{"id":"https://openalex.org/W2890357609","doi":"https://doi.org/10.1080/19490976.2018.1511665","title":"Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy","display_name":"Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy","publication_year":2018,"publication_date":"2018-09-05","ids":{"openalex":"https://openalex.org/W2890357609","doi":"https://doi.org/10.1080/19490976.2018.1511665","mag":"2890357609","pmid":"https://pubmed.ncbi.nlm.nih.gov/30183502","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6546317"},"language":"en","primary_location":{"id":"doi:10.1080/19490976.2018.1511665","doi":"https://doi.org/10.1080/19490976.2018.1511665","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2018.1511665","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2018.1511665?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2018.1511665?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001668616","display_name":"Christopher Sun Strouse","orcid":"https://orcid.org/0000-0003-4964-167X","observed_orcids":["https://orcid.org/0000-0003-4964-167X"]},"institutions":[{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Strouse","raw_affiliation_strings":["Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, Iowa City, IA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4964-167X","affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, Iowa City, IA, USA","institution_ids":["https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005548506","display_name":"Ashutosh Kumar Mangalam","orcid":"https://orcid.org/0000-0002-9926-2531","observed_orcids":["https://orcid.org/0000-0002-9926-2531"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashutosh Mangalam","raw_affiliation_strings":["Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100433067","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0001-7886-6187","observed_orcids":["https://orcid.org/0000-0001-7886-6187"]},"institutions":[{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, Iowa City, IA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7886-6187","affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, Iowa City, IA, USA","institution_ids":["https://openalex.org/I4390039339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100433067"],"corresponding_institution_ids":["https://openalex.org/I4390039339"],"apc_list":{"value":2495,"currency":"GBP","value_usd":3060},"apc_paid":{"value":2495,"currency":"GBP","value_usd":3060},"fwci":null,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"2","first_page":"109","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-microbiome","display_name":"human microbiome","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.800000011920929},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/microbiota-modulation","display_name":"microbiota modulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.8156934380531311},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7643672227859497},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7581713795661926},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6859011650085449},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6710797548294067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6621569395065308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6600587368011475},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.6149991154670715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5348830223083496},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.49336567521095276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.380252480506897},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30006614327430725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11404019594192505}],"mesh":[{"descriptor_ui":"D000069467","descriptor_name":"Fecal Microbiota Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/19490976.2018.1511665","doi":"https://doi.org/10.1080/19490976.2018.1511665","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2018.1511665","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2018.1511665?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5681104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6546317","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6546317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6546317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"Text"},{"id":"pmid:30183502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30183502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut microbes","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/19490976.2018.1511665","doi":"https://doi.org/10.1080/19490976.2018.1511665","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2018.1511665","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2018.1511665?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000339672","display_name":"Environmental Health Sciences Research Center","funder_award_id":"P30ES005605","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320310841","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94"},{"id":"https://openalex.org/F4320333120","display_name":"Holden Comprehensive Cancer Center, University of Iowa","ror":"https://ror.org/01jhe7086"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2890357609.pdf","grobid_xml":"https://content.openalex.org/works/W2890357609.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W837445035","https://openalex.org/W2048469790","https://openalex.org/W2060185417","https://openalex.org/W2078365477","https://openalex.org/W2096322385","https://openalex.org/W2128474861","https://openalex.org/W2128769815","https://openalex.org/W2470063865","https://openalex.org/W2560367415","https://openalex.org/W2587154501","https://openalex.org/W2765190797","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2767791257","https://openalex.org/W2781836545","https://openalex.org/W2783101416","https://openalex.org/W2919663648","https://openalex.org/W2952564192"],"related_works":["https://openalex.org/W2912325577","https://openalex.org/W7126174337","https://openalex.org/W4409910791","https://openalex.org/W2791926234","https://openalex.org/W3110077847","https://openalex.org/W7130961547","https://openalex.org/W4385242217","https://openalex.org/W4417065815","https://openalex.org/W3193692701","https://openalex.org/W3042913477"],"abstract_inverted_index":{"The":[0],"influence":[1,120],"of":[2,5,12,39,44,60,66,76,100,118,121,142,151],"the":[3,6,10,21,37,42,58,70,74,80,92,101,106,109,115,119,131,134,137,144,149],"composition":[4],"human":[7],"microbiome":[8,93,107,135],"on":[9,123],"efficacy":[11,59,75,150],"cancer":[13,45,61,124,152],"directed":[14,19,62],"immunotherapies,":[15,63],"such":[16],"as":[17,36],"antibodies":[18],"against":[20],"programmed":[22],"cell":[23],"death":[24],"1":[25],"protein":[26],"(PD-1)":[27],"or":[28],"its":[29],"ligand":[30],"(PD-L1),":[31],"has":[32,46,51,69],"garnered":[33],"increasing":[34],"attention":[35],"role":[38],"immunotherapies":[40],"in":[41],"care":[43],"grown.":[47],"Dysbiosis":[48],"(altered":[49],"microbiota)":[50],"recently":[52],"been":[53],"reported":[54],"to":[55,72,127,147],"adversely":[56],"affect":[57],"and":[64,108,136,140],"correction":[65],"this":[67,84],"dysbiosis":[68,122],"potential":[71],"improve":[73,148],"these":[77],"treatments.":[78],"However,":[79],"exact":[81],"mechanisms":[82],"underlying":[83],"relationship":[85],"remains":[86],"unknown.":[87],"Current":[88],"methods":[89,126,141],"for":[90],"characterizing":[91],"likely":[94],"capture":[95],"only":[96],"a":[97],"small":[98],"portion":[99],"highly":[102],"complex":[103],"interaction":[104,132],"between":[105,133],"immune":[110,138,145],"system.":[111],"Here":[112],"we":[113],"discuss":[114],"recent":[116],"reports":[117],"immunotherapy,":[125],"more":[128],"fully":[129],"characterize":[130],"system,":[139],"modulating":[143],"system":[146],"immunotherapy.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}
