{"id":"https://openalex.org/W2889913635","doi":"https://doi.org/10.1038/s41598-018-32106-w","title":"Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat","display_name":"Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat","publication_year":2018,"publication_date":"2018-09-06","ids":{"openalex":"https://openalex.org/W2889913635","doi":"https://doi.org/10.1038/s41598-018-32106-w","mag":"2889913635","pmid":"https://pubmed.ncbi.nlm.nih.gov/30209300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6135864"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-32106-w","doi":"https://doi.org/10.1038/s41598-018-32106-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32106-w","pdf_url":"https://www.nature.com/articles/s41598-018-32106-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-32106-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079195646","display_name":"Eleonora Vianello","orcid":"https://orcid.org/0000-0003-0342-4055","observed_orcids":["https://orcid.org/0000-0003-0342-4055"]},"institutions":[{"id":"https://openalex.org/I4210087406","display_name":"Fondazione Italiana Fegato","ror":"https://ror.org/00zpwa373","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210087406"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Vianello","raw_affiliation_strings":["Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I4210087406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055610157","display_name":"Stefania Zampieri","orcid":"https://orcid.org/0000-0003-3921-8405","observed_orcids":["https://orcid.org/0000-0003-3921-8405"]},"institutions":[{"id":"https://openalex.org/I4210126152","display_name":"Ospedale Santa Maria della Misericordia di Udine","ror":"https://ror.org/02zpc2253","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126152"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Zampieri","raw_affiliation_strings":["University Hospital Santa Maria della Misericordia, Udine. P.le Santa Maria della Misericordia 15, 33100, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Santa Maria della Misericordia, Udine. P.le Santa Maria della Misericordia 15, 33100, Udine, Italy","institution_ids":["https://openalex.org/I4210126152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049573093","display_name":"Thomas Marcuzzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210095322","display_name":"Ospedale di Cattinara","ror":"https://ror.org/00nrgkr20","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Thomas Marcuzzo","raw_affiliation_strings":["Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210095322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075443548","display_name":"Fabio Tordini","orcid":"https://orcid.org/0000-0001-9861-6513","observed_orcids":["https://orcid.org/0000-0001-9861-6513"]},"institutions":[{"id":"https://openalex.org/I4210121248","display_name":"Fondazione Edo ed Elvo Tempia","ror":"https://ror.org/01x5t2m44","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210121248"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Tordini","raw_affiliation_strings":["Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia Valenta, Via Malta 3, 13900, Biella, Italy","Computer Science Department, University of Torino, 10100, Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9861-6513","affiliations":[{"raw_affiliation_string":"Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia Valenta, Via Malta 3, 13900, Biella, Italy","institution_ids":["https://openalex.org/I4210121248"]},{"raw_affiliation_string":"Computer Science Department, University of Torino, 10100, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010215553","display_name":"Cristina Bottin","orcid":"https://orcid.org/0000-0002-2242-0706","observed_orcids":["https://orcid.org/0000-0002-2242-0706"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210095322","display_name":"Ospedale di Cattinara","ror":"https://ror.org/00nrgkr20","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Bottin","raw_affiliation_strings":["Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210095322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052930244","display_name":"Andrea Dardis","orcid":"https://orcid.org/0000-0001-7024-8181","observed_orcids":["https://orcid.org/0000-0001-7024-8181"]},"institutions":[{"id":"https://openalex.org/I4210126152","display_name":"Ospedale Santa Maria della Misericordia di Udine","ror":"https://ror.org/02zpc2253","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126152"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Dardis","raw_affiliation_strings":["University Hospital Santa Maria della Misericordia, Udine. P.le Santa Maria della Misericordia 15, 33100, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Santa Maria della Misericordia, Udine. P.le Santa Maria della Misericordia 15, 33100, Udine, Italy","institution_ids":["https://openalex.org/I4210126152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026204894","display_name":"Fabrizio Zanconati","orcid":"https://orcid.org/0000-0001-5357-9579","observed_orcids":["https://orcid.org/0000-0001-5357-9579"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210095322","display_name":"Ospedale di Cattinara","ror":"https://ror.org/00nrgkr20","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Zanconati","raw_affiliation_strings":["Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ospedale di Cattinara, Universit\u00e0 degli Studi di Trieste, Strada di Fiume 447, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210095322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071646464","display_name":"Claudio Tiribelli","orcid":"https://orcid.org/0000-0001-6596-7595","observed_orcids":["https://orcid.org/0000-0001-6596-7595"]},"institutions":[{"id":"https://openalex.org/I4210087406","display_name":"Fondazione Italiana Fegato","ror":"https://ror.org/00zpwa373","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210087406"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Tiribelli","raw_affiliation_strings":["Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6596-7595","affiliations":[{"raw_affiliation_string":"Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I4210087406"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089347075","display_name":"Silvia Gazzin","orcid":"https://orcid.org/0000-0001-9403-3564","observed_orcids":["https://orcid.org/0000-0001-9403-3564"]},"institutions":[{"id":"https://openalex.org/I4210087406","display_name":"Fondazione Italiana Fegato","ror":"https://ror.org/00zpwa373","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210087406"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvia Gazzin","raw_affiliation_strings":["Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy. silvia.gazzin@fegato.it","Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy. silvia.gazzin@fegato.it","institution_ids":["https://openalex.org/I4210087406"]},{"raw_affiliation_string":"Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I4210087406"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089347075"],"corresponding_institution_ids":["https://openalex.org/I4210087406"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.6186,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81651043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"13690","last_page":"13690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.902999997138977},{"id":"https://openalex.org/keywords/h3k14-acetylation","display_name":"H3K14 acetylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/bilirubin-neurotoxicity","display_name":"bilirubin neurotoxicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gunn-rats","display_name":"Gunn rats","score":0.7179999947547913},{"id":"https://openalex.org/keywords/kernicterus","display_name":"kernicterus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neonatal-hyperbilirubinemia","display_name":"neonatal hyperbilirubinemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cerebellar-hypoplasia","display_name":"cerebellar hypoplasia","score":0.968999981880188},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5669999718666077},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.4560000002384186},{"id":"https://openalex.org/keywords/central-nervous-system-development","display_name":"central nervous system development","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dendritogenesis","display_name":"dendritogenesis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7456274032592773},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6279752850532532},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.615263044834137},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.47250545024871826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45574119687080383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.448168009519577},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43464431166648865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3791956305503845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30531370639801025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2744896411895752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2360321283340454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22066324949264526},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.05736750364303589}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002658","descriptor_name":"Developmental Disabilities","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007647","descriptor_name":"Kernicterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009421","descriptor_name":"Nervous System Malformations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011911","descriptor_name":"Rats, Gunn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-32106-w","doi":"https://doi.org/10.1038/s41598-018-32106-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32106-w","pdf_url":"https://www.nature.com/articles/s41598-018-32106-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5088281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6135864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30209300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30209300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6135864","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6135864/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:arts.units.it:11368/2936183","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11368/2936183","pdf_url":"https://arts.units.it/bitstream/11368/2936183/1/Bilirubin.pdf","source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f1edf62e3dfb4a45b867b24b79ce0f90","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f1edf62e3dfb4a45b867b24b79ce0f90","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-32106-w","doi":"https://doi.org/10.1038/s41598-018-32106-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32106-w","pdf_url":"https://www.nature.com/articles/s41598-018-32106-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327547","display_name":"Universit\u00e0 degli Studi di Trieste","ror":"https://ror.org/02n742c10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889913635.pdf","grobid_xml":"https://content.openalex.org/works/W2889913635.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W136122237","https://openalex.org/W611318970","https://openalex.org/W1577577364","https://openalex.org/W1794816422","https://openalex.org/W1970723883","https://openalex.org/W1977657158","https://openalex.org/W1977680780","https://openalex.org/W1984080147","https://openalex.org/W1991908537","https://openalex.org/W2000251389","https://openalex.org/W2002888382","https://openalex.org/W2014677321","https://openalex.org/W2017790277","https://openalex.org/W2020401915","https://openalex.org/W2020915096","https://openalex.org/W2021158227","https://openalex.org/W2026787131","https://openalex.org/W2026820357","https://openalex.org/W2028432740","https://openalex.org/W2031043159","https://openalex.org/W2032680863","https://openalex.org/W2034295826","https://openalex.org/W2046801320","https://openalex.org/W2052141092","https://openalex.org/W2057615104","https://openalex.org/W2067950565","https://openalex.org/W2069164041","https://openalex.org/W2069258818","https://openalex.org/W2072106835","https://openalex.org/W2077066306","https://openalex.org/W2077274456","https://openalex.org/W2077455826","https://openalex.org/W2078149293","https://openalex.org/W2095884976","https://openalex.org/W2103163582","https://openalex.org/W2104488717","https://openalex.org/W2108244474","https://openalex.org/W2109337786","https://openalex.org/W2120095635","https://openalex.org/W2133616653","https://openalex.org/W2135727583","https://openalex.org/W2139655181","https://openalex.org/W2142663409","https://openalex.org/W2164465986","https://openalex.org/W2168420558","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2407766408","https://openalex.org/W2549513265","https://openalex.org/W2578456663","https://openalex.org/W2595696124"],"related_works":["https://openalex.org/W2365967765","https://openalex.org/W2328076684","https://openalex.org/W7101183963","https://openalex.org/W2122233624","https://openalex.org/W4281700489","https://openalex.org/W2744169228","https://openalex.org/W2056257946","https://openalex.org/W3120740073","https://openalex.org/W2897275814","https://openalex.org/W4403417662"],"abstract_inverted_index":{"Bilirubin":[0],"neurotoxicity":[1],"has":[2,8,43,81],"been":[3,9,83],"studied":[4],"for":[5,57,120],"decades":[6],"and":[7,68,78,113,123,161,165],"shown":[10],"to":[11,51],"affect":[12],"various":[13],"mechanisms":[14,26,184],"via":[15,181],"significant":[16],"modulation":[17,56],"of":[18,27,73,92,103,130,140,149,188,196],"gene":[19,28,55,74],"expression.":[20],"This":[21],"suggests":[22],"that":[23,146,170],"vital":[24],"regulatory":[25],"expression,":[29],"such":[30,61],"as":[31,62],"epigenetic":[32,71],"mechanisms,":[33],"could":[34],"play":[35],"a":[36,193],"role":[37,53],"in":[38,47,54,76,99,133,156,175],"bilirubin":[39],"neurotoxicity.":[40,199],"Histone":[41],"acetylation":[42,97],"recently":[44],"received":[45],"attention":[46],"the":[48,90,100,104,111,117,131,134,141,171,176,186,197],"CNS":[49,157],"due":[50],"its":[52],"numerous":[58],"biological":[59],"processes,":[60],"synaptic":[63],"plasticity,":[64],"learning,":[65],"memory,":[66],"development":[67,158],"differentiation.":[69],"Aberrant":[70],"regulation":[72],"expression":[75],"psychiatric":[77],"neurodegenerative":[79],"disorders":[80],"also":[82,180],"described.":[84],"In":[85],"this":[86,189],"work,":[87],"we":[88],"followed":[89],"levels":[91],"histone":[93],"3":[94],"lysine":[95],"14":[96],"(H3K14Ac)":[98],"cerebellum":[101],"(Cll)":[102],"developing":[105],"(2,":[106],"9,":[107],"17":[108],"days":[109],"after":[110],"birth)":[112],"adult":[114],"Gunn":[115,177],"rat,":[116],"natural":[118],"model":[119],"neonatal":[121],"hyperbilirubinemia":[122],"kernicterus.":[124],"We":[125],"observed":[126],"an":[127],"age-specific":[128],"alteration":[129],"H3K14Ac":[132,142,150],"hyperbilirubinemic":[135],"animals.":[136],"The":[137],"GeneOntology":[138],"analysis":[139],"linked":[143],"chromatin":[144],"revealed":[145],"almost":[147],"45%":[148],"ChiP-Seq":[151],"TSS-promoter":[152],"genes":[153],"were":[154],"involved":[155],"including":[159],"maturation":[160,187],"differentiation,":[162],"morphogenesis,":[163],"dendritogenesis,":[164],"migration.":[166],"These":[167],"data":[168],"suggest":[169],"hallmark":[172],"Cll":[173],"hypoplasia":[174],"rat":[178],"occurs":[179],"epigenetically":[182],"controlled":[183],"during":[185],"brain":[190],"structure,":[191],"unraveling":[192],"novel":[194],"aspect":[195],"bilirubin-induced":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-09-27T00:00:00"}