{"id":"https://openalex.org/W2890618895","doi":"https://doi.org/10.3389/fmed.2018.00257","title":"Neprilysin Inhibitors and Bradykinin","display_name":"Neprilysin Inhibitors and Bradykinin","publication_year":2018,"publication_date":"2018-09-19","ids":{"openalex":"https://openalex.org/W2890618895","doi":"https://doi.org/10.3389/fmed.2018.00257","mag":"2890618895","pmid":"https://pubmed.ncbi.nlm.nih.gov/30283782","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6157573"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2018.00257","doi":"https://doi.org/10.3389/fmed.2018.00257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2018.00257","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2018.00257/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2018.00257/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022682140","display_name":"Duncan John Campbell","orcid":"https://orcid.org/0000-0002-6896-7571","observed_orcids":["https://orcid.org/0000-0002-6896-7571"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Duncan J. Campbell","raw_affiliation_strings":["Department of Medicine, The University of Melbourne, Parkville, VIC, Australia","Department of Molecular Cardiology, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia","St. Vincent's Hospital, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Cardiology, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia","institution_ids":["https://openalex.org/I77826658"]},{"raw_affiliation_string":"St. Vincent's Hospital, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210087110"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022682140"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210087110","https://openalex.org/I77826658"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.0748,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.73693859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"257","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neprilysin-inhibitors","display_name":"neprilysin inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.996999979019165},{"id":"https://openalex.org/keywords/angioedema","display_name":"angioedema","score":0.9480000138282776},{"id":"https://openalex.org/keywords/omapatrilat","display_name":"omapatrilat","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.984000027179718},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8820000290870667},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.8870000243186951},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bradykinin-metabolism","display_name":"bradykinin metabolism","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.9010246992111206},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.8916817903518677},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.8583464622497559},{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.7830871343612671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6509896516799927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5306429266929626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5099846124649048},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.49024564027786255},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.47607913613319397},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3596847653388977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.184195876121521},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12321346998214722},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12242269515991211},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.058253198862075806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fmed.2018.00257","doi":"https://doi.org/10.3389/fmed.2018.00257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2018.00257","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2018.00257/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5114529","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6157573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6157573","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6157573","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:30283782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30283782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c46df998d5084ff5a28293d5edbc4f71","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c46df998d5084ff5a28293d5edbc4f71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 5 (2018)","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/249562","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/249562","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2018.00257","doi":"https://doi.org/10.3389/fmed.2018.00257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2018.00257","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2018.00257/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6232201009","display_name":null,"funder_award_id":"CR 02M 0829","funder_id":"https://openalex.org/F4320320442","funder_display_name":"National Heart Foundation of Australia"}],"funders":[{"id":"https://openalex.org/F4320320442","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2890618895.pdf","grobid_xml":"https://content.openalex.org/works/W2890618895.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W109784360","https://openalex.org/W124143665","https://openalex.org/W124634336","https://openalex.org/W1481026332","https://openalex.org/W1484962109","https://openalex.org/W1486819840","https://openalex.org/W1519621899","https://openalex.org/W1535139368","https://openalex.org/W1544396872","https://openalex.org/W1560143001","https://openalex.org/W1569900298","https://openalex.org/W1764686129","https://openalex.org/W1777223861","https://openalex.org/W1800849354","https://openalex.org/W1830082853","https://openalex.org/W1896060457","https://openalex.org/W1964822131","https://openalex.org/W1967467967","https://openalex.org/W1971039109","https://openalex.org/W1971998433","https://openalex.org/W1972212337","https://openalex.org/W1972766768","https://openalex.org/W1973986737","https://openalex.org/W1975952670","https://openalex.org/W1977135574","https://openalex.org/W1977458672","https://openalex.org/W1979105270","https://openalex.org/W1982076095","https://openalex.org/W1982525745","https://openalex.org/W1982782378","https://openalex.org/W1983654162","https://openalex.org/W1986197570","https://openalex.org/W1988500109","https://openalex.org/W1992155766","https://openalex.org/W1994035387","https://openalex.org/W1997335104","https://openalex.org/W1999319209","https://openalex.org/W2000181720","https://openalex.org/W2003331661","https://openalex.org/W2004501435","https://openalex.org/W2004587229","https://openalex.org/W2008315681","https://openalex.org/W2008580181","https://openalex.org/W2011713635","https://openalex.org/W2012252047","https://openalex.org/W2012252766","https://openalex.org/W2016085424","https://openalex.org/W2019034341","https://openalex.org/W2021011733","https://openalex.org/W2024057404","https://openalex.org/W2026921577","https://openalex.org/W2032161953","https://openalex.org/W2036015204","https://openalex.org/W2038612896","https://openalex.org/W2039967952","https://openalex.org/W2053292076","https://openalex.org/W2053982006","https://openalex.org/W2054008469","https://openalex.org/W2055229981","https://openalex.org/W2055253331","https://openalex.org/W2055511533","https://openalex.org/W2057351643","https://openalex.org/W2058755393","https://openalex.org/W2061608226","https://openalex.org/W2062011501","https://openalex.org/W2065634593","https://openalex.org/W2065793802","https://openalex.org/W2070640973","https://openalex.org/W2084130233","https://openalex.org/W2084676138","https://openalex.org/W2086078395","https://openalex.org/W2086204662","https://openalex.org/W2086868114","https://openalex.org/W2089573090","https://openalex.org/W2091567906","https://openalex.org/W2092596981","https://openalex.org/W2094282177","https://openalex.org/W2097698117","https://openalex.org/W2101037152","https://openalex.org/W2102953371","https://openalex.org/W2113698123","https://openalex.org/W2115789382","https://openalex.org/W2121063376","https://openalex.org/W2123281693","https://openalex.org/W2127191583","https://openalex.org/W2129701635","https://openalex.org/W2133217116","https://openalex.org/W2134751690","https://openalex.org/W2138543166","https://openalex.org/W2139153278","https://openalex.org/W2147930568","https://openalex.org/W2149694398","https://openalex.org/W2151498184","https://openalex.org/W2155400583","https://openalex.org/W2155593994","https://openalex.org/W2156574746","https://openalex.org/W2158899054","https://openalex.org/W2159960981","https://openalex.org/W2161204751","https://openalex.org/W2161205883","https://openalex.org/W2164375876","https://openalex.org/W2164395037","https://openalex.org/W2166848757","https://openalex.org/W2168110475","https://openalex.org/W2169589584","https://openalex.org/W2187991480","https://openalex.org/W2259506756","https://openalex.org/W2273726813","https://openalex.org/W2277471552","https://openalex.org/W2283184147","https://openalex.org/W2292537710","https://openalex.org/W2297467343","https://openalex.org/W2300491566","https://openalex.org/W2313183887","https://openalex.org/W2315320121","https://openalex.org/W2318236181","https://openalex.org/W2319658883","https://openalex.org/W2323973694","https://openalex.org/W2326447677","https://openalex.org/W2346904247","https://openalex.org/W2401253743","https://openalex.org/W2409830846","https://openalex.org/W2508951587","https://openalex.org/W2517280325","https://openalex.org/W2562411701","https://openalex.org/W2588081052","https://openalex.org/W2791453970","https://openalex.org/W2793967988","https://openalex.org/W4250423050","https://openalex.org/W4299978430","https://openalex.org/W6684946924"],"related_works":["https://openalex.org/W1898108651","https://openalex.org/W2326447677","https://openalex.org/W2149694398","https://openalex.org/W2033965541","https://openalex.org/W1560143001","https://openalex.org/W2341712610","https://openalex.org/W4254272477","https://openalex.org/W2034088159","https://openalex.org/W1944238625","https://openalex.org/W2004501435"],"abstract_inverted_index":{"Bradykinin":[0,34],"has":[1,117],"important":[2],"physiological":[3],"actions":[4],"related":[5],"to":[6,26,74,129,141,255],"the":[7,47,68,76,83,103,136,142,171,220,232],"regulation":[8],"of":[9,49,107,135,144,161,222,226,235,274],"blood":[10],"vessel":[11],"tone":[12],"and":[13,16,32,61,67,79,111,124,151,195,214],"renal":[14,80],"function,":[15],"protection":[17],"from":[18,92,198],"ischemia":[19],"reperfusion":[20],"injury.":[21],"However,":[22,101,154],"bradykinin":[23,50,65,94,112],"also":[24,97,268],"contributes":[25],"pathological":[27],"states":[28],"such":[29,55,71,86,264],"as":[30,56,87,265],"angioedema":[31,88,162,177,241],"inflammation.":[33],"is":[35,73,267],"metabolized":[36],"by":[37,270],"many":[38],"different":[39,197],"peptidases":[40],"that":[41,89,148,199,209],"play":[42],"a":[43,146,207],"major":[44],"role":[45],"in":[46,121,163,168,181,246],"control":[48],"levels.":[51,95],"Peptidase":[52],"inhibitor":[53,115,173,238],"therapies":[54,72],"angiotensin":[57,138,211],"converting":[58],"enzyme":[59],"(ACE)":[60],"neprilysin":[62,114,131,152,215,237],"inhibitors":[63],"increase":[64],"levels,":[66,113],"challenge":[69],"for":[70,200,219,229,261],"achieve":[75],"beneficial":[77],"cardiovascular":[78],"effects":[81],"without":[82],"adverse":[84],"consequences":[85],"may":[90],"result":[91],"increased":[93,108],"Neprilysin":[96],"metabolizes":[98],"natriuretic":[99,109],"peptides.":[100],"despite":[102],"potential":[104],"therapeutic":[105],"benefit":[106],"peptide":[110],"therapy":[116,202,228,251,260],"only":[118],"modest":[119],"efficacy":[120],"essential":[122],"hypertension":[123,166,266],"heart":[125,184],"failure.":[126],"Initial":[127],"attempts":[128],"combine":[130],"inhibition":[132,134],"with":[133,165,170,183,186,192],"renin":[137],"system":[139],"led":[140],"development":[143],"omapatrilat,":[145],"drug":[147,208],"combines":[149,210],"ACE":[150,172],"inhibition.":[153],"omapatrilat":[155,193],"produced":[156],"an":[157,271],"unacceptably":[158],"high":[159],"incidence":[160,178,242,273],"patients":[164,182,248],"(2.17%)":[167],"comparison":[169],"enalapril":[174,201],"(0.68%),":[175],"although":[176],"was":[179,217,243],"less":[180],"failure":[185],"reduced":[187],"ejection":[188],"fraction":[189],"(HFrEF)":[190],"treated":[191],"(0.8%),":[194],"not":[196],"(0.5%).":[203],"More":[204],"recently,":[205],"LCZ696,":[206],"receptor":[212],"blockade":[213],"inhibition,":[216],"approved":[218],"treatment":[221],"HFrEF.":[223],"The":[224],"approval":[225,234],"LCZ696":[227,250,259],"HFrEF":[230,247],"represents":[231],"first":[233],"long-term":[236],"administration.":[239],"While":[240],"acceptably":[244],"low":[245],"receiving":[249],"(0.45%),":[252],"it":[253],"remains":[254],"be":[256],"seen":[257],"whether":[258],"other":[262],"conditions":[263],"accompanied":[269],"acceptable":[272],"angioedema.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-09-27T00:00:00"}
