","display_name":null,"funder_award_id":"SR/NM/PG-01/2015","funder_id":"https://openalex.org/F4320334972","funder_display_name":"Mission on Nano Science and Technology"},{"id":"https://openalex.org/G711528912","display_name":null,"funder_award_id":"09/963 (0038)2K17\u2010EMR\u2010I","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320334972","display_name":"Mission on Nano Science and Technology","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W229084474","https://openalex.org/W1966315709","https://openalex.org/W1974096559","https://openalex.org/W1977594859","https://openalex.org/W1988736486","https://openalex.org/W2002398258","https://openalex.org/W2016519321","https://openalex.org/W2020338027","https://openalex.org/W2020364703","https://openalex.org/W2021438186","https://openalex.org/W2022591338","https://openalex.org/W2023248222","https://openalex.org/W2032233283","https://openalex.org/W2036348189","https://openalex.org/W2043234704","https://openalex.org/W2043434037","https://openalex.org/W2045211074","https://openalex.org/W2053288021","https://openalex.org/W2061827690","https://openalex.org/W2064230565","https://openalex.org/W2068222178","https://openalex.org/W2068627477","https://openalex.org/W2075364256","https://openalex.org/W2083501148","https://openalex.org/W2114099446","https://openalex.org/W2117599170","https://openalex.org/W2153720415","https://openalex.org/W2154094043","https://openalex.org/W2160319765","https://openalex.org/W2274565482","https://openalex.org/W2322203349","https://openalex.org/W2424519491","https://openalex.org/W2502442841","https://openalex.org/W2530640131","https://openalex.org/W2534183450","https://openalex.org/W2588834493","https://openalex.org/W2626834956","https://openalex.org/W2756356529","https://openalex.org/W2769664355","https://openalex.org/W2770411658","https://openalex.org/W2776143701","https://openalex.org/W2791680037"],"related_works":["https://openalex.org/W7165679051","https://openalex.org/W4387266545","https://openalex.org/W3200314895","https://openalex.org/W4414571876","https://openalex.org/W4393340549","https://openalex.org/W3128902690","https://openalex.org/W4386318828","https://openalex.org/W4310277264","https://openalex.org/W3113296496","https://openalex.org/W3202577666"],"abstract_inverted_index":{"The":[0,67,90,103,118,129,168,187],"in":[1,32,134,169,214,224,251],"situ":[2,33,135],"forming":[3],"injectable":[4],"hydrogels":[5],"are":[6],"appealing":[7],"for":[8,87],"irregular":[9],"bone":[10,88,100,211,227,253],"defects":[11],"because":[12],"of":[13,16,21,82,92,132,153,172,184],"the":[14,19,27,42,74,80,133,159,165,175,206,226,232,240],"ease":[15],"administration":[17],"and":[18,24,39,96,115,127,198,248],"addition":[20],"ceramics,":[22],"molecules,":[23],"proteins":[25],"into":[26,73],"hydrogel.":[28],"We":[29],"have":[30],"developed":[31],"shape-forming":[34],"hydrogel":[35,43,75,120,137,147,177,204,221,237],"using":[36],"oxidized":[37,234],"alginate":[38],"gelatin":[40],"as":[41,52,77,143,245],"matrix.":[44],"Whitlockite":[45],"bioceramic":[46],"nanoparticles":[47,95,105],"(WH":[48],"NPs)":[49],"were":[50,110,116],"incorporated,":[51],"they":[53],"provide":[54,85],"enhanced":[55,205],"osteogenic":[56,207],"stimulation":[57],"compared":[58,228],"to":[59,229,242],"hydroxyapatite":[60],"via":[61],"providing":[62],"higher":[63],"local":[64],"ion":[65],"concentration.":[66],"drug":[68],"simvastatin":[69,97,173],"was":[70,122,138,222],"also":[71,163,192],"incorporated":[72],"system,":[76],"it":[78],"increases":[79],"expression":[81],"BMP-2":[83],"thereby":[84],"environment":[86],"regeneration.":[89],"presence":[91],"both":[93],"WH":[94,154],"would":[98],"enhance":[99],"regeneration":[101,212],"potential.":[102],"whitlockite":[104],"(80":[106],"\u00b1":[107],"8":[108],"nm)":[109],"synthesized":[111],"by":[112,124,140],"precipitation":[113],"method":[114],"characterized.":[117],"nanocomposite":[119,136,176,203,220],"system":[121,238,250],"characterized":[123],"SEM,":[125],"FTIR":[126],"rheologically.":[128],"gelation":[130,160],"time":[131,161],"determined":[139],"rheological":[141],"analysis":[142],"28":[144,185],"s,":[145],"whereas":[146],"alone":[148],"showed":[149,178,193,201,219],"132":[150],"s.":[151],"Addition":[152],"NPs":[155,236],"not":[156],"only":[157],"shortened":[158],"but":[162],"increased":[164],"gel":[166],"strength.":[167],"vitro":[170],"release":[171,180],"from":[174],"a":[179,182,194,246],"over":[181],"period":[183],"days.":[186],"alkaline":[188],"phosphatase":[189],"(ALP)":[190],"level":[191],"significant":[195],"increase.":[196],"RUNX2":[197],"BMP2":[199],"expressions":[200],"that":[202],"differentiation.":[208],"In":[209],"vivo":[210],"studies":[213,218],"mice":[215],"cranial":[216,252],"defect":[217],"effective":[223],"regenerating":[225],"controls.":[230],"Thus,":[231],"simvastatin-incorporated":[233],"alginate-gelatin/WH":[235],"has":[239],"potential":[241],"be":[243],"used":[244],"repairing":[247],"regenerative":[249],"defects.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-09-27T00:00:00"}
