{"id":"https://openalex.org/W28906389","doi":null,"title":"Immature intrinsic nerve innervations of pyloric muscle in idiopathic hypertrophic pyloric stenosis.","display_name":"Immature intrinsic nerve innervations of pyloric muscle in idiopathic hypertrophic pyloric stenosis.","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W28906389","mag":"28906389","pmid":"https://pubmed.ncbi.nlm.nih.gov/15318280"},"language":"en","primary_location":{"id":"pmid:15318280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15318280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association = Taiwan yi zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000052343","display_name":"Edgar D. Sy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Edgar D Sy","raw_affiliation_strings":["Division of Pediatric Surgery, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111544955","display_name":"Yan-Shen Shan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-Shen Shan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111490107","display_name":"Chyi-Her Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chyi-Her Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111588114","display_name":"Pin-Wen Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pin-Wen Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.358,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63081141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"103","issue":"7","first_page":"558","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12150","display_name":"Intestinal Malrotation and Obstruction Disorders","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12150","display_name":"Intestinal Malrotation and Obstruction Disorders","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyloric-muscle","display_name":"pyloric muscle","score":0.9089999794960022},{"id":"https://openalex.org/keywords/myenteric-plexus","display_name":"myenteric plexus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nitrergic-neurons","display_name":"nitrergic neurons","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/pgp-9-5","display_name":"PGP 9.5","score":0.8889999985694885},{"id":"https://openalex.org/keywords/smooth-muscle-development","display_name":"smooth muscle development","score":0.6119999885559082},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.6069999933242798},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2910588904","wikidata":"https://www.wikidata.org/wiki/Q1027995","display_name":"Hypertrophic Pyloric Stenosis","level":2,"score":0.8463293313980103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.795139729976654},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.7842653393745422},{"id":"https://openalex.org/C2778012502","wikidata":"https://www.wikidata.org/wiki/Q290248","display_name":"Pylorus","level":3,"score":0.6860016584396362},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5256175398826599},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5193506479263306},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5048542618751526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44827884435653687},{"id":"https://openalex.org/C2776285903","wikidata":"https://www.wikidata.org/wiki/Q7263098","display_name":"Pyloromyotomy","level":4,"score":0.44054684042930603},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.416940838098526},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.36038923263549805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3520403504371643}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011707","descriptor_name":"Pyloric Stenosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15318280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15318280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association = Taiwan yi zhi","raw_type":"Journal Article"},{"id":"mag:28906389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15318280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2325256671","https://openalex.org/W2081615881","https://openalex.org/W2016871321","https://openalex.org/W2026828770","https://openalex.org/W1987778536","https://openalex.org/W2020547252","https://openalex.org/W2076717496","https://openalex.org/W2026775286","https://openalex.org/W2046529363","https://openalex.org/W2002926363","https://openalex.org/W1968905266","https://openalex.org/W153696573","https://openalex.org/W2160167292","https://openalex.org/W2038050925","https://openalex.org/W2040646526","https://openalex.org/W2052574269","https://openalex.org/W2140638259","https://openalex.org/W2097580001","https://openalex.org/W2114075528","https://openalex.org/W2123310283","https://openalex.org/W2283453836"],"related_works":["https://openalex.org/W2064336519","https://openalex.org/W2052146642","https://openalex.org/W2590097932","https://openalex.org/W2049018992","https://openalex.org/W2095452247","https://openalex.org/W2079990335","https://openalex.org/W2037248495","https://openalex.org/W2410108210","https://openalex.org/W1977527683","https://openalex.org/W3032038476"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Various":[3],"etiologies":[4],"have":[5],"been":[6],"suggested":[7],"to":[8,29,63,71,189],"be":[9,175],"responsible":[10,177],"for":[11,77,132,179],"the":[12,21,31,40,98,139,158,162,176,180,191],"development":[13,181],"of":[14,25,33,94,119,130,151,164,169,182],"idiopathic":[15],"hypertrophic":[16],"pyloric":[17,41,48,140,159],"stenosis":[18],"(IHPS)":[19],"in":[20,39,43,104,108,114,122,138,157],"newborn.":[22],"The":[23,90,166],"purpose":[24],"this":[26],"study":[27,186],"was":[28],"determine":[30],"maturity":[32],"intrinsic":[34,152],"nerves":[35],"and":[36,69,73,83,100,117,136,154],"nitrergic":[37],"neurons":[38,121,156],"muscle":[42,49,102,160],"IHPS.":[44,165],"METHODS:":[45],"Full":[46],"thickness":[47],"specimens":[50],"were":[51],"obtained":[52],"from":[53,61],"6":[54,126],"infants":[55],"with":[56,58],"IHPS":[57],"age":[59],"ranging":[60],"27":[62],"95":[64],"(mean":[65],"58)":[66],"days":[67],"old":[68],"subjected":[70],"immunohistochemical":[72],"double":[74],"chemiluminescence":[75],"staining":[76],"protein":[78],"gene":[79],"product":[80],"9.5":[81],"(PGP9.5)":[82],"neuronal":[84],"nitric":[85],"oxide":[86],"synthase":[87],"(nNOS).":[88],"RESULTS:":[89],"results":[91,145],"showed":[92],"absence":[93,118,148],"myenteric":[95,112],"plexus":[96,113],"between":[97],"circular":[99],"longitudinal":[101],"layers":[103],"2":[105],"patients,":[106],"decrease":[107],"1":[109,115],"patient,":[110,116],"normal":[111],"nNOS-containing":[120,155],"4":[123],"patients.":[124],"All":[125],"patients":[127],"had":[128],"expression":[129],"markers":[131],"supporting":[133],"nerve":[134,153],"cells":[135],"myogenesis":[137],"smooth":[141],"muscle.":[142],"CONCLUSIONS:":[143],"These":[144],"suggest":[146],"that":[147],"or":[149,171],"immaturity":[150],"is":[161,187],"cause":[163],"demonstrated":[167],"lack":[168],"innervation":[170,173],"delayed":[172],"may":[174],"mechanism":[178],"IHPS,":[183],"but":[184],"further":[185],"needed":[188],"elucidate":[190],"pathogenesis.":[192]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}