{"id":"https://openalex.org/W2890614809","doi":"https://doi.org/10.2174/2212796812666180907153901","title":"Antimicrobial Activity of Highly Fluorinated Thiocarbamates and Dithiocarbamates","display_name":"Antimicrobial Activity of Highly Fluorinated Thiocarbamates and Dithiocarbamates","publication_year":2018,"publication_date":"2018-09-07","ids":{"openalex":"https://openalex.org/W2890614809","doi":"https://doi.org/10.2174/2212796812666180907153901","mag":"2890614809"},"language":"en","primary_location":{"id":"doi:10.2174/2212796812666180907153901","doi":"https://doi.org/10.2174/2212796812666180907153901","is_oa":false,"landing_page_url":"https://doi.org/10.2174/2212796812666180907153901","pdf_url":null,"source":{"id":"https://openalex.org/S178760346","display_name":"Current Chemical Biology","issn_l":"1872-3136","issn":["1872-3136","2212-7968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018856015","display_name":"Amal Thebti","orcid":"https://orcid.org/0000-0002-5544-8086","observed_orcids":["https://orcid.org/0000-0002-5544-8086"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Amal Thebti","raw_affiliation_strings":["Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035845685","display_name":"Ines Chniti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ines Chniti","raw_affiliation_strings":["Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024950518","display_name":"M.A.K. Sanhoury","orcid":"https://orcid.org/0000-0003-2599-4999","observed_orcids":["https://orcid.org/0000-0003-2599-4999"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Med Abderrahmane Sanhoury","raw_affiliation_strings":["Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071632104","display_name":"Ikram Chehidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ikram Chehidi","raw_affiliation_strings":["Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Organic Chemistry: Synthesis and Physico-chemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El-Manar 2092, El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059334834","display_name":"Hadda\u2010Imene Ouzari","orcid":"https://orcid.org/0000-0002-3237-554X","observed_orcids":["https://orcid.org/0000-0002-3237-554X"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hadda Imene Ouzari","raw_affiliation_strings":["Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018698789","display_name":"Abdellatif Boudabous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Abdellatif Boudabous","raw_affiliation_strings":["Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microorganisms and Active Biomolecules \u00c3\ufffd\u00c2\u00abLMBA\u00c3\ufffd\u00c2\u00bb, Department of Biology, Faculty of Sciences of Tunis, University of Tunis-El Manar, 2092 El Manar I Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024950518"],"corresponding_institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"],"apc_list":null,"apc_paid":null,"fwci":0.4896,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.47873403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"13","issue":"2","first_page":"120","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.2190999984741211,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8769999742507935},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.8579999804496765},{"id":"https://openalex.org/keywords/aspergillus-niger","display_name":"Aspergillus niger","score":0.9200000166893005},{"id":"https://openalex.org/keywords/aspergillus-flavus","display_name":"Aspergillus flavus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/penicillium-expansum","display_name":"Penicillium expansum","score":1.0},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8670717477798462},{"id":"https://openalex.org/C2911014270","wikidata":"https://www.wikidata.org/wiki/Q413606","display_name":"Thiocarbamates","level":2,"score":0.7107820510864258},{"id":"https://openalex.org/C2775960407","wikidata":"https://www.wikidata.org/wiki/Q132014","display_name":"Aspergillus niger","level":2,"score":0.6915311217308044},{"id":"https://openalex.org/C2777292910","wikidata":"https://www.wikidata.org/wiki/Q137096","display_name":"Aspergillus flavus","level":2,"score":0.6910312175750732},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.6393948793411255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5961946249008179},{"id":"https://openalex.org/C2780630512","wikidata":"https://www.wikidata.org/wiki/Q147358","display_name":"Penicillium expansum","level":3,"score":0.5948914289474487},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5878952741622925},{"id":"https://openalex.org/C2777545050","wikidata":"https://www.wikidata.org/wiki/Q5217682","display_name":"Dithiocarbamate","level":2,"score":0.5584942102432251},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5240443348884583},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.505486011505127},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47486209869384766},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3962233066558838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2663211226463318},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.23407495021820068},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.20285186171531677},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17684438824653625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16500544548034668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C157670687","wikidata":"https://www.wikidata.org/wiki/Q426933","display_name":"Postharvest","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/2212796812666180907153901","doi":"https://doi.org/10.2174/2212796812666180907153901","is_oa":false,"landing_page_url":"https://doi.org/10.2174/2212796812666180907153901","pdf_url":null,"source":{"id":"https://openalex.org/S178760346","display_name":"Current Chemical Biology","issn_l":"1872-3136","issn":["1872-3136","2212-7968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Chemical Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4847856827","display_name":null,"funder_award_id":"LR99ES14","funder_id":"https://openalex.org/F4320322625","funder_display_name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur, de la Recherche Scientifique et des Technologies de l'Information et de la Communication"}],"funders":[{"id":"https://openalex.org/F4320322625","display_name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur, de la Recherche Scientifique et des Technologies de l'Information et de la Communication","ror":"https://ror.org/05v1m8q81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W611976593","https://openalex.org/W1765690709","https://openalex.org/W1968120034","https://openalex.org/W1975947882","https://openalex.org/W1979767547","https://openalex.org/W1989022642","https://openalex.org/W1996648165","https://openalex.org/W2006838082","https://openalex.org/W2010345433","https://openalex.org/W2010901977","https://openalex.org/W2012982120","https://openalex.org/W2017152369","https://openalex.org/W2030830776","https://openalex.org/W2033043158","https://openalex.org/W2042556836","https://openalex.org/W2050513050","https://openalex.org/W2060828284","https://openalex.org/W2063598167","https://openalex.org/W2092196558","https://openalex.org/W2101529654","https://openalex.org/W2127593402","https://openalex.org/W2165713258","https://openalex.org/W2167008723","https://openalex.org/W2168635615","https://openalex.org/W2170993842","https://openalex.org/W2261075101","https://openalex.org/W2302063545","https://openalex.org/W2321559323","https://openalex.org/W2779266340","https://openalex.org/W2949072068","https://openalex.org/W2952866810","https://openalex.org/W6677498224","https://openalex.org/W6725237427"],"related_works":["https://openalex.org/W2318637364","https://openalex.org/W4254028379","https://openalex.org/W2762275065","https://openalex.org/W628093236","https://openalex.org/W3095676061","https://openalex.org/W2970162292","https://openalex.org/W3214457178","https://openalex.org/W2040642899","https://openalex.org/W2166923119","https://openalex.org/W2150050937"],"abstract_inverted_index":{"Background:":[0],"The":[1,30,61,153,168],"widespread":[2],"occurrence":[3],"of":[4,32,40,103,135,147],"resistance":[5],"to":[6,14],"current":[7],"antibiotics":[8],"has":[9],"triggered":[10],"increasing":[11],"research":[12],"efforts":[13],"design":[15],"and":[16,20,46,48,56,87,96,110,120,131,174],"develop":[17],"innovative":[18],"antibacterial":[19,136,163],"antifungal":[21],"agents":[22],"that":[23,171],"could":[24,176],"overcome":[25],"such":[26],"antimicrobial":[27,64,182],"resistance.":[28],"Objective:":[29],"aim":[31],"this":[33],"work":[34],"was":[35,70],"the":[36,67,73,89,100,125,132,139,145],"in":[37,62,157],"vitro":[38,63],"evaluation":[39],"twelve":[41],"highly":[42],"fluorinated":[43,154],"Nmonosubstituted":[44],"thiocarbamates":[45,173],"dithiocarbamates":[47,175],"six":[49],"non-fluorinated":[50,166],"analogs":[51],"against":[52,66],"nine":[53],"bacterial":[54],"strains":[55],"three":[57,90],"fungal":[58],"species.":[59],"Methods:":[60],"activity":[65,164],"tested":[68],"microrganisms":[69],"evaluated":[71],"using":[72],"microdilution":[74],"broth":[75],"method.":[76],"Results:":[77],"Escherichia":[78,112],"coli":[79,113],"ATCC":[80,108],"8739,":[81],"Salmonella":[82],"sp.,":[83],"Staphylococcus":[84],"aureus":[85],"6539":[86],"all":[88],"fungi":[91],"(Aspergillus":[92],"niger,":[93],"Aspergillus":[94],"flavus":[95],"Penicillium":[97],"expansum)":[98],"exhibited":[99],"highest":[101],"rate":[102],"susceptibility,":[104],"whilst":[105],"Enterococcus":[106],"faecuim":[107],"19436":[109],"particularly":[111],"DH5\u03b1":[114],"were":[115],"less":[116],"susceptible.":[117],"Thiocarbamate":[118],"(1i)":[119],"dithiocarbamate":[121],"(2i)":[122],"showed":[123],"both":[124],"lowest":[126],"MIC":[127],"values":[128],"(3.9":[129],"\u00b5g/mL)":[130],"widest":[133],"spectrum":[134],"activity.":[137],"Furthermore,":[138],"N-ethyl":[140],"derivatives":[141],"inhibited":[142],"more":[143,161],"efficiently":[144],"growth":[146],"bacteria":[148],"than":[149,165],"N-aryl":[150],"analogs.":[151],"Conclusion:":[152],"compounds":[155],"showed,":[156],"general,":[158],"a":[159],"relatively":[160],"potent":[162],"counterparts.":[167],"results":[169],"indicate":[170],"these":[172],"be":[177],"promising":[178],"candidates":[179],"as":[180],"potential":[181],"agents.":[183]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-27T00:00:00"}