{"id":"https://openalex.org/W2889930741","doi":"https://doi.org/10.3390/ijms19092763","title":"2-Bromo-4\u2032-methoxychalcone and 2-Iodo-4\u2032-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5\u2032-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice","display_name":"2-Bromo-4\u2032-methoxychalcone and 2-Iodo-4\u2032-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5\u2032-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice","publication_year":2018,"publication_date":"2018-09-14","ids":{"openalex":"https://openalex.org/W2889930741","doi":"https://doi.org/10.3390/ijms19092763","mag":"2889930741","pmid":"https://pubmed.ncbi.nlm.nih.gov/30223438","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6163633"},"language":"en","primary_location":{"id":"doi:10.3390/ijms19092763","doi":"https://doi.org/10.3390/ijms19092763","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19092763","pdf_url":"https://www.mdpi.com/1422-0067/19/9/2763/pdf?version=1538114770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/19/9/2763/pdf?version=1538114770","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109390782","display_name":"Chi\u2010Ting Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Ting Hsieh","raw_affiliation_strings":["Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066399911","display_name":"Fang\u2010Rong Chang","orcid":"https://orcid.org/0000-0003-2549-4193","observed_orcids":["https://orcid.org/0000-0003-2549-4193"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fang-Rong Chang","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan","Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-2549-4193","affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083824063","display_name":"Yi\u2010Hong Tsai","orcid":"https://orcid.org/0000-0003-4674-3363","observed_orcids":["https://orcid.org/0000-0003-4674-3363"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Hong Tsai","raw_affiliation_strings":["Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100753551","display_name":"Yang\u2010Chang Wu","orcid":"https://orcid.org/0000-0001-7815-2686","observed_orcids":["https://orcid.org/0000-0001-7815-2686"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yang-Chang Wu","raw_affiliation_strings":["Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016906794","display_name":"Tusty\u2010Jiuan Hsieh","orcid":"https://orcid.org/0000-0001-5387-6522","observed_orcids":["https://orcid.org/0000-0001-5387-6522"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tusty-Jiuan Hsieh","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan","Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan","Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-5387-6522","affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016906794"],"corresponding_institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.2726,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78960694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"9","first_page":"2763","last_page":"2763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halogenated-chalcones","display_name":"halogenated chalcones","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ampk-activation","display_name":"AMPK activation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase-1","display_name":"acetyl-CoA carboxylase 1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8479999899864197},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/skeletal-myotubes","display_name":"skeletal muscle myotubes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.7837989926338196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6005136966705322},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5186687707901001},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.47740402817726135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46830713748931885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4665757119655609},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.46459197998046875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4565756320953369},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4516918659210205},{"id":"https://openalex.org/C2779876172","wikidata":"https://www.wikidata.org/wiki/Q318369","display_name":"Adenosine monophosphate","level":3,"score":0.4447917938232422},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.42781105637550354},{"id":"https://openalex.org/C2779318131","wikidata":"https://www.wikidata.org/wiki/Q21199067","display_name":"Acetyl-CoA carboxylase","level":4,"score":0.4115787148475647},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3820592761039734},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.37953805923461914},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33037540316581726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2849043011665344},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.25878965854644775},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.24791023135185242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20818081498146057},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10341963171958923}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms19092763","doi":"https://doi.org/10.3390/ijms19092763","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19092763","pdf_url":"https://www.mdpi.com/1422-0067/19/9/2763/pdf?version=1538114770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5126094","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6163633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30223438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30223438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6163633","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6163633/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms19092763","doi":"https://doi.org/10.3390/ijms19092763","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19092763","pdf_url":"https://www.mdpi.com/1422-0067/19/9/2763/pdf?version=1538114770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1070456118","display_name":null,"funder_award_id":"99-2323-B-037-002","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G1287713617","display_name":null,"funder_award_id":"NSC 98-2323-B-037-004-","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G3006427632","display_name":null,"funder_award_id":"NSC99","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G3151321957","display_name":null,"funder_award_id":"KMU-TP103D07","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G4333291328","display_name":null,"funder_award_id":"102-2911-I-037-501","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G5256675408","display_name":null,"funder_award_id":"SNK-79/2013","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G626504085","display_name":null,"funder_award_id":"KMU-TP103D07, KMU-TP103D20, KMU-TP103A21","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G6597203776","display_name":null,"funder_award_id":"NSC 102-2911-I-037-501","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G7266900757","display_name":null,"funder_award_id":"SNK-79/2013","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G7620256132","display_name":null,"funder_award_id":"KMU-TP103D20","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G7751359213","display_name":null,"funder_award_id":"NSC 102-2911-I-037-501","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G8106287116","display_name":null,"funder_award_id":"KMU-TP103A21","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G8453797470","display_name":null,"funder_award_id":"102-2911-I-037-501","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320322811","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889930741.pdf","grobid_xml":"https://content.openalex.org/works/W2889930741.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W76806448","https://openalex.org/W95405264","https://openalex.org/W1511269911","https://openalex.org/W1519014928","https://openalex.org/W1963568376","https://openalex.org/W1966542159","https://openalex.org/W1973486931","https://openalex.org/W1985978432","https://openalex.org/W1996287193","https://openalex.org/W1997362033","https://openalex.org/W2000364773","https://openalex.org/W2000637906","https://openalex.org/W2001098118","https://openalex.org/W2002289010","https://openalex.org/W2004168186","https://openalex.org/W2011286971","https://openalex.org/W2011875616","https://openalex.org/W2013760672","https://openalex.org/W2014959436","https://openalex.org/W2019533812","https://openalex.org/W2023893484","https://openalex.org/W2050696737","https://openalex.org/W2052595862","https://openalex.org/W2054847079","https://openalex.org/W2055011154","https://openalex.org/W2059409217","https://openalex.org/W2059642778","https://openalex.org/W2060229756","https://openalex.org/W2072541255","https://openalex.org/W2073909738","https://openalex.org/W2074178415","https://openalex.org/W2077434210","https://openalex.org/W2087242576","https://openalex.org/W2088917372","https://openalex.org/W2111876001","https://openalex.org/W2127028584","https://openalex.org/W2134304387","https://openalex.org/W2135943330","https://openalex.org/W2137146727","https://openalex.org/W2137940993","https://openalex.org/W2140406095","https://openalex.org/W2156829110","https://openalex.org/W2157193327","https://openalex.org/W2161350979","https://openalex.org/W2162523749","https://openalex.org/W2169673623","https://openalex.org/W2171233986","https://openalex.org/W2172193326","https://openalex.org/W2354700353","https://openalex.org/W2407841529","https://openalex.org/W2580583036","https://openalex.org/W6706231886"],"related_works":["https://openalex.org/W4385463137","https://openalex.org/W2199756175","https://openalex.org/W4410707861","https://openalex.org/W2767224407","https://openalex.org/W4386793124","https://openalex.org/W2028649994","https://openalex.org/W7151469721","https://openalex.org/W95405264","https://openalex.org/W2013019260","https://openalex.org/W4367837486"],"abstract_inverted_index":{"Obesity":[0],"and":[1,20,35,38,70,78,89,98,112,117,139,146,161],"diabetes":[2,37],"are":[3,30,47],"global":[4],"health-threatening":[5],"issues.":[6],"Interestingly,":[7],"the":[8,62,104,125],"mechanism":[9],"of":[10,22,25,127,156],"these":[11],"pathologies":[12],"is":[13],"quite":[14],"different":[15],"among":[16],"individuals.":[17],"The":[18],"discovery":[19],"development":[21],"new":[23,154],"categories":[24],"medicines":[26,157],"from":[27],"diverse":[28],"sources":[29],"urgently":[31],"needed":[32],"for":[33,49,152],"preventing":[34,50],"treating":[36],"other":[39],"metabolic":[40],"disorders.":[41],"Previously,":[42],"we":[43,59],"reported":[44],"that":[45,61,137,158],"chalcones":[46],"important":[48],"biological":[51],"disorders,":[52],"such":[53],"as":[54,143,149],"diabetes.":[55,162],"In":[56,102],"this":[57],"study,":[58],"demonstrate":[60],"synthetic":[63],"halogen-containing":[64],"chalcone":[65],"derivatives":[66],"2-bromo-4\u2032-methoxychalcone":[67,138],"(compound":[68,72],"5)":[69],"2-iodo-4\u2032-methoxychalcone":[71,140],"6)":[73],"can":[74],"promote":[75],"glucose":[76,114],"consumption":[77],"inhibit":[79],"cellular":[80],"lipid":[81],"accumulation":[82],"via":[83],"5\u2032-adenosine-monophosphate-activated":[84],"protein":[85],"kinase":[86],"(AMPK)":[87],"activation":[88],"acetyl-CoA":[90],"carboxylase":[91],"1":[92],"(ACC)":[93],"phosphorylation":[94],"in":[95,129],"3T3-L1":[96],"adipocytes":[97],"C2C12":[99],"skeletal":[100],"myotubes.":[101],"addition,":[103],"two":[105],"compounds":[106,151],"significantly":[107],"prevented":[108],"body":[109],"weight":[110],"gain":[111],"impaired":[113],"tolerance,":[115],"hyperinsulinemia,":[116],"insulin":[118],"resistance,":[119],"which":[120],"collectively":[121],"help":[122],"to":[123],"delay":[124],"progression":[126],"hyperglycemia":[128],"high-fat-diet-induced":[130],"obese":[131],"C57BL/6":[132],"mice.":[133],"These":[134],"findings":[135],"indicate":[136],"could":[141],"act":[142],"AMPK":[144],"activators,":[145],"may":[147],"serve":[148],"lead":[150],"a":[153],"class":[155],"target":[159],"obesity":[160]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-09-27T00:00:00"}
