{"id":"https://openalex.org/W2890036626","doi":"https://doi.org/10.21037/tgh.2018.09.05","title":"Hepatocellular carcinoma in children: hepatic resection and liver transplantation","display_name":"Hepatocellular carcinoma in children: hepatic resection and liver transplantation","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2890036626","doi":"https://doi.org/10.21037/tgh.2018.09.05","mag":"2890036626","pmid":"https://pubmed.ncbi.nlm.nih.gov/30363724","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6182038"},"language":"en","primary_location":{"id":"doi:10.21037/tgh.2018.09.05","doi":"https://doi.org/10.21037/tgh.2018.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tgh.2018.09.05","pdf_url":"https://tgh.amegroups.com/article/viewFile/4534/pdf","source":{"id":"https://openalex.org/S4210220967","display_name":"Translational Gastroenterology and Hepatology","issn_l":"2415-1289","issn":["2415-1289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://tgh.amegroups.com/article/viewFile/4534/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012591564","display_name":"Roberta Angelico","orcid":"https://orcid.org/0000-0002-3439-7750","observed_orcids":["https://orcid.org/0000-0002-3439-7750"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Angelico","raw_affiliation_strings":["Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079285966","display_name":"Chiara Grimaldi","orcid":"https://orcid.org/0000-0003-3551-9286","observed_orcids":["https://orcid.org/0000-0003-3551-9286"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Grimaldi","raw_affiliation_strings":["Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070952613","display_name":"Maria Cristina Saffioti","orcid":"https://orcid.org/0000-0002-8397-9335","observed_orcids":["https://orcid.org/0000-0002-8397-9335"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cristina Saffioti","raw_affiliation_strings":["Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009197038","display_name":"Aurora Castellano","orcid":"https://orcid.org/0000-0002-2316-4927","observed_orcids":["https://orcid.org/0000-0002-2316-4927"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aurora Castellano","raw_affiliation_strings":["Division of Oncohematology, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncohematology, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013323412","display_name":"Marco Spada","orcid":"https://orcid.org/0000-0003-0796-6847","observed_orcids":["https://orcid.org/0000-0003-0796-6847"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Spada","raw_affiliation_strings":["Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9 Children's Hospital IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013323412"],"corresponding_institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"],"apc_list":null,"apc_paid":null,"fwci":0.4963,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.50983146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":null,"first_page":"59","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-hepatocellular-carcinoma","display_name":"pediatric hepatocellular carcinoma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/unresectable-liver-tumors","display_name":"unresectable liver tumors","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6359999775886536},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.546999990940094},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9584007263183594},{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.8204680681228638},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7479785680770874},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.7169752717018127},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.530102014541626},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5079115033149719},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5059062838554382},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.4844096302986145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4338107109069824},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43377557396888733},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.42924734950065613},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.37588924169540405},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3702145218849182},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3681756258010864},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.29717525839805603}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.21037/tgh.2018.09.05","doi":"https://doi.org/10.21037/tgh.2018.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tgh.2018.09.05","pdf_url":"https://tgh.amegroups.com/article/viewFile/4534/pdf","source":{"id":"https://openalex.org/S4210220967","display_name":"Translational Gastroenterology and Hepatology","issn_l":"2415-1289","issn":["2415-1289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5144899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6182038","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30363724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30363724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6182038","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6182038/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Gastroenterol Hepatol","raw_type":"Text"},{"id":"pmh:oai:art.torvergata.it:2108/240813","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2108/240813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21037/tgh.2018.09.05","doi":"https://doi.org/10.21037/tgh.2018.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tgh.2018.09.05","pdf_url":"https://tgh.amegroups.com/article/viewFile/4534/pdf","source":{"id":"https://openalex.org/S4210220967","display_name":"Translational Gastroenterology and Hepatology","issn_l":"2415-1289","issn":["2415-1289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2890036626.pdf","grobid_xml":"https://content.openalex.org/works/W2890036626.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1525838477","https://openalex.org/W1529273541","https://openalex.org/W1682129169","https://openalex.org/W1898182015","https://openalex.org/W1969557766","https://openalex.org/W1971837077","https://openalex.org/W1976106807","https://openalex.org/W1979595515","https://openalex.org/W1986218807","https://openalex.org/W1986512306","https://openalex.org/W1995090158","https://openalex.org/W2005069511","https://openalex.org/W2015107186","https://openalex.org/W2021299297","https://openalex.org/W2037824029","https://openalex.org/W2040188940","https://openalex.org/W2059515207","https://openalex.org/W2068842703","https://openalex.org/W2070396671","https://openalex.org/W2086536784","https://openalex.org/W2089416968","https://openalex.org/W2089873658","https://openalex.org/W2092145724","https://openalex.org/W2096460033","https://openalex.org/W2097229210","https://openalex.org/W2099757777","https://openalex.org/W2102880646","https://openalex.org/W2103310685","https://openalex.org/W2105282413","https://openalex.org/W2110457806","https://openalex.org/W2114048720","https://openalex.org/W2115641957","https://openalex.org/W2115991409","https://openalex.org/W2123951443","https://openalex.org/W2127422095","https://openalex.org/W2143551300","https://openalex.org/W2161689638","https://openalex.org/W2210407883","https://openalex.org/W2243927321","https://openalex.org/W2266111959","https://openalex.org/W2277004004","https://openalex.org/W2315027248","https://openalex.org/W2326502969","https://openalex.org/W2576641191","https://openalex.org/W2590158650","https://openalex.org/W2597872842","https://openalex.org/W2605922284","https://openalex.org/W2611563663","https://openalex.org/W2707060562","https://openalex.org/W2745464193","https://openalex.org/W2760824425","https://openalex.org/W2771979860","https://openalex.org/W2790342294","https://openalex.org/W2794001727","https://openalex.org/W2799517542","https://openalex.org/W3138028127","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W3174452346","https://openalex.org/W2029243704","https://openalex.org/W2707060562","https://openalex.org/W4417287684","https://openalex.org/W4402796724","https://openalex.org/W1991837857","https://openalex.org/W2576641191","https://openalex.org/W2086950056","https://openalex.org/W2811286472","https://openalex.org/W4399240326"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,109,143,214],"a":[4,36,72],"rare":[5],"malignancy":[6],"in":[7,68,96,105,123,130,229],"children":[8,97,106,131],"and":[9,26,41,54,65,80,85,93,166,198,226],"at":[10],"the":[11,43,59,69,101,114,138,144,156,163,217],"time":[12],"of":[13,18,31,38,45,62,77,137,211,219],"diagnosis":[14],"up":[15,120],"to":[16,24,121,178,205,215],"80%":[17],"pediatric":[19,32,66,139,230],"HCC":[20,33,64,108,140,181,231],"are":[21,169],"unresectable":[22,133,180],"due":[23],"large":[25,60],"multiple":[27],"lesions.":[28],"The":[29,135,209],"majority":[30],"occurs":[34],"on":[35,58,83],"background":[37],"normal":[39],"liver,":[40],"consequently":[42],"absence":[44],"concomitant":[46],"chronic":[47,236],"liver":[48,153,227,237],"disease":[49],"generally":[50],"allows":[51],"tolerating":[52],"pre-":[53],"post-operative":[55],"chemotherapy.":[56],"Based":[57],"experiences":[61],"adult":[63],"hepatoblastoma,":[67],"last":[70],"years":[71],"multidisciplinary":[73],"aggressive":[74],"treatment":[75,168,190],"composed":[76],"surgical":[78,158,189,221],"resection":[79,151,225],"chemotherapy":[81],"(based":[82],"cisplatin":[84],"doxorubicin)":[86],"has":[87],"been":[88,176],"proposed,":[89],"improving":[90],"patient":[91],"outcomes":[92],"recurrence":[94],"rate":[95,104,117],"with":[98,107,132,232],"HCC.":[99,134],"However,":[100],"overall":[102],"survival":[103,116],"not":[110],"satisfactory":[111],"yet;":[112],"while":[113],"5-year":[115],"may":[118],"achieve":[119],"70-80%":[122],"non-metastatic":[124],"resectable":[125,183],"HCC,":[126],"it":[127],"remains":[128],"<20%":[129],"mainstay":[136],"therapeutic":[141],"strategy":[142],"radical":[145],"tumor":[146],"resection,":[147],"weather":[148],"by":[149,185],"hepatic":[150,224],"or":[152,233],"transplantation,":[154,228],"nevertheless":[155],"best":[157],"approaches":[159],"as":[160,162,196],"well":[161],"optimal":[164],"neoadjuvant":[165],"adjuvant":[167],"still":[170],"under":[171],"debate.":[172],"Different":[173],"strategies":[174],"have":[175],"explored":[177],"convert":[179],"into":[182],"tumors":[184],"extending":[186],"criteria":[187],"for":[188],"and/or":[191],"associating":[192],"multi-modal":[193],"treatments,":[194],"such":[195],"systemic":[197],"local-regional":[199],"therapy,":[200],"but":[201],"universal":[202],"recommendation":[203],"needs":[204],"be":[206],"defined":[207],"yet.":[208],"purpose":[210],"this":[212],"review":[213],"outline":[216],"role":[218],"different":[220],"approaches,":[222],"including":[223],"without":[234],"underlying":[235],"disease.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-09-27T00:00:00"}