{"id":"https://openalex.org/W2889838768","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","title":"Aspirin use and survival in head and neck squamous cell cancer (HNC) patients.","display_name":"Aspirin use and survival in head and neck squamous cell cancer (HNC) patients.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2889838768","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","mag":"2889838768"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.6042","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041917404","display_name":"Hind Rafei","orcid":"https://orcid.org/0000-0002-5724-4183","observed_orcids":["https://orcid.org/0000-0002-5724-4183"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hind Rafei","raw_affiliation_strings":["Department of Medicine, the George Washington University School of Medicine and Health Sciences, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, the George Washington University School of Medicine and Health Sciences, Washington, DC;","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086439595","display_name":"Catherine J. Lumley","orcid":"https://orcid.org/0000-0001-8609-9002","observed_orcids":["https://orcid.org/0000-0001-8609-9002"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Lumley","raw_affiliation_strings":["Medstar Georgetown University Hospital, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medstar Georgetown University Hospital, Washington, DC;","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002841981","display_name":"Jim Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim Han","raw_affiliation_strings":["Georgetown University School of Medicine, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University School of Medicine, Washington, DC;","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045202493","display_name":"Thomas M. Kaffenberger","orcid":"https://orcid.org/0000-0002-8411-6806","observed_orcids":["https://orcid.org/0000-0002-8411-6806"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Kaffenberger","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061694550","display_name":"Jessica H. Maxwell","orcid":"https://orcid.org/0000-0002-5935-0887","observed_orcids":["https://orcid.org/0000-0002-5935-0887"]},"institutions":[{"id":"https://openalex.org/I4210154891","display_name":"Washington DC VA Medical Center","ror":"https://ror.org/050fz5z96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210154891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica H. Maxwell","raw_affiliation_strings":["Washington DC Veterans Affairs Medical Center, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington DC Veterans Affairs Medical Center, Washington, DC;","institution_ids":["https://openalex.org/I4210154891"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"6042","last_page":"6042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.1281999945640564,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.8389999866485596},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9860000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5400000214576721},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.7369999885559082},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.7329999804496765},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hypopharyngeal-cancer","display_name":"hypopharyngeal cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9503724575042725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6618385314941406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5960180759429932},{"id":"https://openalex.org/C2775969662","wikidata":"https://www.wikidata.org/wiki/Q7923600","display_name":"Veterans Affairs","level":2,"score":0.5228710174560547},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5190377831459045},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.49396783113479614},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.47793203592300415},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.477438747882843},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.44535472989082336},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4446740448474884},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4348791539669037},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.42373931407928467},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3210378885269165},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2792450189590454},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2736162841320038},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2500120997428894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.6042","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.6042","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2904198601","https://openalex.org/W3087649685","https://openalex.org/W2736656064","https://openalex.org/W4388767342","https://openalex.org/W7167624363","https://openalex.org/W3034530335","https://openalex.org/W2740067348","https://openalex.org/W3040621349","https://openalex.org/W3201312685","https://openalex.org/W4248881380"],"abstract_inverted_index":{"6042":[0],"Background:":[1],"The":[2,124],"phosphatidylinositol-3-kinase":[3],"(PI3K)":[4],"signaling":[5],"pathway":[6,24],"is":[7,54,359],"the":[8,22,26,48,67,93,250],"most":[9],"common":[10],"genetic":[11],"alteration":[12],"in":[13,16,32,42,310],"HNC,":[14],"particularly":[15],"oropharynx":[17,154],"cancers":[18],"(OPC).":[19],"Up-regulation":[20],"of":[21,28,50,60,89,98,112,357],"PI3K":[23],"enhances":[25],"production":[27],"prostaglandins":[29],"inhibiting":[30],"apoptosis":[31],"cancer":[33,203],"cells.":[34],"We":[35],"hypothesized":[36],"that":[37],"aspirin":[38,324],"(ASA)":[39],"improves":[40],"survival":[41,135,139],"HNC":[43,64,113,214,358],"patients":[44],"(pts)":[45],"by":[46],"counteracting":[47],"effects":[49],"prostaglandins.":[51],"Methods:":[52],"This":[53],"an":[55,327],"IRB-approved":[56],"retrospective":[57],"cohort":[58],"study":[59],"584":[61],"veterans":[62],"with":[63,332,361],"treated":[65],"at":[66],"Washington":[68],"DC":[69],"Veterans":[70],"Affairs":[71],"Medical":[72],"Center":[73],"between":[74,141],"1995":[75],"and":[76,83,91,96,127,137,143,167,180,199,286,335,346,354,364],"2015.":[77],"Charts":[78],"were":[79,114,120,130,174],"reviewed":[80],"for":[81,92,257,273,339],"clinical-pathologic":[82],"treatment":[84,356],"data;":[85],"recurrence/distant":[86],"metastases;":[87],"cause":[88],"death;":[90],"number,":[94],"date":[95],"dose":[97],"ASA":[99,116,175,216,258,294],"prescriptions.":[100],"Pts":[101],"who":[102],"filled":[103],"more":[104,181],"than":[105],"one":[106],"prescription,":[107],"excluding":[108],"refills,":[109],"after":[110,177],"diagnosis":[111,178,353],"considered":[115,121],"users.":[117,123,211],"All":[118],"others":[119],"non-ASA":[122,210],"Kaplan-Meier":[125],"method":[126],"log-rank":[128],"test":[129],"used":[131],"to":[132,183,209,226],"compare":[133],"disease-free":[134],"(DFS)":[136],"disease-specific":[138],"(DSS)":[140],"users":[142,176,195,217,228,240,244,259,263,274,278,295,299,311,315],"non-users.":[144],"Results:":[145],"332":[146],"pts":[147,173],"met":[148],"inclusion":[149],"criteria.":[150],"Primary":[151],"subsites":[152],"included":[153],"(n":[155,159,164,169],"=":[156,160,165,170,187,192,197,231,266,281,302,319],"146),":[157],"larynx":[158],"105),":[161],"oral":[162],"cavity":[163],"62),":[166],"hypopharynx":[168],"19).":[171],"86":[172],"(25.9%)":[179],"likely":[182],"be":[184],"older":[185],"(p":[186,191,196],"0.002),":[188],"African":[189],"American":[190],"0.03),":[193],"never-alcohol":[194],"0.044),":[198],"have":[200],"early":[201],"stage":[202],"(I/II;":[204],"p":[205,230,246,265,280,301,318],"<":[206,247],"0.0005)":[207],"compared":[208,225],"Among":[212,249],"all":[213],"pts,":[215,252],"demonstrated":[218],"significantly":[219,237,291],"better":[220,272],"5-year":[221],"(y)":[222],"DSS":[223,254,305,334,363],"(82%)":[224],"non":[227,243,262,277,298,314],"(43%;":[229],"0.009).":[232],"5-y":[233,253,268,288,304],"DFS":[234,269,289,336],"was":[235,255,270,290,306],"also":[236,271],"higher":[238,256,292,307],"among":[239,293],"(72%)":[241,275],"vs":[242,261,276,297,313],"(39%;":[245,279],"0.001).":[248],"OPC":[251],"(74%)":[260],"(41%;":[264],"0.024).":[267],"0.004).":[282],"For":[283],"stages":[284],"III":[285],"IV,":[287],"(64%)":[296],"(44%;":[300],"0.035).":[303],"as":[308],"well":[309],"(69%)":[312],"(44%)":[316],"but":[317],"0.098.":[320],"On":[321],"multivariate":[322],"analysis,":[323],"use":[325,351],"remained":[326],"independent":[328],"prognostic":[329],"factor":[330],"associated":[331,360],"improved":[333,362],"when":[337],"accounting":[338],"age,":[340],"race,":[341],"gender,":[342],"subsite,":[343],"stage,":[344],"tobacco":[345],"alcohol":[347],"use.":[348],"Conclusions:":[349],"Aspirin":[350],"following":[352],"curative":[355],"DFS.":[365]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-27T00:00:00"}
