{"id":"https://openalex.org/W2890172293","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","title":"An examination of the use of CD19 CAR NK-92 cells to induce complete remission and vaccine effect against rechallenge in a highly aggressive murine leukemia.","display_name":"An examination of the use of CD19 CAR NK-92 cells to induce complete remission and vaccine effect against rechallenge in a highly aggressive murine leukemia.","publication_year":2018,"publication_date":"2018-05-20","ids":{"openalex":"https://openalex.org/W2890172293","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","mag":"2890172293"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.15_suppl.e15034","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086286309","display_name":"Nathan Thomas Schomer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Thomas Schomer","raw_affiliation_strings":["NantKwest, Medfield, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NantKwest, Medfield, MA;","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005060235","display_name":"Laurent Boissel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurent Boissel","raw_affiliation_strings":["NantKwest, Woburn, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NantKwest, Woburn, MA;","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001820251","display_name":"John H. Lee","orcid":"https://orcid.org/0000-0003-3699-5161","observed_orcids":["https://orcid.org/0000-0003-3699-5161"]},"institutions":[{"id":"https://openalex.org/I1305840828","display_name":"Sanford Health","ror":"https://ror.org/003smky23","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305840828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Lee","raw_affiliation_strings":["Sanford Health, Sioux Falls, SD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Health, Sioux Falls, SD;","institution_ids":["https://openalex.org/I1305840828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111951054","display_name":"Hans Klingemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Klingemann","raw_affiliation_strings":["Tufts Medcl Ctr, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medcl Ctr, Boston, MA;","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087962211","display_name":"Patrick Soon\u2010Shiong","orcid":"https://orcid.org/0000-0002-4682-8298","observed_orcids":["https://orcid.org/0000-0002-4682-8298"]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Soon-Shiong","raw_affiliation_strings":["Nantkwest, Culver City, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantkwest, Culver City, CA;","institution_ids":["https://openalex.org/I4210144466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"15_suppl","first_page":"e15034","last_page":"e15034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd19-car","display_name":"CD19 CAR","score":0.8240000009536743},{"id":"https://openalex.org/keywords/nk-92-cells","display_name":"NK-92 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/l1210-lymphoma","display_name":"L1210 lymphoma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/murine-leukemia","display_name":"murine leukemia","score":0.6480000019073486},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6940000057220459},{"id":"https://openalex.org/keywords/vaccine-effects","display_name":"vaccine effects","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-rechallenge","display_name":"tumor rechallenge","score":0.8410000205039978},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.5839999914169312},{"id":"https://openalex.org/keywords/durable-response","display_name":"durable response","score":0.3610000014305115},{"id":"https://openalex.org/keywords/dba-2-mice","display_name":"DBA/2 mice","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8535885214805603},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5749108791351318},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.4319227635860443},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36846673488616943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3473980724811554},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.32977861166000366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32733434438705444},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3237495720386505}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.15_suppl.e15034","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e15034","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2750705900","https://openalex.org/W1967455230","https://openalex.org/W4368405286","https://openalex.org/W2311158642","https://openalex.org/W3038886185","https://openalex.org/W3100226781","https://openalex.org/W3217645947","https://openalex.org/W1984919090","https://openalex.org/W2991291630","https://openalex.org/W2952367277"],"abstract_inverted_index":{"e15034":[0],"Background:":[1],"The":[2],"L1210":[3,182,284],"malignant":[4],"lymphoma":[5,67,86],"cell":[6,68],"line,":[7],"derived":[8],"from":[9],"DBA/2":[10,97],"mice,":[11],"is":[12],"notable":[13],"both":[14,168,222],"for":[15,24,41,314],"its":[16,25],"short":[17],"doubling":[18],"time":[19],"of":[20,28,37,52,91,132,204,214,237,283],"8-10":[21],"hours":[22],"and":[23,87,115,142,160,172,176,216,228,250,301],"long":[26],"history":[27],"successful":[29],"use":[30],"by":[31,153,169,221],"the":[32,35,50,62,89,116,122,186,205,247,261,266,286],"NCI":[33],"in":[34,246,260,274],"identification":[36],"effective":[38],"clinical":[39,138],"treatments":[40],"hematological":[42],"malignancies.":[43],"In":[44],"previous":[45],"studies":[46],"we":[47,71],"have":[48],"demonstrated":[49],"effectiveness":[51],"intra-tumor":[53,154],"injection":[54,155],"using":[55],"NK-92":[56,140],"cells":[57],"expressing":[58],"a":[59,74,271,280],"CAR":[60,147],"against":[61,83],"murine":[63],"CD19":[64],"positive":[65],"A20":[66],"line.":[69],"Here":[70],"examine":[72],"if":[73],"durable":[75,252],"vaccine":[76,309],"like":[77],"effect":[78,273,310],"can":[79],"be":[80],"elicited":[81],"even":[82],"this":[84],"aggressive":[85],"without":[88],"aid":[90],"additional":[92],"checkpoint":[93],"inhibitors.":[94],"Methods:":[95],"60":[96],"mice":[98],"were":[99,113,126,179],"injected":[100,184],"sc.":[101],"(flank)":[102],"with":[103,145,181,194,234,256],"2x105":[104],"L1210-Luciferase":[105],"(L1210":[106],"Luc)":[107],"cells.":[108,208],"After":[109],"8":[110],"days,":[111],"tumors":[112],"measured":[114],"30":[117,189],"animals":[118,134],"clustering":[119],"closest":[120],"to":[121,277,291],"median":[123],"tumor":[124,207,238,299],"size(~90mm3)":[125],"randomized":[127],"into":[128,185,285],"three":[129,251,269],"treatment":[130,150,248],"cohorts":[131,218,249],"10":[133],"each:":[135],"vehicle,":[136],"unmodified":[137],"grade":[139],"(aNK)":[141],"aNK":[143,262],"modified":[144],"mCD19":[146],"(mCD19-taNK).":[148],"Each":[149],"was":[151,166],"administered":[152],"on":[156],"days":[157,190],"0,":[158],"2,":[159],"4":[161],"post":[162],"randomization.":[163],"Tumor":[164],"growth":[165,239],"traced":[167],"caliper":[170],"measurements":[171],"IVIS":[173],"imaging.":[174],"Complete":[175],"partial":[177,259],"responders":[178],"re-challenged":[180],"Luc":[183],"contralateral":[187,287],"flank":[188],"after":[191],"initial":[192],"treatment,":[193],"continued":[195],"observation":[196],"until":[197],"either":[198],"lethal":[199,302],"outgrowth":[200],"or":[201],"complete":[202,255],"clearance":[203],"re-challenge":[206,281],"Results:":[209],"A":[210],"Kaplan-Meier":[211],"survival":[212],"comparison":[213],"na\u00efve":[215,293],"treated":[217],"reached":[219],"significance":[220],"Mantel-Cox":[223],"test":[224,230],"(p":[225],"=":[226,232,244],".0081)":[227],"Gehan-Breslow-Wilcoxon":[229],"(P":[231,243],".0089),":[233],"significant":[235],"inhibition":[236],"at":[240],"day":[241],"6":[242],".018)":[245],"responses":[253],"(2":[254],"taNK,":[257],"1":[258],"cohort).":[263],"Conclusions:":[264],"Of":[265],"responders,":[267],"all":[268,296],"showed":[270],"vaccine-like":[272],"their":[275],"capacity":[276],"completely":[278],"clear":[279],"dosing":[282],"flank,":[288],"as":[289],"compared":[290],"5":[292],"controls":[294],"which":[295],"displayed":[297],"rapid":[298],"take":[300],"outgrowth.":[303],"To":[304],"our":[305],"knowledge,":[306],"no":[307],"similar":[308],"has":[311],"been":[312],"described":[313],"CAR-T":[315],"based":[316],"therapies.":[317]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2018-09-27T00:00:00"}
