{"id":"https://openalex.org/W2890519443","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","title":"Prognostic differences between male and female patients in virus-negative Merkel cell carcinoma.","display_name":"Prognostic differences between male and female patients in virus-negative Merkel cell carcinoma.","publication_year":2018,"publication_date":"2018-05-20","ids":{"openalex":"https://openalex.org/W2890519443","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","mag":"2890519443"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.15_suppl.e21601","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071060959","display_name":"Lisa Elena Esther Villabona","orcid":"https://orcid.org/0000-0001-7702-4754","observed_orcids":["https://orcid.org/0000-0001-7702-4754"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lisa Villabona","raw_affiliation_strings":["Karolinska Institutet, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091830834","display_name":"Hannah Bjorn-Andtback","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hannah Bjorn-Andtback","raw_affiliation_strings":["Karolinska Institutet, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067145757","display_name":"Viveca Bj\u00f6rnhagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Viveca Bj\u00f6rnhagen-S\u00e4fwenberg","raw_affiliation_strings":["Karolinska Institutet, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073258283","display_name":"Weng\u2010Onn Lui","orcid":"https://orcid.org/0000-0003-4717-4473","observed_orcids":["https://orcid.org/0000-0003-4717-4473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weng-onn Lui","raw_affiliation_strings":["Department of oncology/pathology, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of oncology/pathology, Stockholm, Sweden;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058125456","display_name":"Giuseppe Valentino Masucci","orcid":"https://orcid.org/0000-0002-9583-2306","observed_orcids":["https://orcid.org/0000-0002-9583-2306"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Giuseppe V. Masucci","raw_affiliation_strings":["Karolinska Inst, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Inst, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"15_suppl","first_page":"e21601","last_page":"e21601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merkel-cell-carcinoma","display_name":"Merkel cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/merkel-cell-polyomavirus","display_name":"Merkel cell polyomavirus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7940000295639038},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuroendocrine-skin-cancer","display_name":"neuroendocrine skin cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.671999990940094},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2778342957","wikidata":"https://www.wikidata.org/wiki/Q1711744","display_name":"Merkel cell carcinoma","level":3,"score":0.9629325866699219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7525355815887451},{"id":"https://openalex.org/C2776187983","wikidata":"https://www.wikidata.org/wiki/Q1921796","display_name":"Merkel cell polyomavirus","level":4,"score":0.6313639283180237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5613042712211609},{"id":"https://openalex.org/C2780291066","wikidata":"https://www.wikidata.org/wiki/Q1570264","display_name":"Merkel cell","level":4,"score":0.5429136753082275},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5167214274406433},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5138797760009766},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5099660158157349},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4485973119735718},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4223913252353668},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3593898415565491},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3129434585571289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.15_suppl.e21601","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e21601","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947505455","https://openalex.org/W3121844790","https://openalex.org/W3127067283","https://openalex.org/W7167458138","https://openalex.org/W2005426118","https://openalex.org/W4298140669","https://openalex.org/W4225147760","https://openalex.org/W4406780139","https://openalex.org/W2547701444","https://openalex.org/W4390580793"],"abstract_inverted_index":{"e21601":[0],"Background:":[1],"Merkel":[2,36],"cell":[3,37],"carcinoma":[4],"(MCC)":[5],"is":[6,16,42,85,288],"a":[7,56,76,80,95,224,261,289],"rare":[8],"and":[9,22,90,130,204,250,274,299],"aggressive":[10],"neuroendocrine":[11],"skin":[12],"cancer.":[13],"The":[14],"pathogenesis":[15],"linked":[17],"to":[18,86,102,106,117,172],"the":[19,33,53,59,110,118,178,265,292],"immune":[20,60,295],"system":[21,61],"immunocompromised":[23],"patients":[24,74,115,183,218,232,255],"have":[25,79],"an":[26],"increased":[27],"risk":[28],"of":[29,35,47,55,98,167,177],"developing":[30],"MCC.":[31],"With":[32],"discovery":[34],"polyoma":[38],"virus":[39,220,229,237],"(MCPyV),":[40],"which":[41],"present":[43],"in":[44,94,100,109,163,246,291],"about":[45],"80%":[46],"MCC":[48,114,239,259,276],"(Feng":[49],"et":[50,68],"al":[51,69],"2008)":[52],"suggestion":[54],"connection":[57],"with":[58,75,219,256],"has":[62,71],"been":[63],"strengthened.":[64],"Previous":[65],"reports":[66],"(Moshiri":[67],"2016)":[70],"shown":[72],"that":[73,216,271],"virus-negative":[77],"disease":[78,222,293],"worse":[81],"prognosis.":[82],"Our":[83],"aim":[84],"analyze":[87],"clinical":[88],"variables":[89],"their":[91],"prognostic":[92],"impact":[93],"Swedish":[96],"cohort":[97],"MCC-patients,":[99],"order":[101],"better":[103,226,262],"understand":[104],"possibilities":[105],"personalize":[107],"treatment":[108],"future.":[111],"Methods:":[112],"106":[113],"referred":[116],"plastic":[119],"surgery":[120],"unit":[121],"at":[122,147],"Karolinska":[123],"University":[124],"Hospital":[125],"from":[126],"1989-2017":[127],"were":[128,169,184],"included":[129],"retrospective":[131,174],"data":[132],"was":[133,137,149,156,161,209],"collected.":[134],"65":[135],"(61%)":[136],"identified":[138],"as":[139,143,278],"female,":[140],"41":[141],"(39%)":[142],"male.":[144],"Mean":[145],"age":[146],"operation":[148],"75,5":[150],"years,":[151],"mean":[152],"overall":[153],"survival":[154],"(OS)":[155],"4.2\u00b10.5":[157],"years.":[158],"MCPyV":[159,185,190,202,258,272],"status":[160],"available":[162],"42":[164],"patients,":[165,180],"5":[166],"these":[168],"excluded":[170],"due":[171],"lacking":[173],"data.":[175],"Out":[176],"37":[179],"24":[181],"(65%)":[182],"positive,":[186],"13":[187],"(35":[188],"%)":[189],"negative.":[191],"Results:":[192],"Survival":[193],"analysis":[194,213],"did":[195,240],"not":[196,241],"show":[197,242],"any":[198,243],"significant":[199,225,244],"difference":[200,245,290],"between":[201,248,297],"positive":[203,238,273],"negative":[205,221,230,257,275],"patients.":[206,252,267,301],"When":[207],"gender":[208],"added":[210],"into":[211],"multivariate":[212],"we":[214],"found":[215],"female":[217,249,300],"had":[223,260],"outcome":[227,263],"than":[228,264],"male":[231,251,266,298],"(p":[233],"=":[234],"0.02)":[235],"whereas":[236],"OS":[247],"Conclusions:":[253],"Female":[254],"This":[268],"finding":[269],"indicates":[270],"act":[277],"two":[279],"different":[280],"diseases.":[281],"It":[282],"also":[283],"raises":[284],"questions":[285],"if":[286],"there":[287],"or":[294],"response":[296]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2018-09-27T00:00:00"}