{"id":"https://openalex.org/W2890617618","doi":"https://doi.org/10.1007/s00726-018-2651-2","title":"Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro","display_name":"Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro","publication_year":2018,"publication_date":"2018-09-17","ids":{"openalex":"https://openalex.org/W2890617618","doi":"https://doi.org/10.1007/s00726-018-2651-2","mag":"2890617618","pmid":"https://pubmed.ncbi.nlm.nih.gov/30225664"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-018-2651-2","doi":"https://doi.org/10.1007/s00726-018-2651-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-018-2651-2","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://mie-u.repo.nii.ac.jp/record/13963/files/2020DM0904.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Feng He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Feng He","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan","Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070158905","display_name":"Ning Ma","orcid":"https://orcid.org/0000-0001-7315-8835","observed_orcids":["https://orcid.org/0000-0001-7315-8835"]},"institutions":[{"id":"https://openalex.org/I171559596","display_name":"Suzuka University of Medical Science","ror":"https://ror.org/00tq7xg10","country_code":"JP","type":"education","lineage":["https://openalex.org/I171559596"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ning Ma","raw_affiliation_strings":["Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Japan","institution_ids":["https://openalex.org/I171559596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110782871","display_name":"Kaoru Midorikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Midorikawa","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062182998","display_name":"Yusuke Hiraku","orcid":"https://orcid.org/0000-0002-4351-1498","observed_orcids":["https://orcid.org/0000-0002-4351-1498"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Hiraku","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055562110","display_name":"Shinji Oikawa","orcid":"https://orcid.org/0000-0002-7488-0616","observed_orcids":["https://orcid.org/0000-0002-7488-0616"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Oikawa","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442952","display_name":"Zhe Zhang","orcid":"https://orcid.org/0000-0001-8816-3194","observed_orcids":["https://orcid.org/0000-0001-8816-3194"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Zhang","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003054860","display_name":"Guangwu Huang","orcid":"https://orcid.org/0000-0002-7376-5691","observed_orcids":["https://orcid.org/0000-0002-7376-5691"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangwu Huang","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047844727","display_name":"Kazuhiko Takeuchi","orcid":"https://orcid.org/0000-0001-6855-6425","observed_orcids":["https://orcid.org/0000-0001-6855-6425"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiko Takeuchi","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan. kazuhiko@clin.medic.mie-u.ac.jp","Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan. kazuhiko@clin.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036993838","display_name":"Mariko Murata","orcid":"https://orcid.org/0000-0003-3668-7214","observed_orcids":["https://orcid.org/0000-0003-3668-7214"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mariko Murata","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan. mmurata@doc.medic.mie-u.ac.jp","Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan. mmurata@doc.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036993838","https://openalex.org/A5047844727"],"corresponding_institution_ids":["https://openalex.org/I178574317"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.5215,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.80096495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"50","issue":"12","first_page":"1749","last_page":"1758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":1.0},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7680000066757202},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8209999799728394},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9980000257492065},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8137861490249634},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.673363447189331},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6525402665138245},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.5593847632408142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5429792404174805},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4952601492404938},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.48756855726242065},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4844953715801239},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4827655851840973},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.44358348846435547},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42434653639793396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3469344675540924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17498448491096497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15761691331863403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0954565703868866},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00726-018-2651-2","doi":"https://doi.org/10.1007/s00726-018-2651-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-018-2651-2","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},{"id":"pmid:30225664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30225664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino acids","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01189:0004737978","doi":null,"is_oa":true,"landing_page_url":"https://mie-u.repo.nii.ac.jp/records/13963","pdf_url":"https://mie-u.repo.nii.ac.jp/record/13963/files/2020DM0904.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"pmh:oai:irdb.nii.ac.jp:01189:0004737964","doi":null,"is_oa":true,"landing_page_url":"https://mie-u.repo.nii.ac.jp/records/13949","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01189:0004737978","doi":null,"is_oa":true,"landing_page_url":"https://mie-u.repo.nii.ac.jp/records/13963","pdf_url":"https://mie-u.repo.nii.ac.jp/record/13963/files/2020DM0904.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1506187880","display_name":"Exploration of microRNA to evaluate the risk of low birth weight associated with maternal smoking","funder_award_id":"17K19806","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2511947262","display_name":"Clarification of the role of DAMP in health effects caused by particulate matters and risk assessment","funder_award_id":"18H03038","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2583724098","display_name":"Cancer-prevention by aspirin and the mechanism, from the viewpoint of inflammation-related DNA damage and cancer stem cell","funder_award_id":"17K09168","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3988414705","display_name":"Development of a PET imaging agent and disease biomarker for Alzheimer's disease.","funder_award_id":"15K15237","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4427307880","display_name":"A possible mechanism of Alzheimer's disease caused by lipid peroxidation","funder_award_id":"18K19673","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6731794176","display_name":"Carcinogenic mechanisms of stem cells in inflammation-related cancer and its prevention","funder_award_id":"16H05255","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8167646706","display_name":"A comparative molecular epidemiology study of carcinogenicity on the liver flube infection in the Xijiang (China) and Mekong river (Thailand)","funder_award_id":"17H04654","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2890617618.pdf","grobid_xml":"https://content.openalex.org/works/W2890617618.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W301449119","https://openalex.org/W962931507","https://openalex.org/W1968690534","https://openalex.org/W1980137639","https://openalex.org/W1985882711","https://openalex.org/W1994072420","https://openalex.org/W1999341523","https://openalex.org/W2000084288","https://openalex.org/W2008704159","https://openalex.org/W2008719741","https://openalex.org/W2021592710","https://openalex.org/W2026875866","https://openalex.org/W2030073764","https://openalex.org/W2036871877","https://openalex.org/W2040450013","https://openalex.org/W2041675187","https://openalex.org/W2089923455","https://openalex.org/W2097786201","https://openalex.org/W2104930726","https://openalex.org/W2111163023","https://openalex.org/W2118100760","https://openalex.org/W2125042971","https://openalex.org/W2127238287","https://openalex.org/W2127836541","https://openalex.org/W2162493561","https://openalex.org/W2199573473","https://openalex.org/W2463033812","https://openalex.org/W2513323738","https://openalex.org/W2558812398","https://openalex.org/W2621411875","https://openalex.org/W2736707149","https://openalex.org/W2745541143","https://openalex.org/W2765155026","https://openalex.org/W2766356791","https://openalex.org/W2770638816","https://openalex.org/W2772545410","https://openalex.org/W2775870085","https://openalex.org/W2788679910","https://openalex.org/W2791560369","https://openalex.org/W2800654555","https://openalex.org/W2805023371","https://openalex.org/W2811512808"],"related_works":["https://openalex.org/W2352568601","https://openalex.org/W2374272643","https://openalex.org/W2186965932","https://openalex.org/W2046077454","https://openalex.org/W4390452441","https://openalex.org/W2357679775","https://openalex.org/W2056117715","https://openalex.org/W1964912188","https://openalex.org/W4298172496","https://openalex.org/W2407165303"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}