{"id":"https://openalex.org/W2889940320","doi":"https://doi.org/10.1038/s41467-018-06347-2","title":"Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor","display_name":"Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor","publication_year":2018,"publication_date":"2018-09-17","ids":{"openalex":"https://openalex.org/W2889940320","doi":"https://doi.org/10.1038/s41467-018-06347-2","mag":"2889940320","pmid":"https://pubmed.ncbi.nlm.nih.gov/30242271","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6155060"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-06347-2","doi":"https://doi.org/10.1038/s41467-018-06347-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06347-2","pdf_url":"https://www.nature.com/articles/s41467-018-06347-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-06347-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084882105","display_name":"Yuxuan Guo","orcid":"https://orcid.org/0000-0002-6009-4403","observed_orcids":["https://orcid.org/0000-0002-6009-4403"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxuan Guo","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-6009-4403","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050357612","display_name":"Blake D. Jardin","orcid":"https://orcid.org/0000-0002-1376-5235","observed_orcids":["https://orcid.org/0000-0002-1376-5235"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake D. Jardin","raw_affiliation_strings":["Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA","Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-1376-5235","affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111969594","display_name":"Pingzhu Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingzhu Zhou","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054260695","display_name":"Isha Sethi","orcid":"https://orcid.org/0000-0001-7965-0150","observed_orcids":["https://orcid.org/0000-0001-7965-0150"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isha Sethi","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017541072","display_name":"Brynn N. Akerberg","orcid":"https://orcid.org/0000-0001-6470-6588","observed_orcids":["https://orcid.org/0000-0001-6470-6588"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brynn N. Akerberg","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074752569","display_name":"Christopher N. Toepfer","orcid":"https://orcid.org/0000-0003-4671-2030","observed_orcids":["https://orcid.org/0000-0003-4671-2030"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Christopher N Toepfer","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA","Radcliffe Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK"],"raw_orcid":"https://orcid.org/0000-0003-4671-2030","affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Radcliffe Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066200869","display_name":"Yulan Ai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yulan Ai","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355218","display_name":"Yifei Li","orcid":"https://orcid.org/0000-0002-3096-4287","observed_orcids":["https://orcid.org/0000-0002-3096-4287","https://orcid.org/0009-0009-3498-1955"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yifei Li","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China"],"raw_orcid":"https://orcid.org/0000-0002-3096-4287","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038266752","display_name":"Qing Ma","orcid":"https://orcid.org/0000-0002-5625-1330","observed_orcids":["https://orcid.org/0000-0002-5625-1330"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Ma","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033422340","display_name":"S\u00edlvia Guatimosim","orcid":"https://orcid.org/0000-0001-8386-3722","observed_orcids":["https://orcid.org/0000-0001-8386-3722"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvia Guatimosim","raw_affiliation_strings":["Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100838393","display_name":"Yongwu Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yongwu Hu","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","Wenzhou Medical University, School of Life Sciences, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Wenzhou Medical University, School of Life Sciences, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084025326","display_name":"Grigor Varuzhanyan","orcid":"https://orcid.org/0000-0001-6165-0857","observed_orcids":["https://orcid.org/0000-0001-6165-0857"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grigor Varuzhanyan","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA, 91125, USA"],"raw_orcid":"https://orcid.org/0000-0001-6165-0857","affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022755814","display_name":"Nathan J. VanDusen","orcid":"https://orcid.org/0000-0002-2636-7228","observed_orcids":["https://orcid.org/0000-0002-2636-7228"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. VanDusen","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344036","display_name":"Donghui Zhang","orcid":"https://orcid.org/0000-0001-7258-8577","observed_orcids":["https://orcid.org/0000-0001-7258-8577"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Donghui Zhang","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 430062, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 430062, Wuhan, China","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052542033","display_name":"David C. Chan","orcid":"https://orcid.org/0000-0002-0191-2154","observed_orcids":["https://orcid.org/0000-0002-0191-2154","https://orcid.org/0009-0000-2268-1271"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Chan","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA, 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038587862","display_name":"Guo\u2010Cheng Yuan","orcid":"https://orcid.org/0000-0002-2283-4714","observed_orcids":["https://orcid.org/0000-0002-2283-4714"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo-Cheng Yuan","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-2283-4714","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005091829","display_name":"Christine E. Seidman","orcid":"https://orcid.org/0000-0001-6380-1209","observed_orcids":["https://orcid.org/0000-0001-6380-1209"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine E. Seidman","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA","Division of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA","Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, 20815, USA"],"raw_orcid":"https://orcid.org/0000-0001-6380-1209","affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, 20815, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021544196","display_name":"Jonathan G. Seidman","orcid":"https://orcid.org/0000-0002-9082-3566","observed_orcids":["https://orcid.org/0000-0002-9082-3566"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan G. Seidman","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076662333","display_name":"William T. Pu","orcid":"https://orcid.org/0000-0002-4551-8079","observed_orcids":["https://orcid.org/0000-0002-4551-8079"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William T. Pu","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. wpu@pulab.org","Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA. wpu@pulab.org","Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA"],"raw_orcid":"https://orcid.org/0000-0002-4551-8079","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. wpu@pulab.org","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA. wpu@pulab.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5076662333"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.4194,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.90653446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"3837","last_page":"3837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sarcomere-assembly","display_name":"sarcomere assembly","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.890999972820282},{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chromatin-occupancy","display_name":"chromatin occupancy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/neonatal-cardiomyocytes","display_name":"neonatal cardiomyocytes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/crispr-cas9-screening","display_name":"CRISPR-Cas9 screen","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4860832989215851},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48158764839172363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.481414794921875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3899575471878052},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-018-06347-2","doi":"https://doi.org/10.1038/s41467-018-06347-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06347-2","pdf_url":"https://www.nature.com/articles/s41467-018-06347-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5105248","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6155060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6155060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6155060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:30242271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30242271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:90055","doi":null,"is_oa":true,"landing_page_url":"https://authors.library.caltech.edu/90055/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06347-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-06347-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:42a1c307a18b44e79f9325b4eb45da2f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/42a1c307a18b44e79f9325b4eb45da2f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:79b67194c3e44f45957af9c4b8ff1945","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-06347-2","doi":"https://doi.org/10.1038/s41467-018-06347-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-06347-2","pdf_url":"https://www.nature.com/articles/s41467-018-06347-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1436001325","display_name":"Determine the role of serum response factor signaling in cardiomyocyte maturation","funder_award_id":"18POST33960037","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4505503744","display_name":"Regulation of Cardiac Development in Health and Disease","funder_award_id":"UM1HL098166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5325870837","display_name":"Regulation of Cardiomyocyte Maturation","funder_award_id":"R01HL146634","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5639575814","display_name":null,"funder_award_id":"2UM1 HL098166","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6311928744","display_name":"Forward genetic screen to discover regulators of mammalian cardiomyocyte maturation","funder_award_id":"17IRG33410894","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6717897907","display_name":"Mechanisms by which missense variants in myosin and myosin binding protein C alter cellular contractility in genetic cardiomyopathies.","funder_award_id":"206466/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7416493867","display_name":"Administrative Coordinating Center:  Bench to Bassinet Program","funder_award_id":"U01HL131003","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8391622861","display_name":null,"funder_award_id":"HL098166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309356","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05"},{"id":"https://openalex.org/F4320310151","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889940320.pdf","grobid_xml":"https://content.openalex.org/works/W2889940320.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1517994259","https://openalex.org/W1546671514","https://openalex.org/W1829614136","https://openalex.org/W1969038150","https://openalex.org/W1972476556","https://openalex.org/W1973431915","https://openalex.org/W1975175376","https://openalex.org/W1998457769","https://openalex.org/W1999513322","https://openalex.org/W2001926864","https://openalex.org/W2004107033","https://openalex.org/W2007452508","https://openalex.org/W2011264656","https://openalex.org/W2014677321","https://openalex.org/W2019552331","https://openalex.org/W2020208784","https://openalex.org/W2024595059","https://openalex.org/W2029918174","https://openalex.org/W2030637965","https://openalex.org/W2033765226","https://openalex.org/W2035312069","https://openalex.org/W2036145288","https://openalex.org/W2069043222","https://openalex.org/W2070515279","https://openalex.org/W2072540565","https://openalex.org/W2074878885","https://openalex.org/W2083325714","https://openalex.org/W2086040729","https://openalex.org/W2096151652","https://openalex.org/W2103609151","https://openalex.org/W2104010513","https://openalex.org/W2104135721","https://openalex.org/W2104961127","https://openalex.org/W2109591624","https://openalex.org/W2111204942","https://openalex.org/W2115293476","https://openalex.org/W2117131162","https://openalex.org/W2121169322","https://openalex.org/W2125399852","https://openalex.org/W2130410032","https://openalex.org/W2135739418","https://openalex.org/W2138207763","https://openalex.org/W2141241503","https://openalex.org/W2147551208","https://openalex.org/W2147995143","https://openalex.org/W2149292131","https://openalex.org/W2152674951","https://openalex.org/W2153470431","https://openalex.org/W2154993940","https://openalex.org/W2155828174","https://openalex.org/W2158789637","https://openalex.org/W2162143298","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2406043282","https://openalex.org/W2465639163","https://openalex.org/W2596842683","https://openalex.org/W2602896452","https://openalex.org/W2762069701","https://openalex.org/W2763243798","https://openalex.org/W2767030556","https://openalex.org/W2794616878","https://openalex.org/W2809355380"],"related_works":["https://openalex.org/W3118047787","https://openalex.org/W2980985694","https://openalex.org/W2988217384","https://openalex.org/W2001926864","https://openalex.org/W2910335859","https://openalex.org/W2981024144","https://openalex.org/W2007452508","https://openalex.org/W2007276697","https://openalex.org/W2976269240","https://openalex.org/W3157533063"],"abstract_inverted_index":{"After":[0],"birth,":[1],"cardiomyocytes":[2],"(CM)":[3],"acquire":[4],"numerous":[5],"adaptations":[6],"in":[7,34,52,74],"order":[8],"to":[9,136],"efficiently":[10],"pump":[11],"blood":[12],"throughout":[13],"an":[14],"animal's":[15],"lifespan.":[16],"How":[17],"this":[18],"maturation":[19,139],"process":[20],"is":[21,25,77,85,134],"regulated":[22,89],"and":[23,36,68,93,104],"coordinated":[24],"poorly":[26],"understood.":[27],"Here,":[28],"we":[29],"perform":[30],"a":[31,43,141],"CRISPR/Cas9":[32],"screen":[33],"mice":[35],"identify":[37],"serum":[38],"response":[39],"factor":[40],"(SRF)":[41],"as":[42],"key":[44],"regulator":[45],"of":[46,58,72,108,143],"CM":[47,123,138],"maturation.":[48,124],"Mosaic":[49],"SRF":[50,90,96,116,119,132],"depletion":[51],"neonatal":[53],"CMs":[54,76],"disrupts":[55],"many":[56],"aspects":[57],"their":[59],"maturation,":[60],"including":[61],"sarcomere":[62,102,109,148],"expansion,":[63],"mitochondrial":[64,105,113],"biogenesis,":[65],"transverse-tubule":[66],"formation,":[67],"cellular":[69,144],"hypertrophy.":[70],"Maintenance":[71],"maturity":[73],"adult":[75],"less":[78],"dependent":[79],"on":[80],"SRF.":[81],"This":[82],"stage-specific":[83],"activity":[84,133],"associated":[86],"with":[87],"developmentally":[88],"chromatin":[91],"occupancy":[92],"transcriptional":[94],"regulation.":[95],"directly":[97],"activates":[98],"genes":[99],"that":[100,129],"regulate":[101],"assembly":[103,110],"dynamics.":[106],"Perturbation":[107],"but":[111],"not":[112],"dynamics":[114],"recapitulates":[115],"knockout":[117],"phenotypes.":[118],"overexpression":[120],"also":[121],"perturbs":[122],"Together,":[125],"these":[126],"data":[127],"indicate":[128],"carefully":[130],"balanced":[131],"essential":[135],"promote":[137],"through":[140],"hierarchy":[142],"processes":[145],"orchestrated":[146],"by":[147],"assembly.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-27T00:00:00"}