{"id":"https://openalex.org/W2889911042","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","title":"Phase Ib study of cabozantinib plus panitumumab in KRAS wild-type (WT) metastatic colorectal cancer (mCRC).","display_name":"Phase Ib study of cabozantinib plus panitumumab in KRAS wild-type (WT) metastatic colorectal cancer (mCRC).","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2889911042","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","mag":"2889911042"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.3548","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005968330","display_name":"John H. Strickler","orcid":"https://orcid.org/0000-0001-7579-1175","observed_orcids":["https://orcid.org/0000-0001-7579-1175"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Strickler","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070264002","display_name":"Christel N. Rushing","orcid":"https://orcid.org/0000-0001-7453-2120","observed_orcids":["https://orcid.org/0000-0001-7453-2120"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christel N. Rushing","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000347168","display_name":"Hope Elizabeth Uronis","orcid":"https://orcid.org/0009-0000-1565-1939","observed_orcids":["https://orcid.org/0009-0000-1565-1939"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope Elizabeth Uronis","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074731037","display_name":"Michael Andrew Morse","orcid":"https://orcid.org/0000-0002-5725-4533","observed_orcids":["https://orcid.org/0000-0002-5725-4533"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Morse","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020182936","display_name":"Gerard C. Blobe","orcid":"https://orcid.org/0000-0002-4274-8901","observed_orcids":["https://orcid.org/0000-0002-4274-8901"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard C. Blobe","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yousuf Zafar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yousuf Zafar","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084803094","display_name":"Shiaowen David Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiaowen David Hsu","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113878292","display_name":"Christy Arrowood","orcid":"https://orcid.org/0009-0000-3263-9659","observed_orcids":["https://orcid.org/0009-0000-3263-9659"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy Arrowood","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109391134","display_name":"Sherri T. Haley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherri Haley","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079790497","display_name":"Evan Dropkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Dropkin","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073130519","display_name":"Donna Niedzwiecki","orcid":"https://orcid.org/0000-0002-3566-0450","observed_orcids":["https://orcid.org/0000-0002-3566-0450"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Niedzwiecki","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046311492","display_name":"Herbert I. Hurwitz","orcid":"https://orcid.org/0000-0003-3242-9197","observed_orcids":["https://orcid.org/0000-0003-3242-9197"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Hurwitz","raw_affiliation_strings":["Duke University Medical Center, Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC;","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"3548","last_page":"3548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cabozantinib","display_name":"cabozantinib","score":0.996999979019165},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/kras-wild-type","display_name":"KRAS wild-type","score":0.984000027179718},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.9789999723434448},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.7549999952316284},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/vegfr-inhibition","display_name":"VEGFR inhibition","score":0.652999997138977},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.6399999856948853},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8349999785423279},{"id":"https://openalex.org/keywords/recist-response","display_name":"RECIST response","score":0.4569999873638153},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.3089999854564667},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.328000009059906},{"id":"https://openalex.org/keywords/chemotherapy-refractory-cancer","display_name":"chemotherapy-refractory cancer","score":0.6309999823570251},{"id":"https://openalex.org/keywords/acneiform-rash","display_name":"acneiform rash","score":0.6269999742507935},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.9100143909454346},{"id":"https://openalex.org/C2781064419","wikidata":"https://www.wikidata.org/wiki/Q795057","display_name":"Cabozantinib","level":3,"score":0.8827686309814453},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8785295486450195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8774216175079346},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7216834425926208},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5401446223258972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5181090235710144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4287964701652527},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3922172486782074}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.3548","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.3548","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3123198979","https://openalex.org/W4406870916","https://openalex.org/W2891600471","https://openalex.org/W3024082028","https://openalex.org/W2350748281","https://openalex.org/W2590773246","https://openalex.org/W2888975326","https://openalex.org/W2312590566","https://openalex.org/W4213385724","https://openalex.org/W4416529004"],"abstract_inverted_index":{"3548":[0],"Background:":[1],"Anti-EGFR":[2],"therapy":[3,102],"improves":[4],"survival":[5],"for":[6,166,187,199,355],"patients":[7],"(pts)":[8],"with":[9,76],"RAS":[10],"WT":[11,80],"mCRC,":[12],"but":[13],"nearly":[14],"all":[15],"pts":[16,75,184,196,207,316,325],"develop":[17],"therapeutic":[18],"resistance.":[19],"MET":[20,64,175],"amplification":[21],"(amp)":[22],"is":[23,35,49,359],"a":[24,56,85,115,129,319],"well-described":[25],"driver":[26],"of":[27,39,60,70,136,149,181,340],"acquired":[28],"resistance":[29],"to":[30,62,92,141],"anti-EGFR":[31,51,71,101,211],"therapy.":[32,72,212],"Cabozantinib":[33],"(C)":[34],"an":[36,50,343],"oral":[37,275],"inhibitor":[38],"multiple":[40],"tyrosine":[41],"kinases,":[42],"including":[43,174],"VEGFR1-3":[44],"and":[45,66,120,147,171,194,233,244,293,323,347],"MET.":[46],"Panitumumab":[47],"(P)":[48],"monoclonal":[52],"antibody.":[53],"We":[54],"designed":[55],"phase":[57,96],"Ib":[58],"study":[59],"C+P":[61,341],"target":[63],"amp":[65],"enhance":[67],"the":[68,94,123,137,144,221,241,338,352,356],"activity":[69,350],"Methods:":[73],"Eligible":[74],"chemotherapy":[77],"refractory":[78],"KRAS":[79],"mCRC":[81],"were":[82,111,140,185,197,214,248,268],"enrolled":[83,113],"in":[84,114,220],"3+3":[86],"dose":[87,98,216],"finding":[88],"cohort":[89,118,127,139,224,358],"(Dose":[90],"Find)":[91],"identify":[93],"recommended":[95],"II":[97],"(RPTD).":[99],"Prior":[100],"was":[103,107,164,228,299,308],"permitted.":[104],"Cycle":[105],"length":[106],"28":[108],"days.":[109],"Pts":[110],"then":[112],"single-arm":[116],"expansion":[117],"(EXP)":[119],"treated":[121],"at":[122,351],"RPTD.":[124,353],"The":[125,134,226,259],"EXP":[126,138,245,357],"included":[128],"2-week":[130],"C":[131,229],"monotherapy":[132],"lead-in.":[133],"objectives":[135],"better":[142],"describe":[143],"safety,":[145],"tolerability,":[146],"efficacy":[148],"C+P.":[150],"Response":[151],"assessment":[152],"occurred":[153],"every":[154],"2":[155,315],"months":[156],"(mos)":[157],"using":[158],"RECIST":[159],"version":[160],"1.1.":[161],"Peripheral":[162],"blood":[163],"sequenced":[165],">":[167,265,328],"54":[168],"gene":[169],"mutations":[170],"focal":[172],"amps,":[173],"(Guardant":[176],"Health,":[177],"Inc.).":[178],"Results:":[179],"As":[180],"11/24/2015,":[182],"16":[183],"evaluable":[186,198],"toxicity":[188,218],"(6":[189,201],"Dose":[190,202,222,242],"Find;":[191,203],"10":[192],"EXP),":[193],"14":[195],"response":[200],"8":[204],"EXP).":[205],"13":[206],"had":[208,318,326],"received":[209],"prior":[210],"There":[213],"no":[215,249],"limiting":[217],"events":[219,257],"Find":[223,243],"(0/6).":[225],"RPTD":[227],"60mg":[230],"PO":[231],"daily":[232],"P":[234],"6":[235,329],"mg/kg":[236],"IV":[237],"Q2":[238],"weeks.":[239],"In":[240,332],"cohorts,":[246],"there":[247],"grade":[250],"4":[251],"or":[252],"5":[253,324],"treatment":[254],"related":[255],"adverse":[256],"(TRAEs).":[258],"most":[260],"frequently":[261],"reported":[262],"(all":[263],"grades":[264],"30%)":[266],"TRAEs":[267],"(n,":[269],"%)":[270],"acneiform":[271],"rash":[272],"(10,":[273],"63%),":[274],"mucositis":[276],"(9,":[277],"56%),":[278],"diarrhea":[279],"(8,":[280],"50%),":[281],"increased":[282,289],"AST":[283],"(7,":[284],"44%),":[285],"paronychia":[286],"(6,":[287],"38%),":[288],"ALT":[290],"(5,":[291,295],"31%),":[292],"fatigue":[294],"31%).":[296],"Median":[297,306],"PFS":[298,327],"3.7":[300],"mos":[301,310],"(95%":[302,311],"C.I.,":[303,312],"2.3\u20137.4":[304],"mos).":[305,314],"OS":[307],"7.5":[309],"6.4\u201312.1":[313],"(14%)":[317],"confirmed":[320],"partial":[321],"response,":[322],"months.":[330],"Conclusions:":[331],"this":[333],"heavily":[334],"pre-treated":[335],"patient":[336],"population,":[337],"combination":[339],"demonstrated":[342],"acceptable":[344],"safety":[345],"profile":[346],"encouraging":[348],"clinical":[349],"Recruitment":[354],"now":[360],"complete.":[361],"Blood":[362],"biomarker":[363],"analysis":[364],"will":[365],"be":[366],"presented.":[367],"Clinical":[368],"trial":[369],"information:":[370],"NCT02008383.":[371]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-09-27T00:00:00"}