{"id":"https://openalex.org/W2890077641","doi":"https://doi.org/10.1021/acsinfecdis.8b00174","title":"A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains","display_name":"A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains","publication_year":2018,"publication_date":"2018-09-20","ids":{"openalex":"https://openalex.org/W2890077641","doi":"https://doi.org/10.1021/acsinfecdis.8b00174","mag":"2890077641","pmid":"https://pubmed.ncbi.nlm.nih.gov/30232886"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.8b00174","doi":"https://doi.org/10.1021/acsinfecdis.8b00174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.8b00174","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074822354","display_name":"Raad Jasim","orcid":"https://orcid.org/0000-0001-9531-1802","observed_orcids":["https://orcid.org/0000-0001-9531-1802"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Raad Jasim","raw_affiliation_strings":["Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067380502","display_name":"Mark A. Baker","orcid":"https://orcid.org/0000-0003-3933-9784","observed_orcids":["https://orcid.org/0000-0003-3933-9784"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark A. Baker","raw_affiliation_strings":["Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041077139","display_name":"Yan Zhu","orcid":"https://orcid.org/0000-0001-7342-3782","observed_orcids":["https://orcid.org/0000-0001-7342-3782"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yan Zhu","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026535132","display_name":"Mei\u2010Ling Han","orcid":"https://orcid.org/0000-0002-0861-2437","observed_orcids":["https://orcid.org/0000-0002-0861-2437"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meiling Han","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0861-2437","affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028105305","display_name":"Elena K. Schneider\u2010Futschik","orcid":"https://orcid.org/0000-0001-6044-4824","observed_orcids":["https://orcid.org/0000-0001-6044-4824"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elena K. Schneider-Futschik","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6044-4824","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088232304","display_name":"Maytham H. Hussein","orcid":"https://orcid.org/0000-0001-5922-7312","observed_orcids":["https://orcid.org/0000-0001-5922-7312"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maytham Hussein","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089197450","display_name":"Dani\u00ebl Hoyer","orcid":"https://orcid.org/0000-0002-1405-7089","observed_orcids":["https://orcid.org/0000-0002-1405-7089"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Daniel Hoyer","raw_affiliation_strings":["Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1405-7089","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0017-7952","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020748618","https://openalex.org/A5100402427"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I56590836"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8491,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6588031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"4","issue":"12","first_page":"1692","last_page":"1704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9369999766349792},{"id":"https://openalex.org/keywords/colistin-resistance","display_name":"colistin resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/outer-membrane-proteome","display_name":"outer membrane proteome","score":0.9070000052452087},{"id":"https://openalex.org/keywords/phop-phoq-two-component-system","display_name":"PhoPQ two-component system","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ompk35","display_name":"OmpK35","score":0.6800000071525574},{"id":"https://openalex.org/keywords/ompk36","display_name":"OmpK36","score":0.9419999718666077},{"id":"https://openalex.org/keywords/bacterial-stress-response","display_name":"bacterial stress response","score":0.621999979019165},{"id":"https://openalex.org/keywords/polymyxin-resistance","display_name":"polymyxin resistance","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.8283780813217163},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.6994166374206543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6985936164855957},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.6283421516418457},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5469583868980408},{"id":"https://openalex.org/C2780183148","wikidata":"https://www.wikidata.org/wiki/Q21099571","display_name":"Lipid II","level":4,"score":0.4942188560962677},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.49020010232925415},{"id":"https://openalex.org/C2777317804","wikidata":"https://www.wikidata.org/wiki/Q67101192","display_name":"Porin","level":5,"score":0.4166063666343689},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.4161284565925598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3417738676071167},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.22078529000282288},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2113780379295349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1891985535621643},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1663823127746582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11533144116401672},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.8b00174","doi":"https://doi.org/10.1021/acsinfecdis.8b00174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.8b00174","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:30232886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30232886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Comparative Study"},{"id":"pmh:uon:42820","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1446284","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1965130722","display_name":"Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach","funder_award_id":"R01AI132681","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W607877398","https://openalex.org/W883872831","https://openalex.org/W1466079874","https://openalex.org/W1499726492","https://openalex.org/W1818889778","https://openalex.org/W1895017250","https://openalex.org/W1901594596","https://openalex.org/W1969152624","https://openalex.org/W1973143163","https://openalex.org/W1977185136","https://openalex.org/W1979973356","https://openalex.org/W1983003534","https://openalex.org/W1989978425","https://openalex.org/W1999248333","https://openalex.org/W2004918900","https://openalex.org/W2015432102","https://openalex.org/W2019240775","https://openalex.org/W2026485378","https://openalex.org/W2030963088","https://openalex.org/W2032355465","https://openalex.org/W2032930325","https://openalex.org/W2041039346","https://openalex.org/W2044746614","https://openalex.org/W2045110384","https://openalex.org/W2052899239","https://openalex.org/W2057399524","https://openalex.org/W2061729558","https://openalex.org/W2064779430","https://openalex.org/W2069449656","https://openalex.org/W2074068571","https://openalex.org/W2082423449","https://openalex.org/W2090664858","https://openalex.org/W2099289278","https://openalex.org/W2103171109","https://openalex.org/W2111842378","https://openalex.org/W2116140206","https://openalex.org/W2116245384","https://openalex.org/W2119288091","https://openalex.org/W2120061656","https://openalex.org/W2122097905","https://openalex.org/W2124245343","https://openalex.org/W2124381039","https://openalex.org/W2128601422","https://openalex.org/W2131170758","https://openalex.org/W2133268685","https://openalex.org/W2134519766","https://openalex.org/W2149623513","https://openalex.org/W2152311269","https://openalex.org/W2154556219","https://openalex.org/W2155097212","https://openalex.org/W2155122915","https://openalex.org/W2160969485","https://openalex.org/W2162244438","https://openalex.org/W2162322404","https://openalex.org/W2162792752","https://openalex.org/W2164085556","https://openalex.org/W2169155930","https://openalex.org/W2171780940","https://openalex.org/W2175556135","https://openalex.org/W2177029917","https://openalex.org/W2183446018","https://openalex.org/W2328209447","https://openalex.org/W2333245418","https://openalex.org/W2559133556","https://openalex.org/W2632213991","https://openalex.org/W2728170331","https://openalex.org/W2949638188","https://openalex.org/W4210702584","https://openalex.org/W4234317413","https://openalex.org/W4244732422"],"related_works":["https://openalex.org/W2632213991","https://openalex.org/W2746249114","https://openalex.org/W7141188154","https://openalex.org/W2039360787","https://openalex.org/W4297348306","https://openalex.org/W2549824619","https://openalex.org/W3013657292","https://openalex.org/W3096929092","https://openalex.org/W2064779430","https://openalex.org/W4200069050"],"abstract_inverted_index":{"In":[0,61,173],"the":[1,6,17,36,40,62,67,74,79,86,98,102,127,138,165,176,202,211,223,227,237,243],"present":[2],"report":[3],"we":[4],"characterized":[5],"outer":[7,37,139,147,179,207,238],"membrane":[8,38,140,148,180,208,239],"proteome,":[9],"genomic,":[10],"and":[11,49,55,132,158,190,204,213],"lipid":[12,52,63,76,89],"A":[13,33,53,64,77,90],"remodelling":[14,240],"changes":[15],"following":[16],"evolution":[18],"of":[19,39,66,85,101,137,142,245,249],"a":[20,56,108,114],"colistin-susceptible":[21,41],"K.":[22,168,253],"pneumoniae":[23,169,254],"ATCC":[24,170,228],"13883":[25,171,229],"strain":[26,42,104,144],"into":[27],"an":[28],"extremely":[29,68,166,246],"colistin-resistant":[30,69,103,167],"strain.":[31,172,230],"Lipid":[32],"profiling":[34,136],"revealed":[35,96,145],"is":[43,105,219],"decorated":[44],"primarily":[45],"by":[46,107],"hexa":[47,87],"-":[48],"hepta":[50],"-acylated":[51,59,88],"species":[54],"minor":[57],"tetra":[58],"species.":[60],"profile":[65],"strain,":[70,178],"in":[71,117,126,164,175,222,226,252],"addition":[72],"to":[73],"aforementioned":[75],"species,":[78],"obligatory":[80],"4-amino-4-deoxy-":[81],"l":[82],"-arabinose":[83],"modification":[84],"was":[91],"detected.":[92],"Comparative":[93,135],"genomic":[94],"analysis":[95],"that":[97,146],"mgrB":[99],"gene":[100],"inactivated":[106],"single":[109],"nucleotide":[110],"insertion":[111],"which":[112],"produces":[113],"frame-shift,":[115],"resulting":[116],"premature":[118],"termination.":[119],"We":[120],"also":[121],"detected":[122],"two":[123],"synonymous":[124],"mutations":[125],"two-component":[128],"system":[129],"genes":[130],"phoP":[131],"phoQ":[133],".":[134,255],"proteome":[141],"each":[143],"proteins":[149,181],"from":[150,182],"bacterial":[151],"stress":[152],"response,":[153],"glutamine":[154],"degradation,":[155],"pyruvate,":[156],"aspartate,":[157],"asparagine":[159],"metabolic":[160],"pathways":[161],"were":[162,193,197],"over-represented":[163],"comparison,":[174],"sensitive":[177],"carbohydrate":[183],"metabolism,":[184],"H":[185],"+":[186],"-ATPase,":[187],"cell":[188],"division,":[189],"peptidoglycan":[191],"biosynthesis":[192],"over-represented.":[194],"Notably,":[195],"there":[196],"no":[198],"discernible":[199],"differences":[200],"between":[201,210],"OmpK35":[203],"OmpK36":[205],"major":[206],"porins":[209],"polymyxin-susceptible":[212],"-resistant":[214],"strains":[215],"suggesting":[216],"porin":[217],"deficiency":[218],"not":[220],"involved":[221],"colistin":[224,250],"resistance":[225,251],"These":[231],"findings":[232],"shed":[233],"new":[234],"light":[235],"on":[236],"events":[241],"accompanying":[242],"development":[244],"high":[247],"levels":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}