{"id":"https://openalex.org/W2889984138","doi":"https://doi.org/10.1182/bloodadvances.2018018986","title":"Inter-\u03b1 inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production","display_name":"Inter-\u03b1 inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production","publication_year":2018,"publication_date":"2018-08-09","ids":{"openalex":"https://openalex.org/W2889984138","doi":"https://doi.org/10.1182/bloodadvances.2018018986","mag":"2889984138","pmid":"https://pubmed.ncbi.nlm.nih.gov/30093530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093744"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2018018986","doi":"https://doi.org/10.1182/bloodadvances.2018018986","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018018986","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1182/bloodadvances.2018018986","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033541373","display_name":"Soe Soe Htwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Soe Soe Htwe","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014373106","display_name":"Hidenori Wake","orcid":"https://orcid.org/0000-0002-0160-7379","observed_orcids":["https://orcid.org/0000-0002-0160-7379"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hidenori Wake","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046786082","display_name":"Keyue Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keyue Liu","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101890661","display_name":"Kiyoshi Teshigawara","orcid":"https://orcid.org/0000-0002-6048-2756","observed_orcids":["https://orcid.org/0000-0002-6048-2756"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Teshigawara","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011689741","display_name":"Barbara S. Stonestreet","orcid":"https://orcid.org/0000-0002-6532-7683","observed_orcids":["https://orcid.org/0000-0002-6532-7683"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara S. Stonestreet","raw_affiliation_strings":["Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Warren Alpert Medical School, Brown University, Providence, RI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Warren Alpert Medical School, Brown University, Providence, RI;","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064312491","display_name":"Yow\u2010Pin Lim","orcid":"https://orcid.org/0000-0003-2697-7963","observed_orcids":["https://orcid.org/0000-0003-2697-7963"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210142502","display_name":"ProThera Biologics (United States)","ror":"https://ror.org/03yzb9c23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yow-Pin Lim","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI","ProThera Biologics, Inc, Providence, RI; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"ProThera Biologics, Inc, Providence, RI; and","institution_ids":["https://openalex.org/I4210142502"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052658056","display_name":"Masahiro Nishibori","orcid":"https://orcid.org/0000-0002-5565-6360","observed_orcids":["https://orcid.org/0000-0002-5565-6360"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Nishibori","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014373106","https://openalex.org/A5033541373"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":1.8246,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.84771676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"15","first_page":"1923","last_page":"1934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inter-alpha-inhibitor-proteins","display_name":"inter-alpha inhibitor proteins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8479999899864197},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6999034285545349},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6020464897155762},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4564949572086334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26729199290275574}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053491","descriptor_name":"Proteinase Inhibitory Proteins, Secretory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1182/bloodadvances.2018018986","doi":"https://doi.org/10.1182/bloodadvances.2018018986","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018018986","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5041056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093744","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6093744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093744","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmid:30093530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30093530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:27a4408ce4014aa6b882758e7455a067","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/27a4408ce4014aa6b882758e7455a067","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Advances, Vol 2, Iss 15, Pp 1923-1934 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2018018986","doi":"https://doi.org/10.1182/bloodadvances.2018018986","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018018986","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3739463737","display_name":"Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury","funder_award_id":"R44NS084575","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3957825579","display_name":"Beneficial Effects of Inter-alpha Inhibitors in Fetal Brain Injury","funder_award_id":"R21NS096525","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G838594032","display_name":"Inter-alpha inhibitors:  Novel neuroinflammatory modulator of neonatal brain injury","funder_award_id":"R21NS095130","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1565594577","https://openalex.org/W1593285591","https://openalex.org/W1820585906","https://openalex.org/W1846247192","https://openalex.org/W1965737875","https://openalex.org/W1986711186","https://openalex.org/W1988158019","https://openalex.org/W1989951338","https://openalex.org/W1991963460","https://openalex.org/W2005226810","https://openalex.org/W2016593129","https://openalex.org/W2016698881","https://openalex.org/W2018860370","https://openalex.org/W2020973522","https://openalex.org/W2033433776","https://openalex.org/W2041437444","https://openalex.org/W2042628774","https://openalex.org/W2043108620","https://openalex.org/W2052748040","https://openalex.org/W2071846360","https://openalex.org/W2072406547","https://openalex.org/W2073034336","https://openalex.org/W2073821065","https://openalex.org/W2080085786","https://openalex.org/W2092800556","https://openalex.org/W2095780054","https://openalex.org/W2098433374","https://openalex.org/W2118991879","https://openalex.org/W2122485299","https://openalex.org/W2132318885","https://openalex.org/W2138694950","https://openalex.org/W2161047619","https://openalex.org/W2280404143","https://openalex.org/W2306492911","https://openalex.org/W2408894040"],"related_works":["https://openalex.org/W7111089043","https://openalex.org/W3011434572","https://openalex.org/W3084376572","https://openalex.org/W2335413103","https://openalex.org/W2002935340","https://openalex.org/W7168388108","https://openalex.org/W204244479","https://openalex.org/W2084834478","https://openalex.org/W2013284212","https://openalex.org/W2751914685"],"abstract_inverted_index":{"phosphorylation":[0],"on":[1],"Ser328.":[2],"These":[3],"results":[4],"suggest":[5],"that":[6,10],"IAIP-induced":[7],"morphological":[8],"changes":[9],"render":[11],"neutrophils":[12],"quiescent,":[13],"facilitate":[14],"passage":[15],"through":[16],"the":[17],"microvasculature,":[18],"and":[19,26],"reduce":[20],"adhesion":[21],"to":[22],"vascular":[23],"endothelial":[24],"cells":[25],"production":[27],"of":[28],"ROS.":[29],"Thus,":[30],"IAIP":[31],"plays":[32],"a":[33],"key":[34],"role":[35],"in":[36],"controlling":[37],"neutrophil":[38],"activation.":[39]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-27T00:00:00"}