{"id":"https://openalex.org/W2889975365","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","title":"The impact of sample storage time on calculating tumor mutation burden (TMB).","display_name":"The impact of sample storage time on calculating tumor mutation burden (TMB).","publication_year":2018,"publication_date":"2018-05-20","ids":{"openalex":"https://openalex.org/W2889975365","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","mag":"2889975365"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.15_suppl.e24022","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002901852","display_name":"Shifu Chen","orcid":"https://orcid.org/0000-0001-5799-653X","observed_orcids":["https://orcid.org/0000-0001-5799-653X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shifu Chen","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347836","display_name":"Ming Liu","orcid":"https://orcid.org/0000-0003-3222-8715","observed_orcids":["https://orcid.org/0000-0003-3222-8715","https://orcid.org/0000-0002-2160-6111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Liu","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102232782","display_name":"Yanqing Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanqing Zhou","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062452808","display_name":"Mingyan Xu","orcid":"https://orcid.org/0000-0002-0082-403X","observed_orcids":["https://orcid.org/0000-0002-0082-403X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyan Xu","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051788322","display_name":"Charles E. Melan\u00e7on","orcid":"https://orcid.org/0000-0002-4236-3868","observed_orcids":["https://orcid.org/0000-0002-4236-3868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles E. Melan\u00e7on","raw_affiliation_strings":["HaploX Biotechnology, Shenzhen, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HaploX Biotechnology, Shenzhen, China;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059056673","display_name":"Jeremy S. Edwards","orcid":"https://orcid.org/0000-0003-3694-3716","observed_orcids":["https://orcid.org/0000-0003-3694-3716"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Edwards","raw_affiliation_strings":["University of New Mexico, Albuquerque, NM, US;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, Albuquerque, NM, US;","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"15_suppl","first_page":"e24022","last_page":"e24022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5687999725341797,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5687999725341797,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sample-storage-time","display_name":"sample storage time","score":0.9850000143051147},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.6769999861717224},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.796999990940094},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6923294067382812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5602169036865234},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.48188525438308716},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4711436331272125},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.4551312029361725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3882000744342804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3009975552558899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2541414797306061},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12004175782203674},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.07864415645599365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.15_suppl.e24022","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e24022","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2956906354","https://openalex.org/W2951412130","https://openalex.org/W2979829881","https://openalex.org/W2898368183","https://openalex.org/W4281782912","https://openalex.org/W3206065376","https://openalex.org/W4308569020","https://openalex.org/W4281480621","https://openalex.org/W4387779111","https://openalex.org/W3181346941"],"abstract_inverted_index":{"e24022":[0],"Background:":[1],"Tumor":[2],"mutation":[3,108,123,143,161,179,196,213],"burden":[4],"(TMB)":[5],"has":[6],"recently":[7],"been":[8],"recognized":[9],"as":[10,126],"an":[11],"independent":[12],"predictor":[13],"of":[14,26,110,145,163,181,198,215],"response":[15],"to":[16,152,170,187,239,278,281,287],"immunotherapy":[17],"in":[18,225,250],"diverse":[19],"cancers.":[20],"However,":[21],"there":[22],"is":[23],"a":[24,141,159,177,194,211,279],"lack":[25],"standardized":[27],"methods":[28],"for":[29],"calculating":[30],"TMB":[31,60,84,263,289],"values":[32],"determined":[33],"from":[34,68,95],"high-throughput":[35],"sequencing":[36,45,51,65],"data":[37,66],"obtained":[38,67],"under":[39],"distinct":[40],"conditions.":[41],"Many":[42],"factors,":[43],"including":[44],"method,":[46],"target":[47],"capture":[48],"panel":[49],"used,":[50],"coverage,":[52],"and":[53,105,115,200,266,286],"sample":[54,91,102,128,229,240,253],"storage":[55,92,103,129,230,244,254],"time":[56,130,255],"can":[57],"affect":[58],"the":[59,75,90,106,121,127],"value.":[61,290],"Methods:":[62],"We":[63,81,118,218,232,247],"re-analyzed":[64],"all":[69],"8,136":[70],"patient":[71],"samples":[72,97,147,165,183,201,226,269],"sequenced":[73,133,148,166,184,202],"using":[74],"same":[76],"410":[77],"gene":[78],"MSK-IMPACT":[79],"panel.":[80],"found":[82,119,219,224],"that":[83,120,220,234,267],"value":[85],"was":[86,98,113],"strongly":[87],"impacted":[88],"by":[89,100],"time.":[93,231],"Data":[94],"these":[96],"grouped":[99],"tissue":[101,268],"time,":[104],"mean":[107,122,142,160,178,195,212],"number":[109,124,144,162,180,197,214],"each":[111],"group":[112],"recorded":[114],"compared.":[116],"Results:":[117],"decreased":[125],"increased.":[131],"Samples":[132],"within":[134,149,167,185],"1":[135,150,171,186],"week":[136,151],"(N":[137,155,173,190,207],"=":[138,156,174,191,208],"608)":[139],"had":[140,158,176,193,210],"9.58,":[146],"3":[153,168,188,205],"months":[154,169],"3,825)":[157],"8.06,":[164],"year":[172],"1,728)":[175],"7.22,":[182],"years":[189,206,273],"1,102)":[192],"6.94,":[199],"after":[203],">":[204],"1,975)":[209],"5.23.":[216],"Conclusions:":[217],"fewer":[221],"mutations":[222,285],"are":[223],"with":[227],"longer":[228],"suggest":[233,248],"this":[235],"may":[236],"be":[237,257,275],"due":[238,277],"degradation":[241],"or":[242],"other":[243],"time-dependent":[245],"factors.":[246],"that,":[249],"clinical":[251],"practice,":[252],"should":[256,274],"taken":[258],"into":[259],"account":[260],"when":[261],"setting":[262],"cut-off":[264],"values;":[265],"older":[270],"than":[271],"three":[272],"avoided":[276],"propensity":[280],"miss":[282],"key":[283],"driver":[284],"underestimate":[288]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2018-09-27T00:00:00"}
