{"id":"https://openalex.org/W2889876255","doi":"https://doi.org/10.1177/1076029618796339","title":"The Reversal of Bleeding Caused by New Oral Anticoagulants (NOACs): A Systematic Review and Meta-Analysis","display_name":"The Reversal of Bleeding Caused by New Oral Anticoagulants (NOACs): A Systematic Review and Meta-Analysis","publication_year":2018,"publication_date":"2018-09-03","ids":{"openalex":"https://openalex.org/W2889876255","doi":"https://doi.org/10.1177/1076029618796339","mag":"2889876255","pmid":"https://pubmed.ncbi.nlm.nih.gov/30176738","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714855"},"language":"en","primary_location":{"id":"doi:10.1177/1076029618796339","doi":"https://doi.org/10.1177/1076029618796339","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1076029618796339","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1177/1076029618796339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022674405","display_name":"Sariya Udayachalerm","orcid":"https://orcid.org/0000-0002-9762-5466","observed_orcids":["https://orcid.org/0000-0002-9762-5466"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sariya Udayachalerm","raw_affiliation_strings":["Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072481139","display_name":"Sasivimol Rattanasiri","orcid":"https://orcid.org/0000-0001-7213-6116","observed_orcids":["https://orcid.org/0000-0001-7213-6116"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Sasivimol Rattanasiri","raw_affiliation_strings":["Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":"https://orcid.org/0000-0001-7213-6116","affiliations":[{"raw_affiliation_string":"Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083240155","display_name":"Teeranan Angkananard","orcid":"https://orcid.org/0000-0001-9965-0115","observed_orcids":["https://orcid.org/0000-0001-9965-0115"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]},{"id":"https://openalex.org/I76920116","display_name":"Srinakharinwirot University","ror":"https://ror.org/04718hx42","country_code":"TH","type":"education","lineage":["https://openalex.org/I76920116"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Teeranan Angkananard","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand","Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand","institution_ids":["https://openalex.org/I76920116"]},{"raw_affiliation_string":"Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053331577","display_name":"John Attia","orcid":"https://orcid.org/0000-0001-9800-1308","observed_orcids":["https://orcid.org/0000-0001-9800-1308"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Attia","raw_affiliation_strings":["Centre for Clinical Epidemiology and Biostatistics, Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, New South Wales, Australia","Hunter Medical Research Institute, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Epidemiology and Biostatistics, Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, New South Wales, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"Hunter Medical Research Institute, New South Wales, Australia","institution_ids":["https://openalex.org/I4210087646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010092604","display_name":"Nakarin Sansanayudh","orcid":"https://orcid.org/0000-0001-5668-7559","observed_orcids":["https://orcid.org/0000-0001-5668-7559"]},"institutions":[{"id":"https://openalex.org/I4210087968","display_name":"Phramongkutklao Hospital","ror":"https://ror.org/007h1qz76","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210087968"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nakarin Sansanayudh","raw_affiliation_strings":["Cardiology Unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210087968"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056464791","display_name":"Ammarin Thakkinstian","orcid":"https://orcid.org/0000-0001-9991-386X","observed_orcids":["https://orcid.org/0000-0001-9991-386X"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ammarin Thakkinstian","raw_affiliation_strings":["Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072481139"],"corresponding_institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.3801,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.39108172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"9_suppl","first_page":"117S","last_page":"126S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.996999979019165},{"id":"https://openalex.org/keywords/bleeding-reversal","display_name":"bleeding reversal","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antidotes","display_name":"antidotes","score":0.7009999752044678},{"id":"https://openalex.org/keywords/idarucizumab","display_name":"idarucizumab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dabigatran","display_name":"dabigatran","score":0.9290000200271606},{"id":"https://openalex.org/keywords/andexanet-alfa","display_name":"andexanet alfa","score":0.996999979019165},{"id":"https://openalex.org/keywords/factor-xa-inhibitors","display_name":"factor Xa inhibitors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/direct-thrombin-inhibitors","display_name":"direct thrombin inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.35499998927116394},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8019999861717224},{"id":"https://openalex.org/keywords/warfarin-alternatives","display_name":"warfarin alternatives","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8525409698486328},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.6464201211929321},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.6011074781417847},{"id":"https://openalex.org/C2776413415","wikidata":"https://www.wikidata.org/wiki/Q17630273","display_name":"Idarucizumab","level":5,"score":0.5669424533843994},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5634515881538391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48334166407585144},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4440366327762604},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4366312026977539},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.3706215023994446},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.09716737270355225}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1177/1076029618796339","doi":"https://doi.org/10.1177/1076029618796339","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1076029618796339","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6714855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6714855/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6714855/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Appl Thromb Hemost","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:5682397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714855","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30176738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30176738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/28969655","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_reversal_of_bleeding_caused_by_new_oral_anticoagulants_NOACs_a_systematic_review_and_meta-analysis/28969655","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:vitalprd00.priv:uon:35046","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.13/1402567","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:uon:35046","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.13/1402567","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1177/1076029618796339","doi":"https://doi.org/10.1177/1076029618796339","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1076029618796339","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889876255.pdf","grobid_xml":"https://content.openalex.org/works/W2889876255.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1513839038","https://openalex.org/W1641613989","https://openalex.org/W1744228080","https://openalex.org/W1829866114","https://openalex.org/W1850076143","https://openalex.org/W1887271924","https://openalex.org/W1925320217","https://openalex.org/W1940756716","https://openalex.org/W1968841012","https://openalex.org/W1971941179","https://openalex.org/W1993340298","https://openalex.org/W2014491911","https://openalex.org/W2014822095","https://openalex.org/W2015751459","https://openalex.org/W2029135646","https://openalex.org/W2036506340","https://openalex.org/W2080662564","https://openalex.org/W2096246254","https://openalex.org/W2097854437","https://openalex.org/W2098215452","https://openalex.org/W2113446992","https://openalex.org/W2114962542","https://openalex.org/W2115787552","https://openalex.org/W2119083251","https://openalex.org/W2121796495","https://openalex.org/W2126850212","https://openalex.org/W2133686162","https://openalex.org/W2136489990","https://openalex.org/W2139912660","https://openalex.org/W2146197955","https://openalex.org/W2152623033","https://openalex.org/W2161374186","https://openalex.org/W2162508946","https://openalex.org/W2166402206","https://openalex.org/W2174386486","https://openalex.org/W2201013905","https://openalex.org/W2205187321","https://openalex.org/W2209358119","https://openalex.org/W2220337472","https://openalex.org/W2326383534","https://openalex.org/W2329823765","https://openalex.org/W2340773612","https://openalex.org/W2347298994","https://openalex.org/W2399997588","https://openalex.org/W2460769526","https://openalex.org/W2463608494","https://openalex.org/W2481569543","https://openalex.org/W2514338974","https://openalex.org/W2514781678","https://openalex.org/W2532812314","https://openalex.org/W2553572012","https://openalex.org/W2554062859","https://openalex.org/W2587194661","https://openalex.org/W2588613447","https://openalex.org/W2589128497","https://openalex.org/W2602092873","https://openalex.org/W2606132979","https://openalex.org/W2734827407","https://openalex.org/W2750504927","https://openalex.org/W2783205823","https://openalex.org/W2791026080","https://openalex.org/W2797285878"],"related_works":["https://openalex.org/W2081326224","https://openalex.org/W2117966697","https://openalex.org/W2267344338","https://openalex.org/W2107587895","https://openalex.org/W1995693584","https://openalex.org/W2754585072","https://openalex.org/W170748153","https://openalex.org/W2784115121","https://openalex.org/W3001230339","https://openalex.org/W2284447120"],"abstract_inverted_index":{"New":[0],"oral":[1],"anticoagulants":[2],"(NOACs;":[3],"ie,":[4],"direct":[5],"thrombin":[6],"inhibitor":[7],"[DTI]":[8],"and":[9,25,31,54,64,71,79,100,110,132,139,153,158,164,173,202,209,225,242],"factor":[10],"Xa":[11],"[FXa]":[12],"inhibitors)":[13,30],"were":[14,35,43,51,67,81,91,105,130,150,169,195,237],"used":[15,36,115],"as":[16],"alternatives":[17],"to":[18,52,116],"warfarin.":[19],"Specific":[20],"antidotes":[21,60],"(idarucizumab":[22],"for":[23,28,37,155,162,206,221],"dabigatran":[24],"andexanet":[26],"alfa":[27],"FXa":[29],"hemostatic":[32],"reversal":[33,63,86,133,148,216,222,233],"agents":[34,134,217],"lowering":[38,226],"bleeding,":[39],"but":[40],"their":[41],"efficacies":[42],"still":[44],"uncertain.":[45],"The":[46],"objectives":[47],"of":[48,58,103,144,223,229],"this":[49],"study":[50],"estimate":[53,117],"compare":[55],"the":[56,227],"efficacy":[57],"NOAC":[59],"on":[61,239],"bleeding":[62,224],"death.":[65],"Studies":[66],"identified":[68],"from":[69,107],"MEDLINE":[70],"Scopus":[72],"databases":[73],"until":[74],"May":[75],"2018.":[76],"Case":[77],"reports/series":[78,109,241],"cohorts":[80],"selected":[82,243],"if":[83],"they":[84],"assessed":[85],"or":[87],"death":[88,230],"rates.":[89],"Data":[90],"independently":[92],"extracted":[93,106],"by":[94],"2":[95],"reviewers.":[96],"Individual":[97],"patient":[98],"data":[99,102],"aggregated":[101],"outcomes":[104],"case":[108,146,240],"cohorts.":[111],"Binary":[112],"regression":[113],"was":[114,179],"outcome":[118],"rates,":[119],"risk":[120,228],"ratio":[121],"(RR)":[122],"along":[123],"with":[124],"95%":[125],"confidence":[126],"interval":[127],"(CI).":[128],"Interventions":[129],"NOACs":[131],"(ie,":[135],"DTI-specific,":[136,156,207],"DTI-standard,":[137,167],"FXa-specific,":[138,208],"FXa-standard).":[140],"Among":[141],"220":[142],"patients":[143],"93":[145],"reports/series,":[147],"rates":[149],"95.9%,":[151],"77.6%,":[152],"71.5%":[154],"FXa-standard,":[157],"DTI-standard.":[159,188,212],"Pooled":[160],"RRs":[161,194],"DTI-specific":[163,186],"FXa-standard":[165,210],"versus":[166,187,211],"respectively,":[168],"1.34":[170],"(CI:":[171,175,181,197,200,204],"1.13-1.60)":[172],"1.09":[174],"0.84-1.40).":[176],"Death":[177],"rate":[178],"0.18":[180],"0.06-0.57)":[182],"times":[183],"lower":[184],"in":[185],"For":[189],"pooling":[190],"10":[191],"subcohorts,":[192],"pooled":[193],"1.08":[196],"1.00-1.16),":[198],"1.29":[199],"1.20-1.39),":[201],"1.13":[203],"1.01-1.25)":[205],"In":[213],"conclusion,":[214],"specific":[215],"might":[218],"be":[219],"useful":[220],"than":[231],"standard":[232],"agents.":[234],"Our":[235],"findings":[236],"based":[238],"cohorts,":[244],"further":[245],"comparative":[246],"studies":[247],"are":[248],"thus":[249],"needed.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-09-27T00:00:00"}