{"id":"https://openalex.org/W2890650452","doi":"https://doi.org/10.1042/bst20180112","title":"Extracellular vesicles: translational challenges and opportunities","display_name":"Extracellular vesicles: translational challenges and opportunities","publication_year":2018,"publication_date":"2018-09-21","ids":{"openalex":"https://openalex.org/W2890650452","doi":"https://doi.org/10.1042/bst20180112","mag":"2890650452","pmid":"https://pubmed.ncbi.nlm.nih.gov/30242120"},"language":"en","primary_location":{"id":"doi:10.1042/bst20180112","doi":"https://doi.org/10.1042/bst20180112","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20180112","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002097588","display_name":"Hannah Clemmens","orcid":"https://orcid.org/0000-0001-6572-5828","observed_orcids":["https://orcid.org/0000-0001-6572-5828"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Hannah Clemmens","raw_affiliation_strings":["Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026798553","display_name":"D Lambert","orcid":"https://orcid.org/0000-0001-9003-3145","observed_orcids":["https://orcid.org/0000-0001-9003-3145"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel W. Lambert","raw_affiliation_strings":["Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K","Sheffield Institute for Nucleic Acids, University of Sheffield, S10 2TA Sheffield, U.K"],"raw_orcid":"https://orcid.org/0000-0001-9003-3145","affiliations":[{"raw_affiliation_string":"Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Sheffield Institute for Nucleic Acids, University of Sheffield, S10 2TA Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002097588"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.4259,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.38466615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"46","issue":"5","first_page":"1073","last_page":"1082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/translational-medicine","display_name":"translational medicine","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ev-isolation","display_name":"EV isolation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/ev-purification","display_name":"EV purification","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/therapeutic-use","display_name":"therapeutic applications","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.9412108659744263},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5074633955955505},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4710944592952728},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.4600377678871155},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4367269277572632},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.42599067091941833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41940850019454956},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.4149467647075653},{"id":"https://openalex.org/C3018040386","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Lipid vesicle","level":4,"score":0.41330787539482117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3354199528694153},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3330431580543518},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.2861129641532898},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.16110655665397644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09651023149490356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08218419551849365},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1042/bst20180112","doi":"https://doi.org/10.1042/bst20180112","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20180112","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:30242120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30242120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1499993276","https://openalex.org/W1500925570","https://openalex.org/W1601681275","https://openalex.org/W1877686344","https://openalex.org/W1900516866","https://openalex.org/W1915536483","https://openalex.org/W1924298949","https://openalex.org/W1966294883","https://openalex.org/W1979390153","https://openalex.org/W1986543208","https://openalex.org/W1990597414","https://openalex.org/W2000455734","https://openalex.org/W2003343932","https://openalex.org/W2015898716","https://openalex.org/W2019081320","https://openalex.org/W2022956911","https://openalex.org/W2033112925","https://openalex.org/W2047159195","https://openalex.org/W2052780003","https://openalex.org/W2055313665","https://openalex.org/W2060387475","https://openalex.org/W2085898732","https://openalex.org/W2090412820","https://openalex.org/W2102416146","https://openalex.org/W2109934828","https://openalex.org/W2111560326","https://openalex.org/W2121354606","https://openalex.org/W2123614057","https://openalex.org/W2125987139","https://openalex.org/W2128073255","https://openalex.org/W2130979840","https://openalex.org/W2131840270","https://openalex.org/W2143729276","https://openalex.org/W2155441983","https://openalex.org/W2157514094","https://openalex.org/W2166846320","https://openalex.org/W2169491358","https://openalex.org/W2191816501","https://openalex.org/W2257620318","https://openalex.org/W2259481044","https://openalex.org/W2262684743","https://openalex.org/W2272796193","https://openalex.org/W2276360944","https://openalex.org/W2283320864","https://openalex.org/W2302900931","https://openalex.org/W2323793261","https://openalex.org/W2325305253","https://openalex.org/W2325369955","https://openalex.org/W2330004628","https://openalex.org/W2491244808","https://openalex.org/W2506498379","https://openalex.org/W2516954052","https://openalex.org/W2522821491","https://openalex.org/W2525079554","https://openalex.org/W2560212688","https://openalex.org/W2576116405","https://openalex.org/W2587366712","https://openalex.org/W2589039936","https://openalex.org/W2589546201","https://openalex.org/W2598266163","https://openalex.org/W2608697804","https://openalex.org/W2609386196","https://openalex.org/W2612774616","https://openalex.org/W2624248893","https://openalex.org/W2624317658","https://openalex.org/W2626072141","https://openalex.org/W2752823190","https://openalex.org/W2758978127","https://openalex.org/W2759486891","https://openalex.org/W2762354841","https://openalex.org/W2763644153","https://openalex.org/W2766361739","https://openalex.org/W2769610250","https://openalex.org/W2790358993","https://openalex.org/W2793032642","https://openalex.org/W2796021015","https://openalex.org/W2796225592","https://openalex.org/W2797031148","https://openalex.org/W2797486656","https://openalex.org/W2802715752"],"related_works":["https://openalex.org/W7204029793","https://openalex.org/W4385308116","https://openalex.org/W7128422443","https://openalex.org/W3111531493","https://openalex.org/W4308954520","https://openalex.org/W4417107395","https://openalex.org/W2772306649","https://openalex.org/W4399350707","https://openalex.org/W4387357426","https://openalex.org/W4313421448"],"abstract_inverted_index":{"Extracellular":[0],"vesicles":[1],"(EVs)":[2],"are":[3],"a":[4,49],"heterogeneous":[5],"group":[6],"of":[7,21,30,35,51,75],"small":[8],"lipid-enclosed":[9],"structures":[10],"with":[11],"myriad":[12],"roles":[13],"in":[14,23,63],"physiology":[15],"and":[16,33,43,77,85,88],"disease.":[17],"The":[18],"recent":[19],"surge":[20],"interest":[22],"EVs":[24,58,76,87],"has":[25],"led":[26],"to":[27,82],"greater":[28],"understanding":[29],"their":[31,89],"biology":[32],"appreciation":[34],"how":[36],"they":[37],"might":[38],"be":[39,55,60],"utilised":[40],"as":[41],"diagnostic":[42],"therapeutic":[44],"tools.":[45],"There":[46],"remain,":[47],"however,":[48],"number":[50],"challenges":[52],"that":[53],"must":[54],"overcome":[56],"before":[57],"may":[59],"used":[61],"routinely":[62],"the":[64,72,78],"clinic.":[65],"In":[66],"this":[67],"review":[68],"we":[69],"will":[70],"discuss":[71],"translational":[73],"potential":[74],"current":[79],"technologies":[80],"available":[81],"isolate,":[83],"purify":[84],"analyse":[86],"contents.":[90]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-27T00:00:00"}
