{"id":"https://openalex.org/W2889986213","doi":"https://doi.org/10.1161/circresaha.118.311403","title":"G-Protein\u2013Coupled Receptors in Heart Disease","display_name":"G-Protein\u2013Coupled Receptors in Heart Disease","publication_year":2018,"publication_date":"2018-08-31","ids":{"openalex":"https://openalex.org/W2889986213","doi":"https://doi.org/10.1161/circresaha.118.311403","mag":"2889986213","pmid":"https://pubmed.ncbi.nlm.nih.gov/30355236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6205195"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.118.311403","doi":"https://doi.org/10.1161/circresaha.118.311403","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.118.311403","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.118.311403","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.118.311403","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108282084","display_name":"Jialu Wang","orcid":"https://orcid.org/0009-0001-0316-1083","observed_orcids":["https://orcid.org/0009-0001-0316-1083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jialu Wang","raw_affiliation_strings":["From the Department of Medicine (J.W., C.G., H.A.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine (J.W., C.G., H.A.R.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035074026","display_name":"Clarice Gareri","orcid":"https://orcid.org/0000-0002-4859-8780","observed_orcids":["https://orcid.org/0000-0002-4859-8780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarice Gareri","raw_affiliation_strings":["From the Department of Medicine (J.W., C.G., H.A.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine (J.W., C.G., H.A.R.)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070568570","display_name":"Howard A. Rockman","orcid":"https://orcid.org/0000-0003-2921-1584","observed_orcids":["https://orcid.org/0000-0003-2921-1584"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard A. Rockman","raw_affiliation_strings":["Department of Cell Biology (H.A.R.)","Department of Molecular Genetics and Microbiology (H.A.R.), Duke University Medical Center, Durham, NC","From the Department of Medicine (J.W., C.G., H.A.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology (H.A.R.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (H.A.R.), Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"From the Department of Medicine (J.W., C.G., H.A.R.)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.177,"has_fulltext":true,"cited_by_count":317,"citation_normalized_percentile":{"value":0.90551094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"123","issue":"6","first_page":"716","last_page":"735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.7400000095367432},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/angiotensin-ii-receptor","display_name":"angiotensin II receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.6449999809265137},{"id":"https://openalex.org/keywords/ligand-bias","display_name":"ligand bias","score":0.9570000171661377},{"id":"https://openalex.org/keywords/beta-arrestin-signaling","display_name":"\u03b2-arrestin signaling","score":0.8700000047683716},{"id":"https://openalex.org/keywords/conformational-heterogeneity","display_name":"conformational heterogeneity","score":0.890999972820282},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9509999752044678},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cardiovascular-drug-targets","display_name":"cardiovascular drug targets","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6417160034179688},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.48903951048851013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39549368619918823},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3923836648464203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37688109278678894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37225469946861267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3492259979248047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32397907972335815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/circresaha.118.311403","doi":"https://doi.org/10.1161/circresaha.118.311403","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.118.311403","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.118.311403","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:30355236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30355236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5672730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6205195","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6205195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6205195","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.118.311403","doi":"https://doi.org/10.1161/circresaha.118.311403","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.118.311403","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.118.311403","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8128688842","display_name":"Novel Mechanisms and Therapies in Heart Failure","funder_award_id":"P01HL075443","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000906621","display_name":"Mechanisms of Maladaptation in Heart Failure","funder_award_id":"R01HL056687","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889986213.pdf","grobid_xml":"https://content.openalex.org/works/W2889986213.grobid-xml"},"referenced_works_count":257,"referenced_works":["https://openalex.org/W35116219","https://openalex.org/W104393772","https://openalex.org/W154966463","https://openalex.org/W159380338","https://openalex.org/W938960842","https://openalex.org/W1488836492","https://openalex.org/W1503765703","https://openalex.org/W1515479627","https://openalex.org/W1548131418","https://openalex.org/W1562460830","https://openalex.org/W1603274157","https://openalex.org/W1609108565","https://openalex.org/W1699017532","https://openalex.org/W1769585641","https://openalex.org/W1776221901","https://openalex.org/W1811184201","https://openalex.org/W1948948667","https://openalex.org/W1955508706","https://openalex.org/W1963900982","https://openalex.org/W1965182712","https://openalex.org/W1965742222","https://openalex.org/W1966117168","https://openalex.org/W1968286569","https://openalex.org/W1968363634","https://openalex.org/W1970158782","https://openalex.org/W1971569036","https://openalex.org/W1973739813","https://openalex.org/W1974018894","https://openalex.org/W1974186454","https://openalex.org/W1974344999","https://openalex.org/W1975237053","https://openalex.org/W1976555160","https://openalex.org/W1976944767","https://openalex.org/W1978274173","https://openalex.org/W1978387124","https://openalex.org/W1979411530","https://openalex.org/W1980018281","https://openalex.org/W1980304809","https://openalex.org/W1981469121","https://openalex.org/W1983074420","https://openalex.org/W1983312374","https://openalex.org/W1983595911","https://openalex.org/W1983996730","https://openalex.org/W1984849052","https://openalex.org/W1985470432","https://openalex.org/W1986660466","https://openalex.org/W1988097700","https://openalex.org/W1988799768","https://openalex.org/W1990239810","https://openalex.org/W1990867939","https://openalex.org/W1991343266","https://openalex.org/W1991512318","https://openalex.org/W1992870062","https://openalex.org/W1994539207","https://openalex.org/W1994816216","https://openalex.org/W1996827499","https://openalex.org/W2009687620","https://openalex.org/W2010688793","https://openalex.org/W2011745027","https://openalex.org/W2012714305","https://openalex.org/W2017858139","https://openalex.org/W2018492901","https://openalex.org/W2022723700","https://openalex.org/W2023629636","https://openalex.org/W2025002146","https://openalex.org/W2025444835","https://openalex.org/W2027381170","https://openalex.org/W2028645925","https://openalex.org/W2032546808","https://openalex.org/W2034548022","https://openalex.org/W2036272929","https://openalex.org/W2036415059","https://openalex.org/W2038166642","https://openalex.org/W2039363748","https://openalex.org/W2039724634","https://openalex.org/W2040815912","https://openalex.org/W2042618439","https://openalex.org/W2044267632","https://openalex.org/W2044775506","https://openalex.org/W2044775747","https://openalex.org/W2046494590","https://openalex.org/W2046851561","https://openalex.org/W2047372255","https://openalex.org/W2049253479","https://openalex.org/W2050895944","https://openalex.org/W2051436389","https://openalex.org/W2052110444","https://openalex.org/W2052284285","https://openalex.org/W2054237943","https://openalex.org/W2056982291","https://openalex.org/W2057386289","https://openalex.org/W2058160393","https://openalex.org/W2059258112","https://openalex.org/W2060072724","https://openalex.org/W2061286602","https://openalex.org/W2061457959","https://openalex.org/W2067772003","https://openalex.org/W2075075037","https://openalex.org/W2076160014","https://openalex.org/W2077467518","https://openalex.org/W2077936290","https://openalex.org/W2078748771","https://openalex.org/W2080231335","https://openalex.org/W2080609613","https://openalex.org/W2081088335","https://openalex.org/W2081954647","https://openalex.org/W2083350649","https://openalex.org/W2083834362","https://openalex.org/W2084176896","https://openalex.org/W2084235775","https://openalex.org/W2084784994","https://openalex.org/W2085250186","https://openalex.org/W2085917528","https://openalex.org/W2086041680","https://openalex.org/W2087224015","https://openalex.org/W2087276894","https://openalex.org/W2087663632","https://openalex.org/W2089394474","https://openalex.org/W2089722923","https://openalex.org/W2090334734","https://openalex.org/W2091717038","https://openalex.org/W2093777829","https://openalex.org/W2094777850","https://openalex.org/W2095014491","https://openalex.org/W2095374622","https://openalex.org/W2097253015","https://openalex.org/W2099817260","https://openalex.org/W2100629191","https://openalex.org/W2102421606","https://openalex.org/W2102554866","https://openalex.org/W2105330325","https://openalex.org/W2106632219","https://openalex.org/W2107390778","https://openalex.org/W2109003918","https://openalex.org/W2109379548","https://openalex.org/W2109771867","https://openalex.org/W2110182057","https://openalex.org/W2110192403","https://openalex.org/W2111478093","https://openalex.org/W2112412740","https://openalex.org/W2113130764","https://openalex.org/W2115537569","https://openalex.org/W2117373831","https://openalex.org/W2119340816","https://openalex.org/W2120707690","https://openalex.org/W2121279599","https://openalex.org/W2124073673","https://openalex.org/W2124394725","https://openalex.org/W2126291393","https://openalex.org/W2127771541","https://openalex.org/W2130672315","https://openalex.org/W2132107001","https://openalex.org/W2132150051","https://openalex.org/W2133402952","https://openalex.org/W2135491838","https://openalex.org/W2135782858","https://openalex.org/W2135868180","https://openalex.org/W2138091764","https://openalex.org/W2139749578","https://openalex.org/W2140864873","https://openalex.org/W2141497639","https://openalex.org/W2141884086","https://openalex.org/W2142119280","https://openalex.org/W2142405037","https://openalex.org/W2142982250","https://openalex.org/W2143227312","https://openalex.org/W2144049010","https://openalex.org/W2146195218","https://openalex.org/W2147196684","https://openalex.org/W2147452595","https://openalex.org/W2148598424","https://openalex.org/W2149545177","https://openalex.org/W2151301327","https://openalex.org/W2151312020","https://openalex.org/W2152479803","https://openalex.org/W2152989188","https://openalex.org/W2154656177","https://openalex.org/W2155866739","https://openalex.org/W2156802607","https://openalex.org/W2156835140","https://openalex.org/W2157687771","https://openalex.org/W2157988179","https://openalex.org/W2158800467","https://openalex.org/W2159035725","https://openalex.org/W2159601487","https://openalex.org/W2159801302","https://openalex.org/W2162109316","https://openalex.org/W2163150448","https://openalex.org/W2163421864","https://openalex.org/W2163983069","https://openalex.org/W2165488941","https://openalex.org/W2165775221","https://openalex.org/W2166409314","https://openalex.org/W2166748873","https://openalex.org/W2167857702","https://openalex.org/W2168007598","https://openalex.org/W2168017932","https://openalex.org/W2168336490","https://openalex.org/W2168517269","https://openalex.org/W2170359120","https://openalex.org/W2171777264","https://openalex.org/W2178738676","https://openalex.org/W2197759468","https://openalex.org/W2225113095","https://openalex.org/W2257383956","https://openalex.org/W2270060950","https://openalex.org/W2277413600","https://openalex.org/W2284990108","https://openalex.org/W2315834140","https://openalex.org/W2316114122","https://openalex.org/W2324376012","https://openalex.org/W2326508838","https://openalex.org/W2339046060","https://openalex.org/W2374306663","https://openalex.org/W2403283723","https://openalex.org/W2409167527","https://openalex.org/W2412668871","https://openalex.org/W2417634751","https://openalex.org/W2467221777","https://openalex.org/W2468848920","https://openalex.org/W2505532605","https://openalex.org/W2520297993","https://openalex.org/W2522847382","https://openalex.org/W2540776065","https://openalex.org/W2559626295","https://openalex.org/W2572582369","https://openalex.org/W2577306510","https://openalex.org/W2580855485","https://openalex.org/W2589304322","https://openalex.org/W2590136671","https://openalex.org/W2594031629","https://openalex.org/W2603986418","https://openalex.org/W2604441277","https://openalex.org/W2604638393","https://openalex.org/W2607506319","https://openalex.org/W2608624392","https://openalex.org/W2624652951","https://openalex.org/W2625700766","https://openalex.org/W2714953920","https://openalex.org/W2743877546","https://openalex.org/W2748144823","https://openalex.org/W2748712988","https://openalex.org/W2754957776","https://openalex.org/W2756130218","https://openalex.org/W2768265518","https://openalex.org/W2773978638","https://openalex.org/W2789782807","https://openalex.org/W2791453970","https://openalex.org/W2792983781","https://openalex.org/W2801711247","https://openalex.org/W2803461619","https://openalex.org/W2804249900","https://openalex.org/W2805635184","https://openalex.org/W2894408196","https://openalex.org/W4210662535","https://openalex.org/W4327762499","https://openalex.org/W4405992974"],"related_works":["https://openalex.org/W68555715","https://openalex.org/W4309675312","https://openalex.org/W2508244264","https://openalex.org/W2142119280","https://openalex.org/W1509389952","https://openalex.org/W2087735883","https://openalex.org/W4399848812","https://openalex.org/W1982291947","https://openalex.org/W2794568828","https://openalex.org/W2188389238"],"abstract_inverted_index":{"GPCRs":[0,79,117],"(G-protein":[1],"[guanine":[2],"nucleotide-binding":[3],"protein]-coupled":[4],"receptors)":[5,44],"play":[6],"a":[7,58],"central":[8],"physiological":[9],"role":[10],"in":[11,17,87,135],"the":[12,27,74,88,97,121,136],"regulation":[13],"of":[14,26,30,38,55,61,76,128],"cardiac":[15],"function":[16],"both":[18],"health":[19],"and":[20,22,45,70,90,100,107,124,131,144],"disease":[21],"thus":[23],"represent":[24],"one":[25],"largest":[28],"class":[29],"surface":[31],"receptors":[32],"targeted":[33],"by":[34],"drugs.":[35],"Several":[36],"antagonists":[37],"GPCRs,":[39],"such":[40,64,138],"as":[41,65,139],"\u03b2ARs":[42],"(\u03b2-adrenergic":[43],"Ang":[46],"II":[47],"(angiotensin":[48],"II)":[49],"receptors,":[50],"are":[51],"now":[52],"considered":[53],"standard":[54],"therapy":[56],"for":[57,78,104],"wide":[59],"range":[60],"cardiovascular":[62,122],"disease,":[63,69],"hypertension,":[66],"coronary":[67],"artery":[68],"heart":[71],"failure.":[72],"Although":[73],"mechanism":[75],"action":[77],"was":[80],"thought":[81],"to":[82,96,120],"be":[83],"largely":[84],"worked":[85],"out":[86],"80s":[89],"90s,":[91],"recent":[92],"discoveries":[93],"have":[94],"brought":[95],"fore":[98],"new":[99],"previously":[101],"unappreciated":[102],"mechanisms":[103],"GPCR":[105,129],"activation":[106],"subsequent":[108],"downstream":[109],"signaling.":[110],"In":[111],"this":[112],"review,":[113],"we":[114],"focus":[115],"on":[116],"most":[118],"relevant":[119],"system":[123],"discuss":[125],"traditional":[126],"components":[127],"signaling":[130],"highlight":[132],"evolving":[133],"concepts":[134],"field,":[137],"ligand":[140],"bias,":[141],"\u03b2-arrestin-mediated":[142],"signaling,":[143],"conformational":[145],"heterogeneity.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":60},{"year":2023,"cited_by_count":51},{"year":2022,"cited_by_count":47},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-27T00:00:00"}
