{"id":"https://openalex.org/W2889815180","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","title":"The safety and early efficacy of high-dose ipilimumab (IPI) and the combination nivolumab plus ipilimumab (NIVO + IPI) in patients (pts) with uveal melanoma (UM).","display_name":"The safety and early efficacy of high-dose ipilimumab (IPI) and the combination nivolumab plus ipilimumab (NIVO + IPI) in patients (pts) with uveal melanoma (UM).","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2889815180","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","mag":"2889815180"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.9554","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035218748","display_name":"Sapna Pradyuman Patel","orcid":"https://orcid.org/0000-0003-1339-1517","observed_orcids":["https://orcid.org/0000-0003-1339-1517"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sapna Pradyuman Patel","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103818472","display_name":"Isabella Claudia Glitza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabella Claudia Glitza","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030834372","display_name":"Adi K. Diab","orcid":"https://orcid.org/0009-0000-8944-1547","observed_orcids":["https://orcid.org/0009-0000-8944-1547","https://orcid.org/0000-0002-0153-0244"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adi Diab","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029017725","display_name":"Rodabe Navroze Amaria","orcid":"https://orcid.org/0000-0001-6876-278X","observed_orcids":["https://orcid.org/0000-0001-6876-278X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodabe Navroze Amaria","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Davies","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798832","display_name":"Patrick Hwu","orcid":"https://orcid.org/0000-0002-8293-1313","observed_orcids":["https://orcid.org/0000-0002-8293-1313","https://orcid.org/0000-0003-0554-2856"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Hwu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056045921","display_name":"Hussein Abdul-Hassan Tawbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hussein Abdul-Hassan Tawbi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104110089","display_name":"Wen\u2010Jen Hwu","orcid":"https://orcid.org/0000-0003-1674-0751","observed_orcids":["https://orcid.org/0000-0003-1674-0751"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Jen Hwu","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"9554","last_page":"9554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nivolumab-plus-ipilimumab","display_name":"nivolumab plus ipilimumab","score":0.8949999809265137},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7160000205039978},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.902999997138977},{"id":"https://openalex.org/keywords/metastatic-uveal-melanoma","display_name":"metastatic uveal melanoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dose-finding","display_name":"dose-finding","score":0.6110000014305115},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8690000176429749},{"id":"https://openalex.org/keywords/distant-metastasis-free-survival","display_name":"distant metastasis-free survival","score":0.7950000166893005},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8240000009536743},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/vasculitis","display_name":"vasculitis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9328515529632568},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8604746460914612},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.6888144016265869},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6669553518295288},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6389283537864685},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5649042725563049},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43037623167037964},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4192027747631073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36455947160720825},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2887492775917053},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.16181787848472595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.086809903383255}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.9554","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.9554","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947903267","https://openalex.org/W4400272261","https://openalex.org/W4313837504","https://openalex.org/W4411598187","https://openalex.org/W3090387012","https://openalex.org/W4400228063","https://openalex.org/W4379281425","https://openalex.org/W4400116981","https://openalex.org/W4293755174","https://openalex.org/W2891644192"],"abstract_inverted_index":{"9554":[0],"Background:":[1],"UM":[2,56,79,200,375],"metastases":[3],"occur":[4],"in":[5,55,57,109,137,174,208,241,252,319,329,369,374],"50%":[6],"of":[7,28,44,70,75,84,159,199,233,243,266,274,282,315,321,386],"cases":[8],"and":[9,31,42,172,224,270,272,293,337,348],"high-risk":[10,76],"pts":[11,142,201,216,244,322],"are":[12],"identified":[13],"by":[14,126],"a":[15,66,110,144,153,197],"gene":[16,147],"expression":[17,148],"profile.":[18,149],"High-dose":[19,372],"IPI":[20,34,46,50,71,117,128,207,360,373,389],"is":[21],"approved":[22,212],"for":[23,35,72,122,164,182],"adjuvant":[24],"(adj)":[25],"treatment":[26],"(tx)":[27],"cutaneous":[29],"melanoma":[30],"NIVO":[32,48,205,227,358,387],"+":[33,49,112,206,228,359,388],"metastatic":[36],"(met)":[37],"melanoma,":[38],"yet":[39],"the":[40,58,73,165,183,209,267,275,279,283,352,357,384,402],"safety":[41],"efficacy":[43],"high-dose":[45,301],"or":[47,60,380],"has":[51],"not":[52,377],"been":[53],"established":[54],"adj":[59,88],"met":[61,78,92],"settings.":[62],"Methods:":[63],"We":[64],"performed":[65],"phase":[67],"I/II":[68],"trial":[69,284,405],"tx":[74,239],"&":[77,91,101,187,260,365],"(CA184-187).":[80],"The":[81,139,161,179,190],"study":[82,191],"consisted":[83],"two":[85,96],"arms:":[86],"an":[87],"arm":[89,93,108],"(AA)":[90],"(MA)":[94],"with":[95,143,203,300,311,392],"dose":[97,170],"levels,":[98],"3":[99,111,113,120,286,353,363],"mg/kg":[100,354],"10":[102],"mg/kg.":[103,287],"Dose-finding":[104],"proceeded":[105],"on":[106,219,222,226,245,323],"each":[107],"fashion.":[114],"Pts":[115],"received":[116],"once":[118],"every":[119,129],"weeks":[121,131],"four":[123],"doses":[124],"followed":[125],"maintenance":[127],"12":[130],"(for":[132],"up":[133],"to":[134,177,195,238],"one":[135,255,294,332],"year":[136],"AA).":[138],"AA":[140,166],"treated":[141,202,299],"Class":[145],"2":[146],"This":[150],"score":[151],"imparts":[152],"3-year":[154,175],"distant":[155],"metastasis-free":[156],"survival":[157],"(DMFS)":[158],"50%.":[160],"primary":[162,180],"endpoint":[163,181],"was":[167,185,192,350,390],"maximum":[168],"tolerated":[169],"(MTD)":[171],"improvement":[173],"DMFS":[176],"70%.":[178],"MA":[184],"MTD":[186],"overall":[188],"survival.":[189],"later":[193],"amended":[194],"include":[196],"cohort":[198],"combination":[204,385],"standard":[210],"FDA":[211],"schedule.":[213],"Results:":[214],"Ten":[215],"were":[217,298],"enrolled":[218],"AA,":[220],"18":[221],"MA,":[223],"20":[225],"IPI.":[229],"Adverse":[230],"events":[231],"(AEs)":[232],"any":[234,316],"Grade":[235],"(Gr)":[236],"related":[237,249],"occurred":[240,277,318,368],"80%":[242],"AA.":[246],"Gr":[247,317,325,345,362],"3/4":[248,326,346],"toxicities":[250,327],"observed":[251,328],"more":[253,330],"than":[254,331],"pt":[256,289,304,333,342],"were:":[257,334],"transaminitis":[258,364],"(30%)":[259],"pruritus":[261,276],"(20%).":[262],"Of":[263],"these,":[264],"10%":[265,273],"elevated":[268,366],"AST":[269],"ALT":[271],"during":[278],"dose-finding":[280],"portion":[281],"at":[285,351,401],"One":[288,303],"developed":[290,295,305,344],"biopsy-proven":[291],"colitis,":[292],"diarrhea.":[296],"Both":[297],"steroids.":[302],"vasculitis":[306],"manifesting":[307],"as":[308],"temporal":[309],"arteritis":[310],"resultant":[312],"blindness.":[313],"AEs":[314],"44%":[320],"MA.":[324],"Fatigue":[335],"(11%)":[336],"Hyperbilirubinemia":[338],"(11%).":[339],"Only":[340],"1":[341],"(5.6%)":[343],"diarrhea,":[347],"this":[349],"dose.":[355],"In":[356],"cohort,":[361],"TSH":[367],"10%.":[370],"Conclusions:":[371],"did":[376],"demonstrate":[378],"new":[379,394],"unexpected":[381],"toxicities.":[382,395],"Similarly,":[383],"well-tolerated":[391],"no":[393],"Efficacy":[396],"data":[397],"will":[398],"be":[399],"presented":[400],"meeting.":[403],"Clinical":[404],"information:":[406],"NCT01585194.":[407]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-09-27T00:00:00"}
