{"id":"https://openalex.org/W2890525937","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","title":"Combinatorial genomic and pathological indices for integrated stratification of unfavorable intermediate-risk prostate cancer.","display_name":"Combinatorial genomic and pathological indices for integrated stratification of unfavorable intermediate-risk prostate cancer.","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2890525937","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","mag":"2890525937"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.5051","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078925966","display_name":"Melvin L.K. Chua","orcid":"https://orcid.org/0000-0002-1648-1473","observed_orcids":["https://orcid.org/0000-0002-1648-1473","https://orcid.org/0000-0001-6021-368X"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Melvin Chua","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Hospital, Toronto, Canada, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Hospital, Toronto, Canada, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063690225","display_name":"Jure Murgi\u0107","orcid":"https://orcid.org/0000-0001-8152-0494","observed_orcids":["https://orcid.org/0000-0001-8152-0494"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Jure Murgic","raw_affiliation_strings":["Department of Oncology University Hospital Center Sisters of Mercy University of Zagreb Medical School, Zagreb, Croatia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology University Hospital Center Sisters of Mercy University of Zagreb Medical School, Zagreb, Croatia;","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031467567","display_name":"Melania Pintilie","orcid":"https://orcid.org/0000-0002-8238-8365","observed_orcids":["https://orcid.org/0000-0002-8238-8365"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Melania Pintilie","raw_affiliation_strings":["Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030883605","display_name":"Emilie Lalonde","orcid":"https://orcid.org/0000-0002-8573-1966","observed_orcids":["https://orcid.org/0000-0002-8573-1966"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emilie Lalonde","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087189944","display_name":"Alejandro Berl\u00edn","orcid":"https://orcid.org/0000-0002-1880-6905","observed_orcids":["https://orcid.org/0000-0002-1880-6905"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alejandro Berlin","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061507303","display_name":"Julie M. Livingstone","orcid":"https://orcid.org/0000-0002-8424-3768","observed_orcids":["https://orcid.org/0000-0002-8424-3768"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Livingstone","raw_affiliation_strings":["Informatics &amp; Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics &amp; Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089674017","display_name":"Alan Dal Pra","orcid":"https://orcid.org/0000-0002-1648-6557","observed_orcids":["https://orcid.org/0000-0002-1648-6557"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alan Dal Pra","raw_affiliation_strings":["Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland;","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102968956","display_name":"Alice X. Meng","orcid":"https://orcid.org/0000-0002-0693-8003","observed_orcids":["https://orcid.org/0000-0002-0693-8003"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alice Meng","raw_affiliation_strings":["STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606713","display_name":"Junyan Zhang","orcid":"https://orcid.org/0000-0002-7890-3707","observed_orcids":["https://orcid.org/0000-0002-7890-3707"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Junyan Zhang","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075327765","display_name":"Yves Fradet","orcid":"https://orcid.org/0000-0002-7581-2500","observed_orcids":["https://orcid.org/0000-0002-7581-2500"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yves Fradet","raw_affiliation_strings":["Department of Urology, Laval University, Quebec, QC, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Laval University, Quebec, QC, Canada;","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023267102","display_name":"Bernard T\u00eatu","orcid":"https://orcid.org/0000-0003-2771-2641","observed_orcids":["https://orcid.org/0000-0003-2771-2641"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bernard T\u00eatu","raw_affiliation_strings":["Department of Pathology and Research Center, CHUQ, L'H\u00f4tel-Dieu de Qu\u00e9bec, Quebec, QC, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Research Center, CHUQ, L'H\u00f4tel-Dieu de Qu\u00e9bec, Quebec, QC, Canada;","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I4210121051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007710281","display_name":"Neil Eric Fleshner","orcid":"https://orcid.org/0000-0001-7407-7463","observed_orcids":["https://orcid.org/0000-0001-7407-7463"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Neil Eric Fleshner","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082084084","display_name":"Michael E. Fraser","orcid":"https://orcid.org/0000-0002-9303-9363","observed_orcids":["https://orcid.org/0000-0002-9303-9363"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Fraser","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007657275","display_name":"Paul Christopher Boutros","orcid":"https://orcid.org/0000-0003-0553-7520","observed_orcids":["https://orcid.org/0000-0003-0553-7520"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul Boutros","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057500759","display_name":"Theodorus van der Kwast","orcid":"https://orcid.org/0000-0001-8640-5786","observed_orcids":["https://orcid.org/0000-0001-8640-5786"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Theodorus van der Kwast","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University Health Network, University of Toronto, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University Health Network, University of Toronto, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020744487","display_name":"Robert Glen Bristow","orcid":"https://orcid.org/0000-0002-8553-9544","observed_orcids":["https://orcid.org/0000-0002-8553-9544"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert G. Bristow","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, ON, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, ON, Canada;","institution_ids":["https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"5051","last_page":"5051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermediate-risk-prostate-cancer","display_name":"intermediate-risk prostate cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.6800000071525574},{"id":"https://openalex.org/keywords/intraductal-carcinoma","display_name":"intraductal carcinoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cribriform-architecture","display_name":"cribriform architecture","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.6399999856948853},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.7620000243186951},{"id":"https://openalex.org/keywords/psa","display_name":"PSA","score":0.5059999823570251},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nccn-risk-stratification","display_name":"NCCN risk stratification","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7903084754943848},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7778943777084351},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7125924825668335},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.6474713087081909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5502396821975708},{"id":"https://openalex.org/C2992528526","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Pathological staging","level":3,"score":0.5198807716369629},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5038215517997742},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5019917488098145},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.49746134877204895},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4815578758716583},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44864848256111145},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4338151514530182},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36031845211982727},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33076542615890503},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.15694254636764526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.5051","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.5051","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2490975642","https://openalex.org/W2560729232","https://openalex.org/W3200324071","https://openalex.org/W2158872144","https://openalex.org/W2496102636","https://openalex.org/W2012420343","https://openalex.org/W7214401886","https://openalex.org/W2889201576","https://openalex.org/W6902763517","https://openalex.org/W2061280839"],"abstract_inverted_index":{"5051":[0],"Background:":[1],"Men":[2],"with":[3,12,43,67,91,99,149,238,273,296],"intermediate-risk":[4,68,93,298],"prostate":[5,45,94,299],"cancer":[6,300],"represent":[7],"a":[8,53,86,236,283],"clinically":[9],"heterogeneous":[10],"group":[11],"varying":[13],"prognoses.":[14],"High":[15],"tumor":[16,57],"copy":[17],"number":[18],"alteration":[19],"as":[20],"measured":[21],"by":[22,115,167],"percent":[23],"genome":[24],"aberration":[25],"(PGA),":[26],"intraductal":[27],"carcinoma":[28],"(IDC),":[29],"and":[30,37,59,73,79,139,152,158,193,206,214,246,290],"cribriform":[31],"architecture":[32],"(CA)":[33],"are":[34,41,302],"novel":[35,288],"genomic":[36,291],"pathological":[38,289],"indices":[39,75,241,292],"that":[40],"associated":[42,148],"aggressive":[44],"cancer.":[46],"Our":[47],"primary":[48],"endpoint":[49],"was":[50,112,120,146],"to":[51,254,293,315],"test":[52],"combinatorial":[54],"model":[55,259,286],"integrating":[56,287],"genomics":[58],"pathology":[60],"in":[61,65,85,199,210],"predicting":[62,261],"biochemical":[63,133,191,263],"relapse":[64,145,192,264],"patients":[66,295,308],"disease.":[69],"Methods:":[70],"IDC/CA,":[71,272],"PGA,":[72],"clinical":[74,240],"of":[76,88,154,203,252,305],"T-category,":[77,270],"PSA,":[78,271],"Gleason":[80],"score":[81],"(GS)":[82],"were":[83,97,197],"tested":[84],"cohort":[87],"531":[89],"men":[90],"NCCN-defined":[92],"cancer,":[95],"who":[96,301],"treated":[98],"radical":[100],"prostatectomy":[101],"(N":[102,107],"=":[103,108,169,173,177,184,188,221,228,232,266],"173)":[104],"or":[105,248],"radiotherapy":[106],"358).":[109],"Pathological":[110],"review":[111],"centrally":[113],"performed":[114],"two":[116],"expert":[117],"pathologists.":[118],"PGA":[119,151,165,205,213,253,274],"calculated":[121],"using":[122],"data":[123],"from":[124,311],"SNP":[125],"array":[126],"profiling":[127],"(Affymetrix":[128],"Oncoscan).":[129],"Clinical":[130],"end-points":[131],"included":[132],"relapse-free":[134],"rate":[135,141],"(bRFR),":[136],"18-month":[137,219],"bRFR,":[138],"metastasis-free":[140],"(mFR).":[142],"Results:":[143],"Biochemical":[144],"independently":[147],"high":[150,162,204],"presence":[153],"IDC/CA":[155,180,207,215,255],"on":[156],"univariable":[157],"multivariable":[159],"analyses":[160],"(HR":[161,218],"vs":[163,182,275],"low":[164,212],"defined":[166],"median":[168],"1.61":[170],"[95%":[171],"CI":[172],"1.04-2.49],":[174],"Wald\u2019s":[175],"p":[176,187,224,231],"0.033;":[178],"HR":[179],"present":[181,208],"absent":[183,216],"1.63":[185],"[1.04-2.54],":[186],"0.033).":[189],"Early":[190],"distant":[194],"metastasis":[195],"rates":[196],"higher":[198],"the":[200,211,257],"patient":[201],"subgroup":[202,217],"than":[209],"bRFR":[220],"2.55":[222],"[1.49-4.39],":[223],"<":[225],"0.001;":[226],"mFR":[227],"2.96":[229],"[0.83-10.63],":[230],"0.096),":[233],"even":[234],"for":[235,260,269],"sub-cohort":[237],"unfavorable":[239,297],"(PSA":[242],">":[243],"10":[244],"ng/ml,":[245],"T2b/c":[247],"GS":[249],"4+3).":[250],"Inclusion":[251],"yielded":[256],"strongest":[258],"early":[262],"(AUC":[265],"0.649":[267],"[0.476-0.776]":[268],"0.580":[276],"[0.456-0.675]":[277],"without":[278],"PGA).":[279],"Conclusions:":[280],"We":[281],"developed":[282],"risk":[284,304],"stratification":[285],"identify":[294],"at":[303],"relapse.":[306],"These":[307],"may":[309],"benefit":[310],"systemic":[312],"intensification":[313],"added":[314],"definitive":[316],"local":[317],"treatment.":[318]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2018-09-27T00:00:00"}